Влияние накопления железа в базальных ганглиях на функциональность белого вещества головного мозга у пациентов на ранней и развернутой стадиях болезни Паркинсона

Abstract

Aim: to assess the effect of iron deposition in the basal ganglia on white matter functions at stages 2 and 3 of Parkinson’s disease using susceptibility-weighted imaging (SWI) and diffusion tensor imaging (DTI) MRI. Patients and Methods: ninety-two patients with Parkinson’s disease (42 patients with Hoehn and Yahr stage 2 and 50 patients with Hoehn and Yahr stage 3) were examined. All patients underwent MRI (Magnetom Trio A Tim 3.0T, Siemens, Germany). The parameters of the SWI pulse sequence were as follows: TR (ms): 28, TE (ms): 20, flip angle: 15, slice thickness (mm): 1, voxel size (mm): 0.71875×0.71875, number of slices: 88. In addition, DTI MRI measured fractional anisotropy of brain pathways to assess the functions and integrity of the white matter. Results: our findings demonstrate a strong association between iron deposition in the basal ganglia and brain pathway dysfunctions. These dysfunctions account for many symptoms occurring in early and late Parkinson’s disease. In addition, the study revealed correlations demonstrating the coexistence of iron deposition progression in the extrapyramidal system and the reduction in white matter fractional anisotropy. Conclusions: our findings provide novel data on the pathogenesis of Parkinson’s disease and allow for assessing neuroimaging patterns at various disease stages and explaining clinical phenomena occurring in Parkinson’s disease. KEYWORDS: Parkinson’s disease, iron deposition, susceptibility-weighted imaging (SWI), magnetic resonance imaging, diffusion tensor imaging (DTI). FOR CITATION: Buryak A.B., Trufanov A.G., Rashidova S.N. et al. Effects of iron deposition in the basal ganglia on white matter functions in early and advanced stages of Parkinson’s disease. Russian Medical Inquiry. 2021;5(10):623–629 (in Russ.). DOI: 10.32364/2587- 6821-2021-5-10-623-629.