Myoepithelioma is a relatively common benign tumor that exhibits various cellular morphologies. It primarily occurs in soft tissues, most commonly in the head and neck region, particularly in the salivary glands. Cases of intraosseous myoepithelioma have rarely been reported, with documented occurrences in sites such as the cranium, maxilla, iliac bone, vertebrae, tibia, and fibula. We present a rare case of intraosseous myoepithelioma involving zygomatic bone. 51-year-old male patient visited our clinic presenting zygomatic intraosseous tumor without any symptom. The patient underwent complete surgical excision involving subtotal portion of zygoma including frontal process, body and temporal process. The tumor had epithelial and spindle cell morphology and immunohistochemistry showed positive results for EMA, CK, SMA, S100, and negative results for CD34. After surgery, complete symmetry achieved, with no recurrence observed during a 1-year follow-up.
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