Metronidazole has been used topically and systemically for over 50 years, however research on its antioxidant capabilities is still insufficient, ambiguous, and conflicting. Because its antioxidant qualities are mostly hypothesized based on in vivo data, research to test if metronidazole has antioxidant activity in vitro have been conducted. Narrative review conducted through the electronic databases, for all relevant articles published up to the beginning of 2022. Metronidazole has limited iron-reducing and hydrogen donor action under the conditions employed. The ability to scavenge hydroxyl radicals cannot be established. In the H2O2/.OH-microperoxidase-luminol system, it serves as a pro-oxidant, yet it can reduce induced lipid peroxidation.