Improvement In Health-related Quality Of Life Research Articles

Health-Related Quality of Life Among People Living with HIV in Vietnam, a Three-Year Longitudinal Analysis.

This study examined changes in health-related quality of life (HRQOL) among people living with HIV in Vietnam over three years following antiretroviral therapy(ART) initiation. We analyzed data from a randomized trial of 639 ART-naïve patients in which HRQOL was measured using the SF-8 instrument. Mixed effects logistic regression was used to assess changes in HRQOL over time and identify associated factors. At baseline, 57.5% reported low HRQOL. HRQOL improved rapidly after ART initiation, with 89.0% reporting good HRQOL at 3months and 96.4% at 36months. Compared with men, women had slower improvement in HRQOL over time. Factors positively associated with HRQOL included higher BMI and alcohol use, while food insecurity, history of tuberculosis, advanced clinical stages, and TDF-based regimens were negatively associated. Older age was linked to poorer HRQOL outcomes. These findings highlight the effectiveness of ART in improving HRQOL while also revealing disparities in HRQOL improvements.

Effectiveness of a community intervention program on healthy lifestyles (PREDICOL) among adults with prediabetes in two Latin American cities: A quasi-experimental study.

Effectiveness of a community intervention program on healthy lifestyles (PREDICOL) among adults with prediabetes in two Latin American cities: A quasi-experimental study.

The association between recreational physical activity and health-related quality of life among breast cancer survivors: A systematic review.

e23183 Background: Breast cancer survivors are at increased risk of poor health-related quality-of-life (HRQOL). Clinical trials suggest that physical activity may improve HRQOL among cancer survivors. However, there are limited data on the generalizability of clinical trial findings to real-world settings. We aimed to fill this gap by evaluating the observational literature on post-diagnosis recreational physical activity and HRQOL among breast cancer survivors. Methods: A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted using MEDLINE/PubMed and six other databases to identify studies published from January 2003 to October 2024. Study characteristics and adjusted analyses of the association between physical activity and HRQOL among breast cancer survivors were extracted. A qualitative synthesis was performed, categorizing HRQOL outcomes into global, physical, emotional, social, and breast cancer-specific domains. Clinically meaningful differences were assessed by comparing adjusted mean differences to established minimally important differences (MIDs). Risk of bias was evaluated using the Risk of Bias In Non-randomized Studies - of Exposure (ROBINS-E) tool. Results: The search identified 5,831 sources, with 11 studies meeting inclusion criteria across the U.S. and internationally. Most studies reported positive associations between physical activity and HRQOL. For breast cancer survivors meeting aerobic physical activity guidelines, five studies found clinically meaningful improvements in global HRQOL, two found clinically meaningful improvements in physical HRQOL, and one found clinically meaningful improvement in the breast cancer-specific subscale of HRQOL. Only one study found that meeting muscle-strengthening guidelines was associated with improved global and physical HRQOL; however, the estimates did not meet the MID threshold. There was no evidence on effective dosage or types of physical activity for optimal HRQOL. Studies had high to very high risk of bias due to participant selection, subjective outcome measurement (self-report), and reporting bias. Conclusions: Observational studies suggest that meeting aerobic physical activity guidelines could lead to clinically meaningful improvements in global and physical HRQOL. Further research is needed to determine the effects of muscle-strengthening exercise, dosage, and types of physical activity useful to increase HRQOL among breast cancer survivors.

Health- related quality of life after surgery for spinal metastases.

Health- related quality of life after surgery for spinal metastases.

Patients aged 80years and older have an equal improvement in joint-specific outcome health related quality of life and level of satisfaction when compared to those aged 65-75years old undergoing knee arthroplasty.

Patients aged 80years and older have an equal improvement in joint-specific outcome health related quality of life and level of satisfaction when compared to those aged 65-75years old undergoing knee arthroplasty.

EHealth disease educational intervention vs. outpatient palliative care as usual among incurable cancer patients cared by family caregivers at home.

12062 Background: To determine whether ehealth disease educational interventions (eDEI) with fast-delivering interfaces and concise key messages can enhance capability of family caregivers and improve physical and psychological aspects of health-related quality of life (HRQoL) of incurable cancer patients at home. Methods: A randomized, open-label controlled trial was conducted in cancer center in Shanghai, China. Eligible participants (age≥18 years) with incurable cancer receiving palliative care and Karnofsky performance ≤ 70, along with a family caregiver (age ≥18 years), were randomly assigned 1:1 to either intervention (eDEI plus palliative care as usual (CAU)) or control group (CAU only). eDEI as a mobile application provides family caregivers with texts, audios and videos of symptom/side effect management and nursing skills. The intervention lasted for two months.The primary outcomes were physical aspects of HRQoL on the European Organization for Research and Treatment of Cancer Core Quality of Life Scale (EORTC QLQ-C30) and psychological aspects of HRQoL on the Hamilton Anxiety Rating Scale (HAM-A) from baseline to the end of 2 nd month. The secondary outcome was caregiver satisfaction on a questionnaire focusing on skill enhancement using Mann-Whitney tests at the end of 2 nd month. The exploratory outcome was survival benefit using Kaplan-Meier method with log rank hazard model from the enrollment to the death. The primary analyses were based on intention-to-treat principles, covering all patients who completed baseline assessment. False discovery rate (FDR) was used for multiple testing correction. Results: From Jul 28 to Nov 3, 2023, 154 eligible patients with family caregivers were randomly and evenly assigned to the intervention group and control group. 74 and 73 patients with their caregivers, in the intervention and control group respectively, completed baseline assessment. Among the 147 patients (mean age 59.9 years, 42.9% female) from baseline to the end of 2 nd month, Linear Mixed Model analyses showed that the intervention group had significant improvement of HRQoL compared with the control group, evidenced by EORTC QLQ-C30 score (FDR-adjusted p < 0.0001, Cohen’s d 0.42) and HAM-A score (FDR-adjusted p < 0.0001, Cohen’s d -0.43). There was a significant difference of caregiver satisfaction at the end of 2 nd month (mean difference score 0.57, p < 0.0001, Cohen’s d 1.19). Besides, a post-trial exploratory survival analysis showed that the intervention group had longer survival compared to the control group (median 220 days vs. 141 days, p = 0.012, hazard ratio 1.83, 95%CI 1.14 to 2.92) after adjustment of baseline characteristics. Conclusions: The fast-delivering and concise eDEI can enhance caring capability of family caregivers, improve physical and psychological aspects of HRQoL, and prolong survival among incurable cancer patients. Clinical trial information: 2300077346 .

Comparison of perceived social support and health-related quality of life in adults with type 2 diabetes before and after the COVID-19 pandemic

BackgroundThis study investigates the impact of the COVID-19 pandemic on perceived social support and health-related quality of life (HRQoL) in individuals with type 2 diabetes in the capital of Iran.MethodsThis longitudinal study, part of the Tehran Lipid and Glucose Study (TLGS), was conducted from 2017 to 2019. Among 389 eligible participants, 321 adults (61.4% women) with type 2 diabetes were enrolled. Data on social support and health-related quality of life (HRQoL) were collected both prior to the pandemic and 3–4 months after its onset in Iran. Standardized, validated, and reliable questionnaires were employed to evaluate social support and HRQoL. Paired t-tests and repeated measures analyses were used to compare scores before and after the pandemic.ResultsParticipants had a mean age of 56.6 ± 13.2 years and a body mass index of 28.5 ± 4.6 kg/m2. Before the pandemic, mean scores for the PCS and MCS were 45.7 ± 8.6 and 49.7 ± 10.6, respectively, compared to 48.5 ± 7.9 and 44.2 ± 10.1 after the pandemic. While total perceived social support scores showed no significant change, subscale differences emerged by sex. Notably, both men and women reported significantly lower MCS scores post-pandemic (p < 0.01), while PCS scores significantly increased in women (43.45 ± 9.0 vs. 47.9 ± 8.0; p < 0.001).ConclusionThe study indicates an improvement in physical HRQoL for women with diabetes, alongside a decline in mental HRQoL for both sexes, possibly associated with varying social support dynamics during the early stage of the pandemic in an urban Iranian population.

Health-related quality of life, physical and mental capacity at one year follow up of COVID-19 ICU patients: A prospective cohort study

PurposeIn 2020 as COVID-19 rapidly overwhelmed ICU resources, patient care capacity was reduced thus increasing the risk of development of post intensive care syndrome (PICS). Therefore, an increased incidence of survivors with neurocognitive and neuromuscular impairment could be anticipated. This study aimed to describe residual reductions in health-related quality of life (HRQoL) and risk factors for PICS as they pertain to outcomes one year after intensive care.Patients and MethodsBetween 01-03-2020 and 31-08-2020, all adult COVID-19 ICU patients discharged alive in two Swedish ICU were included. At 2-, 6- and, 12-months post discharge follow up was conducted. Primary outcome parameters were HRQoL up to 12-months after ICU discharge. Secondary outcome parameters were clinimetric results for physical, mental, and cognitive functions at 6 months after intensive care stay.ResultsData from 41 patients were analyzed. Fatigue, anxiety, respiratory impairments, and experienced decline in physical stamina were the dominating findings at 6 months. Criteria for PICS were fulfilled in 93% of the study population and a 60% reduction in overall HRQoL, compared with a normal age adjusted population, was seen at follow up. A slight improvement was seen at 6 months whereafter no further significant improvement in HRQoL was detected. Fatigue was the most dominant complaint, expressed by almost all patients at follow up.ConclusionLong term outcome reported in this study showed longstanding impairment in HRQoL, mostly related to reduced well-being and perceived limitations in physical ability. Overall, our findings show similarities with previously reported recovery patterns after intensive care. However, the COVID-19 cohort displayed a more profound reduction in HRQoL paralleled with severe fatigue and respiratory limitations. This signals the need for a deeper understanding of pathophysiological mechanisms of COVID-19 induced residual impairments and more precise instruments to tailor an individually designed aftercare.

Exploring Predictors of Post-Surgical Health-Related Quality of Life and Revision Surgery in Patients With Chronic Rhinosinusitis With Nasal Polyps: A Cohort Study.

Functional endoscopic sinus surgery (FESS) has been shown to be effective in improving health-related quality of life (HRQoL) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), though patient selection remains crucial for optimising outcomes. This study aimed to identify predictors of improved postoperative HRQoL and predictors of revision surgery in CRSwNP patients undergoing FESS. Cohort study. Tertiary referral hospital. A total of 153 patients were enrolled in this study. They were asked to fill out the Endonasal Endoscopic Sinus and Skull Base Surgery Questionnaire (EES-Q) preoperatively, and then at 2 weeks, 3 months and 1 year postoperatively. Linear mixed model (LMM) analyses were performed to evaluate the overall postoperative HRQoL and the separate health domains, as well as the impact of specific variables (sex, age, ASA classification, smoking, asthma, aspirin-exacerbated respiratory disease, allergic rhinitis, Lund-Mackay score, surgical procedure, postoperative antibiotics, postoperative prednisolone, FESS history, eosinophilia and preoperative EES-Q score) on HRQoL improvement. Using the same variables, a logistic regression analysis was performed to identify predictors of revision surgery. The total EES-Q score (p < 0.001), as well as the physical (p < 0.001) and social (p < 0.001) domains, significantly improved postoperatively. In the LMM analysis, the preoperative EES-Q score was the only significant variable on the postoperative HRQoL outcome (p < 0.001). Eosinophilia was the only significant variable on revision surgery (p = 0.036). FESS significantly improved postoperative HRQoL. Patients reporting worse preoperative HRQoL showed the greatest improvement postoperatively. Proven eosinophilia was the only significant predictor of revision surgery.

Sex-based difference in functional performance and quality of life 1 year after supervised exercise training in patients with symptomatic peripheral artery disease.

The long-term effects of supervised exercise training (SET) on functional performance and health-related quality of life (HRQoL) in symptomatic peripheral artery disease (PAD) are poorly investigated, especially in women. This study investigated these outcomes 1 year after SET in both women and men. In this single-arm, prospective, nonrandomized study, patients with symptomatic PAD participating in the 3-month SET program were investigated. Functional performance (6-minute walking distance [6MWD], the stair-climbing test [SCT], and the short physical performance battery [SPPB]), and HRQoL (physical component summary [PCS] score of the Short Form-36 questionnaire) were assessed before and following SET, as well as at 6 and 12 months after SET completion. Ninety patients (women: n = 30; men: n = 60) with chronic symptomatic PAD (ankle-brachial index 0.78 ± 0.22; mean age 65.4 ± 10.2 years) were included in the study. The 6MWD (women: before: 387.2 ± 88.6 m; after: 472.4 ± 57.0 m; 12 months: 469.9 ± 57.8 m; men: before: 431.7 ± 94.0 m; after: 477.5 ± 88.6 m; 12 months: 467.2 ± 73.4 m), SPPB score (women: before: 9.6 ± 2.4; after: 11.3 ± 1.0; 12 months: 11.2 ± 0.5; men: before: 10.6 ± 1.4; after: 11.5 ± 0.9; 12 months: 11.3 ± 0.8), and SCT (women: before: 8.6 ± 4.4 s; after: 5.6 ± 1.6 s; 12 months: 5.8 ± 1.2 s; men: before: 6.2 ± 2.3 s; after: 5.0 ± 1.9 s; 12 months: 5.3 ± 1.6 s) significantly improved over time (p ≤ 0.001), with no significant differences between women and men. The PCS score (women: before: 30.3 ± 8.0; after: 38.8 ± 8.4; 12 months: 35.7 ± 7.4; men: before: 32.4 ± 10.5; after: 35.7 ± 9.5; 12 months: 35.4 ± 7.6) significantly improved in women only (p = 0.020). One year after SET, both women and men with PAD exhibit similar functional benefits, whereas HRQoL improvements were observed exclusively in women.

The Effects of Interventions on Health-Related Quality of Life of People Living With Cardiovascular Disease: A Systematic Review.

To synthesise the evidence from randomised controlled trials on the effectiveness of interventions to improve health-related quality of life in people living with cardiovascular disease. Systematic review and narrative synthesis. A systematic search of eight databases was conducted to identify relevant papers that were published in English and peer-reviewed. The titles and abstracts of the articles were screened by two independent reviewers. The remaining articles underwent full text screening, followed by quality appraisal conducted by two independent reviewers. This review included 13 studies. The intervention in all studies was cardiac rehabilitation. In spite of this, the studies used different measures of health-related quality of life (HRQL) which prevented the conduct of a meta-analysis. Four themes were identified in the reported findings. Understanding the specific aspects of cardiac rehabilitation that are related to the improvement of physical and mental HRQL of people living with cardiovascular disease requires further consideration and then incorporation into nursing plans and nursing interventions to enhance health outcomes.

A Digital Outpatient Service With a Mobile App for Tailored Care and Health Literacy in Adults With Long-Term Health Service Needs: Multicenter Nonrandomized Controlled Trial.

Patients with long-term health needs are often expected to actively participate in outpatient care, assuming that they have appropriate health literacy and digital health literacy. However, the association between participation in a digital outpatient service and health literacy remain unclear. This study aims to evaluate whether digital outpatient care for 6 months improved health literacy, health-related quality of life (HRQoL), digital/eHealth literacy, and the use of health care services compared with usual care. We conducted a multicenter nonrandomized trial with 1 intervention arm and 1 control arm. Patients aged ≥18 years receiving outpatient care in the pain, lung, neurology, or cancer departments at 2 Norwegian university hospitals were allocated in a 1:2 ratio, favoring the intervention arm. The intervention arm received digital outpatient care using tailored patient-reported outcome measures, self-monitoring, and chats for timely contact with the outpatient clinic. Patient responses were assessed by health care workers via a dashboard with a traffic light system to draw attention to the most urgent reports. The control arm received usual care. The data were collected at baseline and after 3 and 6 months. The primary outcome was the change in health literacy according to the Health Literacy Questionnaire domain understanding health information well enough to know what to do from baseline to 6 months. The mean difference in change between the 2 treatment arms was the effect measure. The secondary outcomes were additional domains from the Health Literacy Questionnaire, digital/eHealth literacy, HRQoL, acceptability of the digital intervention, and health service use. Overall, 162 patients were recruited, 55 (34%) in the control arm and 107 (66%) in the intervention arm, with a 17.3% attrition rate after 6 months. There was no statistically significant difference in the primary outcome, "understanding health information well enough to know what to do," between the arms at 6 months (mean difference -0.05, 95% CI -0.20 to 0.10; P=.53). After 3 months, the health literacy domains actively managing my own health (-0.15, 95% CI -0.30 to -0.00; P=.048) and understanding health information well enough to know what to do (-0.17, 95% CI -0.34 to -0.00; P=.03), as well as both physical (-3.29, 95% CI -5.62 to -0.96; P=.006) and mental HRQoL (-3.08, 95% CI -5.64 to -0.52; P=.02), improved in the digital outpatient intervention arm compared with the control arm. This study explored digital outpatient care. Although no statistical differences were observed in patients' health literacy after 6 months, our data indicate an improvement in health literacy domains and HRQoL at 3 months. The participants reported high satisfaction with the digital outpatient care intervention, and our findings highlight the potential of digital interventions in outpatient care. ClinicalTrials.gov NCT05068869; https://clinicaltrials.gov/ct2/show/NCT05068869. RR2-10.2196/46649.

Abstract 4512: Impact of clinical response and treatment tolerability on HRQoL in patients treated with ponatinib or imatinib for newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL)

Abstract In the PhALLCON trial (NCT03589326), ponatinib demonstrated superior minimal residual disease (MRD)-negative complete remission (CR) rate, patient-reported treatment tolerability, and health-related quality of life (HRQoL) over imatinib in combination with reduced intensity chemotherapy in adults with newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). To further substantiate the effect of treatment benefits on HRQoL, we assessed the effect of clinical response and treatment tolerability on changes in HRQoL over time in PhALLCON trial patients. HRQoL was assessed using prespecified primary domains from the Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu) questionnaire and the EQ-5D-5L. Treatment tolerability was assessed using the FACT-GP5 item “bothered by treatment side effects”. Linear mixed-effects regression models were used to examine changes in HRQoL over time, with CR status and treatment tolerability as time-varying predictors, while controlling for significant covariates. The analysis included 238 patients (ponatinib 159, imatinib 79). Achieving CR was linked to significant HRQoL improvement in all FACT-Leu domains and the EQ-5D visual analogue scale (EQ-VAS), with clinically meaningful improvements in the FACT-Leu Trial Outcome Index, FACT-G Total Score, and FACT-Leu Total Score domains (Table). Treatment-related side effects led to significant and clinically meaningful deterioration in all scales. Higher levels of “bother” were associated with greater worsening in HRQoL. Given the 2-fold higher MRD-negative CR rate of ponatinib compared to imatinib, these analyses further support the HRQoL benefit of ponatinib over imatinib in patients with Ph+ ALL. Citation Format: Ajibade Ashaye, Ling Shi, Ibrahim Aldoss, Pau Montesinos, Pankit Vachhani, Vanderson Rocha, Cristina Papayannidis, Jessica T. Leonard, Maria R. Baer, Jose-Maria Ribera, James McCloskey, Yanyu Wu, Meliessa Hennessy, Alexander Vorog, Shien Guo. Impact of clinical response and treatment tolerability on HRQoL in patients treated with ponatinib or imatinib for newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 4512.

UK medical cannabis registry: an updated clinical outcomes analysis of patients with post-traumatic stress disorder

ABSTRACT Background Cannabis-based medicinal products (CBMPs) are a potential treatment for post-traumatic stress disorder (PTSD), but their long-term efficacy and safety need further investigation. This study assessed the changes in health-related quality of life (HRQoL) and adverse events in PTSD patients prescribed CBMPs. Research design and methods This observational cohort study included PTSD patients enrolled on the UK Medical Cannabis Registry for 18 months or longer. Changes in PTSD-specific symptoms (IES-R), anxiety (GAD-7), sleep quality (SQS), and general HRQoL (EQ-5D-5 L) were assessed at 1, 3, 6, 12, and 18 months. Results In 269 patients, significant improvements in PTSD symptoms, anxiety, sleep quality, and HRQoL were observed at all follow-up points (p < 0.001). On multivariate logistic regression, male gender (OR = 0.51; 95% CI:0.28–0.94; p = 0.034) was associated with a reduced chance of reporting improvements in IES-R. Adverse events were reported by 70 (26.02%) patients, with insomnia (n = 42, 15.61%) and fatigue (n = 40, 14.87%) being the most common. Conclusions CBMPs were associated with improvements in PTSD symptoms, anxiety, sleep, and HRQoL at up to 18 months. Although the study’s observational nature limits causal conclusions, these findings support further assessment of medical cannabis. Trial registration This is an observational study and is not registered as a clinical trial.

Long-term efficacy of 10 kHz spinal cord stimulation in managing painful diabetic neuropathy: A post-study survey.

To evaluate the longer-term efficacy of 10 kHz spinal cord stimulation (SCS) in managing painful diabetic neuropathy (PDN) in a routine clinical setting after the transition from the 24-month SENZA-PDN study. We contacted 142 participants who completed 24 months of postimplantation follow-up in the former randomized controlled trial (SENZA-PDN). Of these, 57 consented and responded to this longer-term post-study survey. Outcomes assessed included pain relief, health-related quality of life (HRQoL) measured using the EuroQol 5-Dimensional 5-Level (EQ-5D-5L) instrument, Patient Global Impression of Change (PGIC), HbA1c, and weight. Our survey captured patient-reported outcomes at a median of 4.1 years after implantation of a permanent 10 kHz SCS system. Among the surveyed participants, 76.8% (43 of 56) reported clinically meaningful pain relief (≥2 points), and 84.6% (44 of 52) achieved a clinically meaningful improvement in their EQ-5D-5L index score, with a final mean EQ-5D-5L index score of 0.825. Additionally, 74.5% (38 of 51) reported being "Better" or "A great deal better" on the PGIC scale. The surveyed participants reported a mean HbA1c level decrease of 0.4% (p = 0.027), with a more substantial improvement of 1.6% (p < 0.001) among those with type 2 diabetes (T2D) and a higher preimplantation HbA1c (>8%). Significant weight loss was also observed, with a mean reduction of 7.0 kg (p < 0.001) in the overall cohort and 8.7 kg (p < 0.001) in the subgroup with T2D and a higher BMI at preimplantation (≥35 kg/m2). High-frequency SCS at 10 kHz provided sustained and clinically meaningful improvements in pain and HRQoL for PDN patients at 4.1 years postimplantation, with no explants in the cohort due to inefficacy. Alongside these benefits, participants experienced metabolic changes that included reductions in body weight and HbA1c beyond that achieved at 24 months, although changes in lifestyle and medication were not accounted for in this analysis. Notably, the cohort's final mean EQ-5D-5L index score was comparable to the US norm. These findings support 10 kHz SCS as a durable and effective treatment option for PDN in routine clinical practice.

The Role of Direct-Acting Antivirals in Enhancing Quality of Life Among Individuals with Chronic Hepatitis C.

Background: Chronic hepatitis C virus (HCV) infection significantly impairs health-related quality of life (HRQoL) and poses a substantial global health concern. Direct-acting antiviral (DAA) therapies have revolutionized HCV treatment, but their impact on HRQoL, particularly considering clinical and psychological factors, requires further investigation. This study aimed to evaluate the influence of DAA therapy on HRQoL in Romanian patients with chronic HCV infection, analyzing the effects of treatment on HRQoL and the role of associated factors. Methods: A prospective, single-center study was conducted on 90 HCV-infected patients treated with a 12-week DAA regimen (Ombitasvir/Paritaprevir/Ritonavir/Dasabuvir). HRQoL was assessed at baseline (BSL), end of treatment (EOT), and 12 weeks post-treatment (SVR) using the WHOQOL BREF questionnaire. Clinical data, including fibrosis degree, prior PegIFN treatment, and psychological assessments (HADS, PSS), were collected. Statistical analyses examined HRQoL trends and associations with clinical and psychological parameters. Results: Significant improvements in HRQoL were observed across all domains over time (p < 0.0001). Gender and residence did not significantly influence HRQoL changes. Fibrosis severity and prior PegIFN treatment had no significant impact on HRQoL progression. However, comorbidities such as anemia and chronic kidney disease moderated improvements in specific HRQoL domains. Anxiety also affected HRQoL, while perceived stress and depression did not show significant effects. Conclusions: DAA therapy significantly enhances HRQoL in HCV-infected patients. While clinical and treatment-related factors had limited influence, comorbidities and anxiety played a moderating role. These findings underscore the importance of personalized care and integrated mental health assessments in HCV management.

The Role of Dysphagia on Head and Neck Cancer Patients' Quality of Life, Functional Disabilities and Psychological Distress: Outcomes of Cancer Rehabilitation from an Observational Single-Center Study.

Many patients with head-and-neck cancer (HNC) suffer from speech or swallowing disorders. We investigated the impact of dysphagia on health-related quality of life (HRQOL), functioning, and distress in HNC survivors, and whether cancer rehabilitation can alleviate these conditions. Before admission (T0) and at discharge (T1) of three-week inpatient cancer rehabilitation, patient-reported outcomes were collected. HRQOL, symptoms, functioning, and psychological distress were assessed with EORTC QLQ-C30 and Hospital Anxiety and Depression Scale (HADS) questionnaires. Of 63 HNC patients, 22 had dysphagia, 23 needed no speech therapy (Control-1), and 18 needed speech therapy, but showed no symptoms of dysphagia (Control-2). Before rehabilitation, HRQOL, physical, social, and emotional functioning were significantly lower in dysphagia patients than in controls. Dysphagia patients reported more severe general symptoms including fatigue, pain, sleep disturbances, nausea/vomiting, diarrhea, and financial worries. Furthermore, the emotional and social functioning of Control-2 was significantly worse than Control-1. For all HNC patients, social, emotional, and role functioning, fatigue, nausea/vomiting, insomnia, and appetite loss significantly improved at T1. Improvements in HRQOL were most noticeable in dysphagia patients. Psychooncological counseling reduced depression in dysphagia and Control-2 patients to levels seen in the general population. In conclusion, dysphagia patients suffer severely from impaired functioning and systemic symptoms but benefit substantially from rehabilitation.

Epidemiology, disease burden of pulmonary arterial hypertension in China: A systematic literature review.

Epidemiology, disease burden of pulmonary arterial hypertension in China: A systematic literature review.

The role of physical activity, sedentary behaviour, diet, adiposity and body composition on health-related quality of life and cancer-related fatigue after diagnosis of colorectal cancer: a Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.

The role of physical activity, sedentary behaviour, diet, adiposity and body composition on health-related quality of life and cancer-related fatigue after diagnosis of colorectal cancer: a Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.

Impact of liver transplantation on the quality of life of a cohort of high-risk recipients.

Liver transplantation significantly improves the health-related quality of life of patients with cirrhosis and high MELD scores. This study highlights rapid health-related quality of life gains after transplantation that were sustained during the one-year follow-up period, emphasizing the role of multidisciplinary care in achieving these outcomes. To assess the effects of liver transplantation on the health-related quality of life of patients with cirrhosis on the waiting list for transplantation. This retrospective study analyzed HRQOL using the EQ-5D questionnaire before (T0), and 3 (T3), 6 (T6), and 12 (T12) months after, transplantation. The questionnaire comprised five health status scores, which were also combined into a single utility score. Changes in each dimension and in the utility score were examined. A total of 212 patients were included in the study, with a mean age of 54 (SD, 12) years, and a median Model for End-Stage Liver Disease score of 17 (Q1= 11; Q3= 24). The most frequent etiology was chronic alcoholism (26.9%). Improvements in EQ-5D utility scores were registered at all post-transplantation time points compared to the score at T0: an increase of 0.22 points (p<0.001) at T3, 0.27 (p<0.001) at T6, and 0.268 (p<0.001) at T12. Scores increased over time in all domains of the EQ-5D. In a large sample of high-risk transplant recipients, a significant improvement in HRQOL occurred three months after transplantation, and was sustained over the one-year follow-up period. ■ Liver transplantation improves health-related quality of life in patients with cirrhosis and high MELD scores. ■ Significant health-related quality of life improvements occur within three months of transplantation. ■ Multidisciplinary care programs enhance post-iver transplantation physical and mental recovery. ■ Sustained health-related quality of life gains highlight the long-term benefits of liver transplantation.