Hot Topics Research Articles

B vitamins and colorectal cancer: exploring research hotspots and frontiers from a bibliometric and visual analysis (1994-2024).

Most studies suggest that B vitamins can reduce the risk of colorectal cancer (CRC), and research in this field has been growing. Focusing on 2617 articles in the field, this study used CiteSpace and VOSviewer software to evaluate the contributions of various countries/regions, institutions, authors and journals. The United States and Harvard University were identified as the most productive nation and institution, respectively, with Edward L. Giovannucci (Harvard) being the top contributor. Cancer Epidemiology Biomarkers & Prevention was recognized as the leading journal. Through the analysis of keywords and citations, we found that the potential of B vitamins (B1, B2, B6, B9, and B12) in the prevention and treatment of CRC and their mechanisms including regulation of gene expression, anti-inflammatory and antioxidant, and modulation of gut microenvironment are hot topics of research in this field. Burst detection analysis further revealed that the application of nanoparticle-based targeted drug delivery systems (such as folate-conjugated nanocarriers) in the treatment of CRC represents both a current hotspot and a future trend. This study offers a comprehensive overview of the field, highlights research hotspots and trends, and offers valuable information for researchers to further grasp the research direction.

PREFACE: SPECIAL ISSUE ON RECENT DEVELOPMENTS ON THE FRACTAL AND FRACTIONAL CALCULUS IN PHYSICS AND CIRCUITS AND SYSTEMS — PART II

Fractal and fractional calculus are hot topics widely used to describe many complex phenomena in physics and circuits and systems. Thus, this special issue compiles a series of recent works on fractal and fractional calculus in physics and circuits and systems. The topics include soliton solutions of the fractional partial differential equations, fractal MIMO radar, fractional model of the convective straight fins, existence and stability of the fractional differential equations, local fractional nonlinear oscillation, fractal heat flow in superconductors, fractal-fractional smoking model, fractal-fractional cholera epidemic system, and fractional Cahn–Allen equation.

BERT-Based Code Learning for Exception Localization and Type Prediction

Exception handling is crucial but challenging in program development. It needs to identify and handle all potential exceptions within programs to ensure system security and stabilization. Traditional exception handling relies on the expertise and experience of programmers, which often leads to oversights. Therefore, identifying exceptional code and recommending handling solutions are hot research topics with significant practical value. This paper presents a model called CodeHunter for exception localization and type prediction. The model first utilizes BERT-based model to represent code features and then uses Bi-LSTM for sequence labeling to pinpoint exceptional code. Additionally, this model also considers contextual features of the exception code and learns weights for the code within the try block and its context through the self-attention mechanism. Subsequently, it performs exception localization and predicts exception types. We conduct experiments on three different datasets. The results demonstrate that in the task of exception localization, our model can achieve a maximum accuracy of 98.6%, exceeding SOTA baselines by 11.2%. In the task of exception type prediction, our model can surpass the accuracy of SOTA baselines by a maximum of 18.7%, achieving 92.0% Top-1 accuracy. The rationality of techniques used in our model is also proved by the ablation testing. The model is implemented as an IDE plugin for programming convenience.

Insights into the history and trends of nanotechnology for the treatment of hepatocellular carcinoma: a bibliometric-based visual analysis

BackgroundNanotechnology has great potential and advantages in the treatment of hepatocellular carcinoma (HCC), but the research trends and future directions are not yet clear.ObjectivesAnalyze the development trajectory, research hotspots, and future trends of nanotechnology and HCC research globally in the past 20 years, providing a more comprehensive and intuitive reference for researchers in this field.MethodsRetrieve relevant literature on nanotechnology and HCC research in the Web of Science (WOS) Core Collection database, and conduct bibliometric analysis using software such as CiteSpace, VOSviewer, and SCImago Graphica.ResultsA total of 852 English publications meeting the criteria were retrieved from the WOS database, with an overall increasing trend in the number of publications and citation frequency over the years. China leads in the number of publications and international collaborations, followed by the USA and India. The most influential research institution is the Chinese Academy of Sciences, the most influential scholar/team is the Rahman, Mahfoozur team, and the journal with the most publications is the International Journal of Nanomedicine. A comprehensive analysis reveals that the current main research directions include new types of nanoparticles, targeted drug delivery systems, photothermal/photodynamic therapy, gene delivery systems, diagnostics, and imaging. It is anticipated that further collaboration among scholars, institutions, and countries will accelerate the development of nanotechnology in the field of HCC research.ConclusionThis study provides an in-depth analysis of the research status and development trends of nanotechnology in treating HCC from a bibliometric perspective, offering possible guidance for researchers to explore hot topics and frontiers, select suitable journals, and partners in this field.

The application of mendelian randomization in cancer research: a bibliometric analysis

Cancer is a major public health and economic issue faced globally today, significantly affecting human health and life. Due to various constraints, exploring the causal relationship between risk factors and cancer is challenging and not exactly accurate. The advent of Mendelian randomization (MR) effectively addresses these issues, providing new avenues for exploring causal relationships. We downloaded literature related to the application of MR in cancer from the Web of Science Core Collection (WoSCC) from 2005 to October 21, 2024, limiting the document type to articles and the language to English, resulting in a total of 2058 articles. We downloaded them in plain text format and extracted information on countries, authors, institutions, keywords, journals, citation counts, and publication dates, utilizing VOSviewer, CiteSpace, and R language for bibliometric analysis. From 2005 to 2024, the number of publications on the application of MR in cancer has shown a growth trend. China was the most productive country (1305); the University of Bristol was the most prolific institution (213); Smith, George Davey published the most articles in this field (59) with a total citation count of 5344; the most prolific journal in this field is Scientific Reports (71). Chronic diseases and cancer, inflammation and cancer, and sex hormones and cancer are three hot topics in the current research on the application of MR in cancer. In the future, optimizing statistical methods, standardizing research processes, collecting data from a broader range of populations, expanding data scale, and integrating other research methods to enhance research quality will be the development trends of MR in cancer research. In summary, this study employed bibliometric methods to comprehensively analyze the literature on the application of MR in cancer over the past 20 years, evaluating the historical development, current applications, research hotspots, and future trends of MR in the field of cancer.

Metasurface biosensors: Status and prospects

Metasurfaces have emerged as a rapidly evolving frontier in the fields of optics and photonics, with a growing emphasis on their potential for practical applications. The considerable volume of contributions to the study on metasurfaces has expanded, creating challenges in tracking all the advancements within this dynamic field. In this review, we select practically useful metasurfaces among the diverse metasurfaces studied so far. We refer to the selected hot research topics in metasurfaces at the beginning, succeedingly outline the status of several applications that are nearing practical applications, and then focus on biosensing applications, with particular attention to metasurface fluorescence (FL) biosensors, because FL detection is a major approach in bioscience and biotechnology. However, the contributions to FL detection by metasurface biosensors have not been reviewed in an extensive and comprehensive manner. Indeed, the metasurface FL biosensors have demonstrated capability of detecting a wide range of biomolecules including nucleic acids and proteins, such as antigens and antibodies. Notably, they offer enhanced sensitivity assays and reduced assay time when compared to conventional commercial assays. We here provide a focused review on the current status and future directions of metasurface biosensors.

Pulmonary fibrosis complicated by lung cancer: bibliometric analysis from 2004 to 2024 - research status, trends and future directions.

Although research on the association between pulmonary fibrosis and lung cancer is of great significance, to date, no bibliometric analysis has been conducted on the comorbidity of these two diseases. This study aims to explore the current status and cutting - edge trends in this field through bibliometric analysis, and to establish new directions for future research. Using the Web of Science Core Collection database, statistical calculations, graphic, and data visualization tools such as CiteSpace, VOSviewer, and Biblimatrix - biblioshiny were adopted. A total of 2,234 original Articles and Reviews on pulmonary fibrosis complicated by lung cancer published between 2004 and 2024 were identified. A slow growth trend in publications related to pulmonary fibrosis complicated by lung cancer was observed. The United States, Japan, and China were the countries with the greatest contributions. Professor Michael Kreuter from Marienhaus Clinic, Mainz, Germany, and the University of Michigan published the most articles. Through cluster analysis of co - cited literature, five main clusters were identified. Keyword analysis predicted that "nintedanib", "pirfenidone", "immunotherapy", etc. might become hot topics in the field of the comorbidity of pulmonary fibrosis and lung cancer. This bibliometric analysis shows that the literature related to the comorbidity of pulmonary fibrosis and lung cancer is on a continuous upward trend. The research hotspots and trends identified in this study provide a reference for in - depth research in this field, aiming to promote the development of research on the comorbidity of pulmonary fibrosis and lung cancer.

Antimicrobial peptides: from discovery to developmental applications.

Antimicrobial resistance (AMR) has emerged as a significant crisis in global health. Due to their advantageous properties, antimicrobial peptides (AMPs) have garnered considerable attention as a potential alternative therapy to address the AMR crisis. These peptides might disrupt cell membranes or cell walls to exhibit antimicrobial activity, or modulate the immune response to promote recovery from diseases. In recent years, significant progress has been made in the research of AMPs, alongside the emergence of new challenges. This review first systematically summarizes and critically discusses recent advancements in understanding the characteristics and current landscapes of AMPs, as well as their regulatory mechanisms of action and practical applications, particularly those reported or approved within the last 5 years. Additionally, the principles, paths for their identification, and future research trends in AMPs are also analyzed following a discussion of the advantages and disadvantages of AMPs in comparison to conventional antibiotics. Unlike significant prior literature in this field, this report has summarized the latest major discovery methods for AMPs and, more importantly, emphasized their practical applications by supporting various viewpoints using selected examples of AMPs' applications in real-life scenarios. Besides, some emerging hot topics of AMPs, including those derived from gut microbiota and their potential synergistic effects in combating AMR, were profiled. All of these indicate the originality of the report and provide valuable references for future AMP discoveries and applications.

The influence of IMPDH activity on ciliogenesis and adipogenesis of 3T3-L1 cells while undergoing differentiation.

The influence of IMPDH activity on ciliogenesis and adipogenesis of 3T3-L1 cells while undergoing differentiation.

Getting Started in Leadership: Mindsets and Skillsets for Leading in Complex Systems.

Getting Started in Leadership: Mindsets and Skillsets for Leading in Complex Systems.

Impact of digitalization on entrepreneurial ecosystems: a bibliometric exploration

PurposeThis study emphasizes digitalization in entrepreneurial ecosystems, fostering sustainability and redefining how businesses operate and entrepreneurs innovate. This study aims to examine trends and key contributions to digitalization in entrepreneurial ecosystems, focusing on organizational cultures and their influence.Design/methodology/approachUsing the PRISMA framework, the authors analyzed 500 articles from Web of Science (2010–2024) using VOSviewer. The methodology included tracking annual production, identifying prolific journals, analyzing countries, citing top articles and identifying hot topics in digitalization and entrepreneurial ecosystems.FindingsThe findings of this study highlight 2023 as the peak year for article production, with Zhang being the most productive author. The Sustainability (Switzerland) Journal leads in publications, China dominates contributions and “digital transformation” emerges as a prominent keyword in research on digitalization in entrepreneurial ecosystems.Originality/valueThis study innovatively analyses how digital technologies and innovation transformed the entrepreneurial ecosystem, identifying trends and gaps for fostering sustainability in business practices.

620 Communication in a Flash: Evolution of Nurse-led Newsletters in a Burn Center

Abstract Introduction Newsletters, a common method of standardizing communication, are aimed at engaging and informing teams, yet often fall short of their objectives. Historically, our center distributed a monthly newsletter, and staff were accountable for reading and incorporating content into their practice. Despite expectations, it was common for individuals to report they had not been informed. Recognizing that communication vital to cultivate integrated knowledge was limited by space and time, the newsletter was rebranded to the Friday Flash with weekly distribution. Only modest improvements were noted. In 2020, nurse leaders reconceptualized the newsletter’s function and design to expand readership and optimize communication. The purpose of this study was to evaluate efficacy of these changes. Methods The ‘Flash’ was redesigned for ease of weekly manipulation, via six-page template amenable to varying themes and color schemes. Weekly content was solicited from team leaders. A 28-item anonymous survey with positive (POS), neutral, and negatively phrased questions was distributed via Forms. Questions were categorized into four groups: informational, performance, outreach/support and recognition. Descriptive statistics were performed. Results Forty-six team members responded. A majority (89.1%) read the Flash each week via email. Aesthetic variation in themes and color had the greatest POS association (97.8%), followed by variety of topics (95%). Most (97.9%) felt that it was a valuable communication tool and it performed well providing interdisciplinary knowledge (93.5%). Respondents indicated content was informative (100%), and 60.9% refer to prior editions of the Flash to refresh knowledge. Content was rated by interest level. Topics of greatest interest were informational (82.8%). The most favored section was “Hot Topics for Huddle” (95.7%), then education opportunities (93.5%), peer recognition (93.5%), patient feedback (89.1%), quality improvement (87%), volunteer opportunities (80.4%), cover stories (80%), clinical documentation for providers (77.4%), research updates (76.1%), Benchmark Briefs (76.9%), patient experience (69.6%), pharmacy-related info (69.6%), employee resources (67.4%), and Charting Champions (41.3%). Conclusions Nurse leaders successfully enhanced the newsletter. Interest and readership were met with positive feedback, indicating value as a resource and mode for interdisciplinary communication. In our center ‘Flash’ has become more than a mechanism of burn injury; it is synonymous with communication. Applicability of Research to Practice Communication amongst burn professionals is critical to an interdisciplinary approach to patient care. This project may serve as a framework for nurse-led enhancement of communication. Funding for the Study N/A

Hot Spots in Urogenital Basic Cancer Research and Clinics.

Urogenital cancer is very common in the male population of Western countries, a problem of major concern for public health systems, and a frequent test subject for oncological research. In this narrative, we identify the main hot topics for clinics and the basic science of urological cancer in the last few years (from 2021 onwards), considering the information given in the abstracts of almost 300 original articles published in outstanding journals of pathology, urology, and basic science. Once defined, for the top ten list of hot topics (the 2022 WHO update on the classification of urinary and male genital tumors, new entities in kidney cancer, urinary cancer-omics, update on the Gleason grading system, targeted therapies and other novel therapies in renal cancer, news on non-muscle invasive urothelial carcinoma, artificial intelligence in urologic cancer, intratumor heterogeneity influence in therapeutic failures in urologic neoplasms, intratumor microbiome and its influence in urologic tumor aggressiveness, and ecological principles and mathematics applied to urogenital cancer study), each issue is independently reviewed in an attempt to put together the most relevant updates and/or useful features accompanied by selected illustrations. This review article addresses some of the most interesting and current hot spots in urogenital basic cancer research and clinics and is mainly aimed toward clinicians, including pathologists, urologists, and oncologists. Readers are invited to explore each topic for further, more detailed information, in addition to the references provided.

Frontiers and hotspots of 3D technology in prostatectomy from 1999 to 2024: a bibliometric analysis and visualization.

Prostate cancer is a major global health issue. Radical prostatectomy is an effective treatment for prostate cancer. The integration of three-dimensional (3D) technology in prostatectomy offers numerous benefits. We intended to perform a bibliometric analysis of the role of 3D technology in prostatectomy. Articles and review articles related to "3D" and "prostatectomy" were retrieved from Web of Science Core Collection. Microsoft Office Excel, CiteSpace, and VOSviewer were utilized for analysis and visualization. A total of 441 articles were collected. The annual publication volume and journal distribution were illustrated. Visualizations of collaborations among countries/regions, institutions, and authors were provided. Networks of reference co-citations and keyword co-occurrences, along with their respective clusters were plotted. The number of published papers significantly increased over the last 25 years. The most productive and influential country was the USA, and The University of California System was the most influential institution. The journal with the highest number of publications was BJU International. Among all authors in this field, Wijkstra H has published the most papers. Porpiglia F was the most cited author. Previous hot topics included advanced imaging and clinical trials, whereas augmented reality (AR) and robotics are likely to be hot topics in the future.

State of Telehealth and Digital Health Trends 2025

Join Telehealth and Medicine Today (THMT) editors for this face paced conversation. Hear two frontline early adopter clinicians discuss real world experiences and opinions about AI, improving patient care and operational efficiency within the healthcare sector. Questions asked during the conversation include: What’s AI powered virtual care for the consumer and physician end user? What are new features in automation to adopt and ease workflow stress and efficiency What the impact on the administration and revenue cycle? How do we automate simple tasks to reduce duplicative efforts? How do we get data and patients in front of clinicians faster? What’s the trust level using AI for clinicians today vs. next year? How good is early detection and vital signs with AI? Hot topics and trends include: Automation of dictation Commodity products, pricing, scale, and differentiation Unlimited access to agentic agents Ambient AI, AI and radiology, homecare, wearables, RPM and virtualists, Access and effectiveness - and does telehealth save money? Getting companies and clinicians to share and publish their frontline research and outcomes The program ends with advice to students and researchers on whether, and how, AI will affect them.

Progress and gaps in ecological risk under climate change research: A bibliometric and literature review approach

In the past 20 years, the ecological risks arising from climate change have attracted increasing attention. Understanding its research progress and the evolution of hot topics is paramount. However, efficient, in-depth, and robust analysis of massive and complex unstructured literature is difficult. This study employs a novel approach integrating data mining, bibliometrics, and systematic review to analyze 9122 interdisciplinary publications from 2000 to 2023. Our findings reveal a consistent annual increase in publications, with a marked acceleration post-2015. The United States and China have emerged as leading contributors to this field. Over time, the theme has traversed three pivotal hotspots and over 100 hot words. We have summarized research progress from the early to late stages into nine aspects: (1) species and population responses; (2) ecosystem impacts; (3) social-ecological system risks; (4) land use/cover change interactions; (5) ecological processes; (6) ecosystem services; (7) sustainable development goals; (8) ecosystem conservation, management, and adaptation; and (9) ecological risk assessment and major models. Additionally, we summarized international policies and efforts to combat climate risks, research gaps, and potential directions for future progress: establish the unified and comparable regional risk assessment framework; strengthen research on ecological processes, multiple sources of pressure, and composite risks; enhance research on the space-time and flow of risks; establish high-precision basic datasets; and improve communication and cooperation among multiple stakeholders. This study provides a systematic and comprehensive review of climate change’s ecological risks, which may inspire researchers interested in this field.

Quantitative Analysis on Coal Dust Explosion Research Field Based on Visualization Methods

ABSTRACT To comprehensively understand the current research status of coal dust explosions and accurately predict future research directions. This study employed visualization software to visually display and quantitatively analyze the spatio – temporal distribution characteristics of 1,058 relevant literatures. The results show that the development of this research field has gone through the fluctuating – development stage, the steady – development stage, and the achievement – explosion stage. Currently, the framework of basic theories and research methods is complete. The research on the mechanism, characteristics, propagation features, and explosion suppression of coal dust explosion forms the main foundation of the knowledge framework in this field. The research on coal dust explosion has extended to the microscopic level. At present, theories such as quantum chemistry, molecular simulation, and density functional theory are hot topics in the field of coal dust explosion and will remain at the forefront of research for a certain period in the future.

Microsampling techniques and patient-centric therapeutic drug monitoring of immunosuppressants.

Immunosuppressive pharmacotherapy after solid organ transplantation (SOT) requires therapeutic drug monitoring (TDM) for therapy individualization. The venous whole blood is still considered as routine matrix for monitoring immunosuppressive drug concentration. On the other hand, as an alternative, capillary blood collected using noninvasive sampling is convergent with a patient-centric approach. Despite their disadvantages regarding sample homogeneity and the hematocrit effect, well-known dried blood spot techniques have shown promising results. Volumetric absorptive microsampling (VAMS) and quantitative dried blood spot (qDBS) have successfully eliminated these unfavorable biased elements. Microsampling can be used in transplant recipients' care, mainly due to long-term therapy under control drug concentrations and the long distance between the place of the patient's residence and the diagnostic laboratory in the transplant center. The study aimed to discuss the clinical consequences of implementing microsampling techniques for TDM of immunosuppressants. Additionally, we have discussed the 'hot topics' in microsampling: home-based self-sampling, adherence to therapy monitoring, and drug concentration conversion to estimated traditional matrices. Finally, based on our experience and current practice, we propose best practices for microsampling implementation from bench to bedside. Microsampling techniques can potentially revolutionise immunosuppressive pharmacotherapy by enabling patient-centric individualisation in various subpopulations, significantly improving post-transplant care.

Approaches to Setting and Developing Topical Discussions in Ideological and Political Theory Courses for Applied Colleges and Universities

Based on the data and content of the topic discussions formed by lecturer and undergraduates in applied colleges and universities, it has been confirmed that the majority of undergraduates in these institutions have a clear and definite understanding of the value of Marxist theory, personal growth, and its influencing factors. Additionally, they have put forward diversified demands for ideological and political education. In order to better achieve the purpose of education and meet the learning and practical needs of undergraduates, it is necessary to set interactive questions and discussion topics in combination with the purpose and content of the course. These may include certain option questions, open voting questions, and open discussion questions characterized by unity of indoctrination and inspiration as well as dominance and the unity of dominance and subjectivity. The resource pool of discussion topics and interactive questions mainly relies on joint supply from teachers and undergraduates. The main development paths of development include: lecturers proposing questions and leading discussions; finding out questions through communication between lecturers and students; soliciting hot topics from students.

Influencing Factors and Enhancement Strategies of Political Short Video Content Communication Power in Prefecture-level Municipalities

At present, political short video has become one of the important ways of information dissemination and city image shaping in prefecture-level cities. "Bengbu Daily" is an important political communication platform in Bengbu City, and this paper takes this account as an example to explore in depth the factors affecting its content dissemination power, and through empirical analysis, it is found that the fusion of political information and hot topics, the use of celebrity effect, and the matching of popular music and labels have a facilitating effect on the dissemination effect. Meanwhile, it is further found that the account has problems such as officialization of style, lack of original content, and lack of operation skills. Accordingly, this paper describes the strategies to improve the communication power of Bengbu Daily's political short video content from three aspects: breaking the officialized expression, creating high-quality original content to explore local characteristics, and upgrading the use of skills.