Abstract
to assess in patients with arterial hypertension and type 2 diabetes the effect of perindopril / amlodipine fixed combination on arterial wall stiffness (AWF) and microcirculation, and relationship between AWF parameters and the state microcirculation. We included in this study 30 patients aged 45-65 years. All patients received fixed perindopril arginine / amlodipine besylate combination for 12 weeks. Examination included measurement of AWF of main arterial blood vessels and evaluation of the state of microcirculation. Target blood pressure was achieved in 100 % of patients. Mean values of pulse wave velocity of elastic and muscle-type vessels decreased by 8.5 and 10.3 %, respectively; number of patients with paradoxical test also significantly decreased (p>0.05). Shunting index and myogenic tone significantly decreased by 21 and 33.6 %, respectively. We also observed significant reduction of endothelium-dependent tone component (Δ%=36.3 %), significant rise of mean value of perfusion (Δ%=19.7 %), and significant increase of the respiratory test index (Δ%=4.5 %). There was a statistically significant redistribution of patients by types of microcirculation: the percentage of patients with hyperemic type increased from 26.7 to 43.3 %. In patients with arterial hypertension and type 2 diabetes mellitus perindopril arginine / amlodipine besylate fixed combination demonstrated high antihypertensive efficacy, positive effect on parameters of elasticity of main vessels and microcirculation.
Highlights
We included in this study 30 patients
Target blood pressure was achieved in 100 % of patients
Отмеченные особенности терапии с применением комбинации периндоприла аргинат / амлодипина бесилат могут способствовать уменьшению прогрессирования как макро-, так и микрососудистых осложнений у больных артериальной гипертензией и сахарным диабетом 2‐го типа
Summary
Цель исследования: оценить влияние 12‐недельной терапии с применением фиксированной комбинации периндоприла с амлодипином на жесткость артериальной стенки и микроциркуляцию у больных АГ и СД 2‐го типа. Что улучшения как микро-, так и макрокровотока в группе больных с АГ и СД 2‐го типа на фоне 12‐недельной терапии с применением фиксированной комбинации периндоприла аргинат и амлодипина бесилат благоприятно коррелируют между собой.
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