Abstract
The relation between maternal immune response to bacterial, viral and other antigens in pregnancy and postnatal development and function of offspring immune system is little studied. The aim of the research was to study morphological changes of the thymus in the offspring of female mice exposed in early pregnancy single immune-stimulated у effects of T-cell mitogen concanavalin, and control of females after the introduction of the half-lethal dose of endotoxin gram-negative bacteria. The experiment was performed in 44 male C57BL/6 mice at the age of 2,5 weeks. The animals were removed from the experiment through 24 and 48h. after the introduction of lipopolysaccharide of E. coli in a dose of 15 mg/kg. Morphological and histological, physiological changes of thymus mice in the control and experimental groups have similar nature (thymic involution, migration mature thymocytes, reducing the number of fat cells). In the offspring exposed to prenatal exposure, thymic involution and migration mature thymocytes are developing more slowly and to a lesser extent. These data show a decrease in the immune system reactivity offspring subjected to early prenatal development of a massive influence of cytokines secreted by their mother´s lymphocytes under the influence of concanavalin A.
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