The launching of UN SDGs and 2030 resolution has sparked a new concept and perspective regarding the problem that we faced right now. The framework explicitly mention 5P as the main pillars of SDG while having the same characteristics as triple bottom line, with addition of peace and partnership aspects. This research uses purposive sampling to gain a proper sample from Indonesia's energy sector from 2020-2022. Data extracted from company's sustainability report using content analysis approach with several criteria. The number then fitted into a model with PLS-SEM and analysed using path coefficient and significance of p value. Some company disclosed more sustainability information through their sustainability report compared to the other. Planet aspect are having a positive and significant correlation, with People and Prosperity having a positive but not significant correlation and Peace and Partnership are having a negative and insignificant correlation. This study needs to be confirmed or re-evaluate by other researcher to further justify the proposition of the new concept, namely 5P.

The spontaneous aggregation of infectious or misfolded forms of prion protein is known to be responsible for neurotoxicity in brain cells, which ultimately leads to the progression of prion disorders. Bovine spongiform encephalopathy (BSE) in animals and Creutzfeldt-Jakob disease (CJD) in humans are glaring examples in this regard. Square-planar complexes with labile ligands and indole-based compounds are found to be efficiently inhibitory against protein aggregation. Herein, we report the synthesis of an indole-based cyclometallated palladium complex. The ligand and complex were characterized by various spectroscopic techniques such as UV-visible, NMR, IR, and HRMS. The molecular structure of the complex was confirmed by single-crystal X-ray crystallography. The interaction of the complex with PrP106-126 was studied using UV-visible spectroscopy, CD spectroscopy, MALDI-TOF MS, and molecular docking. The inhibition effects of the complex on the PrP106-126 aggregation, fibrillization and amyloid formation phenomena were analysed through the ThT assay, CD, TEM and AFM. The effect of the complex on the aggregation process of PrP106-126 was determined kinetically through the ThT assay. The complex presented high binding affinity with the peptide and influenced the peptide's conformation and aggregation in different modes of binding. Furthermore, the MTT assay on neuronal HT-22 cells showed considerable protective properties of the complex against PrP106-126-mediated cytotoxicity. These findings suggest that the compound influences peptide aggregation in different ways, and the anti-aggregation action is primarily associated with the metal's physicochemical properties and the reactivity rather than the ligand. As a result, we propose that this compound be investigated as a potential therapeutic molecule in metallopharmaceutical research to treat prion disease (PD).

ABSTRACT Background The severity of diabetic ketoacidosis (DKA) at diagnosis increased during the global COVID-19 pandemic. This study aimed to analyze the impact of the pandemic on the clinical and biological severity of DKA in patients with new-onset diabetes mellitus (DM) in Tunisia. Research design and methods The study included patients hospitalized for new-onset DKA 2 years prior and 2 years during the COVID-19 pandemic. Data was collected retrospectively, and DKA severity was classified based on biological parameters like potential of hydrogen (pH) and HCO3-. Results The results showed that DKA was more severe during COVID-19, as evidenced by lower potential of hydrogen (pH) (p = 0.006), and serum bicarbonate (HCO3-) levels (p = 0,005). Despite the higher severity of DKA was higher during COVID-19, intensive care unit hospitalizations remained equivalent (p = 0.359). The prevalence of hyponatremia was also higher during COVID-19 (p = 0.024). Conclusion The findings suggest that delayed diagnosis and COVID-19 May contribute to the increased severity of DKA and electrolyte imbalance during the pandemic. Further research is needed to better understand the underlying mechanisms and develop appropriate strategies to address this issue.

ABSTRACT In this essay, we theorize how terms like “decolonization” and “decoloniality” have entered into the vernacular of the discipline of Communication Studies and remained largely as metaphors. We connect to a conversation among scholars in Indigenous Studies, Cultural Studies, and others who have turned attention to “decolonial” critiques in academic environments, and how they remain detached from their activist origins. We begin with a discussion of metaphor and the cultural and political implications for adopting and misattributing a term like decolonization. Moreover, this study develops a critical method to make sense of the rapid and vast uptake of the term decolonization as a harmful metaphor in the discipline’s most widely read journals. Our critical thematic meta-analysis is driven by a quantifying tool – we turn our research lens to the body of literature written by the collective of scholars in the discipline who refer to or rely on decolonization in their research to reveal the way in which the term is connoted over the last decade. Our analysis reveals “decolonization” is often used as a liberal abstract concept divorced from material contexts. We critique this reductionism, noting how decolonization becomes a buzzword for institutional change without genuine engagement with anti-colonial movements. We end by inviting scholars to reconsider the study of colonization and those materially resisting it with new energies and orientations.

ABSTRACT Whilst research examining transgender identities within educational contexts in recent years has increased, there is limited research focused specifically on transgender and non-binary (TNB) experiences in Physical Education (PE). PE is a context where dominant gendered ‘ideals’ raise the potential for exclusion for those who do not ‘fit’. This paper explores the reflective experiences of thirty TNB individuals (aged 18–25 years) and identifies the barriers to/facilitators of their participation in PE. It presents data collected from an online survey and semi-structured interviews with TNB young adults. Findings show that both the implicit and explicit curriculum are strongly binary, making it hard for students who do not conform to dualistic expectations to negotiate the setting. While these findings support the broader view that TNB young people can feel excluded from PE, there is much to learn from the participants’ experiences. The paper closes by discussing the implications for shaping more inclusive practice.

The ongoing demographic transition within aging single-family house neighborhoods in Germany poses a significant challenge for municipalities. The scarcity of data and information related to demographic composition and location quality complicates research efforts and the development of adaptive strategies for these residential areas. This issue is particularly pronounced in rural regions where resources for capturing and analyzing demographic trends are limited. To address this gap, we propose a methodology based on geographic information systems. In this approach, municipal population registers serve as a central data source for extracting insights about the residents. We present the findings primarily in the form of maps, as they are intended to be easily comprehensible for urban planners and local government staff. Additionally, we outline the initial steps in establishing a small-scale monitoring system that incorporates demographic indicators as well as reachability estimates. A case study from northern Bavaria is used as an illustration.

Introduction: Diffusion of Innovation Theory explains how ideas or products gain momentum and diffuse (or spread) through specific populations or social systems over time. The theory analyzes primary influencers of the spread of new ideas, including the innovation itself, communication channels, time, and social systems. Methods: The current study reviewed published medical literature to identify studies and applications of artificial intelligence (AI) in endourology and used E.M. Rogers' Diffusion of Innovation Theory to analyze the primary influencers of the adoption of AI in endourological care. The insights gained were triaged and prioritized into AI application-related action items or "tips" for facilitating the appropriate diffusion of the most valuable endourological innovations. Results: Published medical literature indicates that AI is still a research-based tool in endourology and is not widely used in clinical practice. The published studies have presented AI models and algorithms to assist with stone disease detection (n = 17), the prediction of management outcomes (n = 18), the optimization of operative procedures (n = 9), and the elucidation of stone disease chemistry and composition (n = 24). Five tips for facilitating appropriate adoption of endourological AI are: (1) Develop/prioritize training programs to establish the foundation for effective use; (2) create appropriate data infrastructure for implementation, including its maintenance and evolution over time; (3) deliver AI transparency to gain the trust of endourology stakeholders; (4) adopt innovations in the context of continuous quality improvement Plan-Do-Study-Act cycles as these approaches have proven track records for improving care quality; and (5) be realistic about what AI can/cannot currently do and document to establish the basis for shared understanding. Conclusion: Diffusion of Innovation Theory provides a framework for analyzing the influencers of the adoption of AI in endourological care. The five tips identified through this research may be used to facilitate appropriate diffusion of the most valuable endourological innovations.

This study examined the human resource management challenges faced by heads of departments in managing a multigenerational academic workforce in the South African higher education sector. A qualitative research approach was followed, and a multiple case study research design was applied. A purposive sampling technique was used to select 16 participants. Data was collected through semi-structured interviews, and it was analysed thematically with the aid of Atlas.ti. The study revealed several challenges related to the management of a multigenerational academic workforce, namely, differences in career expectations, skills, and experience among generations; conflict management; implementation of plans and strategies; succession planning; and teamwork. The findings have implications for higher education institutions as different generations have varying expectations for career development. Human resource departments should establish clear and transparent career pathways to meet these expectations. The study also provides supporting evidence for the dimensions outlined in the framework for understanding generational identities in organisations. Exploring generational diversity in workplace relationships and interactions within the education context complements the existing research focused on pedagogical aspects and cultural characteristics in academic settings.

ABSTRACT In this concluding reflection, we value the special issue’s focus on how power asymmetries among civil society organisations (CSOs) affect their relations with international organisations (IOs) and micro-level dynamics of in – and exclusion. Yet we propose to pay further attention to the crisis of liberal institutions and the shrinking spaces provided to some CSOs . We also encourage revisiting the liberal assumption that CSOs seek to democratise IOs and the proposition that the majority of CSOs are keen to cooperate with IOs. The pressing question for us is not how CSOs push in- or exclusion in IOs but how dynamics of in- and exclusion are generated in the web of practices performed by diverse actors. In our perspective, the question is best addressed in reflexive research that is aware of power relations, the methodological difficulties of researching CSOs and often inaccessible IOs, and the dangers of silencing non-academic voices.

ABSTRACT In this special issue, the authors theoretically, methodologically, and empirically address challenges and opportunities associated with comparative social media analysis in political contention. Actors from civil society, media, and institutional politics use social media to coordinate, mobilise, and communicate, turning public online communication into an arena of conflict that offers researchers valuable windows of observation. In this introduction to the special issue, we systematise comparative perspectives on social media and political contention. We outline the traditional comparative dimensions of space, time, platform, and case; and suggest an approach for comparison within dimensions that are less dependent on the rapidly changing social media environment and more attuned to the interconnection between social media and political contention.