Особенности атеросклеротического поражения коронарных артерий у пациентов с ранним развитием острого коронарного синдрома среди носителей различных полиморфных вариантов генов ангиогенеза

Abstract

The purpose was to examine atherosclerotic changes in the anatomy of coronary arteries in patients with early acute coronary syndrome among carriers of different genotypes: rs3825807 of the ADAMTS7 gene and rs699947 of the VEGF-A gene.The study included 116 patients, 69 (59%) men and 47 (41%) women with the first manifestation of acute coronary syndrome (ACS) before 55 years and 65 years respectively. Coronary angiography revealed at least one stenosis ≥ 40% in all patients during in-house treatment. The genotype of rs3825807 ADAMTS7 gene and rs699947 VEGF-A gene was determined by PCR in all patients. The prevalence of CC genotype rs699947 VEGF-A gene in patients with left circumflex artery stenosis was less than in patients without such a lesion (0.26 versus 0.46, p = 0,03; OR = 0,419; 95% CI: 0,187–0,941). The prevalence of TT genotype rs3825807 ADAMTS7 gene in patients with early manifestation of ACS with stenosis of the posterior basal branch and posterior interventricular branch of the right coronary artery was significantly higher (0,78 versus 0,35, p = 0,027) than in patients without these lesions (OR = 6,36; 95% CI: 1,27–32,59). Thus, with the development of acute coronary syndrome in men up to 55 years old, in women up to 65 years old, the carriage of the Аallele rs699947 VEGF-A gene is associated with lesions of left circumflex artery, and the carriage of TT genotype rs3825807 ADAMTS7 gene is associated with lesions of the posterior interventricular branch and the posterior basal branch of the right coronary artery.