ОСОБЕННОСТИ МИКРОБИОЦЕНОЗА ТОЛСТОГО КИШЕЧНИКА У ДЕТЕЙ ПЕРВОГО ГОДА ЖИЗНИ С ФУНКЦИОНАЛЬНЫМИ НАРУШЕНИЯМИ ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА НА ФОНЕ ВЫСОКОЙ ПОПУЛЯЦИОННОЙ ПЛОТНОСТИ БАКТЕРИЙ РОДА KLEBSIELLA

Abstract

The aim of the research was to determine the features of large intestinal microbiocenosis during the vegetation of bacteria of the genus Klebsiella in children with functional disorders of the gastrointestinal tract in different age periods of the first year of life. The material for the study is based on 210 coprological samples isolated from infants of both sexes with functional disorders of the gastrointestinal tract and indication of Klebsiella spp. in the titer of 105-108 CFU/g. The children were grouped according to the age: 1st − children from 1 to 3 months old, 2nd − children from three to six months old, 3rd − children from 6 to 12 months old. All of them were divided into two groups for comparison, depending on the type of isolated Klebsiella species: K. pneumoniae (n=105) and K. oxytoca (n=105). The investigation of the intestinal microflora was performed in accordance with conventional methodology, and the assessment of the results was done according to Industry Standard. Identified bacteria were divided by their morphologic, tinctorial, cultural and biochemical properties. As a result of the study, dysbiotic disturbances of the 3rd degree were observed in children, complicated by the proliferation of bacteria of the genus Klebsiella, especially by its diagnostically important bacterial agent K. oxytoca. Most critical for the development of functional disorders of the gastrointestinal tract for the children of the first year of life is the age of 3-6 months. Long-term persistence of the Klebsiella spp. in high titer (105-108 CFU/g) in the large intestine of the children with functional disorders of the gastrointestinal tract dictates the need for selective decontamination of the Klebsiella from the gut microbiota.