Abstract
At present, there is a close relationship between age-related changes in the endocrine system, metabolic disorders and the development of diseases of internal organs, characteristic of the elderly. Rhythmic extreme cold influence (RECI) (–120°C) are a powerful physiotherapeutic procedure that activates the body's adaptive reserves. However, in opposition the high therapeutic efficacy of the RECI, in some cases the use of extreme cooling, especially in the elderly, is accompanied by the occurrence of side effects. Therefore, the effect of different modes of RECI on the content of hormones and lipids in the blood serum of young and old rats was studied. It has been established that in the young and old animals the use of RECI in temperature regimes (–120°C; –120°C; –120° C) and (–60°C; –120°C; –120°C) led to stable stimulation of the thyroid, adrenal and reproductive system in comparison with the (–60°C; –60°C; –60°C). At the same time, the regime (–60°C; –120°C; –120°C) had a "milder" effect on the lipid profile of the blood serum of young and old rats, since it was not accompanied by a pronounced stress reaction of the organism in the form of hyperlipidemia. Probl Cryobiol Cryomed 2019; 29(3): 206–220.
Highlights
Rhythmic extreme cold exposures (RECE) (–120°C) are a powerful physiotherapeutic procedure, activating the body’s adaptive reserves
We have found that one week after 9 procedures of RECE by the temperature regimen of –120; –120; –120°C (Table 1), the level of T3 and T4 in blood serum of young rats decreased relative to the indices of the control animals
We demonstrated that one week after RECE performance to young rats (Table 1) at temperature regimens of –120; –120; –120°С and –60; –120; –120°C the DHEA level in blood serum significantly augmented
Summary
Rhythmic extreme cold exposures (RECE) (–120°C) are a powerful physiotherapeutic procedure, activating the body’s adaptive reserves. A combined regimen of –60; –120; –120°C caused a ‘milder’ effect on lipid profile of blood serum of young and aged rats, because no stress response of a body as a hyperlipidemia occurred. Thyroid hormones are involved into regulation and coordination of the main homeostasis-providing body functions They actively affect the state of the autonomic nervous system under various stressful situations, implementing thereby an adaptive function of body, they enhance or sup-. Вследствие угнетения тиреотропной функции нарушается тиреоидная регуляция обменных процессов, изменяется чувствительность органов-мишеней к действию гормонов [17]
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