The liver, as a crucial metabolic organ, undergoes significant pathological changes during the aging process, which can have a profound impact on overall health. To gain a comprehensive understanding of these alterations, we employed data-driven appr... Read More
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Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging.
- GeroScience
on Sep 20, 2023
- Biochemical Methods
- PCSK9
- National Institute Of Aging
- Disrupted Lipid Metabolism
- Significant Pathological Changes
- Aging Process
- More +
Engineering Plastic Eating Enzymes Using Structural Biology
- Biomolecules
- VOL. 13
on Sep 19, 2023
- Biochemical Methods
- Industrial Scalability
- Biophysical Methods
- Plastic Pollution
- Plastic Materials
- Atomic Level
- More +
Plastic pollution has emerged as a significant environmental concern in recent years and has prompted the exploration of innovative biotechnological solutions to mitigate plastic’s negative impact. The discovery of enzymes capable of degrading specif... Read More
Quantitative and Qualitative Determination of Biofilm Formation Pattern in Multidrug Resistance Acinetobacter baumannii in Correlation with COVID-19 and Respiratory Infected Patients
- Bionatura
- VOL. 8
on Sep 15, 2023
- Biofilm Formation Patterns
- Acinetobacter Baumannii
- Multidrug Resistance Acinetobacter Baumannii
- Baumannii Biofilm Formation
- COVID-19 Infected Patients
- Biofilm Formation
- More +
Respiratory tract infection (RTI) is one of the triggering factors that cause severe and life-threatening health problems. Acinetobacter baumannii frequently causes nosocomial infections, especially in intensive care units (ICUs). Multidrug-resistant... Read More
Detection, Identification and Diagnostic Characterization of the Staphylococcal Small Colony-Variant (SCV) Phenotype
- Antibiotics
- VOL. 12
on Sep 14, 2023
- Biochemical Methods
- Growth-based Methods
- Solid Agar Media
- Tiny Colonies
- Reduced Growth Rate
- Special Approach
- More +
While modern molecular methods have decisively accelerated and improved microbiological diagnostics, phenotypic variants still pose a challenge for their detection, identification and characterization. This particularly applies if they are unstable a... Read More
Case report: Francisella philomiragia bacteremia in a patient with acute lymphoblastic leukemia
- Frontiers in Cellular and Infection Microbiology
- VOL. 13
on Sep 14, 2023
- Francisella Philomiragia
- Conventional Gram-staining
- Sphingomonas Paucimobilis
- Gram-negative Coccobacillus
- False Identification
- Biochemical Tests
- More +
Francisella philomiragia is a Gram-negative coccobacillus, which is a very rare human opportunistic pathogen causing pneumonia and systemic infection. It is difficult to identify this bacterium through conventional Gram-staining and biochemical metho... Read More
Phytonutrients and Anti-Nutrient Composition of Aqueous Extract of Fermented Seeds of Prosopis africana
- Asian Journal of Research in Biochemistry
- VOL. 13
on Sep 13, 2023
- Aqueous Extract Of Seeds
- Gas Chromatography-mass Spectrophotometer
- Prosopis Africana
- Genus Prosopis
- Food Condiment
- Extract Of Seeds
- More +
Prosopis africana is a perennial leguminous plant in the genus Prosopis. The seeds are used as food condiment. This study was aimed at evaluating the phytochemical, proximate, vitamin and anti-nutrient compositions of aqueous extract of fermented see... Read More
Protective effect of paricalcitol in rat testicular damage induced by subchronic 1800MHz radiofrequency radiation.
- Biochemical and biophysical research communications
- VOL. 680
on Sep 12, 2023
- Biochemical Methods
- Testicular Damage
- RFR
- RFR Exposure
- Paricalcitol Administration
- Seminiferous Tubule Diameters
- More +
In the present study, the possible protective effects of paricalcitol (P) were investigated in testicular damage because of 1800MHz radiofrequency radiation (RFR) exposure. Male Sprague Dawley rats 8-10 weeks old (n=28) were randomly divided into fou... Read More
Морфофункциональные изменения в органах экспериментальных животных при применении фармацевтических композиций на основе низина
- Agrarian Bulletin of the
- VOL. 237
on Sep 12, 2023
- Organs Of Animals
- Pharmaceutical Compositions
- Experimental Group Of Animals
- Silicon Glycerolates
- Compensatory Changes
- Female Laboratory Rats
- More +
Abstract. The use of new drugs on highly productive animals is impossible without identifying the permissible consequences of the use of substances included in the composition on the functional state of individual organs, tissues and body systems. In... Read More
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir.
- Nature
on Sep 11, 2023
- Biochemical Methods
- Loss In Enzymatic Activity
- Mpro Inhibitor
- High Mutation Rates
- Viral Fitness
- Loss Of Fitness
- More +
Nirmatrelvir is a specific antiviral targeting the main protease (Mpro) of SARS-CoV-2, and has been approved to treat COVID-191,2. As an RNA virus characterized by high mutation rates, whether SARS-CoV-2 will develop resistance to nirmatrelvir is a c... Read More
Osteological, multi-isotope and proteomic analysis of poorly-preserved human remains from a Dutch East India Company burial ground in South Africa
- Scientific Reports
- VOL. 13
on Sep 6, 2023
- Biochemical Methods
- Dutch East India Company
- Dental Pathological Conditions
- Cape Town Region
- Childhood Origins
- Pathological Conditions
- More +
Skeletal remains discovered in Simon’s Town, South Africa, were hypothesised as being associated with a former Dutch East India Company (VOC) hospital. We report a novel combined osteological and biochemical approach to these poorly-preserved remains... Read More
Diversity and Composition of Gastrointestinal Helminths and Gram-Negative Bacteria of the West African Rainbow Lizard (Agama picticauda) in a Human-Modified Landscape: Implications for Conservation and Zoonosis
- International Journal of Zoology
- VOL. 2023
on Sep 5, 2023
- Biochemical Methods
- Wet Season
- Prevalence Of Ascaris
- Urban Lizards
- Human-Modified Landscape
- Spillover Events
- More +
Emerging infectious diseases are negatively impacting herpetofaunal populations globally, posing a major conservation threat. Anthropogenic perturbations of natural habitats may influence wildlife disease dynamics and spillover events. Although viral... Read More
Evidence for preexisting prion substrain diversity in a biologically cloned prion strain.
- PLoS pathogens
- VOL. 19
on Sep 5, 2023
- Prion Strains
- TME
- DY
- Prion Formation
- Prion Diseases
- Dominant Strain
- More +
Prion diseases are a group of inevitably fatal neurodegenerative disorders affecting numerous mammalian species, including Sapiens. Prions are composed of PrPSc, the disease specific conformation of the host encoded prion protein. Prion strains are o... Read More
Vascular Endothelial Growth Factor Supplementation Enhance Skin Antioxidant Capacity in Hyperglycemic Rats
- GAZI UNIVERSITY JOURNAL OF SCIENCE
on Sep 1, 2023
- Negative Control Group
- Parameters In Skin Tissue
- Days Of Wound Healing
- VEGF Group
- Healing Process Of Skin Wounds
- AA Levels
- More +
The fundamental reasons for delayed wound healing in diabetic animals include inadequate production of growth factors or their increased devastation. Vascular Growth Factor (VEGF) has a biological role in the healing process of mucosal and skin wound... Read More
Nitrogen supply in the upwelling of mid-west region of the South China Sea: The case of mesopelagic fishes
- Ecological Indicators
- VOL. 153
on Sep 1, 2023
- Biochemical Methods
- Non-upwelling Areas
- Mesopelagic Fishes
- Differences In δ15N
- δ13C Of Fatty Acids
- Species Of Mesopelagic Fishes
- More +
Coastal upwelling zone hosts most fishing grounds worldwide and nitrogen dynamics in those systems mainly have been addressed through the nutrients replenished the ecosystem. Compared with coastal and upper-layer ecosystems, relatively limited knowle... Read More
Phenotypic and genotypic resistance to antibiotics in Staphylococcus aureus strains isolated from cattle milk in Northern Kazakhstan
- Veterinary World
on Sep 1, 2023
- Prevalence Of Resistance
- DD Method
- Northern Kazakhstan
- Genetic Determinants Of Antibiotic Resistance
- Distribution Of Antibiotic Resistance Genes
- Antibiotic Resistance Genes
- More +
Background and Aim: Staphylococcus aureus is the most frequent and ubiquitous cause of mastitis in cows. In recent decades, antibiotic resistance has rapidly spread among infectious disease pathogens in Kazakhstan and globally. This study examined th... Read More
Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species.
- Ecotoxicology and environmental safety
- VOL. 263
on Sep 1, 2023
- Responses In Marine Organisms
- Phosphorylation Modifications
- Tyrosine-protein Kinase Src
- Molecular Regulation Network
- Heat Stress
- Sublethal Temperature
- More +
High-temperature stress caused by global climate change poses a significant threat to marine ectotherms. This study investigated the role of protein phosphorylation modifications in the molecular regulation network under heat stress in oysters, which... Read More
D-Glucose- and d-mannose-based antimetabolites. Part 4: Facile synthesis of mono- and di-acetates of 2-deoxy-d-glucose prodrugs as potentially useful antimetabolites.
- Carbohydrate research
- VOL. 531
on Sep 1, 2023
- Biochemical Methods
- Poor Pharmacokinetic Properties
- Potential Antiviral Agent
- Antiviral Agent
- Tumor Penetration
- Drug-like Properties
- More +
2-Deoxy-d-glucose (2-DG), a compound known to interfere with d-glucose and d-mannose metabolism, has been tested as a potential anticancer and antiviral agent. Preclinical and clinical studies focused on 2-DG have highlighted several limitations rela... Read More
The Prevalence of Peripheral Vascular Disease (PVD) and Its Correlation with Biochemical Parameters in Type 2 Diabetes Mellitus (T2DM) - A Tertiary Care Hospital Based Study in Eastern India
- Journal of Clinical Cases and Reports
- VOL. 6
on Sep 1, 2023
- PVD
- T2 DM
- Prevalence Of Peripheral Vascular Disease
- Biochemical Parameters In Type
- T2DM
- Low Levels Of HDL
- More +
INTRODUCTION PVD, one of the major macrovascular complications of T2DM, usually begins at an earlier age and remains subclinical for a long duration. So early detection of PVD will help to assess its true prevalence and hence prevention of overt mani... Read More
Force-induced biphasic regulation of VWF cleavage by ADAMTS13.
- Thrombosis research
- VOL. 229
on Sep 1, 2023
- Biochemical Methods
- VWF
- Proteolytic Activity Of ADAMTS13
- VWF Cleavage
- Presence Of ADAMTS13
- Shear Stress
- More +
It is crucial for hemostasis that platelets are rapidly recruited to the site of vascular injury by the adhesive ligand von Willebrand factor (VWF) multimers. The metalloproteinase ADAMTS13 regulates this hemostatic activity by proteolytically reduci... Read More
Assessing the physicochemical stability and intracellular trafficking of mRNA-based COVID-19 vaccines.
- International journal of pharmaceutics
- VOL. 644
on Sep 1, 2023
- mRNA-based Vaccines
- Storage Conditions
- Effects Of Thermal Denaturation
- Stability Of Vaccines
- Physicochemical Stability
- Biophysical Methods
- More +
The emergence of SARS-CoV-2 in Wuhan, China in 2019 has had a profound impact on humanity in every facet. While vaccines against this viral pathogen have been approved a year later, limitations to this therapeutic intervention persist, such as drug s... Read More