O objetivo desta pesquisa foi compreender o estilo de liderança de diretores escolares da educação infantil e sua influência no clima organizacional da escola. Para atender ao objetivo proposto, foi realizada uma pesquisa qualitativa com corte transversal, tendo como instrumento de produção de dados primários a entrevista semiestruturada. As entrevistas foram realizadas com 12 diretoras que estão em efetivo trabalho nos Centros Municipais de Educação Infantil do município de Serra, Espírito Santo, no ano de 2023. Os dados foram analisados por meio da análise de conteúdo e categorizados pelo processo indutivo. Os resultados apontaram que as diretoras reconhecem sua reponsabilidade pela unidade de ensino e adotam os estilos de liderança transformacional, liderança instrucional e liderança autocrática. Os estilos transformacional e instrucional apontaram influência positiva no clima. Embora a literatura relacione o estilo autocrático como um impacto desfavorável ao clima, ele se revelou importante para o funcionamento e organização da unidade escolar. Este estudo contribuiu de forma teórica com a literatura de liderança e clima organizacional voltada para a educação, especificamente para a atuação dos diretores escolares, principais responsáveis pelas unidades de ensino. De forma prática, buscou-se apresentar possibilidades de desenvolvimento de ações de aprimoramento de práticas de liderança dos diretores escolares, a fim de articular um clima organizacional favorável ao desempenho organizacional.

Objetivo: Analisar os efeitos das divulgações de notícias das investigações da operação Lava Jato no volume de negociação das empresas brasileiras.
 Método: Para avaliar os efeitos das divulgações das operações sobre o volume anormal de negociação, utilizou-se a metodologia de estudos de eventos destacando a semana da operação como evento de análise, no período de 2014 a 2017, compreendendo da primeira a quadragésima segunda fase da operação Lava Jato.
 Originalidade/Relevância: A pesquisa utiliza uma abordagem que analisa o volume de negociação em resposta às notícias de corrupção, o que pode complementar os estudos anteriores que focaram principalmente nas mudanças de preços. Isso amplia o conhecimento sobre o comportamento do mercado diante da divulgação de notícias de corrupção.
 Resultados: Os resultados indicam que a Lava Jato provocou efeitos no mercado financeiro brasileiro aumentando o volume de negociação das empresas citadas na operação, e para as empresas que atuam no setor das empresas citadas evidenciou-se um efeito negativo no volume de negociação. Tais resultados sugerem que notícias de corrupção afetam o comportamento dos investidores que diante das incertezas do mercado e reagindo de forma mais eficiente às notícias tendem a comprar ou vender com mais facilidade provocando uma anormalidade nos volumes negociados.
 Contribuições teóricas/metodológicas/práticas: Os resultados contribuem para a literatura atual ao identificar os efeitos das notícias de corrupção no volume de negociações das empresas envolvidas e apresentam evidências da existência de transferência informacional no mercado brasileiro. Esses achados fornecem informações importantes para investidores, analistas e empresas que buscam uma melhor compreensão dos impactos das notícias de corrupção no ambiente de negócios. Além disso, os resultados podem ser relevantes para o desenvolvimento de políticas e práticas mais eficazes de governança corporativa e ainda para auxiliar na tomada de decisões por parte dos investidores.

PurposeThis study analyzes the impacts of trust in the confessional institution of primary education on a students’ spirituality and performance and the moderating effect of the families' religion on the relationship between trust in the school and the student's spirituality as perceived by parents and guardians.Design/methodology/approachThis study takes the form of a survey with 346 parents and guardians from a Brazilian Adventist education network. The authors used partial least squares structural equation modeling by SmarPLS 4 to analyze the data.FindingsThe results reveal that parents' and guardians' trust in the confessional institution of primary education positively influences their perception of students' spirituality, which, in turn, has a positive impact on their performance. In addition, the families’ religion does not strengthen the relationship between school trust and students’ spirituality. It does not matter to which religious group the family belongs – as their overall spiritual development that favors the students’ academic performance.Originality/valueThe research contributes to the literature on school management, individual spirituality and relationship marketing – particularly customer relationship management in schools, involving parents, guardians and students.

This study aims to understand how new CEOs construct, revise, and maintain in their narrative, repertoire stories that represent their identity as it is associated with their new occupational role. For this purpose, we conducted a qualitative study using the Grounded Theory method, involving 47 CEOs from different sectors residing in Brazil. Our results allowed for the construction of a central category called Storytelling Identity Work, which refers to stories that individuals tell about themselves, and enable them to propose and redefine who they are during major life transitions. This paper seeks to explain: (a) under what conditions this phenomenon tends to occur; (b) what characterizes the success of Storytelling Identity Work and; (c) what leads to the revision or retention of stories in the self. Our results show that storytelling identity work tends to be used by new CEOs during their transition period into the role, and when their new position involves higher levels of visibility and alteration of prestige levels in comparison to their previous position. They also suggest that storytelling identity work tends to be more successful when the stories are co-constructed and validated with other significant individuals and when they enable new CEOs to feel "sufficiently authentic" and "sufficiently impressive." Finally, we theorize that such feelings, along with a sense of coherence between the story being told and other narratives consciously or unconsciously being narrated by the interviewees throughout their lives, lead to the retention of the story within the individual's self. This article innovates by connecting the literature on personal storytelling with identity work and exploring processes that are not only useful during the process of transitioning into the role of new CEOs but also influence the constitution of the narrative repertoire and, consequently, the identity of these individuals.

Major depressive disorder (MDD) is a debilitating illness that affects millions of people worldwide. Currently available antidepressants often take weeks to months to reach their full effect, which leads to an increased risk of suicidal behavior in patients with MMD. Intranasally, esketamine has emerged as an alternative to current antidepressants because of its rapid onset and long-lasting effects in patients with MDD. Animal models are useful for the initial pharmacological screening and for a better understanding of the mechanisms underlying the effects of new drugs with potential against MDD. There is a lack of data on alternative routes of drug administration, either oral or injectable, that can be used in preclinical studies. This study aimed to test whether ketamine has antidepressant-like effects in mice when administered via nebulization using a low-cost apparatus. When mice whose depressive-like behavior was induced by corticosterone were treated with nebulized ketamine at concentrations of 1.3, 2.6, and 5.2 mg/mL, immobility was reduced by 38.6 %, 62.0 %, and 61.1 %, respectively, in the forced swimming test (FST) and 43.6 %, 42.1 %, and 57.9 %, respectively, in the tail suspension test (TST). When depression-like behavior was induced by dexamethasone, nebulization with ketamine reduced immobility by 79.7 %, 49.2 %, and 44.4 % in the FST and 80.9 %, 71.4 %, and 80.4 %, respectively, in the TST. When depression-like behavior was induced by the association between dexamethasone and unpredictable chronic mild stress (UCMS) exposure, immobility was reduced by 26.1 %, 55.3 %, and 19.1 % in FST. Mice treated with nebulized ketamine did not show significant changes in the distance covered or in the time spent moving in the open field test. The efficacy of intraperitoneal and nebulized ketamine is equivalent, which shows that nebulization can be an alternative inexpensive route of drug administration for behavioral studies in rodents.

This study aims to understand (a) how remote workers respond to threats to their identity and (b) the conditions in which each coping response tends to occur more frequently. To this end, we pursued a grounded theory approach, conducting interviews with 71 individuals who chose to work remotely. Our model and theoretical propositions create insights into how remote workers respond to negative stigma from a range of origins. While some responses lead to restructuring the remote workers' identity (identity restructuring responses), others involve keeping the enactment of such identity (identity-preserving responses) or maintaining a paradoxical relationship between restructuring and preserving the identity (paradoxical identity work responses). We also theorise on the conditions under which each response is more likely to occur. We expand the predominant focus on the meso and macro aspects of this type of work to the micro-interactions in which these individuals engage, thus highlighting how identity is made, performed, created, and enacted, within specific boundary conditions. In addition, by reflecting upon remote workers' identity threats in light of the wider macro context. We also explore the conditions under which specific kinds of responses tend to emerge.

Problem consideredThe rational use of antimicrobials (ATMs) is a challenge for global health services. One strategy used to control the spread of multidrug-resistant (MDR) bacteria is antimicrobial management programs. This is a pre- and post-intervention study that assesses the impact of an antimicrobial stewardship program in a hospital through evaluating clinical and microbiological outcomes, usage measures and costs. MethodsThe sample comprised adult patients hospitalized for more than 24 h during a seven-month pre-intervention, and an eleven-month post-intervention period. Primary outcomes included length of therapy (LOT) and days of therapy (DOT) per 1000 patient-days (pd), the DOT/LOT ratio, the incidence of a number of the main multi-drug resistant bacteria, and the costs of therapy. Secondary outcomes were the use of antimicrobials and antimicrobial prescriptions by class, hospital length of stay rates, and mortality rates. Data were obtained from medical prescriptions, pre-authorization forms for restricted antibiotics, and microbiological tests. Non-critical and critical care units were compared, with a significance level of 0.05. ResultsA total of 2704 patients were evaluated and there was a significant post-intervention reduction of exposure to antimicrobials of 8.1% and of 90 days in respect of the LOT in non-critical units. There was a reduction of more than 50% in the costs of therapy and of 1.2 days in the length of hospital stay in non-critical units. There was no variation in bacterial resistance. ConclusionsAlthough the stewardship program and its interventions reduced antimicrobial consumption, costs and the length of hospital stay further studies are required to identify the components that can produce the impact on microbiological outcomes seen in other studies.

O objetivo é verificar o papel moderador dos choques de carreira na relação indireta entre vivenciar um chamado ocupacional e a percepção de empregabilidade, via desenvolvimento profissional proativo. A metodologia utilizou modelagem de equações estruturais com estimativa por mínimos quadrados parciais. Os resultados indicam que não houve relação positiva entre vivenciar um chamado e percepção de empregabilidade. Além disso, o desenvolvimento profissional proativo não mediou a relação entre vivenciar um chamado e percepção de empregabilidade, assim como choques de carreira positivos e negativos não moderam a relação indireta entre vivenciar um chamado e percepção de empregabilidade via desenvolvimento profissional proativo.

BackgroundEmesis is a complex physiological phenomenon that serves as a defense against numerous toxins, stressful situations, adverse medication responses, chemotherapy, and movement. Nevertheless, preventing emesis during chemotherapy or other situations is a significant issue for researchers. Hence, the majority view contends that successfully combining therapy is the best course of action. In-vivo analysis offers a more comprehensive grasp of how compounds behave within a complex biological environment, whereas in-silico evaluation refers to the use of computational models to forecast biological interactions. ObjectivesThe objectives of the present study were to evaluate the effects of Sclareol (SCL) on copper sulphate-induced emetic chicks and to investigate the combined effects of these compounds using a conventional co-treatment approach and in-silico study. MethodsSCL (5, 10, and 15 mg/kg) administered orally with or without pre-treatment with anti-emetic drugs (Ondansetron (ODN): 24 mg/kg, Domperidone (DOM): 80 mg/kg, Hyoscine butylbromide (HYS): 100 mg/kg, and Promethazine hydrochloride (PRO): 100 mg/kg) to illustrate the effects and the potential involvement with 5HT3, D2, M3/AChM, H1, or NK1 receptors by SCL. Furthermore, an in-silico analysis was conducted to forecast the role of these receptors in the emetic process. ResultsThe results suggest that SCL exerted a dose-dependent anti-emetic effect on the chicks. Pretreatment with SCL-10 significantly minimized the number of retches and lengthened the emesis tendency of the experimental animals. SCL-10 significantly increased the anti-emetic effects of ODN and DOM. However, compared to the ODN-treated group, (SCL-10 + ODN) group considerably (p < 0.0001) extended the latency duration (109.40 ± 1.03 s) and significantly (p < 0.01) decreased the number of retches (20.00 ± 0.70), indicating an anti-emetic effect on the test animals. In in-silico analysis, SCL exhibited promising binding affinities with suggesting receptors. ConclusionSCL-10 exerted an inhibitory-like effect on emetic chicks, probably through the interaction of the 5HT3 and D2 receptors. Further studies are highly appreciated to validate this study and determine the precise mechanism(s) behind the anti-emetic effects of SCL. We expect that SCL-10 may be utilized as an antiemetic treatment in a single dosage form or that it may function as a synergist with other traditional medicines.

Objetivo: O presente artigo teve como objetivo analisar a influência dos arranjos flexíveis de trabalho (AFT) no equilíbrio trabalho-lar (ETL), estresse tecnológico (ET) e na satisfação com o trabalho (ST) dos contadores, funcionários de empresas contábeis e de auditoria no Brasil.&#x0D; Método: O estudo contou com 394 respondentes, sendo a amostra final de 276 pessoas cujas respostas foram analisadas por meio de equações estruturais (PLS-SEM).&#x0D; Resultados: Os resultados demonstram que o AFT tem efeito positivo sobre o ET, e este impacta negativamente na ST. Porém, não se mostrou estatisticamente significativo quanto ao impacto sobre o ETL. Por fim, os achados apontam para uma relação positiva do ETL na ST.&#x0D; Contribuições: Do ponto de vista teórico contribui com as discussões dos impactos da tecnologia e do AFT no universo das empresas de contabilidade e auditoria no Brasil. Autores têm pesquisado esse efeito em outros países, porém, o tema não foi pesquisado no Brasil, e num contexto de pandemia. Quanto aos aspectos práticos, o trabalho foi pioneiro ao discutir a realidade de empresas brasileiras que utilizaram o AFT durante a pandemia, considerando a necessidade de adaptação compulsória por parte de empregadores e empregados.