Abstract
Многоцентровое проспективное эскалационно- деэскалационное исследование с ПЭТ контролем при классической лимфоме Ходжкина в Северо-Западном Федеральном Округе Российской Федерации (RNWOHG-HD1): обоснование и дизайн
Highlights
Treatment of classical Hodgkin’s disease (HD) is one of the successful stories in hematology
This led to development of more intensive protocols, like BECOPP [3], and subsequently BEACOPPescalated and BEACOPP14 [4] that produced failure-free-survival (FFS) of 85-89% in advanced HD
The omission of radiotherapy after 4xBEACOPPesc is based on German Hodgkin Study Group (GHSG) HD12 trial, where there was no difference in FFS between radiotherapy and stop therapy groups [17]
Summary
Treatment of classical Hodgkin’s disease (HD) is one of the successful stories in hematology. Hodgkin’s disease, multicenter study, positron emission tomography (PET), RNWOHG-HD1. This finding was the foundation of several escalation studies [10,11] where absence of complete response led to switching therapy from ABVD to BEACOPPesc.
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