Динамика состояния кожи нижних конечностей у пациентов с хронической венозной недостаточностью на фоне применения негормонального противовоспалительного и увлажняющего средства на основе нафталанской нефти

Abstract

Background: chronic venous insufficiency with venous hypertension results in skin trophic changes as well as the proliferation and keratinization of epidermal cells that leads to multiple microinjuries. These microinjuries are a portal of entry for secondary infections. A group of medicines, skin protectors, aims to normalize these processes. Medications that improve skin regeneration and also demonstrate anti-inflammatory and antibacterial effects are of particular interest. Aim: to assess the effect of 3% naphthalan cream Losterin on the skin of the lower extremities in patients with chronic venous insufficiency. Patients and Methods: 15 patients (5 men and 10 women, mean age 67.27±1.03 years) were examined. All participants applied Losterin® on the right tibial and foot skin while the left lower limb was the control. Optical coherence tomography (OCT) of symmetrical tibial and foot skin areas was performed before and after one week of the treatment to evaluate its efficacy. The brightness, height, and border sharpness of skin layers as well as blood vessels were assessed. Results: all patients reported on the improvement of dryness, itching, desquamation, and skin elasticity after the topical treatment versus no-treatment. OCT performed after one week of the treatment with Losterin demonstrated less edema, lower height and brightness of the 1st and 2nd optical layers thus illustrating reduced hyperkeratosis. Additionally, reduced stratum corneum thickness was revealed after the topical treatment. Conclusions: Losterin allows for higher efficacy of the complex treatment for chronic venous insufficiency by reducing the risk of skin microinjuries, regenerating the hydrolipid mantle of the skin, and improving physiological desquamation. Moreover, subjective perceptions are fully in line with OCT findings. KEYWORDS: Losterin, skin protectors, optical coherence tomography, trophic ulcers, venous hypertension. FOR CITATION: Petrova K.S., Nemirova S.V., Islamov R.A., Karpenko A.A. Dynamics of skin lesions of the lower leg in patients with chronic venous insufficiency after the applications of a non-hormonal anti-inflammatory moisturizer based on naphthalan oil. Russian Medical Inquiry. 2020;4(10):632–636. DOI: 10.32364/2587-6821-2020-4-10-632-636.