Abstract
The spectral composition of the auditory cortex electrocorticogram (ECoG) was studied in 20- and 30-day-old rabbit pups exposed to hypoxia at different stages of prenatal life. Oxygen deficiency had differential effects on the formation of the auditory cortex ECoG spectrum at the embryonic (E1–8), pre-fetal (E8–18), and fetal (E18–28) stages of prenatal development. These differences were mainly manifested in an increased number of slow waves of electrical activity. Both in 20- and 30-day-old rabbit pups exposed to hypoxia at the embryonic stage, ECoG spectral characteristics insignificantly deviated from the normal level. By contrast, hypoxia experienced at the pre-fetal and fetal stages led to more pronounced, though similar, changes in spectral characteristics. These data suggest that neural structures of the rabbit auditory cortex are more sensitive to oxygen deficiency at the pre-fetal and fetal stages of prenatal development compared to the embryonic stage.
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