Комплекс лікувально-профілактичних заходів для жінок з неалкогольною жировою хворобою печінки на етапі підготовки до програм допоміжних репродуктивних технологій

Abstract

The objective: To evaluate the effectiveness of complex therapeutic and preventive measures for women with non-alcoholic fatty liver disease in preparation for ART programs. Materials and methods. To evaluate the effectiveness of therapeutic and preventive measures on the basis of the prediction algorithm in women with infertility and non-alcoholic fatty liver disease (NAFLD) identified 60 women with a high risk of inefficiencies ART. The method of randomization, patients were divided into: basic group - 30 women with a recommended set of preparations for the holding of ART, the comparison group - 30 women with preparations for ART according to the Ministry of Health protocols. Results. Application reference system in women with infertility and NAFLD, which includes forecasting inefficiency ART and additional therapeutic and preventive measures to include gepatoprotektors, acid ursodeoxycholicum drugs, L-arginine, щ-3 fatty acids and probiotics, helped to improve the overall condition of the woman, a liver condition, cardiovascular regulation reduce symptoms of dysbiosis, hormonal status and reproductive system, as a result, increase the effectiveness of ART programs to population-wide level (pregnancy occurred in 36.7% of women). Conclusions. Prove safety and high efficiency of complex therapeutic and preventive measures for women with infertility and NAFLD can be recommended for implementation in practice of reproductive medicine clinics, which will increase the effectiveness of ART, to preserve a woman’s health. Key words: infertility, assisted reproductive technologies, non-alcoholic fatty liver disease, treatment.