Moderate-intensity aerobic exercise is safe and beneficial in atrial fibrillation (AF) and coronary heart disease (CHD). Irregular or rapid heart rates (HR) in AF and other heart conditions create a challenge to using HR to monitor exercise intensity. The purpose of this study was to assess the potential of breathing frequency (BF) to monitor exercise intensity in people with AF and CHD without AF. This observational study included 30 AF participants (19 Male, 70.7 ± 8.7 yrs) and 67 non-AF CHD participants (38 Male, 56.9 ± 11.4 yrs). All performed an incremental maximal exercise test with pulmonary gas exchange. Peak aerobic power in AF ( O2peak; 17.8 ± 5.0ml.kg-1.min-1) was lower than in CHD (26.7ml.kg-1.min-1) (p < .001). BFresponses in AF and CHD were similar (BF peak:AF34.6 ± 5.4 and CHD36.5 ± 5.0 breaths.min-1; p = .106);at the 1st ventilatory threshold (BF@VT-1: AF 23.2 ± 4.6; CHD 22.4 ± 4.6 breaths.min-1; p = .240). % O2peak at VT-1were similar inAF and CHD (AF: 59%; CHD: 57%; p = .656). With the use of wearable technologies on the rise, that now include BF, this first study provides an encouraging potential for BF to be used in AF and CHD. As the supporting data are based on incremental ramp protocol results, further research is required to assess BF validity to manage exercise intensity during longer bouts of exercise.