ЛАТЕНТНАЯ ТУБЕРКУЛЕЗНАЯ ИНФЕКЦИЯ У ЛИЦ С НАЛИЧИЕМ ОСТАТОЧНЫХ ПОСТТУБЕРКУЛЕЗНЫХ ИЗМЕНЕНИЙ В ОРГАНАХ ДЫХАНИЯ ПО ДАННЫМ КОЖНОЙ ПРОБЫ С ПРЕПАРАТОМ ДИАСКИНТЕСТ®

Abstract

Aim: to study the prevalence of latent tuberculosis infection (LTI) among individuals with residual post-tuberculosis changes in the lungs and assess the effectiveness of the Diaskintest® for LTI detection. Materials and methods. We carried out a retrospective analysis of results of the skin test with recombinant tuberculosis allergen (RTA), i.e. Diaskintest®, in 181 patients (109 men and 72 women) with residual post-tuberculosis changes in the lungs in 2011–2022. The study did not include household or occupational contacts of active TB patients or HIV-infected individuals. Results. We established LTI in 52.5% of individuals with residual post-tuberculosis changes in the lungs. LTI was common among young men (56%) with history of active TB and TB treatment (69%), and those with large residual changes (57.3%). The frequency of LTI detection in individuals with inactive residual post-tuberculosis changes in the lungs allowed classifying them as high riskgroup for TB recurrence. This group requires dynamic observation including yearly fluorography screening and sputum examination for M. tuberculosis detection. Conclusion. Frequent detection of LTI among individuals with residual post tuberculosis changes in the lungs justifies the use of the Diaskintest® during dynamic follow-up of this group, which is predisposed to TB recurrence.