Background- Dandruff is a common scalp condition caused by an imbalance in the scalp microflora leading to the overgrowth of Malassezia fungi. Although not a serious medical condition, it does cause considerable discomfort and embarrassment to those affected. Despite the availability of synthetic treatment options, India's diverse botanical heritage offers to provide hopeful alternatives based on traditional medicine practices. Some of the plants that have been tested to show efficacy in inhibiting Malassezia populations include lemongrass, eucalyptus and Indian gooseberry (amla). Utilizing the advantages of modern topical cosmetic serums, which are recognized for increasing consumer acceptance and longer contact time with treatment surface, a new formulation was created for dandruff therapy. Objective: Utilizing the advantages of modern topical cosmetic serums, which are recognized for increasing consumer acceptance and longer contact time with treatment surface, a new formulation was created for dandruff therapy. So, the aim of the present study is to formulate an antidandruff scalp serum of three herbal drugs. The serum incorporates the oils of lemongrass, eucalyptus and amla, blending them into an o/w type emulsion which is simple to use and easy to apply, and safe. Methods:To prepare the serum emulsion, we have combined all active essential oils together with a carrier oil and Vitamin E, then we added it to the aqeous base of water and glycerin. Emulsifying agents and other necessary excipients were also added as per the requirement. The product was then evaluated for its quality. Results: The resultant product showed good rheological properties and was well formulated. User satisfaction is a factor that is satisfied. Conclusion: The new method offers a safe, efficient herbal solution for dandruff, while also providing nourishment for the scalp and tackling inflammation

Burns are complex dermatological injuries requiring innovative therapeutic approaches. This study tested the hypothesis that Snail Mucus and Aloe vera gel combinations could enhance the healing of second-degree burns more effectively than treatments using Bioplacenton as a comparative control. The experiment was conducted with 25 Wistar rats, divided into five groups, each treated with different gel formulations: 10% Aloe vera with 10%, 15%, and 20% Snail Mucus, a placebo, and Bioplacenton as the positive control. Second-degree burns were induced, and treatments were applied twice daily for 21 days. Healing progress was monitored through measurements of wound diameter and colour changes. Histopathological evaluation was carried out to see the presence of macrophages and fibroblasts and assess the number of fibroblasts, epithelialization, and expression of Platelet-Derived Growth Factor-Beta (PDGF-BB). Statistical analysis was done using ANOVA and Kruskal-Wallis tests to determine real differences. All Snail Mucus and Aloe vera gel formulations significantly accelerated wound healing compared to the placebo. The 20% Snail Mucus formulation exhibited the most rapid healing rates, comparable to the Bioplacenton control. Statistical analysis showed significant differences (p<0.05) in wound healing rates, increase in fibroblast activity, epithelialization and PDGF-BB expression between treated and control groups, with the highest concentration gel mirroring the positive control's efficacy. Snail Mucus and Aloe vera gels are potent agents in accelerating the healing of second-degree burns, with the 20% Snail Mucus formulation performing on par with Bioplacenton.

Mainaim of current research was to determine feasibility of developing, designing, and testing liposomal formulations loaded with Fulvestrant for purpose of targeted drug transfer in management of breast cancer. With an impressive encapsulation effectiveness of 85%, they were made utilizing the thin-film hydration approach solvent evaporation followed high pressure homogenization technique for particle size reduction..The physicochemical characterization, these liposomess were seen to be in the dimension of <150-200nm with low polydispersity index (<0.3), -25 mV of the zeta potential, and indicated stability and will also be best for an in vivo application. Ex-vivo diffusion will reveal high numbers of drugs being released as compared to free Fulvestrant and further made the release sustained over 48 hours. Cytotoxic evaluation of MCF-7 breast cancer cells was exhibited that for fulvestrant-loaded liposomes at 5 μM, there was a 50% reduction of cell viability-which is an extremely significant increase compared with free drug (30% reduction). Pharmacokinetic study did exhibit an improvement in bioavailability due to increased circulation time, fetching changes in drug accumulation into tumor tissues through enhancement of permeability and retention phenomenon. It means nearly all formulations have comparatively mild hemolytic activity less than 5%, thereby exhibiting probable safety. This study brings into light a very feasible total approach of Fulvestrant-loaded liposomes for a prolonged tumor targeting by showing diminished exposures to such drug as compared to conventional injectable therapies offering therapeutic potential enhancement with lesser side effects. The overall findings would provide good ground to conduct further in vivo testing of these formulations for clinical applicability.

Objective The persistent need to discover plant species with anti-arthritic properties prompted the investigation of A. racemosa Wight. The objective is to study anti-arthritic attributes of ethanolic extracts made from A. racemosa leaves and stems. Methods Using in vivo model, the anti-arthritic property was evaluated. Acute toxicity was performed as per OECD strategies to determine dose. Formaldehydeinduced model was used to investigate anti-arthritic action. 200 mg/kg of ethanolic extracts of leaves and stems were given orally. To know the antiarthritic potential of A. racemosa radiology as well as histopathology was performed. Results The stem ethanolic extract demonstrated significant reduction in arthritis by showing 49.65% inhibition than leaf ethanolic extract which shows 38.89% inhibition. Chemical examination of the plant's ethanolic leaf and stem extracts shown existence of flavonoids, terpenoids, and steroids. Antiarthritic activity of A. racemosa is supported by histopathology, radiology and haematological analysis. Conclusion This study indicates that A. racemosa may be useful as a bioactive chemical source for the treatment of inflammatory disorders and orthopedic pain.

The whole plant of Leucas zeylanica (Lamiaceae) was tested for hepatoprotection in Wistar rats after paracetamol (PCM), ethyl alcohol (ALC), and ranitidine (RTD) produced hepato the albino mouse acute toxicity maximum dosage was 2000 mg/kg. Six animal groups were utilized in all models. Modelling followed Silymarin. MELZWP contains saponins, carbohydrates, flavonoids, tannins, and phenolic from Leucas zeylanica whole plant. LD50 experiments showed these extracts did not kill or alter mice at 2000 mg/Kg body weight. Silymarin and MELZWP dosages increased thiopental sleeping time, wet liver weight, and volume than PCM, ALC, and RTD-induced hepatotoxic mice. Albumin (ALB) and protein (PRO) increased whereas ALT, ALP, AST, CHO, BILT, and TG dropped. Steatosis, necrosis, and other histological abnormalities were disallowed. Saponins and flavonoids protect the liver, study finds

Human skin can occur infection by viruses, bacteria, fungi, or parasites. One of the pathogenic bacteria that often infect the skin is Staphylococcus aureus. The incidence of bacterial infections on the skin continues to increase and pathogenic bacteria S. aureus easily experience antibiotic resistance. The development of herbal treatments from plants with antibacterial potential can be one of the alternative treatment options. One of the plants often used for alternative traditional medicine is moringa seeds (Moringa oleifera). Purpose: Knowing and analyzing the gel formulation of moringa seed extract (Moringa oleifera), which has optimal physical characteristics and antibacterial activity against S. aureus. Methods: The type of research conducted was true experimental with a post-test-only control group design. In this study, there was a treatment group that was given moringa seed extract gel with a concentration of 5%, 10%, 20%, 40%, and 80%, a positive control group of clindamycin gel, and a negative control group of sterile aquadest with S. aureus as test bacteria. The method of antibacterial testing uses the disc diffusion method. The results of the study were analyzed using the Kruskal-Wallis statistical test. Results: All formulations of gel preparations have optimal physical characteristics. The diameter of moringa seed extract gel inhibition zone against S. aureus bacteria at concentrations of 5%, 10%, and 20% have a weak antibacterial potential. In comparison, a concentration of 40% (5.05 mm) is categorized as medium potential, and a concentration of 80% (11.70 mm) is classified as having strong potential. The analysis results found significant differences between treatment groups with a significance value of p < 0.05. Conclusion: Formula 4 and 5 are optimal formulations of moringa seed extract gel preparations because they have optimal physical characteristics and antibacterial activity against S. aureus bacteria.

Now a days multicomponent formulations are becoming more popular in order to ensure timely and complete medication in multidrug therapy and enhancement of patient compliance. Through, analytical methods for single drug are extensively available, still due to complexity in multicomponent formulation, method development for the individual active component is sort of challenge for the analytical chemist. Information in the books also do not provide methods of simultaneous estimation of the newly developed and marketed formulations. Most of the methods are available after separation of active components, which become tedious, time consuming, and lack of accuracy.Therefore, the attention in the present project was focused on to foster simple easy economical reproducible analytical method for the assessment of Ciprofloxacin (CP) and Tinidazole (TZ) in combinations by using HPTLC Method.

Sutures are essential after surgery as they allow for tissue re-approximation, stimulate early healing, and regulate bleeding. To avoid postoperative suture related complications like surgical site infection due to wicking effect, various antimicrobial agents have been incorporated into sutures. In this study, black silk suture was scoured for impurities and coated with metronidazole and povidone-iodine for comparison with the uncoated suture. Blood agar plates were prepared and inoculated with putative periodontal pathogens. The three groups of sutures were studied for their action against specific microbe by measuring the zone of inhibition. Based on the statistical analysis, it is established that povidone iodine and metronidazole coated suture have higher antimicrobial efficacy when compared to non-coated suture against anaerobic periodontal pathogens.

Elevated blood sugar and lipid levels are a growing global health concern and N. Cordelia presents potential therapeutic benefits. Therefore, this study aimed to identify active compounds and mechanisms in N. cordifolia using a network pharmacology method. Active compounds were screened for target proteins associated with elevated blood sugar and lipids through PPI networks, enrichment analysis, docking, and MM/GB (PB) SA. The results showed 6 compounds from N. cordifolia, and 24 proteins were obtained using Cluster One analysis at the PPI network stage. An important mechanism, such as the PPAR signaling pathway was identified through enrichment. The proteins in this mechanism were FABP, PPARα, and PPARλ, obtained by docking and MMGB (PB) A. The key compounds were 9-Oxo-10 (E) and 12 (E)- octadecadienoic acid, suggesting the potential of N. cordifolia to overcome increased blood sugar and lipids.

Introduction: Herbal oils and its formulas are in increasing demand in the cosmetic and pharmaceutical industry. The research paper highlights the potent anti-inflammatory, antioxidant, and antimicrobial capabilities of neem and castor oils. Objective: The objective of research work is to prepare oil-filled Microcapsules incorporated in a cream formulation. This formulation further subjected to analytical evaluation by sophisticated instrument. Methods: Microcapsule were prepared by ionic gelation process. The microcapsule containing cream was created using batches of varying concentrations, denoted as F1, F2, F3, F4 and F5. Further microcapsules morphology was studied by TGA, SEM, LE was calculated and FTIR was used to characterize manufactured microcapsules. As a part of biological study formulation was subjected for animal study and in vitro DPPH free radical scavenging assay. Results: A variety of parameters, including pH, spreadability, homogeneity, and viscosity, were used to evaluate each composition. Formulations F4 and F5, according to the study, had good spreadability, homogeneity with a decent look, good consistency, a pH of 7, no phase separation, and were easy to get rid of. Further these batches namely F4 and F5 was tested for non-irritancy using animal study according to CPCSEA guidelines. These investigations imply that the cream of the F5 batch has a safer and more stable composition, that might result in a synergistic effect. Conclusion: The F5 batch was showing best formulation in order to prevent aging of the skin, it can be served as a barrier for shielding the skin