- New
- Research Article
- 10.12200/j.issn.1003-0034.20250722
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Hanwei Kang + 5 more
To explore clinical efficacy of closed reduction and percutaneous pinning technique in treating Lauge-Hansen typeⅡankle fractures with posterior-external rotation. A retrospective analysis was conducted on clinical data of 106 patients with Lauge-Hansen posterior and external rotation typeⅡankle fractures who were admitted from January 2021 to February 2024. The patients were divided into closed reduction and percutaneous pinning internal fixation group (minimally invasive group) and open reduction and internal fixation (ORIF) group based on surgical methods. There were 53 patients in minimally invasive group, included 24 males and 29 females;aged from 32 to 75 years old with an average of (52.40±9.12) years old;27 patients on the left side and 26 patients on the right side. There were 53 patients in ORIF group, included 23 males and 30 females;aged from 30 to 72 years old with average of (51.72±9.65) years old;25 patients on the left side and 28 patients on the right side. Operation time, intraoperative blood loss, hospital stay, and complication rate between two groups were compared. The pain condition was evaluated by visual analogue scale (VAS) at 1, 2, 3, 7 and 30 days after operation;clinical efficacy was evaluated by American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score and Olerud-Molander ankle score (OMAS) at 3 and 6 months after operation;ankle joint range of motion at 6 months after operation was recorded and compared. Both groups of patients were successfully completed operation and followed up. The follow-up period ranged from 9 to 15 months with an average of (12.15±2.37) months. Operation time, hospital stay and intraoperative blood loss in minimally invasive group were (19.09±6.87) min, (10.19±2.91) days and (5.94±3.00) mL respectively, while those in ORIF group were (26.57±6.92) min, (12.58±3.49) days and (12.87±4.65) mL respectively;there were statistically significant differences between two groups (P<0.05). The comparison of VAS between two groups at 30 days after operation showed no statistically significant difference (P>0.05). The comparisons of AOFAS ankle-hind foot scores and OMAS scores between two groups at 3 and 6 months after operation also showed no statistically significant differences (P>0.05). There were no statistically significant differences in ankle joint flexion and extension ranges of motion between the healthy and the affected sides at 6 months after operation (P>0.05). The differences of internal and external rotation activities in minimally invasive grou were (2.60±1.52)° and(1.36±0.59)°, which were better than those of ORIF group (5.49±1.72)° and (2.57±1.37)°;the differences were statistically significant (P<0.05). The incidence of complications in minimally invasive group was 5.66%(3/53), which was lower than that in ORIF group 20.75% (11/53), and the difference was statistically significant (P<0.05). No patients of nonunion of fractures or loss of reduction occurred in either group. Closed reduction and percutaneous pinning for Lauge-Hansen typeⅡankle fractures with posterior-external rotation has shorter operation time and hospital stay, less bleeding, relieve pain, improve the range of motion of ankle internal and external rotation, and reduce the occurrence of complications.
- New
- Research Article
- 10.12200/j.issn.1003-0034.20251112
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Jianjiang Wei + 3 more
To explore related factors and preventive strategies of functional ankle instability (FAI) in patients with ankle fracture (AF) after surgery. Clinical data of 348 patients with atrial fibrillation (AF) who underwent surgical treatment from January 2022 to September 2023 were retrospective analyzed, including 143 males and 205 females;aged 65 years or above for 150 patients, and younger than 65 years old for 198 patients;body mass index(BMI) of≥24 kg·m-2 for 217 patients, and BMI<kg·m-2 for 131 patients. All patients were divided into unstable group(71 patients) and stable group (277 patients) based on whether FAI occurred at 1 year after operation. The occurrence of FAI was statistically analyzed;gender, age, BMI, injury cause, smoking history, drinking history, hypertension, diabetes, posterior malleolus fracture Haraguchi classification, the time from injury to operation, proportion of fracture fragments on joint surface, combined ankle dislocation, deltoid ligament injury, surgical method, postoperative complications, whether there was nerve injury during operation, whether calcaneal traction was performed, and the start time of rehabilitation between two groups were compared. Using multivariate Logistic regression analysis was identified the risk factors for the occurrence of FAI after AF. A total of 348 patients who underwent AF were followed up for 1 year after operation. Among them, 71 patients developed FAI, with an incidence rate of 20.40%. The proportions of patients in unstable group who were≥65 years old, Haraguchi typeⅡposterior malleolus fractures, a post-injury to surgery time of≥8 h, fracture block occupying ≥25% of joint surface, had combined ankle dislocation, treated with tension screws, had infection or incision dehiscence, and start-to-rehabilitation time of ≥7 days were all higher than those in stable group, and the differences were statistically significant (P<0.05). Multivariate Logistic regression analysis showed age above 65 years old [OR=2.221, 95%CI(1.207, 4.086), P=0.010], posterior malleolar fracture Haraguchi classification typeⅡ[OR=2.664, 95%CI (1.718, 4.133), P<0.001], fracture block occupying≥25% of joint surface [OR=1.902, 95%CI(1.241, 2.916), P=0.003], combined with ankle joint dislocation [OR=2.385, 95%CI(1.330, 4.276), P=0.004], and the start of rehabilitation time≥7 days [OR=1.972, 95% CI(1.296, 2.999), P=0.002] were independent risk factors for FAI after AF (P<0.05). Age above 65 years old, Haraguchi classification of posterior malleolar fracture for typeⅡ, fracture fragment occupying≥25% of the joint surface, combined with ankle joint dislocation, and the start of rehabilitation time being≥7 days are independent risk factors for FAI after AF. To reduce the occurrence of postoperative FAI, clinical measures could be taken based on these factors to intervene in high-risk patients.
- New
- Research Article
- 10.12200/j.issn.1003-0034.20250097
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Shangzeng Wang + 7 more
To compare clinical efficacy of TightRope button-loop titanium plate elastic fixation and hollow tension screw fixation in treating ankle fractures with accompanying tibiofibular syndesmosis injury. A retrospective analysis was conducted on 42 patients with ankle fractures accompanied by syndesmosis injury who were admitted from January 2020 to January 2023. The patients were divided into TightRope group and cannulated screw group based on fixation methods. There were 19 patients in TightRope group, including 8 males and 11 females;aged from 34 to 67 years old with an average of (45.63±8.75) years old;body mass index (BMI) ranged from 20.1 to 26.7 kg·m-2 with an average of (23.36±1.88) kg·m-2;the course of disease ranged from 1 to 6 days with an average of(2.42±1.58) days;9 patients on the left side and 10 patients on the right side;4 patients with pronation abduction type, 12 patients with pronation eversion type, and 3 patients with supination eversion type according to Lauge-Hansen classification;elastic fixation was performed using TightRope button band titanium plates. There were 23 patients in cannulated screw group, including 15 males and 8 females;aged from 32 to 56 years old with an average of (43.22±6.82) years old;BMI ranged from 19.6 to 28.6 kg·m-2 with an average of(24.18±1.96) kg·m-2;the course of disease ranged from 1 to 5 days with an average of (2.61±1.03) days;10 patients on the left side and 13 patients on the right side;4 patients with pronation abduction type, 14 patients with pronation eversion type, and 5 patients with supination eversion type according to Lauge-Hansen classification;hollow pull force screws were used for fixation. American Orthopaedic Foot and Ankle Society(AOFAS) ankle-hindfoot scores, the distance between the lower tibia and fibula, the length of the lower tibia-fibula overlap, AOFAS-AH grade, total gait score, the partial and complete weight-bearing time, and complications between two groups before operation and 3, 6, and 12 months after operation were compared. Both groups were followed up after operation, the follow-up period for TightRope group ranged from 12 to 16 months with an average of (13.68±1.11) months, while that for cannulated screw group ranged from 12 to 16 months with an average of (13.83±0.98) months. At 3 months after operation, pain and total score of TightRope group on AOFAS ankle-hindfoot scale were (37.37±4.52) and (91.16±7.79) points respectively, which were higher than those of hollow screw group (30.87±6.68) and (83.78±13.06) points, and the differences were statistically significant (P<0.05). There were no statistically significant difference in scores of the other items and total score of AOFAS ankle-hindfoot between two groups before operation and 3, 6, and 12 months after operation (P>0.05). The scores for each item and total score between two groups at 3, 6, and 12 months after operation were all higher than those before operation, and the differences were statistically significant (P<0.05). There was no statistically significant difference in excellent rate of AOFAS ankle-hindfoot between two groups at 12 months after operation (P>0.05). There were no statistically significant difference in distance between the lower tibia and fibula, the length of the lower tibia-fibula overlap between two groups at preoperative stage and at 3, 6, and 12 months after operation(P>0.05). The distance and overlap length of the lower tibiofibular interval at 3, 6, and 12 months after operation between two groups were significantly improved compared to those before operation, and the differences were statistically significant(P<0.05). Postoperative gait score of TightRope group at 12 months was (90.47±2.27) points, which was higher than that of cannulated screw group (88.78±2.35) points, and the difference was statistically significant (P<0.05). The duration of partial weight-bearing in TightRope group was (4.05±0.91) weeks, which was shorter than that in cannulated screw group (5.09±1.47) weeks, and the difference was statistically significant (P<0.05). There was no statistically significant difference in duration of complete weight-bearing between two groups (P>0.05). After operation, the gap between the tibia and fibula was normal between groups, and the fracture alignment was good. There was no infection or poor fracture healing. In cannulated screw group, 2 patients had screw fractures after partial weight-bearing and the screws were removed through surgery. TightRope button-loop titanium plate with elastic fixation could maintain the stability of distal tibiofibular syndesmosis while promoting the early recovery of ankle joint function, reducing postoperative complications and the need for the secondary surgeries. However, its long-term efficacy still requires further research and verification.
- New
- Research Article
- 10.12200/j.issn.1003-0034.20241146
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Jie Guo + 5 more
Intervertebral disc degeneration (IVDD) is one of the main causes of lower back pain. The chronic accumulation of aging and apoptosis of nucleus pulposus cells (NPCs) is believed to be related to IVDD. In recent years, mitochondrial autophagy which as an important clearance mechanism within cells, has gradually attracted attention. The PINK1/Parkin signaling pathway is regarded as the key pathway regulating mitochondrial autophagy, and it plays a significant role in physiological and pathological processes of NPCs. The mechanism by which PINK1/Parkin signaling pathway mediates mitochondrial autophagy could be understood as follows, PINK1, as the sensor for mitochondrial quality regulation, is activated. It recruits and activates Parkin to the mitochondrial membrane through phosphorylation of ubiquitin, and then undergoes Parkin-dependent substrate ubiquitination, recruitment of autophagy receptors, formation of autophagosomes, and fusion with lysosomes, ultimately completing the extremely important autophagy process. Current research indicates that abnormality of PINK1/Parkin signaling pathway may be closely related to IVDD, but the specific mechanism still requires further exploration. The paper explores research progress of mechanism by which mitochondrial autophagy affects IVDD based on PINK1/Parkin signaling pathway, with the aim of providing new strategies and targets for the treatment of IVDD.
- New
- Research Article
- 10.12200/j.issn.1003-0034.20250331
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Shutao Zhang + 2 more
Foot and ankle assistive devices are a type of external apparatus that improves functional impairment or structural abnormalities of the lower limbs through biomechanics. They act on ankle and musculoskeletal system of foot through customized or standardized structural designs, aiming to alleviate patients' pain, improve gait stability, and delay progression of disease. At present, there are a wide variety of foot and ankle assistive devices in China, but their application in the field is not sufficient. Their main function still remains at long-term immobilization. For diseases such as abnormal lower limb muscle strength after stroke, congenital clubfoot, and congenital flatfoot, there are already various innovative assistive devices that could play a corrective role and improve the lower limb activity function of patients. In recent years, 3D printing technology has been able to achieve both "static" and "dynamic" correction functions, meeting the evolving process of orthopedic diseases. Meanwhile, the intelligent sensing and real-time feedback system could use algorithms to monitor abnormal gait or pressure distribution in the foot in real time, and adjust the supporting force of the auxiliary device. Based on this, through an overview of common classifications of ankle-foot assistive devices currently available, and by reviewing and summarizing the latest clinical research progress of ankle-foot assistive devices, it is hoped to provide ideas for clinical application.
- New
- Research Article
- 10.12200/j.issn.1003-0034.20240912
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Weixiang Pang + 1 more
To explore the role of Hippo signaling pathway-related genes in osteoarthritis (OA), identify potential diagnostic biomarkers, and provide a basis for precision diagnosis and targeted therapy. Transcriptomic data from GSE114007 and GSE57218 in GEO database were analyzed. Differentially expressed genes (DEGs) were identified using DESeq2 and intersected with Hippo pathway genes and weighted gene co-expression network analysis (WGCNA) results to obtain differentially expressed Hippo-related genes (DE-HRGs). Candidate genes were screened using the least absolute shrinkage and selection operator (LASSO) regression, support vector machine-recursive feature elimination (SVM-RFE), and the Boruta algorithm. Their diagnostic value was assessed with receiver operating characteristic (ROC) curves and neural network model. To validate the findings, a rat OA model was established by using Hulth method with control and model groups, 8 rats in each group. The control group received no treatment, while OA group were underwent surgical modeling. Four weeks after modeling, X-ray examinations of knee joints were conducted to observe joint space, the shape of joint surfaces, and the formation of bone spurs. The expression levels of epidermal growth factor receptor (EGFR) and protein kinase AMP-activated non-catalytic subunit beta 2 (PRKAB2) in cartilage tissue were detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR). Gene set enrichment analysis (GSEA) was employed to analyze functional pathways of EGFR and PRKAB2, and single-sample gene enrichment analysis (ssGSEA) was used to evaluate the relationship between key genes and immune cell infiltration. A total of 3, 996 DEGs were identified, and 11 DE-HRGs were obtained. LASSO regression, SVM-RFE and Boruta algorithms jointly selected 5 candidate genes. Among them, EGFR and PRKAB2 had an area under the curve (AUC) greater than 0.8 in both training set and validation set (0.823 and 0.811 respectively), demonstrating excellent diagnostic performance. Neural network model further demonstrated its discriminative ability (with an AUC of 0.835). In rabbit OA model, X-ray images showed control group had narrowed knee joint space accompanied by bone spurs formation. The results of RT-qPCR showed compared with control group, the expressions of EGFR (1.5±0.8) and PRKAB2 (1.2±0.7) in OA group were lower than those in control group (3.8±1.5), (2.9±1.3), and the differences were statistically significant (P<0.05). The functional enrichment analysis revealed both EGFR and PRKAB2 were involved in signaling pathways such as Hippo and adenosine monophosphate-activated protein kinase (AMPK). The analysis of immune infiltration results showed PRKAB2 was positively correlated with Th17 cells (r=0.47, P<0.01), while EGFR was negatively correlated with natural killer T cells (r=-0.61, P<0.001). EGFR and PRKAB2 can serve as potential biomarkers for OA. They may participate in the occurrence and development of OA by regulating Hippo pathway and immune microenvironment, providing new ideas for molecular mechanism research and targeted therapy of OA.
- New
- Research Article
- 10.12200/j.issn.1003-0034.20250848
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Yongxing Jia + 4 more
To explore t predictive value of Wells score combined with D-dimer (D-D) test for the risk of deep venous thrombosis(DVT) before ankle fracture surgery. From May 2023 to May 2024, clinical data of 80 patients with ankle fractures were retrospective analyzed, included 50 males and 30 females;age from 35 to 69 years old with an average of (52.61±8.91) years old;body mass index (BMI) ranged from 20.5 to 24.9 kg·m-2 with an average of (23.41±2.09) kg·m-2;43 patients caused by high-energy injuries and 37 patients by low-energy injuries;30 patients with single ankle fractures and 50 patients with multiple ankle fractures;21 patients had combined vascular and nerve injuries;13 patients had a history of diabetes;the time from injury to medical consultation ranged from 40 to 103 min (69.77±5.53) min;preoperative waiting time ranged from 19 to 38 min with an average of (25.98±10.24) min;preoperative risk assessment and prediction (RAPT) score ranged from 6 to 11points with an average of (8.02±1.87) points. The patients were divided into DVT group (21 patients) and non-DVT group (59 patients) based on whether DVT occurred. Wells scores, D-D levels, thrombin-antithrombin complex (TAT), plasmin-α2-plasmin inhibitor complex (PIC), thrombomodulin (TM), and tissue plasminogen activator-inhibitor complex (t-PAIC) between two groups were conducted by Pearson correlation analysis. Logistic regression was used to analyze risk factors for DVTin ankle fractures, receiver operating characteristic curve (ROC) was employed to evaluate diagnostic value of Wells score and D-D levels for DVT of ankle joint. There were statistically significant differences in proportion of high-energy injuries, the proportion of combined nerve and vascular injuries, the time from injury to medical consultation, Wells score, D-D, TAT, PIC, TM, and t-PAIC between non-DVT group and DVT group (P<0.05). Pearson correlation analysis results showed TAT (r=0.291, P=0.009), PIC (r=0.254, P=0.023), TM (r=0.469, P<0.001), and t-PAIC (r=0.598, P<0.001) were positively correlated with Wells score;TAT (r=0.308, P=0.005), PIC (r=0.340, P=0.002), TM (r=0.501, P<0.001), and t-PAIC (r=0.650, P<0.001) were positively correlated with D-D level. Logistic regression analysis showed high-energy injury [OR=3.390, 95%CI(1.950, 4.713), P=0.004], combined with vascular and nerve injury[OR=2.169, 95%CI(1.494, 3.610), P<0.001], elevated TAT level[OR=3.965, 95%CI(2.569, 5.474), P<0.001], increased Wells score[OR=1.233, 95%CI(0.905, 1.761), P=0.032], and elevated D-D level[OR=2.087, 95%CI(0.356, 3.881), P<0.001] were all risk factors for the occurrence of DVT after ankle fracture surgery;ROC curve analysis showed area under the curve (AUC) for combined diagnosis of Wells score, D-D level, and their combination were 0.674[95%CI(0.549, 0.799), P=0.018], 0.656[95%CI(0.510, 0.801), P=0.035], and 0.837[95% CI(0.727, 0.947), P<0.001], respectively. The combined diagnosis was > Wells score >D-D level (P<0.05). Wells score and D-D level of patients with ankle joint fracture and DVT showed a significant increase. The combined detection of these two indicators has a better diagnostic value for ankle joint fracture DVT than the detection of a single indicator, and it has good clinical value.
- New
- Research Article
- 10.12200/j.issn.1003-0034.20250808
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Cheng Wang + 11 more
To explore surgical technique and mid-term efficacy of treating talar body fractures through lateral malleolus osteotomy approach with absorbable rod fixation. From January 2021 to April 2023, clinical data of 25 patients with talar body fractures who underwent anatomical reduction with absorbable rods via the lateral malleolus osteotomy were retrospectively analyzed, included 15 males and 10 females;aged from 20 to 54 years old with an average of (34.3±8.2) years;8 patients were typeⅡand 17 patients were type Ⅲ according to Sneppen classification of talar body fractures. Fracture healing time, American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, visual analogue scale (VAS), and the occurrence of complications were evaluated. All 25 patients were followed up after operation, the follow-up period ranged from 24 to 52 months with average of(35.7±6.5) months. All patients were achieved fracture healing, and the healing time ranged from 12 to 18 weeks with an average of(15.1±1.7) weeks. AOFAS ankle-hindfoot score increased from (45.28±4.41) points before operation to (88.96±5.19) points at 2 years after operation;13 feet were excellent, 9 feet were good, and 3 feet were fair. VAS decreased from 8.0 (7.0, 9.0) points before operation to 2.0 (1.0, 2.5) points at 2 years after operation, and the differences at each follow-up time point were statistically significant(P<0.05). The imaging examinations showed all patients had good healing of talus body fractures and the osteotomy sites. The absorbable rods gradually degraded over a period of 20 to 24 months after operation, without any failure or displacement of internal fixation. No traumatic arthritis or talus necrosis occurred. The lateral malleolus osteotomy approach could provide a good surgical field, and achieve satisfactory reduction results for talus body fractures combined with absorbable rods for fixation. The postoperative functional recovery is satisfactory, and it avoids the need for secondary surgery to remove internal fixation. The mid-term efficacy is also good.
- New
- Research Article
- 10.12200/j.issn.1003-0034.20241126
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Liangzhi Zhang + 9 more
To explore effects of needle knife on autophagy and matrix degradation-related proteins of chondrocytes in rabbits with knee osteoarthritis (KOA). Eighteen healthy male New Zealand rabbits aged 6 months, with a body weight of (2.0±0.5) kg, were selected and randomly divided into blank group, model group and needle knife group, with 6 rabbits in each group. KOA rabbit animal model was established by fixing and immobilizing left hind limb of rabbits in an extended position with a plaster cast for 6 weeks, following the modified Videman method. The control group was not immobilized. Both of control group and model group were not intervened. The needle knife group received needle knife intervention once a week for 4 weeks. One week later, Kellgren-Lawrence(K-L) grading and Magnetic Resonance Knee Osteoarthritis Score (MOAKS) were used to evaluate bone spurs, joint space, cartilage smoothness and effusion on the left knee joint of rabbits; Lequesne MG score was used to evaluate effects of acupuncture knife on symptoms, signs and functional activities of rabbit's knee joint. After killing rabbits, cartilage morphology of left knee joint was observed;pathological changes of cartilage on the left knee joint of rabbits were examined by hematoxylin O-eosin staining under a light microscope;TdT-mediated dUTP nick end labeling (TUNEL) staining technique was used to detect apoptosis rate of chondrocytes on the left knee joint of rabbits. Real-time quantitative polymerase chain reaction (RT-PCR) and Western blot were used to detect autophagy of chondrocytes on the left knee joint and expressions of regulatory molecules for cartilage matrix degradation, including myosin-like bcl2 interacting protein (Beclin-1), light chain 3 (LC3), miR-107, cysteine aspartate-specific protease 1 (Caspase-1), interleukin-1β (IL-1β), collagen typeⅡ(CollagenⅡ), matrix metalloproteinase-3 (MMP-3), and matrix metalloproteinase-13 (MMP-13), at mRNA and protein levels. Compared with blank group, the surface of left knee joint cartilage in model group showed defects, with unclear structure, reduced matrix staining, disordered cell arrangement, mostly in clustered distribution, significantly reduced in quantity, and chaotic and unclear marginal lines;the apoptosis rate of chondrocytes increased, while K-L grading level, MOAKS score, Lequesne MG score rose, and visual assessment score also increased. The expressions of Caspase-1, IL-1β, MMP-3, and MMP-13 mRNA and proteins in cartilage tissue were upregulated, and all the differences were statistically significant (P<0.01). The expressions of Beclin-1, LC3, miR-107, CollagenⅡmRNA, as well as Beclin-1, LC3Ⅱ/Ⅰ, and CollagenⅡproteins in cartilage tissue were all decreased, and the differences were statistically significant (P<0.01). Compared with model group, the surface of left knee joint cartilage in needle knife group was smoother, with fewer defects, clearer structure, more uniform and normal matrix staining, more orderly cell arrangement and an increase in cell number, and the ridges were clearer and more complete;K-L grade, MOAKS, and Lequesne MG scores decreased, the visual assessment score decreased(P<0.05), apoptosis rate of chondrocytes decreased, and mRNA and protein expressions of Caspase-1, IL-1β, MMP-3, and MMP-13 in cartilage tissue were all downregulated;all the differences were statistically significant (P<0.01);expressions of Beclin-1, LC3, miR-107, CollagenⅡmRNA, and Beclin-1, CollagenⅡproteins in cartilage tissue were significantly increased (P<0.01), and expression of LC3Ⅱ/Ⅰprotein in cartilage tissue was also increased, with a statistically significant difference (P<0.05). Based on the theory of meridians, acupuncture and knife therapy could promote chondrocyte autophagy by regulating the expression of proteins such as Beclin-1, LC3, miR-107, and Caspase-1, reduce apoptosis, inhibit the degradation of cartilage matrix, lower the level of inflammation, delay degeneration of articular cartilage, and exert functions of protecting cartilage and improving knee joint pain and functional disorders.
- New
- Research Article
- 10.12200/j.issn.1003-0034.20250564
- Jun 25, 2026
- Zhongguo gu shang = China journal of orthopaedics and traumatology
- Yingjie Liu + 3 more
To explore short-term efficacy of technique of single-bundle anterior cruciate ligament (ACL) reconstruction combined with residual end repair and suturing under arthroscopic. From February 2020 to February 2024, clinical data of 62 patients with ACL injury who underwent single-bundle residual preservation reconstruction were retrospective analyzed, including 36 males and 26 females;aged from 16 to 58 years old with an average of (35.7±11.0) years old;patients were divided into two groups based on classification of tibial residual end of ACL observed during arthroscopic. In control group (Sherman type Ⅲ/ Ⅳ), there were 32 patients, including 20 males and 12 females;aged from 17 to 58 years old with an average of (34.88±11.40) years old;treated with single-bundle hamstring tendon reconstruction using residual tibial portion of ACL, and the retained residual part formed a sleeve-like covering for the reconstructed ligament. In observation group (Sherman typeⅠ/Ⅱ), there were 30 patients, included 16 males and 14 females;aged from 16 to 55 years old with an average of (36.53±10.57) years old;during the reconstruction of hamstring tendon single bundle, ACL stump was repaired and sutured to lateral wall of intercondylar fossa of femur to restore the tension of tibial ACL stump tissue. The occurrence of postoperative complications were observed;the stability of knee joint was evaluated by pivot shift test, Lachman test, and KT-1000 bilateral knee anterior laxity difference at 9 months after operation;knee joint function was assessed by International Knee Documentation Committee (IKDC) score and Lysholm score. All patients were followed up from 9 to 12 months with an average of (10.5±1.6) months. In control group, 1 patient was developed Cyclops syndrome without further surgery;1 patient was suffered from longitudinal tear of medial meniscus, which was cured after the modified Lemaire anterior-lateral ligament reinforcement surgery and meniscus repair;and there were not corresponding complications in observation group. There was no statistically significant difference in positive rates between two groups of axial displacement tests (P>0.05);the positive rate of Lachman test in control group (10/32) was higher than that in observation group (3/30), and the difference was statistically significant (P<0.05);at 9 months after operation, anterior laxity of both knees of KT-1000 device in control group (1.71±1.02) mm was greater than that in observation group (1.22±0.81) mm, and the difference was statistically significant (P<0.05). At 9 months after operation, IKDC score of control group was (88.21±6.50) points, which was lower than that of observation group (93.10±4.71) points, and the difference was statistically significant (P<0.05);Lysholm score of control group was (92.11±4.32) points, which was lower than that of observation group (96.42±3.13) points, and the difference was also statistically significant (P<0.05). The combined ACL single-bundle reconstruction and residual stump repair technique significantly improves early stability of knee joint and enhances knee joint function after operation, achieving better clinical outcomes. It is particularly suitable for Sherman typeⅠ/Ⅱpatients with good residual stump quality on tibia side of ACL. This technique restores tension of natural ACL tissue, providing an optimized treatment method for ACL reconstruction. However, the surgical difficulty and benefit-risk ratio need to be balanced due to obstruction of ACL residual stump field of view.