ВЕРОЯТНОСТЬ ИЗМЕНЕНИЯ ПОКАЗАТЕЛЕЙ ФУНКЦИИ ВНЕШНЕГО ДЫХАНИЯ ПРИ РАЗВИТИИ ХОБЛ В ЗАВИСИМОСТИ ОТ КОЛИЧЕСТВА ВЫКУРИВАЕМЫХ СИГАРЕТ НА ФОНЕ ГОРМОНАЛЬНЫХ ИЗМЕНЕНИЙ ПРИ БЕРЕМЕННОСТИ

Abstract

Introduction. This is a study of possible changes in the respiration function indicators in the development of chronic obstructive pulmonary disease (COPD), depending on the number of cigarettes smoked and associated with pregnancy-related hormone fluctuations. Aim. Our study aimed to determine the dependence of changes in first- second forced expiratory volume upon the level of anti-inflammatory hormones cortisol and progesterone in female smokers with different number of cigarettes smoked. Materials and Methods. The study is based on the findings of the analysis of changes in the level of hormones cortisol and progesterone in 243 pregnant women in antenatal care and on how such changes affect the first-second forced exhalation volume. The control group consisted of healthy non-smoking female patients. 4 groups were formed. For each group, the expected values of the first-second forced exhalation volume were calculated, in parallel with changes in the cortisol and progesterone profile and with forming the relevant statistical data matrices. Results and Discussion. With an increase in cortisol and progesterone levels, there is an increase in the first-second of forced exhalation volume, which indicates an increase in the lung tissue elasticity and in the air flow rate in the first second under the influence of hormones that have a pronounced anti-inflammatory effect. Conclusion. Pregnancy progress in smokers consuming different amounts of cigarettes is accompanied by an increase in the cortisol and progesterone levels. Hormone fluctuations improve the functional state of external respiration in pregnant smokers with COPD, creating the illusion of preserving the physiological capabilities of lungs regardless of the number of cigarettes smoked. With this variant of the COPD developing during pregnancy, a temporary physiological increase in the anti-inflammatory hormonal profile masks the extent, to which the number of cigarettes smoked affects the COPD severity.