Abstract
The effect of repeated peripheral inflammatory pain in newborn female rats, born to mothers subjected to chronic stress during pregnancy, was investigated on the adaptive behavior and cognitive abilities of the females when they reached prepubertal period of development. In addition, the effect of drugs (serotonin (5-HT) reuptake inhibitor antidepressant fluoxetine and an agonist 5-HT1A receptor anxiolytic buspirone) injected to the stressed pregnant dams was studied on the offspring behavior. The obtained new data on the effect of stress in the perinatal critical period of individual development on adaptive behavior and ability for spatial learning support the hypothesis of the possible beneficial effect of moderate stressful events at an early age on stress tolerance in subsequent ontogenesis. The effect of the applied drugs on the studied adaptive behavior and cognitive abilities of prenatally stressed offspring subjected to inflammatory pain in newborn state is characterized.
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