A patient had complete left facial palsy followed by minimal residual left facial palsy for the next nine years. In anticipation of oncoming waves of new SARS-CoV-2 variants, and after due consideration, he took the BNT-162b2 vaccine. To his surprise his residual facial palsy gradually and almost entirely recovered after completing the two-dose vaccination, with no relapse up to six months’ followup. The mechanism and significance of such an off-target beneficial effect is discussed with conceptual projection into the future development.

The notion of stress has becae as the same time very popular but is sometimes used improperly or with many exaggerations especially concerning the recommendations of practical solutions suggested for stress management. The stress producing stimuli, many physiological processes go into action, probably through different paths in close connection; the response is, therefore, an interaction between the organism and his environment. The emotional component takes part in the response reactions through the somatic effect of which it influences the behaviour. The man having lost his last connection with the world grieves duple and his environment must pay great attention not to lose also him. Every medico-surgical intervention belongs to the stress factors. Both contain psychopathological elements and a long psychotherapy accomplished by a specialist is needed, considerate-protective environment for the accommodation in the normal life, for the resocialization. The biological stress is a long succession of active, interactive mutual effect. This relation which always consists of the difference of value-power-intensity is, like an example of today, a chain of action of two fighter during which they get the offensive and defensive conduct in exchanged role. From the point of view of the human individual life the psyche (psychism) is a subsystem. If still we take it out of this relationship with investigational aim then we have to consider it a system.

Type 1 diabetes mellit us (T1DM) is an autoimmune disease characterized by the destruction of beta cells and absolute insulin deficiency. T1DM usually appears in childhood and adolescence, but it can also be diagnosed in adulthood. For decades, American Diabetes Association (ADA) guidelines recommended consuming 50-60% of a diabetic's daily calories as carbohydrates. With these guidelines, the average number of patients with T1DM in the therapeutic goal (less than 7%) of glycated hemoglobin (HbA1c) in the world is no more than 10-15%, that is, we are not being effective in the treatment, either due to inadequate guidance, such as poor adherence due to difficulty in following the diet proposed by the ADA. Since 2019, the ADA recognized, albeit timidly, the low-carbohydrate diet (low-carb diet) as an acceptable approach, being the most studied, safe and effective strategy for the treatment of type 2 diabetes mellit us (T2DM). We recognize these advances, but we know that much remains to be elucidated, especially with regard to the treatment of T1DM. With that in mind, we developed a protocol [1], which aim a reduction in glycemic levels, a longer time on target with less hypoglycemia, a reduction in glycated hemoglobin and insulin doses, thus promoting an improvement in the patient's health and quality of life.

Vaccines against infectious diseases including emerging etiological agent are being produced through various major steps in Good Manufacturing Practices approved world class facilities with the core divisions of Upstream & Downstream processes followed by quality attribute testings as per approved license from the regulatory authorities. The current review article will afford the reviewer to get hold of awareness on the operation and qualification of downstream equipment's especially Tangential Flow Filtration system and its validation as a purification tool for the manufacturing of Drug substance in vaccines against various pathological agents. The Scope of current article nourish and educate the industrial scientific personnel’s and entrepreneur, who are working in biopharmaceutical industries like vaccines and Bio-therapeutics to acquire the scientific knowledge for operation, optimization, qualification and documentation of tangential flow filtration system to produce drug substance of vaccines in GMP facility. Even though the article summarizes and offers the methodological approach for the selection of TFF system as a purification tool for downstream process, The authors opinionated that the thorough familiarity given in this article regarding the pre-process concepts which starts from the industrial equipment selection & purchase procedure of the system and its operation, dual side qualification, validation, optimization of process variables with experimental execution for the successful production of vaccine drug substance would be definitely be unique and worthy. After review of this article, one can gain the complete comprehensive knowledge and assurance about the Selection, Purchase, Qualifications, Validation and Process utilization and Optimization of process variables with sustaining consistent quality of the product as output with benefit of expertise.

Cerebral palsy is the most common chronic motor disorder in children and frequently associated with sensorineural pathology. Deafness is very important public health concern. Because it determines long-term life span disability in individuals, decrease their quality of life. To observe the rate of occurrence of hearing impairment in children with cerebral palsy (CP) and to assess the severity of hearing impairment children with CP and correlate the auditory impairment with different types of CP were aim of the study. Total 50 children with Cerebral Palsy were taken. A structured questionnaire was filled up including history of patient and important variables related to hearing status like family history of deafness, consanguinity, antenatal history, preterm LBW, perinatal asphyxia, kernicterus, neonatal septicemia, neonatal seizure and meningitis were included in study. Physical examination and neurological examination like hearing, vision, motor, cognitive, speech delay were assessed. In this study, among the 50 children with CP, Tympanometry showed that negative middle ear pressure was 32% in spastic quadriplegia (SQ), 24% in spastic hemiplegia (SH), 16% in spastic diplegia (SD) and 24% in mixed type. Eustachian tube dysfunction was 62.5% in spastic hemiplegia. Secretory otitis media was 36.4% in spastic quadriplegia. Auditory brain stem response revealed severe sensorineural hearing loss was 8% in spastic quadriplegic type. Moderate sensorineural hearing loss was 2% in spastic hemiplegia group. Hearing loss was frequent in children with Cerebral Palsy. Spastic Quadriplegic cerebral palsy patients had the maximum incidence of hearing impairment.

A migraine is a headache episode ordinarily happens in stages and can keep going for a considerable length of time. Serious cases can influence an individual's everyday existence, including their capacity to work or study. Headache can influence individuals in various ways, and the triggers, seriousness, manifestations, and recurrence can change. Certain individuals have more than one episode every week, while others have them just incidentally. The reasons for migraine aren't actually clear, however hereditary qualities and climate really do assume a part. Migraine frequently runs in families, so there's probable an inherited connection.

From the view of sociology, the developing world is facing the problem of imbalance between the three variables of environment, population and food supply. Currently, a large number of countries in Africa, Asia and even Latin America are confronting it. Such a hazard usually leads to economic inflation, unbridled migration, density of population in urban areas, loss of active and fruitful earth in rural areas, losing the local currency value in trade interactions and many more. Such a situation is projected to increase in a multiplying manner in the years to come. So, under such threatening circumstances, adequate population policies need to be applied to prevent further escalation. Many countries have experienced famine. China for example, experienced a wide food shortage in 1961, in which over 30 million people died. Even in present modern time, many people within the African nations are starving. Many people in such countries destroy forests to earn their livelihoods.

In the human organism, the stress is a perturbation. The existence of the perturbations imposes a permanent control of the way the exit size is realized, so that any deviation can be corrected. Stress represents a normal reaction of the organism which appears as a response to an aggression situation which requires an unusual and quick adaptation effort from the organism. Stress is a state of putting in alert, of mobilizing the forces of the organism in the occasion of an event which requires, in order to be kept under control, a big amount of energy in a very short time. This alert state or action preparation translated through physical and psychological manifestations. Psychical stressors are those which come into being independently from the man’s will and destroy – as social factors – psychic and organic components taking place in the response, the organism consequently get tired. During the harmonic life gradually all human psycho-organic components shall get exhausted. During the individual evolution, the immediate vicinity imparts the codex of the principles of the moral motions. This is also a matter of opinion a kind of scale of values, more one can say it is very favourable for the individual from the healthy-spiritual point of view, because they are hardly touched by the negative effect of stress usually people beyond the pale of the society, in straits to the periphery. The physical discomfort feeling with the concomitant psychical reaction is realized by the measure of the personality’s sensitiveness. The modeling method in biophysics consists in the negative inverse connection

This descriptive type of cross sectional study was conducted to find out pattern of frozen shoulder patients attending to different services in selected hospitals of Dhaka city with a sample size of 100. Non randomized purposive sampling was done. Pretested structured questionnaire was used to get data and verbal consent was taken prior interview. All the data were entered and analyzed by using statistical packages for social science (SPSS) software version 16.0. Mean age of the respondents were 50.66 + 13.406 year. Among the respondents 52% were female and 48% were male. Result found that most of the respondents (93%) had done investigation and rest of them (7%) did not. Besides 47% of respondents were suffering from left frozen shoulder followed by 45% were right and 8% were both respectively. Result also revealed that majority of the respondents (60%) had movement restriction & muscle spasms and 40% were no muscle spasm. Half of the respondents (52%) were in stage 2 followed by 35% stage 1 and 13% stage 3 respectively. Half of the respondents (49%) had diabetic mellitus and rests of them 51% were absent. All of the respondents received different type of medications, 18% intra-articular steroids and 63% were taken different type of physiotherapy. Of the respondents 98% feel better after treatment and rest of them did not. Study found that advanced age and females were more sufferers in different stage of frozen shoulder. Limitation of movement and muscle spasm were more prominent complain. Physiotherapy treatment should be available.

Background:Adolescence, a period of transition between childhood and adulthood, occupies a crucial position in the life of human beings. Hence, it is essential to improve health status through interventions. Objective:To assess and compare nutritional status of adolescent school girls in nutritional intervention and non-intervention area. Methods: A cross-sectional analytic study was conducted at Laxmipur sadar upazila as nutrition intervention area & neighboring Chatkhil upazila as non–nutrition intervention area. A total of 367 adolescent girls of age 10-19 years were selected purposively of them 177 and 190 were selected from intervention and non-intervention area respectively. Anthropometric data of the study subjects were collected by using standard techniques. Body mass index (BMI) and anemia were classified according to WHO cut off levels. Results:Study reveals that hemoglobin status was 72.3% normal, 20.3% mild anemia and 7.3% moderate anemia in intervention area and 51.6% normal, 43.7% mild anemia and 4.7% moderate anemia in non-intervention area. Significant difference was found both BMI and hemoglobin status among intervention and non-intervention area. Significant difference was found between intervention and non-intervention area of different illness, typhoid and jaundice. Conclusion:This study concludes that health status was better in intervention area than non-intervention area so community-based intervention is effective for better health status of young girls.