Minas Gerais Research Articles

Study of the Relation between Aging and Pesticides: A Review

Aims: The main aim of this study was to use specific data from the literature on ageing, correlating this with the pesticide contamination, in order to understand the relationship with an increasingly ageing population. Study Design: A systematic review was performed. Place and Duration of Study: Laboratory of Biomathematics of the Federal University of Alfenas, Minas Gerais State, Brazil, between April 2023 and August 2023. Methodology: A systematic search of articles was performed using the CAPES Periodic platform, a searcher from the Education Ministry of Brazil that contains Web of Science, Scopus, MedLine, from August 2020 to May 2023. For this review, the subject’s “aging theory”; “neuroscience and pathologies to aging”; “aging and aging-associated changes”; “pesticides and pesticide toxicity”; “pesticide toxicity and neurotoxicity”; “longevity and healthy aging”; “aging human and pesticides” were searched together using the type of material “articles” in English language. Some articles about “population growth”; “world population”; “population-aging” were used for epistemological composition of this work content subjects. Results: From the 19.720 articles after the exclusion and the inclusion criteria made with the subjects most pertinent to the objectives of this work; 19.570 articles were excluded, remaining 150 ones, of which 116 were qualitative in scope and 34 quantitative. Conclusion: The complex relationship between the pesticide contamination and the condition of the exposed individual may be associated with premature ageing and a greater susceptibility to debilitating age-related diseases. Although technology is increasingly improved in its innovations, health and environmental regulations have not been able to rid the production processes of their potential to pollute the environment and cause health problems for those exposed to them.

Mining tailings alter insects: revealing fluctuating asymmetry in the caddisfly Smicridea coronata.

The Samarco/Vale/BHP mine tailing dam breach that took place in Minas Gerais, southeastern Brazil, in 2015, deposited high concentrations of metals and metalloids in the Rio Doce basin, severely impacting freshwater and riverine forest ecosystems. To assess developmental instability of caddisflies in response to the environmental impacts of the dam breach, we investigated the fluctuating asymmetry (FA) in the species Smicridea (Rhyacophylax) coronata (Trichoptera: Hydropsychidae). FA was assessed at individual and populational scales using geometric morphometric methods in the cephalic capsule and mandibles of larvae and also on the forewings of adults, both collected under the impacted condition, and under the least disturbed condition. The levels of FA increased in response to stressors on the forewings at the populational scale, and on the mandibles, at individual scale. These morphological variations in the larval and adult stages may lead to detrimental effects and result in high mortality rates as well as lower adult fitness. Trichoptera forewings are revealed as suitable traits for assessing FA, holding potential for applications in biomonitoring programs. Directional asymmetry levels were higher than FA levels for all traits, and this correlation could be explained by a transition from fluctuating to directional asymmetry in the presence of heightened disturbance. Our results validate the relationship between the impacts from the dam breach and increased developmental instability in this species with likely cascade effects on the insect community.

Fire danger in the supply areas of hydroelectric reservoirs under the restoration process in the south of Minas Gerais, Brazil

The partial or complete loss of vegetation cover triggers an increase in surface runoff, erosion, and sedimentation of water bodies, including reservoirs for hydroelectric power generation, reducing their life expectancy. To control or mitigate this issue, ecological restoration interventions should prioritize the recovery of areas most vulnerable to these processes, such as springs. Conversely, wildfires cause damage to vegetation cover and hinder ecological restoration and/or natural regeneration processes. Therefore, this study aimed to identify - with the aid of Geographic Information Systems - the temporal and spatial likelihood of fire occurrences in spring recharge areas undergoing ecological restoration and contributing to hydroelectric reservoirs in southern Minas Gerais, Brazil. The findings indicated that the months with the highest probability of wildfire occurrences were August and September (accounting for 66% of cases), requiring increased attention to prevention efforts. Furthermore, locations most susceptible to fires (steeper slopes, more flammable vegetation, and higher anthropogenic use) should be treated as priorities for both prevention and ecological restoration actions.

Ecological Requirements for Abundance and Dispersion of Brazilian Yellow Fever Vectors in Tropical Areas

In the Americas, wild yellow fever (WYF) is an infectious disease that is highly lethal for some non-human primate species and non-vaccinated people. Specifically, in the Brazilian Atlantic Forest, Haemagogus leucocelaenus and Haemagogus janthinomys mosquitoes act as the major vectors. Despite transmission risk being related to vector densities, little is known about how landscape structure affects vector abundance and movement. To fill these gaps, we used vector abundance data and a model-selection approach to assess how landscape structure affects vector abundance, aiming to identify connecting elements for virus dispersion in the state of São Paulo, Brazil. Our findings show that Hg. leucocelaenus and Hg. janthinomys abundances, in highly degraded and fragmented landscapes, are mainly affected by increases in forest cover at scales of 2.0 and 2.5 km, respectively. Fragmented landscapes provide ecological corridors for vector dispersion, which, along with high vector abundance, promotes the creation of risk areas for WYF virus spread, especially along the border with Minas Gerais state, the upper edges of the Serra do Mar, in the Serra da Cantareira, and in areas of the metropolitan regions of São Paulo and Campinas.

Esporotricose felina: Sinais clínicos e prevenção em animais e humanos

Sporotrichosis is a mycosis caused by the fungus Sporothrix sp, which is found in plants, trees, and soil, associated with decomposing plant remains. The disease can affect various species, especially felines which, in turn, are the main transmitters of sporotrichosis to humans. Infection by Sporothrix sp. occurs through contact between injured skin and surfaces contaminated with the fungus, or scratching or biting by diseased animals. In addition to the skin manifestation, sporotrichosis can also occur in extracutaneous form, affecting multiple organs such as the lungs, lymph nodes, liver, spleen and kidneys. There is no preventive vaccine for the disease and it is treated with synthetic fungistatic agents with a broad spectrum of antifungal activity. Sporotrichosis is considered one of the most relevant mycoses in veterinary medicine and an underdiagnosed zoonosis, mainly due to the lack of control and prevention initiatives, which consequently leads to a lack of public awareness. In the states of Pernambuco, Rio de Janeiro and in some cities in states of São Paulo, Minas Gerais Bahia, Rio Grande do Norte and Paraíba have compulsory notification of cases. Since December 1, 2020, the notification of sporotrichosis in dogs and cats has become mandatory in the city of São Paulo. The purpose of this review is to emphasize that sporotrichosis is an emerging zoonosis that is underdiagnosed in Brazil. Information and publicity campaigns are needed to reinforce the importance of treatment and the potential for a cure, as well as effective educational measures related to public health programs for the control of human and animal sporotrichosis. Responsible pet ownership campaigns, which emphasize the importance of neutering and restricting street access, are of paramount importance for the epidemiological control of the disease. Veterinarians have a fundamental role to play in guiding the guardian, emphasizing that the lack of treatment, in addition to causing great suffering to the affected animal, can contribute to the spread of the disease, including to humans.

Unveiling the phenology and associated floral regulatory pathways of Humulus lupulus L. in subtropical conditions.

The hop phenological cycle was described in subtropical condition of Brazil showing that flowering can happen at any time of year and this was related to developmental molecular pathways. Hops are traditionally produced in temperate regions, as it was believed that vernalization was necessary for flowering. Nevertheless, recent studies have revealed the potential for hops to flower in tropical and subtropical climates. In this work, we observed that hops in the subtropical climate of Minas Gerais, Brazil grow and flower multiple times throughout the year, independently of the season, contrasting with what happens in temperate regions. This could be due to the photoperiod consistently being inductive, with daylight hours below the described threshold (16.5h critical). We observed that when the plants reached 7-9 nodes, the leaves began to transition from heart-shaped to trilobed-shaped, which could be indicative of the juvenile to adult transition. This could be related to the fact that the 5th node (in plants with 10 nodes) had the highest expression of miR156, while two miR172s increased in the 20th node (in plants with 25 nodes). Hop flowers appeared later, in the 25th or 28th nodes, and the expression of HlFT3 and HlFT5 was upregulated in plants between 15 and 20 nodes, while the expression of HlTFL3 was upregulated in plants with 20 nodes. These results indicate the role of axillary meristem age in regulating this process and suggest that the florigenic signal should be maintained until the hop plants bloom. In addition, it is possible that the expression of TFL is not sufficient to inhibit flowering in these conditions and promote branching. These findings suggest that the reproductive transition in hop under inductive photoperiodic conditions could occur in plants between 15 and 20 nodes. Our study sheds light on the intricate molecular mechanisms underlying hop floral development, paving the way for potential advancements in hop production on a global scale.

Demographic, socioeconomic, and health structure factors associated with the use of HIV pre-exposure prophylaxis in Brazil: A nationwide ecological study.

Aims: To assess the cumulative rate of HIV Pre-Exposure Prophylaxis (PrEP) users in Brazil since its 2018 implementation and to analyze the association between PrEP usage and state-level structural factors. Methods: A nationwide ecological study from 2018 to 2022 was conducted, examining the 5-year cumulative rate of PrEP users in relation to demographic, socioeconomic, and healthcare infrastructure variables. Multiple linear regression analysis identified significant predictors of PrEP utilization. Results: Between 2018 and 2022, 124,796 individuals used PrEP, with a cumulative rate of 61.5 per 100,000 population. The highest usage was in Minas Gerais, São Paulo, and Santa Catarina, while the lowest was in Distrito Federal, Maranhão, and Alagoas. Regression analysis showed that higher PrEP usage was associated with lower population density, a younger median age, a lower male to female ratio, and reduced social vulnerability. Additionally, PrEP usage was positively associated with the density of medical doctors and the number of dispensing units. Conclusions: The study reveals significant regional disparities in PrEP usage across Brazil, influenced by socioeconomic and healthcare factors. It highlights the need for targeted public health strategies to enhance PrEP access and uptake, especially in socially vulnerable regions.

Simulation of a catalytic deoxygenation reaction of fatty acids to produce biohydrocarbons and evaluation of the influence of reaction parameters on the conversion and selectivity of products

Nowadays, there has been an urgency in the search for sustainable energy sources, such as those derived from biomass. This search is not only limited to minimizing greenhouse gas emissions but is also related to the increasing scarcity of fossil fuels. This work aims to investigate and analyze the production of bio-hydrocarbons from fatty acids through the simulation of the deoxygenation reaction by the DWSim software. In this simulation, a continuous catalytic deoxygenation reactor of the stirred tank with fluidized bed type was selected, aiming to understand the influence of operating parameters on this reaction. The parameters evaluated were temperature, pressure, hydrogen feed, and catalyst mass. For this simulation, hydrogen and stearic acid were chosen as feedstocks, focusing on the heptadecane and octadecane production. The rate law was chosen based on an extensive literature review, as well as reaction conditions. The kinetic model used as a reference was based on reactions of stearic acid and hydrogen in the presence of NiMo/Al2O3 as a catalyst. A stearic acid feed of 2.4 x 104 m3 year-1 was used as a base, representing the average feed of fatty raw material practiced in biodiesel plants located in the state of Minas Gerais, Brazil. From the variation of these parameters for a sensitivity analysis, with conversion as the key response, the following optimal operating conditions were defined: temperature of 650 K, pressure of 50 bar, molecular hydrogen feed of 4.1 x 10-3 m³ s-1, and catalyst mass of 8 kg. Under these new circumstances, the conversion of stearic acid reached a value of 99.23 %. The simulation of this reaction allowed us to understand the effect of the main reaction parameters on the reaction products, proved to be an important and robust tool to be used in projects and feasibility analyses of plants and biorefineries.

A healthcare claims analysis to identify and characterize patients with suspected X-Linked Myotubular Myopathy (XLMTM) in the Brazilian Healthcare System

BackgroundX-linked myotubular myopathy (XLMTM) is a rare, life-threatening congenital disease, which is not well-defined. To our knowledge, no studies characterizing the XLMTM disease burden have been conducted in Brazil. We identified and described patients with suspected XLMTM using administrative claims data from the Brazilian public healthcare system.MethodsData from 2015 to 2019 were extracted from the DATASUS database. As no XLMTM-specific ICD-10 code was available, a stepwise algorithm was applied to identify patients with suspected XLMTM by selecting male patients with a congenital myopathies code (G71.2), aged < 18 years at index date (first claim of G71.2), with an associated diagnostic procedure (muscle biopsy/genetic test) and without spinal muscular atrophy or Duchenne muscular dystrophy. We attempted to identify patients with suspected severe XLMTM based on use of both respiratory and feeding support, which are nearly universal in the care of XLMTM patients. Analyses were performed for the overall cohort and stratified by age at index date < 5 years old and ≥ 5 years old.ResultsOf 173 patients with suspected XLMTM identified, 39% were < 5 years old at index date. Nearly all (N = 166) patients (96%) were diagnosed by muscle biopsy (91% of patients < 5 years old and 99% of patients ≥ 5 years old), six (3.5%) were diagnosed by clinical evaluation (8% of patients < 5 years old and 1% of patients ≥ 5 years old), and one was diagnosed by a genetic test. Most patients lived in Brasilia (n = 55), São Paulo (n = 33) and Minas Gerais (n = 27). More than 85% of patients < 5 years old and approximately 75% of patients ≥ 5 years old had physiotherapy at the index date. In both age groups, nearly 50% of patients required hospitalization at some point and 25% required mobility support. Respiratory and feeding support were required for 3% and 12% of patients, respectively, suggesting that between 5 and 21 patients may have had severe XLMTM.ConclusionIn this real-world study, genetic testing for XLMTM appears to be underutilized in Brazil and may contribute to underdiagnosis of the disease. Access to diagnosis and care is limited outside of specific regions with specialized clinics and hospitals. Substantial use of healthcare resources included hospitalization, physiotherapy, mobility support, and, to a lesser extent, feeding support and respiratory support.

First molecular detection of Borrelia sp. in tapirs (Tapirus terrestris).

Borrelia theileri is a tick-borne spirochete causative agent of fever, apathy and reduced food consumption in cattle. Molecular diagnosis has expanded the understanding of Borrelia theileri with new hosts and geographical locations being described. The present study aimed to describe the first molecular detection of B. theileri in wild tapirs (Tapirus terrestris) from South America. Blood DNA samples obtained from 99 tapirs sampled in Pantanal (n = 61) and Cerrado (n = 38) biomes were screened using a qPCR assay based on the 16S rRNA gene of Borrelia sp. Positive samples in the qPCR assay were subjected to PCR assays to allow characterization of fragments from 16S rRNA and flaB genes. Two (2/99; 2.0%) animals from Pantanal biome were positive in the qPCR and one sample presented bands of expected size for the flaB protocol. Amplicons from this sample were successfully cloned and sequenced. In the phylogenetic analysis, Borrelia sp. from T. terrestris grouped together with B. theileri sequences previously detected in Rhipicephalus microplus ticks and cattle from Minas Gerais State in Brazil, Rhipicephalus geigyi from Mali, and R. microplus and Haemaphysalis sulcata from Pakistan. This finding contributes to our knowledge regarding susceptible hosts species for B. theileri. More studies are necessary to understand the potential effects of B. theileri on tapir's health.

Spatial analysis of fire sevetiry and its relationship with landscape configuration in savanna areas of Sempre Vivas National Park, Brazil

Fire is a natural disturbance in the Cerrado (Brazilian savanna) but its effects on the landscape are capable of altering its pattern of severity and frequency. Because of that, some areas of the Biome can be in dangerous in the National Park of Sempre Vivas, in Minas Gerais State. Within this context, we spatially analyzed fires in areas of Cerrado during the years 2003 and 2017 according to severity, frequency and the influence of the spatial configuration of the area. We used pre- and post-fire Landsat satellite images to calculate the dNBR index to analyze fire severity per year and used fire metrics to analyze the relationship between fire severity and the spatial configuration of the landscape. Fire-scar severity was considered low, probably due to the density and structure of the typical Cerrado vegetation and the change in annual precipitation. Thus, fires in the Cerrado can be intense and spread quickly if no proper control is implemented.

Modelling the Governance of Reconstruction after a Mining Disaster in Brumadinho, Brazil

The present study aims to analyze the relationships between actors from civil society, the State and the private sector, in the dynamics of reconstruction of the territory after the environmental disaster caused by the rupture of the tailings dam of the mining company Vale S.A in the Córrego do Feijão mine, in Brumadinho, Minas Gerais, Brazil, on January 25, 2019. This study is characterized by being an empirical, quantitative research, which aimed to evaluate a theoretical model for the reconstruction of the territory of Brumadinho in the post-environmental disaster scenario. The tested hypotheses show that if the actors responsible for the reconstruction were dedicated to taking more just actions and aimed at meeting the real needs of the territories, in order to improve the pessimistic scenario identified, better results could be found in the final analysis. This reflects the current image of mining, demonstrating that the actions currently carried out are not aligned with the principles of sustainability.

Landscaping characterization of the campus at the UEMG Ituiutaba, Minas Gerais, Brazil

The purpose of this work was to characterize the landscape of the campus at the University of the Minas Gerais State (in portuguese, Universidade do Estado de Minas Gerais - UEMG), located at Ituiutaba. As for such, the local plants were identified ranging from herbaceous to shrub type, due to them being the most commonly employed to perform alterations for landscape purposes. Subsequently, some areas of the campus were photographed to create a landscape characterization of the scenery in regard to its landscape's composition and vegetation. 102 species of herbaceous, subshrub, and shrub plants were found belonging to 39 families; 38.23% being native and the other 61.77% being non-native (cultivated, naturalized, and exotic). In regard to the landscape’s composition in loco, the principles of message, equilibrium, scale, dominance, harmony, and climax were contemplated. Furthermore, in regard to the guiding principles for the selection of vegetable species, it was observed that aesthetic, functional and temporal attributes were incorporated in all the analyzed areas. In conclusion, the landscape’s composition of the campus at the UEMG Ituiutaba fulfills its aesthetic, functional and ecological roles, however it’s worth highlighting that the adequate handling can be the defining factor in assuring the continuity of these functions.

Distribution of root-knot nematode on coffee production in the Cerrado region of Minas Gerais state in Brazil

Distribution of root-knot nematode on coffee production in the Cerrado region of Minas Gerais state in Brazil

PSII-14 Economic impact of adding exogenous enzymes in a sorghum-based diet for growing and finishing pigs

Abstract Food efficiency in production aims for better productive results in body weight gain and reduction of dietary costs. Sorghum is a great cereal to use in pig feed, but it has a greater concentration of phytate than corn, which is not degraded by monogastric animals. The addition of exogenous enzymes aims to increase nutrient digestibility, providing greater efficiency of use. The study aim was to evaluate the performance of the animals and the economic viability of the joint use of protease and phytase in sorghum-based diets of sorghum for finishing pigs. The experiment was carried out on a commercial farm, in Patos de Minas, Minas Gerais, Brazil. Commercial hybrid pigs (n = 240; 70 d old; body weight = 26 kg) were used. Individually identified and distributed in pens respecting body weight and sex blocks in a randomized block design, two treatments with 12 replications each were evaluated, totaling 24 experimental plots, with 10 animals each. In treatment 1, control diet based on sorghum and soybean meal (SBM) with phytase 600 FYT/kg of feed (HiPhorius); and treatment 2, same composition as treatment 1 with addition of 30,000 NFP/kg of feed of protease (ProAct 360). The diets were formulated according to Brazilian tables and use nutritional matrix of enzymes (phytase and protease), excepted in control group. At 0, 48, 70 and 89 d of the experiment, the animals were weighed individually, and all the food provided was weighed and the leftovers were quantified, providing information for calculating the variables: average daily gain (ADG), average daily feed intake (ADFI) and feed conversion ratio (FCR). The feeding program costs were calculated. The results were submitted to the variance test, using the statistical program SAS, version 9.4. The difference between mean values was considered statistically significant when P &amp;lt; 0.050, using the Turkey test. There was no statistical difference (P &amp;gt; 0.05) between treatments in relation to ADFI between 0 to 49 d (P = 0.110), 0 to70 d (P = 0.431) and 0 to 89 d of experiment (P = 0.490). There was also no impact on ADG at 0 to 49 d (P = 0.325), 0 to 70 d (P = 0.834) and 0 to 89 experimental days (P = 0.915); and FCR at 0 to 49 days (P = 0.304), 0 to 70 d (P = 0.470) and 0 to 89 experimental days (P = 0.177). Although, there was no effect on the performance indices evaluated in this study, the use of exogenous enzymes such as proteases can have an economic impact on the composition of the pig diet, as it reduced the nutritional cost, increased the revenue per pig produced, increased the margin on feed in 1.06% and reducing the cost per kilogram produced by 1.18%. Therefore, the association of protease and phytase showed a significant economic impact when used in diets based on sorghum and SBM for growing and finishing pigs, even with no direct impact on performance indices.

Multi-locus sequence typing, antimicrobials resistance and virulence profiles of Salmonella enterica isolated from bovine carcasses in Minas Gerais state, Brazil.

The aim of this study was to identify virulence and antimicrobial resistance profiles and determine the sequence type (ST) by multilocus sequence typing (MLST) of Salmonella enterica isolates from bovine carcasses from slaughterhouse located in Minas Gerais state, Brazil, and its relationship with bovine isolates obtained on the American continent based on sequence type profile. The MLST results were compared with all Salmonella STs associated with cattle on American continent, and a multi-locus sequence tree (MS tree) was built. Among the 17 S. enterica isolates, five ST profiles identified, and ST10 were the most frequent, grouping seven (41.2%) isolates. The isolates presented 11 different profiles of virulence genes, and six different antibiotics resistance profiles. The survey on Enterobase platform showed 333 Salmonella STs from American continent, grouped into four different clusters. Most of the isolates in the present study (13/17), were concentrated in a single cluster (L4) composed by 74 STs. As a conclusion, five different STs were identified, with ST10 being the most common. The isolates showed great diversity of virulence genes and antibiotics resistance profiles. Most of the isolates of this study were grouped into a single cluster composed by 74 STs formed by bovine isolates obtained on the American continent.

Abstract PO4-25-11: Inconclusive Her2 by immunohistochemistry compared to in situ hybridization in breast cancer: a cross-sectional study

Abstract Introduction: Breast cancer stands as the most common malignancy diagnosed among women worldwide, with the Her2-positive subtype accounting for approximately 15% of the cases. The introduction of HER-targeted therapies has changed the natural history of this subtype, however, evaluating the Her2 status using immunohistochemistry (IHC), can yield inconclusive results in a significant percentage of cases, which requires the use of in situ hybridization techniques. The study of such cases has not been thoroughly explored, particularly in the brazilian population, and increasing interest in this subgroup of patients arises as the "Her2 low" category gathers evidence of clinical applicability. The present study aimed to assess the final Her2 status of samples with indeterminate IHC results and compare these findings with current literature. Methods: We conducted a cross-sectional study at the breast unit service of a private health network in the state of Minas Gerais, Brazil (Rede Mater Dei de Saúde). Breast tissue samples obtained over the past 5 years were analyzed, and specimens with inconclusive IHC results for Her2 were included in the study. Subsequently, the final Her2 status was determined through fluorescence in situ hybridization (FISH) test, or reanalysis in cases in which a new sample (surgical specimen) was obtained. Results: Among the initially identified 73 samples with indeterminate IHC results for Her2, a total of 15 patients were excluded due to lack of follow-up within the breast unit service. The final cohort consisted of 58 women aged between 28 and 71 years. Notably, approximately 91% of the patients exhibited positive hormone receptor tumors, whereas 9% displayed negative hormone expression. After reviewing the medical records, approximately 36% of the patients were classified as having a positive final Her2 status, while 62% had a negative final status. One patient had an inconclusive FISH result. Conclusion: The present study revealed that approximately 10% of the breast tissue samples included in the study yielded inconclusive results for Her2 by immunohistochemistry. Following FISH testing, the majority of these patients were reclassified into the negative final Her2 status category. The classification of most patients to what is known as the emerging "Her2 low" category, aligns with international publications, and highlights the clinical relevance of exploring this subset of breast cancer that gains relevance as advances provide prospects for targeted therapies. Table 1. Summarized results for the final Her2 status Absolute and percentage values for the final HER2 status in the study cohort Citation Format: Felipe Marcondes de Oliveira Coelho, Renata Capanema Saliba Franco, Enaldo Melo de Lima, Marco Antonio Dias, Anna Dias Salvador, Waldeir José de Almeida Junior, Julia Wanderley Rennó, José Tadeu Campos de Avelar. Inconclusive Her2 by immunohistochemistry compared to in situ hybridization in breast cancer: a cross-sectional study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-25-11.

Prevalence of urinary tract infection for 13 years in a public hospital in minas gerais, Brazil

Prevalence of urinary tract infection for 13 years in a public hospital in minas gerais, Brazil

Analysis of a hailstorm in the south of Minas Gerais state on October 13, 2020

Analysis of a hailstorm in the south of Minas Gerais state on October 13, 2020

Assessment of childhood dyslipidemia in the Brazilian population: Study based on the database of a large support laboratory in the state of Minas Gerais

Assessment of childhood dyslipidemia in the Brazilian population: Study based on the database of a large support laboratory in the state of Minas Gerais