Особенности взаимодействия когнитивных функций с работой магноцеллюлярной и парвоцеллюлярной нейронных систем у больных шизофренией и больных с эндогенной депрессией

Abstract

The article presents a study devoted to the study of cognitive dysfunctions in patients with schizophrenia and endogenous depression in their relationship with the functioning of the magnocellular and parvocellular systems. Mismatch in the work of neural systems leads to violations of the integrity of visual perception and to a violation of the selectivity of thinking in endogenous patients, which makes it difficult to assess and select meaningful, essential information in the formation of judgments. 60 patients with schizophrenia (43 (75%) male and 17 (25%) female; mean age ― 34.0±12.0 years) and 25 patients with endogenous depression (11 (44%) male and 14 (56%) female, mean age ― 38.0±13.6 years) with the use of psychophysiological (the method of visocontrastometry with an assessment of the contrast sensitivity of the visual system, the method of assessing the noise immunity of the visual system) and experimental psychological methods (Trial-Making test by Reitan, Memorizing 10 words, Poppelreiter's figures, Incomplete images, Excluding the 4th superfluous). The established features of cognitive dysfunctions in endogenous depression and schizophrenia are associated with the features of the functional state of the magnocellular and parvocellular neuronal systems and the nature of the interaction of these systems. The specificity of impairments in cognitive functions in patients with endogenous depression is due to changes in the dynamic component of cognitive activity, while the specificity of impairments in cognitive functions in patients with schizophrenia is associated with changes in the selectivity of information and early sensory defects. The data obtained make it possible to develop an idea of the profiles of sensory-cognitive impairments in endogenous depression and schizophrenia, which is of particular importance for differential diagnosis.