Оксидативний стрес як важливий патогенетичний механізм розвитку змін репродуктивного здоров’я у жінок з соматоформними захворюваннями та порушенням вегетативного гомеостазу

Abstract

The objective: to investigate the status of phospholipids and neutral lipids of blood cells in fertile aged women with violation of autonomic homeostasis and changes in reproductive health. Patients and methods. We examined 360 women with violation of autonomic homeostasis in the form of autonomic dysfunction syndrome and somatofom dysfunction of the autonomic nervous system of hypertonic, hypotonic and cardiac type and changes in reproductive health such as: artificial abortions, infertility and uterine leiomyoma. Results. The article presents data from a study of lipid peroxidation of cell membranes in fertile aged women with violation of autonomic homeostasis and changes in reproductive health. The obtained data of decay products concentrations of phospholipids and neutral lipids of cellular membranes indicate the ravages of free radical compounds to form intermediates and final products of lipid peroxidation. The results confirm the role of oxidative stress as an important pathogenetic mechanism of changes in the reproductive health of women with somatoform disorders and violations of autonomic homeostasis. Conclusion. Changes in the concentration of phospholipids, neutral lipids and lipid peroxidation products indicate a destabilizing effect on cell membranes in women with violation of autonomic homeostasis and reproductive health changes. Increasing the number of phospholipid degradation products show a decrease in the liquid component of cell membranes, which in turn changes the nature receptor interaction, as evidenced by a study hormonal and leads to disruption of feedback mechanisms concentration of hormones in the blood. Key words: oxidative stress, lipid peroxidation, women of fertile age, violations of autonomic homeostasis, changes in reproductive health.