Abstract
From the perspective of evidence-based medicine, it is recommended that each patient receive all the components of guideline-directed medical therapy (GDMT) that have been proven to have a positive impact on morbidity and mortality. Individualization of treatment is considered a useful tool for achieving GDMT in patients with tolerability issues. Tailoring the treatment approach to the individual characteristics of patients with progressive chronic heart failure (CHF), as well as incorporating innovative strategies targeting different pathways of CHF with vericiguat, can lead to improved prognosis in patients with CHF. The VICTORIA algorithm was developed to identify patients with advanced HF for whom vericiguat may be most effective. The core concept of the VICTORIA algorithm is that most patients with HF are elderly individuals with multiple comorbidities who require pharmacotherapy, leading to a significant increase in the risk of side effects, tolerability issues, and drug interactions. Consequently, the majority of patients are not prescribed drugs at target doses. In such cases, vericiguat will be the drug of choice to either replace or supplement the current treatment.
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