Abstract
The publication is devoted to the study of markers of endothelial function, pro- and anti-inflammatory cytokines in patients with chronic obstructive pulmonary disease depending on the severity of chronic respiratory failure and disorders of arterial blood hemoglobin oxygen saturation. The authors established a decrease in the activity of cellular immunity, insufficient activation of humoral immunity, decrease in antioxidant protection and anti-inflammatory activity of the immune system. Signs of the key link in the development of atherosclerosis – endothelial dysfunction – were revealed in patients with COPD. The results of the study suggest that the degrees of chronic respiratory failure are interrelated with the stages of atherosclerotic process development. Disturbances of hemoglobin saturation of arterial blood with oxygen and pronounced degrees of chronic respiratory failure are considered as factors contributing to the stage of atheromatosis, which underlies the formation of unstable atherosclerotic plaque.
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