Oxidative Stress Research Articles (Page 1)

Sorbic acid resistance and metabolism of Brettanomyces bruxellensis in the spoilage of low sugar soft drinks.

Ergosterol synthase reduces ochratoxin A synthesis in Aspergillus carbonarius via oxidative stress pathway.

L-epicatechin partially alleviates Ochratoxin A-induced oxidative and endoplasmic reticulum stress and improves developmental competence of porcine embryos during in vitro culture.

The oxyR negatively regulates processing stress resistance in Escherichia coli O157:H7 by reducing ROS scavenging capacity.

Human mitochondrial CYP2E1-mediated styrene metabolism increases oxidative stress and impairs antioxidant rescue in Caenorhabditis elegans.

Arterial hypertension is a silent and progressive disease with deleterious vascular implications on all target organs, including the heart, the brain, the kidneys, and the eyes. Oxidative stress, defined as the overproduction of Reactive Oxygen Species (ROS) over antioxidants, is capable of deteriorating not only the normal endothelial but also the cellular function with further cardiovascular implications. Xanthine oxidase activity, NADPH oxidase overexpression, and ROS production lead to hypertension and high arterial tone, culminating in end-organ damage. The inactivation of NO by superoxide reduces vasodilation and promotes peroxynitrite formation, which damages cellular components. Activation of MMPs by oxidative stress contributes to pathological neovascularization and angiogenesis. Salucin-β-induced activation of Angiotensin-II and NADPH results in vascular remodeling and fibrosis, while lipid peroxidation and PARP- 1 activation further exacerbate cellular apoptosis and vascular calcification. Moreover, to reliably assess the oxidative status an emerging number of biomarkers are under investigation. Antioxidant therapy, alongside traditional antihypertensive agents such as beta-blockers and ACE inhibitors, offers the potential to mitigate oxidative stress and its detrimental effects. Additionally, polyphenols, found in plant-based foods, show promise in managing oxidative stress in hypertensive patients although this data has not been confirmed in randomized clinical trials. Understanding the intricate relationship between oxidative stress and hypertension underscores the importance of developing comprehensive therapeutic strategies to reduce cardiovascular risk and improve patient outcomes.

Imidacloprid exacerbates the physiological and biochemical effects of rice (Oryza sativa L.) under salt stress: A systematic evaluation based on chlorophyll synthesis and oxidative stress.

Selenium improves behavioral performance in a rat model of autism spectrum disorder by mitigating oxidative stress and modulating the Sirt1/Keap1/Nrf2/HO-1 signaling pathway.

Cardiorespiratory fitness as a key predictor of metabolic, inflammatory, and oxidative stress biomarkers in adults with different physical activity levels.

Metoprolol exacerbates dementia in scopolamine-induced cognitive impairment in rats: A potential role of NADPH oxidase.

Research progress on the role of oxidative stress in the pathogenesis of vascular dementia and its treatment.

Mild hypothermia regulates neuronal inflammation and oxidative stress through HSP70 to alleviate brachial plexus injury.

DNA methylation signature of oxidative stress and its mediating role in response to metal exposure.

Enhancing myocardial injury recovery: Nrf2 activation by sulforaphane regulates ferroptosis and oxidative stress in takotsubo-like models.

Kaempferol inhibits atherosclerotic plaque development via dual-targeting of p53-p21-p16 senescence pathway and Nrf2/HO-1/NQO1 antioxidant mechanism: Insights from combined in vivo and in vitro research.

Aging impairs urethral function in male rats: Increased outlet resistance and oxidative stress.

Aluminum oxide nanoparticles induce neurodegeneration via oxidative stress, amyloidogenic pathway activation, and BDNF suppression in rat brain.

Effects of oral and intravenous dimethylglycine treatment on hematobiochemical profiles and total oxidant/antioxidant status in low-intensity exercised horses.

ANGPTL3 nanobody-FGF21 fusion protein ameliorates metabolic dysfunction-associated fatty liver disease via regulation of lipid and glucose metabolism and attenuation of oxidative stress.

Unveiling the role of trace elements in modulating inflammatory and oxidative pathways in CAG repeat-driven spinocerebellar ataxia.