Особенности хориоидального кровотока и их влияние на формирование периферических дегенераций сетчатки у детей школьного возраста с недифференцированной дисплазией соединительной ткани

Abstract

Purpose. To study choroidal thickness (CT) and assess its effect on frequency of occurrence dangerous types of peripheral retinal degenerations (PRD) in school-age children with myopia associated with undifferentiated connective tissue dysplasia (UCTD). Material and methods. The object of study was 62 children (124 eyes) aged 10–15 years (mean age 12.3±0.8 years) with progressive myopia associated with moderate (48 people, 77.4%) and pronounced (14 people, 22.6%) degree of UCTD. Special ophthalmologic examination included macular imaging by optical coherence tomography (RTVue 100, «Optovue», USA) to measure CT. Diagnostic criteria by T.M. Milkovskaya-Dimitrova et al (1987) were used to identify phenotypic characters of UCTD. Results. Comparative characteristic of CT in macula showed high (p <0.05) relationship between the blood-filled of choroidal vessels and degree of UCTD. Analysis frequency of occurrence of PRD depending on CT demonstrated that against the background accumulation of phenotypic characters of UCTD increase in frequency of occurrence of PRD was observed. Statistical analysis confirmed presence of significant negative correlation between decrease CT and increase in incidence of prognostically dangerous forms of PRD. Conclusion. It was found that in school-age children with myopia with increase degree of UCTD, CT decreases. With choroidal thinning in children with myopia associated with UCTD, the frequency of occurrence dangerous forms of PRD increases. The research results are of clinical importance for the development of rational approaches to clinical examination and treatment children with school myopia with clinical signs of UCTD. Key words: progressive myopia, undifferentiated connective tissue dysplasia, choroidal thickness, peripheral retinal degeneration, rhegmatogenous retinal detachment.