Background: According to the World Health Organization (WHO) in 2008, in Southeast Asia, as many as 36% of adults aged 25 years and over had high blood pressure, and 1.5 million deaths occur each year due to complications of high blood pressure. In Indonesia, hypertension is still a big challenge. This is a health problem with a high prevalence of 25.8% according to Riskesdas data in 2013. Hypertension is a chronic increase in blood pressure 140/90 mmHg. Non-pharmacological therapy needs to be applied to prevent the occurrence of hypertension, namely by modifying lifestyle to control blood pressure. Used cooking oil contains free fatty acids formed from the process of oxidation and hydrolysis, then these free fatty acids reshape saturated fatty acids and trans fatty acids and free radicals, which can cause various disorders such as endothelial dysfunction, which can lead to hypertension. Purpose(s): The purpose of this study was to determine the correlation between the used cooking oil and triglyceride profile with hypertension. Methods: The design of this study was observational analytic with cross-sectional research design. The sample of this study amounted to 96 people with purposive sampling technique. The instrument of this study was Questionnaire to determine the used cooking oil and automatic Spectrophotometer (TRX-7010) to measure triglyceride profiles. Data analysis was performed by chi-square test with significance value p < 0,05. Results: The results of this study showed that there was a correlation between the used cooking oil and hypertension (p = 0.002) and triglyceride profile with hypertension (p = 0.004). Conclusions: Hypertension had a correlation with the used cooking oil and increase in triglycerideprofile.Keywords : Hypertension., triglyceride profile, used cooking oil
 

Background: Acceptance or refusal of vaccinations can be influenced by hesitancy about the COVID-19 vaccine. Hesitancy is determined by knowledge, attitudes, practices, and public concerns about the safety, efficacy, risks, and benefits associated with the COVID-19 vaccination program. Purpose: To determine the association between knowledge and hesitancy about the COVID-19 vaccine in pregnant women in the Ranomeeto Health Center Working Area. Methods: This is an analytic observational study with a cross-sectional approach. This study was conducted at the Ranomeeto Health Center, Konawe Selatan District. The number of samples is 77 people, collected by purposive sampling technique. Knowledge was measured using a knowledge questionnaire about the covid-19 vaccine. Hesitation was measured using a questionnaire about the COVID-19 vaccine. Data were collected and analyzed using the Chi-Square statistical test with a significance value of p<0.05. Results: The results showed that most pregnant women had good knowledge about the COVID-19 vaccine (42.9%) and had no hecitation about the COVID-19 vaccine (61.0%). Statistical tests obtained a significant p-value between knowledge and hesitancy about the COVID-19 vaccine (p=0.010). Conclusion: There is a significant correlation between knowledge and hesitancy about the COVID-19 vaccine in pregnant women in the Working Area of the Ranomeeto Health Center. Keywords: covid-19 vaccine; hesitancy; knowledge; pregnant women

Prevalence of diabetes mellitus according to WHO been projected increase from 2.8% in 2000 to 4.4% in 2030. Various studies have been conducted to find alternative sources of antidiabetic therapy, Momordica charantia known has mimetic insulin compounds. Ethanol extract of Momordica charantia reported show optimal results in reducing blood glucose levels and stimulating pancreatic beta cells in secreting insulin hormone. This study aims to determine effect of bitter melon extract on insulin levels in streptozotosin-induced rat. This study consisted in 3 groups test namely streptozotosin-induced rat, streptozotosin-induced rat given ethyl acetate fraction of Momordica charantia extract, and not induced-streptozotosin rats. Insulin levels measured by ELISA method. Data analysis used Unpaired T-test considered if (p value >0,05). Research result show that there is not different between the insulin levels of streptozotosin-induced rat with streptozotosin-induced rat given ethyl acetate fraction of Momordica charantia extract group (p=0,081). There is not different between insulin levels of streptozotosin-induced rat given ethyl acetate fraction of Momordica charantia extract with not induced-streptozotosin rats (p=0,505). Conclusion. There is not different between insulin levels of streptozotosin-induced rat, streptozotosin-induced rat given ethyl acetate fraction of Momordica charantia extract and not induced streptozotosin rats group.

Background. Corona Virus Disease 19 (COVID-19) is caused by SARS-COV 2 which is of global public health concern. Hydroxychloroquine is a drug that is thought to be useful in treating COVID-19, but the mechanism of action of this drug is to block potassium channels and potentially extend the QTc interval. The purpose of this study was to determine the difference in QTc intervals before and after hydroxychloroquine therapy in COVID-19 patients at Kendari City Hospital. Methods. This research is an observational analytic study, with a cross-sectional design, which was conducted at the Regional General Hospital of Kendari City. The number of samples in this study were 106 patients. Qtc interval values ​​before and after hydroxychloroquine therapy were collected using medical record data according to the inclusion criteria. Data was processed using paired t test analysis. Results. Bivariate analysis showed that there was a difference in the average Qtc interval before and after hydroxychloroquine therapy (409.02 vs 426.10, p<0.05). Conclusion. There are differences in QTc intervals before and after hydroxychloroquine therapy in COVID-19 patients at Kendari City Hospital.

Background. Postoperative nausea and vomiting are one of the complications experienced by patients with anesthesia and surgery. There are many factors that influence this occurrence, including age and BMI, where young age and obese BMI tend to experience postoperative nausea and vomiting. This is based on the fact that older age is easier to control nausea and vomiting than young people and obese BMI has more fat tissue to store anesthetic drugs so that the side effects of drugs can last longer. Method. This study used an observational analytic method with a cross sectional approach carried out at Aliyah Hospital 2. The number of samples in this study were 38 people who were taken using total sampling technique. Data collection was obtained from filling in the observation sheet and then the data was analyzed using the Fisher's Exact Test statistical test. The dependent variable in this study was postoperative nausea and vomiting and the independent variables were age and BMI. Results. The results of this study found that age did not have a significant relationship with the incidence of postoperative nausea and vomiting at Aliyah Hospital 2 (p = 0.298) and BMI had a significant relationship with the incidence of postoperative nausea and vomiting at Aliyah Hospital 2 (p = 0.019). Conclusion. From this study it can be concluded that the incidence of postoperative nausea and vomiting after spinal anesthesia is higher in patients with older age and excessive BMI.

Background : Low Back Pain (LBP) is an unpleasant condition accompanied by activity limitations caused by pain when moving. Physiotherapy conducted on LBP patients is intended to reduce pain and restore functional abilities. This study aims to determine the differences in VAS values ​​before and after physiotherapy conducted on LBP patients at the Orthopedic Poly of Santa Anna Kendari Hospital. Method : This observational analytical study used a cross-sectional approach. The study used secondary data in the form of medical records from 30 LBP patients who were undergoing physiotherapy. The observed dependent variable was the VAS value before physiotherapy and the independent variable observed was the VAS value after physiotherapy. The data analysis used the Wilcoxon statistical test. If the value was p≤0.05. Results :The Wilcoxon analysis test showed that there was a significant difference in VAS values ​​(p≤0.05) before and after physiotherapy conducted on LBP patients at the Orthopedic Poly of Santa Anna Kendari Hospital. Conclusion:There is a difference between the VAS values ​​before and after physiotherapy conducted on LBP patients at the Orthopedic Poly of Santa Anna Kendari Hospital. 
 Keywords: LBP, Physiotherapy, VAS Value.

Background: Rates of depression and anxiety disorders are increasing worldwide. Anxiety and depression are one of the comorbidities of cardiovascular disease, cardiovascular conditions are worse with no comorbid depression and anxiety. Depression and anxiety are independent risk factors for hypertension. Previous studies involving groups of patients who received psychotherapy were found to have decreased blood pressure. Objective: To determine the effect of Ventilation Technique Supportive Psychotherapy on Blood Pressure (BP) and Pulse Rate in Depressed and Anxious Patients. Methods: Experimental research with a pre-test, post-test design was conducted at dr.Wahidin Sudirohusdo Makassar General Hospital and its network in May - July 2020. The samples of this study were patients with depressive disorders and anxiety disorders who underwent routine treatment as many as 12 samples and 12 controls. The research subjects were measured with the Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale (HDRS) and then checked blood pressure and pulse rate before and after the subject was given psychotherapy for 30 minutes. Data were analyzed using Pearson test. Results: The total sample was 12 treatment and 12 control people with an average age of 45.8. Statistically significant changes in systole blood pressure, diastole blood pressure and pulse rate were obtained before and after the provision of supportive psychotherapy ventilation techniques with a significant p value (p < 0.001). Based on the Pearson correlation test, the comparison of systole blood pressure, diastole blood pressure and pulse rate of the two groups was significant and the correlation was very strong (0.938) in systole blood pressure and (0.908) in diastole blood pressure and a strong correlation (0.729) in pulse rate. Conclusion: There was a significant reduction in systole blood pressure, diastole and pulse rate in the treatment group after receiving Ventilation Technique Supportive Psychotherapy when compared to the control. Keywords: blood pressure; pulse; Anxiety; depression; supportive psychotherapy; ventilation

Background. Osteoarthritis (OA) is a joint disease that most often occurs in adulthood to old age throughout the world, according to the world health organisation (WHO) in 2014 stated that the world's population experiencing osteoarthritis is 335 million people worldwide. Risk factors that affect the incidence of Osteoarthritis include age, gender, obesity, genetics, joint injury, exercise and work, and other risk factors. One of the OA treatments is physiotherapy to reduce the pain intensity of Osteoarthritis sufferers. This study aims to determine the difference in VAS values before and after physiotherapy in Osteoarthritis patients at the Mulia Hati General Hospital Kendari. Method. This study used a descriptive analytic method with a cross sectional approach. This research was conducted at the Mulia Hati General Hospital Kendari from November to December 2022. This sampling uses total sampling that meets the inclusion criteria with a total sample of 37 patients. Data analysis using the Wilcoxon test. Result. The results showed a P value of 0.000 (p value <0.05), so Ha was accepted, which means that the results of the research conducted showed a difference in VAS values before and after physiotherapy. Conclusion. The conclusion of this study is a decrease in VAS value after physiotherapy is performed at the Mulia Hati General Hospital Kendari. 
 Keywords. Osteoarthritis, Pain, physiotherapy

Latar Belakang: Salah satu populasi yang berisiko tinggi HIV/AIDS adalah Wanita Pekerja Seks (WPS) dikarenakan perilaku seks yang tidak aman yakni berganti-ganti pasangan. Penggunaan kondom merupakan salah satu inisiatif untuk mencegah penularan HIV/AIDS, dan penggunaannya dapat dipengaruhi oleh berbagai variabel. Tujuan: Menganalisis berbagai faktor yang berhubungan dengan penggunaan kondom pada WPS sebagai upaya pencegahan HIV/AIDS. Metode: Penelitian cross sectional ini merupakan penelitian observasional analitik yang dilakukan di Kota Kendari dengan jumlah sampel 65 orang sesuai kriteria inklusi dan eksklusi yang dipilih menggunakan purposive sampling, analisis data menggunakan uji chi-square Pearson dengan nilai p-value ≤ 0.05 dinyatakan bermakna. Hasil: Pengetahuan baik tentang HIV/AIDS dan kondom (58,5%), memiliki sikap tentang penggunaan kondom positif (66,2%), ada paparan informasi tentang kondom untuk mencegah HIV/AIDS (95,4%) serta selalu menggunakan kondom (55,4%). Terdapat hubungan antara pengetahuan (p-value=0,012) dan sikap (p-value=0,027) penggunaan kondom pada WPS. Tidak terdapat hubungan keterpaparan informasi (p-value=0,084) dengan penggunaan kondom pada WPS. Simpulan: WSP yang memiliki pengetahuan kurang dan sikap negative cenderung berimplikasi pada menurunnya penggunaan kondom

Inflammation is a response process to tissue injury and infection. The inflammatory response causes the release of pro-inflammatory mediators such as IL-1, IL-6 and TNF-α which are the main cytokines in the acute inflammatory response. Plants that have the potential to be anti-inflammatory are notika leaves (Archboldiodendron calosericeum KOBUSKI). This research was conducted to determine the anti-inflammatory activity of the ethanol extract of notika leaves against the levels of Tumor Necrosis Factor Alpha (TNF-a) in wistar mice. This study used a post test only control group design. Using 5 treatment groups, namely positive control (diclofenac sodium), negative control (NaCMC 0.5%), 100 mg/kgBW extract test group, 200 mg/kgBW extract group and 300 mg/kgBW extract group. In vivo tests were carried out by induction of inflammatory substances, administering preparations and measuring TNF-α levels using the ELISA method. Data were analyzed using the One Way ANOVA test. The results showed that the mean levels of TNF-α in the positive control group (0.475 ng/L), negative control (0.816 ng/L), extract dose 100 mg/kgBW (0.67 ng/L), extract dose 200 mg/kgBW (0.7285 ng/L) and extract dosage of 300 mg/kgBW (0.7785 ng/L). The conclusion obtained is that the ethanol extract of notika leaves has anti-inflammatory activity against the levels of Tumor Necrosis Factor Alpha (TNF-a) in Wistar rats based on the reduction in levels with negative control and the best dose was 100 mg/kgBW.