Морфологическая особенность слизистой оболочки барабанной полости при экссудативном среднем отите и ее изменения на фоне ультразвуковой региональной лимфотропной терапии

Abstract

The article presents the comparative results of the morphological studies of the mucous membrane of the tympanic cavity in experimental exudative and purulent otitis media (EOM, POM). Thirty male Wister rats with a body weight between 180 g and 250 g were included into the experiment and divided into four groups, including intact individuals with simulated EOM and POM, ultrasonic regional lymphotropic therapy in EOM modeling. The material for morphological examination taken on the 4th and 12th days was processed according to the standard method and studied by light microscopy at different magnifications (×40, ×100, ×200, ×400). It was shown that in the initial stage (4th day) of the process in the second and third groups a similar reaction takes place in the form of the formation of serous exudate and leukocyte infiltration of the mucous membrane of the tympanic cavity. By the 12th day of the experiment, in each otitis forms, a discrepancy in morphological manifestations was detected, such as sluggish serous inflammation, edema, round cell leukocyte infiltration of the mucoperiost, without pronounced destruction of the epithelial tissue in exudative otitis media; and prominent destruction of the epithelium with disintegration of its deep structures in purulent otitis. Ultrasound regional lymphotropic therapy of exudative otitis media led to a decrease in the severity of the infiltrative reaction and restoration of the integrity of the epithelial layer of the mucous membrane of the tympanic cavity. The conducted studies incline the authors to recognize the inflammatory theory of the pathogenesis of exudative otitis media.