Restricted Repetitive Behaviors Research Articles

Benefit or Problem: Exploration of How Response Options Affect Self-Reported Behaviors and Interests in Autistic Adults.

Assessment of restricted, repetitive behaviors (RRB) in autism evaluations often assumes that these behaviors negatively impact the individual. Qualitative studies of first-person accounts indicate the negative impact of the stigma associated with RRBs but also provide insights into the positive aspects. The current study explores how framing response options as negative (i.e., level of problem associated with occurrence) or positive (i.e., level of benefit associated with occurrence) affects RRB self-reports in autistic adults. Sixty-six autistic adults aged 18-59 filled out the Repetitive Behavior Scale-Revised (RBS-R) and a modified RBS-R+, assessing problems and benefits of reported behaviors, respectively. There was a moderate to strong correlation between the forms, each assessing problems and benefits in terms of the number of behaviors endorsed (r = 0.746) and the levels of benefits and problems (r = 0.637). Autistic adults reported a higher number of RRBs in the form that assessed problems, but the number of behaviors was comparable between the forms when counting in the response option of the occurrence of behavior without having a benefit. Despite some variability in the level of problems and the benefits across the subdomains of RRB, autistic adults largely rated comparable levels of associated benefits and problems, highlighting the complexity of RRBs as having both positive and negative impacts. Future screening and diagnostic tools for adults should aim to assess both positive and negative aspects of autistic features to afford a more nuanced understanding of individual experiences while still yielding diagnostically relevant information. Qualitative studies are needed to better understand the complex experiences associated with these behaviors; however, it may be important to ensure that options for endorsement of behaviors without a specific benefit are also needed to ensure some behaviors (e.g., self-injurious behaviors) are not missed.

Family-Centric Applied Behavior Analysis Facilitates Improved Treatment Utilization and Outcomes.

Background/Objective: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by lifelong impacts on functional social and daily living skills, and restricted, repetitive behaviors (RRBs). Applied behavior analysis (ABA), the gold-standard treatment for ASD, has been extensively validated. ABA access is hindered by limited availability of qualified professionals and logistical and financial barriers. Scientifically validated, parent-led ABA can fill the accessibility gap by overcoming treatment barriers. This retrospective cohort study examines how our ABA treatment model, utilizing parent behavior technicians (pBTs) to deliver ABA, impacts adaptive behaviors and interfering behaviors (IBs) in a cohort of children on the autism spectrum with varying ASD severity levels, and with or without clinically significant IBs. Methods: Clinical outcomes of 36 patients ages 3-15 years were assessed using longitudinal changes in Vineland-3 after 3+ months of pBT-delivered ABA treatment. Results: Within the pBT model, our patients demonstrated clinically significant improvements in Vineland-3 Composite, domain, and subdomain scores, and utilization was higher in severe ASD. pBTs utilized more prescribed ABA when children initiated treatment with clinically significant IBs, and these children also showed greater gains in their Composite scores. Study limitations include sample size, inter-rater reliability, potential assessment metric bias and schedule variability, and confounding intrinsic or extrinsic factors. Conclusion: Overall, our pBT model facilitated high treatment utilization and showed robust effectiveness, achieving improved adaptive behaviors and reduced IBs when compared to conventional ABA delivery. The pBT model is a strong contender to fill the widening treatment accessibility gap and represents a powerful tool for addressing systemic problems in ABA treatment delivery.

The Efficacy of Music Therapy Programs on the Development of Social Communication in Children with Autism Spectrum Disorder: A Systematic Review

Autism spectrum disorder (ASD) in children is characterized by difficulties in social communication and restricted repetitive behavior patterns. Music therapy appears to have beneficial effects in the area of social interaction and communication. The aim of this systematic literature review is to investigate the effectiveness of music therapy programs on the development of social communication among preschool- and school-aged children with ASD. For this purpose, a detailed study of the relevant literature that has been published in the last decade in peer-reviewed scientific journals was conducted. Web of Science, Springer Link, PsyINFO, and ERIC databases were searched, and according to the eligibility and exclusion criteria, 12 studies were finally selected from the 167 initially found. From the analysis of the results, the following categories were defined to contribute to enhancing social communication: (a) improvisational music therapy; (b) joint attention and eye contact; (c) therapeutic relationship, synchronization, and attunement; (d) imitation; (e) understanding and interaction; (f) family-centered music therapy; and (g) language and socioemotional adjustment. The results of the review were mixed, as music therapy appeared to have a positive effect on improving the social communication of children with ASD, but a general conclusion could not be drawn about the degree of its effectiveness compared to the standard treatments that children usually receive. In the future, further research in this field, especially on the improvisational music Therapy technique, is recommended. Moreover, an increased focus on the development of a common methodological practice regarding the sample selection process and measurement tools is suggested.

The Connection Between Sleep Problems and Emotional and Behavioural Difficulties in Autistic Children: A Network Analysis.

The interactions between sleep problems, autism symptoms and emotional and behavioural difficulties were explored using network analysis in 240 autistic children (mean age: 8.8 years, range 5-13 years) with moderate to severe sleep problems. Findings revealed a highly connected and interpretable network, with three separate clusters identified of the modelled variables. Depression, anxiety and behavioural difficulties were the most central variables of the network. Depression, anxiety and restricted repetitive and stereotyped patterns behaviours (RRBs) were the strongest bridging variables in the network model, transmitting activation both within and between other symptom clusters. The results highlight that depression and anxiety were highly connected symptoms within the network, suggesting support in these areas could be helpful, as well as future research.

Effects of hyperbaric oxygen therapy on autistic behaviors and GRIN2B gene expression in valproic acid-exposed rats.

Autism is a complex neurodevelopmental condition characterized by deficits in social interaction, communication, and restricted repetitive behaviors. Hyperbaric oxygen therapy (HBOT) has emerged as a potential treatment for autism, although its effects on behavior and gene expression are not well understood. The GRIN2B gene, known for its involvement in encoding a glutamate receptor subunit crucial for neuron communication and associated with autism, was a focus of this study. Using a rat model induced by prenatal exposure to valproic acid, we examined the impact of HBOT on autism-like behaviors and GRIN2B gene expression. Male Wistar rats were categorized into four groups: control, VPA (valproic acid-exposed), VPA+HBOT [2 atmosphere absolute (ATA)], and VPA+HBOT (2.5 ATA). The rats underwent several behavioral tests to assess social behavior, anxiety, stereotype and exploratory behaviors, and learning. Following the behavioral tests, the HBOT groups received 15 sessions of HBOT at pressures of 2 and 2.5 (ATA), and their behaviors were re-evaluated. Subsequently, real-time PCR was employed to measure GRIN2B gene expression in the frontal lobe. Our results indicated that HBOT significantly increased social interaction and exploratory behaviors in VPA-exposed rats, alongside elevated GRIN2B gene expression in their frontal lobe. Our findings imply that HBOT might have a potential role in ameliorating autism-related behaviors in the VPA rat model of autism through potential modulation of GRIN2B gene expression. However, additional research is essential to fully comprehend the underlying mechanisms and refine the HBOT protocol for optimizing its effectiveness in improving autism-related symptoms.

Dietary intake and gastrointestinal symptoms are altered in children with Autism Spectrum Disorder: the relative contribution of autism-linked traits

BackgroundDietary and gastrointestinal (GI) problems have been frequently reported in autism spectrum disorder (ASD). However, the relative contributions of autism-linked traits to dietary and GI problems in children with ASD are poorly understood. This study firstly compared the dietary intake and GI symptoms between children with ASD and typically developing children (TDC), and then quantified the relative contributions of autism-linked traits to dietary intake, and relative contributions of autism-linked traits and dietary intake to GI symptoms within the ASD group.MethodsA sample of 121 children with ASD and 121 age-matched TDC were eligible for this study. The dietary intake indicators included food groups intakes, food variety, and diet quality. The autism-linked traits included ASD symptom severity, restricted repetitive behaviors (RRBs), sensory profiles, mealtime behaviors, and their subtypes. Linear mixed-effects models and mixed-effects logistic regression models were used to estimate the relative contributions.ResultsChildren with ASD had poorer diets with fewer vegetables/fruits, less variety of food, a higher degree of inadequate/unbalanced dietary intake, and more severe constipation/total GI symptoms than age-matched TDC. Within the ASD group, compulsive behavior (a subtype of RRBs) and taste/smell sensitivity were the only traits associated with lower vegetables and fruit consumption, respectively. Self-injurious behavior (a subtype of RRBs) was the only contributing trait to less variety of food. Limited variety (a subtype of mealtime behavior problems) and ASD symptom severity were the primary and secondary contributors to inadequate dietary intake, respectively. ASD symptom severity and limited variety were the primary and secondary contributors to unbalanced dietary intake, respectively. Notably, unbalanced dietary intake was a significant independent factor associated with constipation/total GI symptoms, and autism-linked traits manifested no contributions.ConclusionsASD symptom severity and unbalanced diets were the most important contributors to unbalanced dietary intake and GI symptoms, respectively. Our findings highlight that ASD symptom severity and unbalanced diets could provide the largest benefits for the dietary and GI problems of ASD if they were targeted for early detection and optimal treatment.

Combined repetitive transcranial magnetic stimulation and gut microbiota modulation through the gut-brain axis for prevention and treatment of autism spectrum disorder.

Autism spectrum disorder (ASD) encompasses a range of neurodevelopmental conditions characterized by enduring impairments in social communication and interaction together with restricted repetitive behaviors, interests, and activities. No targeted pharmacological or physical interventions are currently available for ASD. However, emerging evidence has indicated a potential association between the development of ASD and dysregulation of the gut-brain axis. Repetitive transcranial magnetic stimulation (rTMS), a noninvasive diagnostic and therapeutic approach, has demonstrated positive outcomes in diverse psychiatric disorders; however, its efficacy in treating ASD and its accompanying gastrointestinal effects, particularly the effects on the gut-brain axis, remain unclear. Hence, this review aimed to thoroughly examine the existing research on the application of rTMS in the treatment of ASD. Additionally, the review explored the interplay between rTMS and the gut microbiota in children with ASD, focusing on the gut-brain axis. Furthermore, the review delved into the integration of rTMS and gut microbiota modulation as a targeted approach for ASD treatment based on recent literature. This review emphasizes the potential synergistic effects of rTMS and gut microbiota interventions, describes the underlying mechanisms, and proposes a potential therapeutic strategy for specific subsets of individuals with ASD.

Examining the Authenticity of Autistic Portrayals in US Adult and Children's Television Shows Using Medical and Social Models of Disability.

Television programs have introduced viewers to characters on the autism spectrum (e.g., Sesame Street, The Good Doctor), impacting audiences' knowledge and attitudes. Thus, it is essential that character representations convey accurate health information. This study explores how autistic portrayals across six adult and children's television programs align with the medical (e.g., American Psychiatric Association in Diagnostic and statistical manual of mental disorders, 5th ed., text rev., 2022, https://doi.org/10.1176/appi.books.9780890425787 ) and social models of disability. A content analysis methodology was used to investigate defining characteristics of autism (i.e., medical model) and how characters navigated their environment (i.e., social model) in 252 scenes (across six characters in 22 episodes). Measures included the frequency with which autism characteristics (e.g., social-communicative difficulties, restrictive repetitive behaviors) were present across autistic portrayals and the valence (e.g., positive, negative, neutral) with which characters interacted with their environment (e.g., character and neurodiversity affirming valence). Findings indicate that (a) television portrayals depict social-communication difficulties significantly more than behavioral characteristics, (b) children's programming portrays autistic characters with significantly more positive personal attributes (i.e., character valence) than adult programs, and (c) the majority of programs portray characters navigating autism in positive or neutral ways (i.e., neurodiversity affirming valence). Results offer stakeholders (e.g., writers, advocates, neurodiverse community) insight into how autistic characters are portrayed on television, adding to a growing body of literature examining how such representations impact public knowledge, attitudes, and behaviors towards individuals on the autism spectrum. Collectively, such studies highlight how changes in diagnostic criteria, legal protections, and social inclusivity are presented to viewers, who are seeking entertainment but gaining public health information.

AYURVEDIC MANAGEMENT OF AUTISM: A CASE REPORT

In Aayurvedd, Unmada is a term that represents mental ailments. It is a broad term that covers autism spectrum disorders, too. The primary cause of Unmada, as explained in Ayurveda, is the derangement in Manas (mental functioning), Budhi (application of the acquired knowledge), Samjna(perceptions), Jnana(experiences), Smriti(memory), Bhakti (emotional adhesions), Seela (conditioned activities). According to Ayurveda, the symptoms of autism spectrum disorders as per DSM V criteria are diminished social interaction, impaired language and restricted repetitive behaviours (RRB), which can be co-related with Unmada. Aim and Objective- Ayurvedic management of Autism symptoms w.s.r. Unmada: A case study in the present case study, A diagnosed case of ASD, age four years female, came to OPD of Kaumarbhritya, Rishikul Ayurvedic College and Hospital, Haridwar. Along with the addiction to watching mobile. Materials and methods: The treatment protocol of Unmada, like Balpanchkarma, speech therapy, and parent counselling, are adopted with classical medication according to the Dosha predominance. Result -Balpanchkarma, like Nasya being the Dwara to Shiras, opens up the Manovaha Srotas, Speech therapy for speaking and communication skills development, Parental counselling for social skill development, restriction of watching mobile, etc. These procedures, along with the internal medications, have improved the present case.

Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder

BackgroundRestricted repetitive behavior (RRB) is one of two behavioral domains required for the diagnosis of autism spectrum disorder (ASD). Neuroimaging is widely used to study brain alterations associated with ASD and the domain of social and communication deficits, but there has been less work regarding brain alterations linked to RRB.MethodsWe utilized neuroimaging data from the National Institute of Mental Health Data Archive to assess basal ganglia and cerebellum structure in a cohort of children and adolescents with ASD compared to typically developing (TD) controls. We evaluated regional gray matter volumes from T1-weighted anatomical scans and assessed diffusion-weighted scans to quantify white matter microstructure with free-water imaging. We also investigated the interaction of biological sex and ASD diagnosis on these measures, and their correlation with clinical scales of RRB.ResultsIndividuals with ASD had significantly lower free-water corrected fractional anisotropy (FAT) and higher free-water (FW) in cortico-basal ganglia white matter tracts. These microstructural differences did not interact with biological sex. Moreover, both FAT and FW in basal ganglia white matter tracts significantly correlated with measures of RRB. In contrast, we found no significant difference in basal ganglia or cerebellar gray matter volumes.LimitationsThe basal ganglia and cerebellar regions in this study were selected due to their hypothesized relevance to RRB. Differences between ASD and TD individuals that may occur outside the basal ganglia and cerebellum, and their potential relationship to RRB, were not evaluated.ConclusionsThese new findings demonstrate that cortico-basal ganglia white matter microstructure is altered in ASD and linked to RRB. FW in cortico-basal ganglia and intra-basal ganglia white matter was more sensitive to group differences in ASD, whereas cortico-basal ganglia FAT was more closely linked to RRB. In contrast, basal ganglia and cerebellar volumes did not differ in ASD. There was no interaction between ASD diagnosis and sex-related differences in brain structure. Future diffusion imaging investigations in ASD may benefit from free-water estimation and correction in order to better understand how white matter is affected in ASD, and how such measures are linked to RRB.

Profiling Autism and Attention Deficit Hyperactivity Disorder Traits in Children with SYNGAP1-Related Intellectual Disability.

SYNGAP1-related ID is a genetic condition characterised by global developmental delay and epilepsy. Individuals with SYNGAP1-related ID also commonly show differences in attention and social communication/interaction and frequently receive additional diagnoses of Autism Spectrum Disorder (ASD) or Attention Deficit Hyperactivity Disorder (ADHD). We thus set out to quantify ASD and ADHD symptoms in children with this syndrome. To assess ASD and ADHD, parents and caregivers of a child with SYNGAP1-related ID (N = 34) or a typically developing control (N = 21) completed the Social Responsiveness Scale-2, the Social Communication Questionnaire with a subset of these also completing the Conners-3. We found that those with SYNGAP1-related ID demonstrated higher levels of autistic traits on both the SRS and SCQ than typically developing controls. On the SRS, those with SYNGAP1-related ID scored highest for restricted repetitive behaviours, and were least impaired in social awareness. On the Conners-3, those with SYNGAP1-related ID also showed a high prevalence of ADHD traits, with scores demonstrating difficulties with peer relations but relatively low occurrence of symptoms for DSM-5 conduct disorder and DSM-5 oppositional defiant disorder. Hierarchical clustering analysis highlighted distinct SYNGAP1-related ID subgroups for both ASD and ADHD traits. These findings provide further characterisation of the SYNGAP1-related ID behavioural phenotype, guiding diagnosis, assessment and potential interventions.

Camouflage, self-esteem and gratitude in young adults with varying degrees of autistic traits in Poland

Autistic spectrum conditions (ASC) imply functioning difficulties in adulthood due to the fact that they are caused by early-onset problems in social communication, unusually restricted repetitive behavior, and narrow interests. Living with ASC might be difficult for young adults who face specific developmental tasks, such as undertaking a professional career and engaging in social and civic responsibilities. Because of the need to hide their dysfunctions and to conform to social norms and conventions, affected people use camouflage strategies. In order to improve their well-being and functioning, they may also use the regulatory function of self-esteem and gratitude. The presented research carried out in Poland aimed to determine the relations between the intensity of camouflage, self-esteem, and gratitude and to test for differences in the levels of these variables, taking into consideration the intensity of the autism spectrum conditions (ASC). The study comprised a total of 104 young adults (68 women = 65.38%, and 36 men = 34.62%) who graduated from secondary or tertiary education aged between 19 and 35 years. The entire group was divided into two subgroups based on the screening questionnaire Autism Spectrum Quotient (AQ10), a ten-item abridged version. One subgroup consisted of 52 adults with a high intensity of autistic traits, and the other consisted of individuals with a low intensity of autistic traits. The results showed a correlation between the level of autism spectrum conditions and camouflage. The level of camouflage was significantly higher in the subgroup with an increased severity of autistic traits compared with the subgroup with a low severity. In contrast, no significant differences were detected between the subgroups in the levels of self-esteem and gratitude, nor were any linear correlations between spectrum conditions and self-esteem and gratitude found.

Intellectual, Adaptive, and Behavioral Functioning Associated with Designated Levels of Support in a Sample of Autistic Children Referred for Tertiary Assessment.

The diagnostic criteria for autism spectrum disorder in the DSM-5-TR features the option to designate levels of support for social communication (SC) and restricted, repetitive behaviors (RRB). These levels are conceptual in nature, but research indicates standardized assessment outcomes correspond with clinician-assigned levels of support. The purpose of the present study was to identify factors that influence designated levels of support for SC and RRBs when diagnosing autism. Standardized assessment scores across intellectual functioning, adaptive skills, and ASD symptomology were analyzed to determine corresponding levels of support in SC and RRBs assigned by clinicians for 136 autistic children following a comprehensive diagnostic evaluation. At diagnosis, approximately 46% of participants were described as needing substantial support (Level 2) for SC and 49% were described as needing substantial support (Level 2) for RRB. There was a consistent pattern of higher to lower intellectual and adaptive functioning needing Level 1-Level 3 support. Autism assessment results followed a gradient of fewer to greater autism symptoms from Level 1 to Level 3 support. Findings indicated clinician-assigned levels of support for SC and RRB were associated with intellectual functioning, adaptive functioning, autism symptomology, and age, but not sex.

A - 177 The Self-Concept Scale of Conners Adult Rating Scale in the Diagnosis of Autism Spectrum Disorder in Adults.

Self-report scales are beneficial in identifying symptoms of Autism Spectrum Disorder (ASD) in adults (Hayashi et al., 2021; Hull et al., 2019). Symptoms of ASD and attention-deficit/hyperactivity disorder (ADHD) overlap significantly even without dual-diagnosis (Nakagawa et al., 2021). The Conners Adult ADHD Rating Scale (CAARS) is a reliable and valid screening tool when identifying ADHD in adults, 78% sensitivity and 56% specificity (Abbass et al., 2021). Distinguishing features of ASD include restricted repetitive behaviors (RRB) and social interaction and communication deficits (SIC) (American Psychiatric Association, 2022). In adults, CAARS has shown a moderate correlation of RRB with the inattention (IA) and hyperactivity/impulsivity (HI) of ADHD; SIC moderately correlates with IA and mildly with HI. This study explores group differences when comparing Self-Concept (SC) Scale of CAARS in those diagnosed with ASD from clinical comparisons. Data composed of 93 adult participants, 7 diagnosed with ASD, were extracted from a midwest neuropsychological outpatient clinic and analyzed to determine the sensitivity of CAARS-SC in diagnosing ASD. Independent t-Test identified no significant effect for diagnosis, t(91) = -0.301, p = 0.764, despite those in the ASD group (M = 62.00, SD = 12.432) endorsing more concerns than those without the diagnosis (M = 60.47, SD = 12.996). This study did not identify significant group differences on the CAARS-SC when comparing those diagnosed with ASD to the clinical comparisons. Further implications and limitations will be explored to distinguish ASD from overlapping diagnoses to employ appropriate treatment and future psychometric research directions.

Impaired neural circuitry of hippocampus in Pax2 nervous system-specific knockout mice leads to restricted repetitive behaviors.

Restricted repetitive behaviors (RRBs), which are associated with many different neurological and mental disorders, such as obsessive-compulsive disorder (OCD) and autism, are patterns of behavior with little variation and little obvious function. Paired Box 2 (Pax2) is a transcription factor that is expressed in many systems, including the kidney and the central nervous system. The protein that is encoded by Pax2 has been implicated in the development of the nervous system and neurodevelopmental disorders. In our previous study, Pax2 heterozygous gene knockout mice (Pax2+/- mice) showed abnormally increased self-grooming and impaired learning and memory abilities. However, it remains unclear which cell type is involved in this process. In this study, we deleted Pax2 only in the nervous system to determine the regulatory mechanism of Pax2 in RRBs. In this study, Pax2 nervous system-specific knockout mice (Nestin-Pax2 mice) aged 6-8 weeks and Pax2 flox mice of the same age were recruited as the experimental group. Tamoxifen and vehicle were administered via intraperitoneal injection to induce Pax2 knockout after gene identification. Western blotting was used to detect Pax2 expression. After that, we assessed the general health of these two groups of mice. The self-grooming test, marble burying test and T-maze acquisition and reversal learning test were used to observe the lower-order and higher-order RRBs. The three-chamber test, Y-maze, and elevated plus-maze were used to assess social ability, spatial memory ability, and anxiety. Neural circuitry tracing and transcriptome sequencing (RNA-seq) were used to observe the abnormal neural circuitry, differentially expressed genes (DEGs) and signaling pathways affected by Pax2 gene knockout in the nervous system and the putative molecular mechanism. (1) The Nestin-Pax2 mouse model was successfully constructed, and the Nestin-Pax2 mice showed decreased expression of Pax2. (2) Nestin-Pax2 mice showed increased self-grooming behavior and impaired T-maze reversal behavior compared with Pax2 flox mice. (3) An increased number of projection fibers can be found in the mPFC projecting to the CA1 and BLA, and a reduction in IGFBP2 can be found in the hippocampus of Nestin-Pax2 mice. The results demonstrated that loss of Pax2 in the nervous system leads to restricted repetitive behaviors. The mechanism may be associated with impaired neural circuitry and a reduction in IGFBP2.

Psychological intervention combined with female image analysis in Japanese literature on autistic women

BackgroundThe core symptoms of Autism Spectrum Disorder (ASD) are impaired social communication and restricted repetitive behavior. The diagnosis of autism is extremely complex and affects the judgment of differences in autism groups. With the attention paid to female patients with autism, research adopted psychological intervention therapy and combined female images in Japanese literature to attach importance to the diagnostic tools of female autistic population.Subjects and MethodsFirstly, 80 patients with autism were selected and randomly divided into two groups with 40 cases in each group. The observation group received psychological intervention treatment using female images from Japanese literary works, while the control group only received psychological intervention treatment. Three months later, the two groups were scored on the Autism Rating Scale (ARS) and the Positive and Negative Affect Scale (PANAS). Finally, SPSS23.0 was used for data analysis and t-test.ResultsAfter 3 months, the positive emotion score on the PANAS scale in the observation group was higher than that in the control group (t=4.412, P<0.001), the negative emotion score (t =-2.552, P<0.05), and Autism Treatment Evaluation Scale (ATCE) score (t=4.183, P<0.001). The degree of reduction in various indicators of the control group is much greater than that in the control group. Indicating the effectiveness and feasibility of its treatment.ConclusionsMore attention should be paid to female patients with autism, and the development and changes of female images in literary works should be analyzed for auxiliary treatment, in order to promote the development of patients’ mental health and improve their quality of life.

Serum Amino Acid Profiling in Children with Autistic Spectrum Disorder: Insights from a Single-Center Study in Southern Romania.

The objective of this study was to analyze the serum amino acid profile in children diagnosed with autistic spectrum disorder (ASD) in southern Romania. The analysis aimed to provide insights into the underlying metabolic dysregulations associated with ASD. ASD is a neurodevelopmental disorder characterized by impaired social interaction, communication deficits, and restricted repetitive behaviors. Although the exact cause of ASD is largely unknown, recent evidence suggests that abnormalities in amino acid metabolism may contribute to its pathogenesis. Therefore, studying the amino acid profile in children with ASD could offer valuable information for understanding the metabolic disturbances associated with this complex disorder. This single-center study examined serum samples from children diagnosed with ASD, utilizing advanced analytical techniques to quantify the levels of different amino acids, amino acid derivatives, and amino acid-like substances. The results showed a lower level of taurine and a higher level of asparagine and leucine in the ASD group versus the control group. In the ASD group, we observed significant differences in tryptophan and alpha-aminobutyric acid levels based on age, with higher tryptophan levels in children older than 7 years when compared to children younger than 7 years; however, no significant correlations were found with the ASD group older than 7 years old. Additionally, younger children with ASD exhibited higher levels of alpha-aminobutyric acid than older children with ASD. The findings from this study contribute to the growing body of knowledge on the metabolic aspects of ASD, highlighting potential biomarkers and therapeutic targets for improving the management and treatment of ASD in children.

국립특수교육원 자폐성장애 검사도구(NISE-K․ART) 표준화 연구

The purpose of this study was to standardize the National Institute of Special Education- Korean·Autism Rating Scale for Teachers(NISE-K·ART). The NISE-K·ART assess two domains: social communication and social interaction(SC) and the restricted repetitive behaviors, interests, and activities(RRB). The scale was developed for preschoolers (3-5 years old), elementary school students (6-12 years old), and middle and high school student (13-18 years old) and is capable of assessing different grade levels. The NISE-K·ART was administered to 561 students with ASD for standardization and to 318 students with intellectual disabilities and 319 students without disabilities for assessing clinical utility. For item analysis, item difficulty and discrimination were analyzed based on item response theory. For validity, construct validity, quasi-validity, and discriminant validity were examined; and for reliability, internal consistency (Cronbach’s α), test-retest reliability, and inter-rater agreement were tested. The study revealed the following. First, after we examined the difficulty and discrimination of the NISE-K·ART, we found that the scale consisted of items of varying difficulty (severity) and had fair discrimination. Second, the reliability analysis showed that the NISE-K·ART had high internal consistency, test-retest reliability, and inter-rater agreement. Lastly, the study confirmed that the NISE-K·ART had high validity and high discrimination between groups. Based on these findings, we discuss the significance of the NISE-K·ART and how to utilize it.

Behavioural deficits of autism spectrum disorder and associations with different gene clusters: a study with the whole-genome transmission disequilibrium test

BackgroundAutism spectrum disorder (ASD) is a diverse neurodevelopmental disease primarily distinguished by limited and stereotyped activities as well as impaired social interaction. Due to the high heritability of ASD, research...

THE IMPACT OF COVID-19 ON CHILDREN WITH AUTISM AND THEIR TREATMENT WITH MEDICAL REHABILITATION METHODS

The post-Covid condition can affect a person's physical functioning and daily activities. The pandemic threatens the realization of development goals. The symptoms and consequences of the post-COVID-19 condition cannot be explained by an alternative diagnosis. Statistics in children are different, the indirect impact of the pandemic on adolescents is also great. The spread of the coronavirus pandemic (COVID-19) has caused uncertainty, anxiety and stress, and these feelings are especially strong among children. As you know, people with autism spectrum disorder mainly show deficits in two areas: social communication and social relationships (restricted repetitive behaviors). This is a group of children who are constantly dependent on rehabilitative or educational services. Based on the above, it was interesting to determine the correlation. We conducted a small study involving only two groups of children on the autism spectrum. Two groups were selected, the first group was infected with the virus more than once, and the second group only once. Both groups were under observation for 5 months. In both groups, intervention, and rehabilitation were carried out based on a multidisciplinary approach. The study was conducted at a Mental Health Center. ADOS-observation of child behavior and ADI-R-structured interview with parents were used for assessment, also a record of physiotherapist ship and consultation. The first thing the study showed, most clearly, was the change in breathing rate. Finally, 5 months after resuming the rehabilitation process, after continuous delivery of therapeutic procedures, the respiratory rate returned to normal, in both groups of children, under investigation. The frequency of stereotyped movements is greatly reduced, appearing only during strong emotions. At the end of the study, when performing physical activity, the degree of independence increased by almost 50%.