We give a universal formula describing derivation operators on a Hilbert space for a large class of interpolation methods. It is based on a simple new technique on “critical points” where all the derivations attain the maximum. We deduce from this a version of Kalton uniqueness theorem for such methods, in particular, for the real method. As an application of our ideas is the construction of a weak Hilbert space induced by the real J-method. Previously, such space was only known arising from the complex method. To complete the picture, we show, using a breakthrough of Johnson and Szankowski, nontrivial derivations whose values on the critical points grow to infinity as slowly as we wish.