Abstract
Background: Endothelial dysfunction is the main link in the development of cardiovascular diseases, which leads to ischemic heart disease (coronary artery disease) and its complications. There are many medicines available for the treatment of coronary artery disease. However, not all groups of drugs are able to positively affect endothelial function. Purpose. Based on the literature data, to study the effect of the main groups of drugs for the treatment of coronary artery disease on endothelial function and systemic hemodynamics in cardiac surgery patients after myocardial revascularization. Material and methods: The review and analysis of literature data from 46 sources are presented. Results: Angiotensin converting enzyme receptor inhibitors, calcium sensitizers, phosphodiesterase type III inhibitors as well as beta blockers have a positive effect on endothelial function. Nitrates have a negative effect on its function in conditions of critical circulation and should be used with caution in endothelial dysfunction. Conclusion: The data obtained indicate a positive effect of angiotensin converting enzyme receptor inhibitors, calcium sensitizers, type III phosphodiesterase inhibitors and beta blockers on endothelial function. However, these groups of drugs can negatively affect systemic hemodynamics in the perioperative period, which requires a deliberate approach when prescribing them.
Highlights
Endothelial dysfunction is the main link in the development of cardiovascular diseases, which leads to ischemic heart disease and its complications
Levosimendan induces NO production through p38 MAPK, ERK and Akt in porcine coronary endothelial cells: role for mitochondrial K(ATP) channel / E
The authors declare no conflict of interest
Summary
Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects / A. Levosimendan induces NO production through p38 MAPK, ERK and Akt in porcine coronary endothelial cells: role for mitochondrial K(ATP) channel / E. Grossini [et al.] // British Journal of Pharmacology. Effects of levosimendan on flow-mediated vasodilation and soluble adhesion molecules in patients with advanced chronic heart failure / J. Levosimendan exerts anti-inflammatory effects on cardiac myocytes and endothelial cells in vitro / K. Leppikangas [et al.] // British Journal of Anaesthesia.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
