ОЦЕНКА ПРО-/АНТИОКСИДАНТНОГО СТАТУСА И ПОКАЗАТЕЛЕЙ ФУНКЦИОНАЛЬНОЙ АКТИВНОСТИ НЕЙТРОФИЛЬНЫХ ЛЕЙКОЦИТОВ У ДЕТЕЙ С ОСТРОЙ ПНЕВМОНИЕЙ В ЗАВИСИМОСТИ ОТ ЭТИОЛОГИЧЕСКОГО ФАКТОРА

Abstract

Background. At the moment, an important task of pediatric pulmonology is to closely study a wide range of pathogenetic and etiological mechanisms through which the effects of the inflammatory process are realized, immunological disorders and changes in the pro-/antioxidant status in the body are determined. Objective. To evaluate the indicators of the functional activity of neutrophil leukocytes and the pro-/antioxidant status in children with acute pneumonia, depending on the etiological factor. Material and methods. The main group consisted of 60 patients diagnosed with acute pneumonia. The evaluation of the indicators of the functional activity of neutrophil leukocytes and the pro-/antioxidant status, depending on the etiological factor, was carried out. Results. When assessing the pro-/antioxidant status, a decrease in the stability of the pro-/antioxidant balance, the power of the antioxidant system and the initial anti-radical activity was noted in the group of atypical pathogens, and a decrease in the functional activity of neutrophils was also determined, an increase in the activity for the formation of reactive oxygen species increased, as well as an increase in the level of NET-forming ability of neutrophils. Conclusion. Complex violations of the pro-/antioxidant status and indicators of the functional activity of neutrophil leukocytes were observed only in acute community-acquired pneumonia caused by atypical pathogens – M. Pneumoniae, Chl. Pneumoniae.