During periodontitis, pathogenic oral bacteria like Porphyromonas gingivalis may exert systemic effects directly by translocating into the bloodstream and indirectly by deregulating the gut microbiota, aggravating obesity-related complications. This study aimed to evaluate the links between the periodontal infection, the oral and gut microbiota composition, and the inflammatory and metabolic profile during obesity. Thirty-nine patients suffering from severe obesity, with (n = 23) or without (n = 16) periodontitis, were enrolled. We examined the subgingival microbiota composition, periodontal status and salivary inflammatory response. The fecal microbiota composition was assessed by metagenomic analysis. Inflammatory and metabolic markers were measured in the plasma and epiploon visceral adipose tissue collected during bariatric surgery. Results show that patients with periodontitis exhibited an oral microbiota dysbiosis characterized by an increased abundance of bacteria from the red and orange complexes, worsened periodontal parameters (plaque index, bleeding index, gingival recession, probing depth and clinical attachment level), and higher IL-6 salivary levels. In fecal samples of patients with periodontitis, a higher proportion of the Proteobacteria phylum and changes in functional profile of bacteria were detected. Periodontitis was also linked to higher circulating concentrations of anti-P. gingivalis IgG, total cholesterol and lipoprotein (a). Moreover, periodontitis was associated with an enhanced production of TLR2, MyD88 and TGFβ, as well as higher activities of SOD and catalase antioxidant enzymes in the adipose tissue. Overall, these findings demonstrate that during obesity, the periodontal infection correlates with deregulated oral and gut microbiota composition, higher levels of pro-inflammatory mediators, and altered markers of oxidative stress and lipid metabolism.

Investigating gut microbiome dysbiosis in adults with chronic kidney disease: Diabetes-induced alterations via metagenomics and qPCR.

Mediterranean diet, gut microbiota, and type 2 diabetes: A systematic review and meta-analysis of intervention trials.

Analysis of gut microbiota and intestinal secondary bile acids metabolism in rats after short-term antibiotic treatment.

The amplification of bacteriophages using Salmonella YB1 as a host and its therapeutic efficacy against salmonellosis in broilers.

The impact of adverse childhood experiences on gut microbiota and markers of inflammation is mediated by obesity and depression.

Microplastic-induced alterations in the intestinal environment: Aging as a modulating factor.

Precision nutrition and food biomanufacturing for space missions: Toward intelligent and bioregenerative life-support systems.

The mechanism of honeysuckle peptides in ameliorating hyperuricemia in mice via the PGC-1α/PPARγ/ABCG2 pathway.

Xiayuxue decoction alleviates MASH by regulating gut microbiota, bile acid metabolism, and m6A modification.

Short-chain fatty acid salts are known to influence lipid metabolism, yet the specific impact of dietary sodium acetate on adipose deposition and flavor profile in yellow-feathered broilers remains to be fully characterized. This study evaluated the effects of graded sodium acetate supplementation (0%, Con;0.15%, L; 0.30%, M and 0.45%H) on lipid metabolism, and meat quality over a 70-day feeding period in 640 one-day-old male broilers.While supplementation did not significantly alter overall growth performance metrics (average daily gain, feed intake, and feed conversion ratio), it elicited a dose-dependent modulation of lipid deposition and composition. Notably, the 0.30% sodium acetate group demonstrated a significant increase in serum triglyceride (TG) concentrations and intramuscular fat (IMF) content in the breast muscle (P < 0.05). This group also exhibited elevated levels of monounsaturated fatty acids (C18:1n9) and saturated fatty acids,(C18:0) (P < 0.05),alongside enhanced concentrations of sweet and umami amino acids and a reduction in cooking loss.Hepatic analysis revealed increased concentrations of total cholesterol (TC) and TG, accompanied by upregulated expression of lipogenic and modulatory genes (LXRα, SREBP-1c, ACC, FAS, SCD1, FABP4) in the 0.30% and 0.45% sodium acetate groups (P < 0.05). Cecal microbiota profiling indicated an enrichment of beneficial taxa such as Shuttleworthia. However, the highest sodium acetate dose (0.45%) was associated with an elevated abdominal fat rate and increased liver function indices (ALT, AST, TBIL), suggesting potential metabolic overload.Liver metabolomic analysis of the 0.30% sodium acetate group identified significant enrichment of metabolites involved in cofactor biosynthesis pathways. Collectively, these findings suggest that a 0.30% dietary sodium acetate supplementation optimally enhances intramuscular fat deposition and flavor attributes, potentially mediated by alterations in gut microbiota composition, hepatic lipogenic activity, and cofactor metabolism. In contrast, higher supplementation levels may impose hepatic metabolic stress. This study underscores the importance of precise sodium acetate dosing to improve meat quality while safeguarding metabolic health in poultry production.

Targeting gut-microbiota-dependent choline metabolite trimethylamine N-oxide ameliorates bone health in ovariectomized mice.

Gut microbiota, sleep quality, and cognitive function in adults: A systematic review.

Gut microbiota communities and their multifaceted roles in immune defense and social behavior of the red imported fire ant (Solenopsis invicta).

Research progress on Rosa laevigata polysaccharides and perspectives on their potential mechanisms based on gut microbiota.

Phosphorylated Cyclocarya paliurus polysaccharide alleviates DSS-induced ulcerative colitis by improving intestinal barrier function, inhibiting inflammation and regulating gut microbiota.

Toxic effects of tire wear particle leachate on benthic fish Misgurnus anguillicaudatus: An integrated assessment of immunosuppression, metabolic disruption, and microbiome dysbiosis across concentration gradients.

Discovery and functional validation of a gut microbiota-metabolite-miRNA axis in diabetic encephalopathy.

Zinc oxide quantum dots enhanced growth performance and zinc metabolism in weaned piglets.

Inflammatory bowel disease (IBD), a gastrointestinal inflammatory ailment, presents substantial therapeutic hurdles. These challenges primarily arise from the excessive generation of reactive oxygen species (ROS) and the lack of targeted treatment strategies. To address this, ultrasmall and defect-rich MoO3-x nanozymes were fabricated through a simple liquid-phase synthesis method for boosting ROS scavenging in the treatment of inflammatory bowel disease. More specifically, the as-prepared MoO3-x nanozymes with multivalent states and oxygen vacancies not only curtail the levels of proinflammatory cytokines and showcase notable antibacterial effects but also display catalase- and superoxide dismutase-like activities, along with hydroxyl radical scavenging properties, making them more efficient in scavenging ROS than noncatalytic antioxidants. Moreover, the greater the amount of ligands, the more excellent the nanoenzyme activity. The optimized MoO3-x (-200) nanozymes exhibited stability in the gastric environment, making them suitable for oral delivery. In a murine model of IBD, these nanozymes alleviated colonic inflammation by reducing the levels of proinflammatory factors and myeloperoxidase (MPO) activity in colon tissues. Importantly, no significant systemic exposure was observed throughout the treatment. Furthermore, 16S rRNA sequencing analysis revealed that MoO3-x (-200) nanozyme intervention partially modulated the composition of gut microbiota in mice with colitis, specifically promoting the augmentation of advantageous bacterial communities. This study offers novel perspectives regarding the advancement of highly effective oral formulations for the treatment of inflammatory diseases.