Body mass index and mortality: The "Obesity Paradox" in critically ill patients with intra-abdominal infection or sepsis - An international cohort study.

Getting the right measure: Gait speed assessment and outcomes in older patients with cancer.

Association between anesthetic administration and mortality in patients with hemorrhagic stroke: Analysis of the MIMIC-IV database.

Bacterial infection is a major cause of morbidity and mortality in patients with acute decompensation (AD) of cirrhosis. This study aimed to investigate patient plasma-induced dysfunction of healthy neutrophils (PIND) as a predictor of subsequent infection and mortality in patients with AD. One hundred sixty AD patients (117 AD-NoACLF and 43 AD-ACLF), with a predominantly alcohol-related liver disease, were prospectively recruited. Plasma from 21 healthy controls and 74 patients with stable compensated cirrhosis was used as controls. Patient plasma was co-incubated with neutrophils from healthy donors to assess neutrophil function, including reactive oxygen species (ROS) production and phagocytic capacity, and CD62L surface expression. Plasma from AD patients induced a primed state in healthy neutrophils, characterised by increased constitutive and N-formyl-Met-Leu-Phe (fMLP)-induced ROS production. However, effector functions were impaired, with significantly reduced phorbol 12-myristate 13-acetate (PMA)-induced ROS production, phagocytic capacity and CD62L expression. Escherichia coli- induced ROS production predicted subsequent infection in the total AD and AD-NoACLF cohorts (p = 0.043 and p = 0.013, respectively), while PMA-induced ROS production predicted 90-day mortality in the AD-NoACLF group (p = 0.041). None of the neutrophil function assays were predictive of clinical outcomes in AD-ACLF patients. Plasma from patients with AD induces a 'primed but exhausted' neutrophil phenotype, characterised by a paradoxical failure to respond to stimuli. This dysfunction was associated with an increased risk of infection and mortality, particularly in AD-NoACLF patients. PIND offers a promising strategy to improve risk stratification in this high-risk population.

Machine learning-based prediction of three-year mortality in elderly inpatients with coronary artery disease combined with heart failure.

Joint effects of pulse pressure and LVEF on 12-month mortality in acute coronary syndrome patients undergoing PCI.

Association between beta-blocker use and outcomes in patients with sepsis-induced myocardial injury: An analysis based on MIMIC-IV and eICU databases.

Persistence of sex differences and stable trends in mortality in patients with mycosis fungoides and Sézary syndrome in Spain (1983-2022).

Acute Type A aortic dissection (ATAAD) remains a surgical emergency with high morbidity and mortality despite improvements in operative management. The influence of age on outcomes among patients undergoing surgical repair remains incompletely characterized. Using the Nationwide Inpatient Sample (2010-2018, 2020), we identified adult hospitalizations with a primary diagnosis of ATAAD who underwent surgical repair. Patients were stratified into 3 age groups (<65, 66-75, and >75 years). Weighted analyses compared demographics, comorbidities, hospital characteristics, and outcomes across groups. Multivariable logistic regression identified independent predictors of in-hospital mortality, adjusting for comorbidities and hospital factors. Among 32,798 weighted admissions, 48.1% were aged <65 years, 23.3% were 66-75 years, and 28.6% were >75 years (median age 65 years). Overall, in-hospital mortality was 11.9%, increasing from 8.9% in younger patients to 17.1% in those >75 years (P < 0.001). Older adults had greater comorbidity burden (with most comorbidities differing significantly), shorter median length of stay (5 vs. 6 days, P < 0.001), and lower total hospital charges (P < 0.001). On multivariable analysis, age remained an independent predictor of mortality in patients 66-75 years old (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.34-1.63; P < 0.001) and in patients >75 years (OR, 2.29; 95% CI, 2.10-2.5; P < 0.001). Larger hospitals demonstrated modestly higher adjusted mortality, while hospital teaching status was not independently associated with outcomes. Advancing age substantially increases in-hospital mortality after ATAAD repair. These findings emphasize the need for individualized operative decision-making, early referral to experienced centers, and system-level strategies to optimize outcomes for older adults with ATAAD.

Association between phase angle and one-year heart failure rehospitalization and all-cause mortality in patients with heart failure.

Demographic and regional trends in all-cause mortality among adults with coexisting multiple myeloma and cardiovascular disease in the United States, 1999-2023: A CDC WONDER analysis.

"The 4D Approach"-An Effective Strategy to Improve Emergency Department Boarding and Operational Outcomes.

The impact of ketamine on ICU mortality in patients with sepsis: A retrospective cohort study.

Femoral neck fractures (FNF) in older adults are frequently managed with either total hip arthroplasty (THA) or hemiarthroplasty (HA). Despite improvements in surgical techniques, mortality rates after hip fracture surgery remain high. Identifying predictors of early mortality may enhance surgical decision-making, optimize perioperative management, and improve patient outcomes. The purpose of this study was to determine the short- and mid-term mortality rates after THA and HA for FNF, to identify clinical, demographic, and laboratory factors associated with 30-, 90-, and 180-day mortality, and to establish clinically relevant cutoff thresholds for significant continuous variables to stratify risk. We retrospectively reviewed 2379 consecutive patients treated for sub-capital FNF at a tertiary trauma center between [insert study years]. Of these, 831 underwent THA and 1548 underwent HA. Mortality was assessed at 30, 90, and 180 days postoperatively. Demographic, clinical, and laboratory parameters were analyzed using univariate and multivariate logistic regression models. Receiver operating characteristic (ROC) curve analysis was performed to identify optimal cutoff thresholds for significant continuous predictors. Among THA patients, mortality was 1.4% at 30 days, 3.4% at 90 days, and 5.1% at 180 days. Postoperative albumin ≤2.85g/dL predicted 30-day mortality, while C-reactive protein (CRP)>19.15mg/dL was independently associated with mortality at 90 and 180 days. Among HA patients, mortality was 6.6% at 30 days, 12.9% at 90 days, and 17.6% at 180 days. Predictors of 30-day mortality included white blood cell count (WBC)>14.48×109/L, albumin <3.55g/dL, and Charlson Comorbidity Index (CCI)>7.5. At 90 and 180 days, age >83.65 and>89.34 years, WBC >13.49×109/L, albumin <3.35-3.45g/dL, creatinine >1.08mg/dL, and CCI >6.5 were associated with higher mortality risk. This study identified several laboratory and clinical markers that predict short- and mid-term mortality following hip arthroplasty for FNF. Hypoalbuminemia, elevated inflammatory markers, renal dysfunction, and high comorbidity burden were consistent risk factors. Incorporating these parameters into preoperative assessment may improve patient selection, perioperative optimization, and shared decision-making. III.

Tumor-derived S100A14 targeted astrocytes via TLR4 to Recruit myeloid-derived suppressor cells promoting brain metastasis and Curdione reversal effect.

Prognostic value of abdominal obesity indicators for all-cause mortality in familial hypercholesterolemia.

To investigate the association between denosumab use and 2-year all-cause mortality and incident skeletal-related events (SREs) in patients with lung cancer and bone metastases. This retrospective cohort study utilised electronic records from an international clinical database. The enrolment period was between January 1, 2010, and December 31, 2020, followed by a 2-year follow-up period. Data were extracted from TriNetX, a global clinical research platform with electronic medical records from more than 120 healthcare organisations for over 250 million patients in 19 countries. A total of 52,521 eligible patients were recruited and divided into 2 groups based on the use of denosumab. Propensity score matching (PSM) was used to balance baseline demographic and clinical characteristics between study groups. After PSM, the study and control groups each comprised 2735 patients with similar baseline characteristics. The primary outcome was all-cause mortality during the 2-year follow-up period. Incident SRE diagnoses, encompassing pathologic fractures, radiation therapy to bone, spinal cord compression, and hypercalcaemia, were examined as secondary outcomes. During the 2-year follow-up period, overall mortality was significantly lower in the study group than in the control group (53.8% vs 55.1%; hazard ratio [HR], 0.74; 95% CI, 0.69-0.80; P < .001). The study group also had a longer median survival time (467 days vs 292 days), a higher survival probability during the follow-up period (P < .001), and a significantly lower risk of SREs (HR, 0.42; 95% CI, 0.33-0.53; P < .001). Survival benefits and reduction of SRE risk associated with denosumab were consistent across most subgroups. In this large international cohort, patients treated with denosumab had lower mortality and fewer SREs than those who did not receive denosumab, adding to the growing body of evidence supporting its clinical benefit.

Association between the platelet to white blood cell ratio and short term mortality in critically ill patients with atherosclerotic cardiovascular disease: A retrospective study and machine learning with external validation.

Characteristics and short-term outcomes of patients with hematological malignancies admitted to Intensive care units: a retrospective cohort study using the Japanese Intensive care PAtient Database.

Clinical impact of cardiac ejection fraction and atrial fibrillation on elderly hemodialysis patients.