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APA et l’enfant avec déficience intellectuelle légère

Introduction Le retard mental se caracterise par une insuffisance des facultes et du niveau global d’intelligence, notamment des fonctions cognitives, du langage, et de la motricite [1] . Le but de cette etude est d’evaluer les effets de la pratique des activites physiques adaptees (APA) sur la condition physique generale (CPG) et l’integration sociale chez les adolescents deficients intellectuels legers et moyens. Materiels et methodes Notre etude est realisee a l’Institut superieur d’education specialisee (ISES) de la Manouba sur une periode de deux mois concernant 16 adolescents âges de 12 a 17 ans, presentant une deficience intellectuelle legere. Les adolescents sont soumis a une evaluation anthropometrique, du comportement socio-adaptatif et de la CPG par des tests specifiques evaluant la vitesse, la detente verticale, l’equilibre, la souplesse, le lancer de balle, l’endurance des abdominaux et des membres superieurs. Le protocole d’APA est compose de 12 seances (1 heure, 3 fois par semaine) visant ameliorer leur autonomie fonctionnelle et leur integration au sein d’un groupes ainsi que leur CPG [2] . Resultats Les 16 adolescents (12 ♂, 4 ♀) presentaient un âge moyen de 14,6 ans et un Indice de Masse Corporel de 19,5. Les resultats obtenus apres le programme d’APA montrent une amelioration des performances pour l’equilibre et l’agilite (p Conclusion L’APA proposee a des effets benefiques sur la CPG et l’integration dans le groupe des jeunes deficients intellectuels legers comme retrouve dans la litterature [3] .

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Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion<i>Hemiscorpius lepturus</i>

Hemitoxin (HTX) is a new K+ channel blocker isolated from the venom of the Iranian scorpion Hemiscorpius lepturus. It represents only 0.1% of the venom proteins, and displaces [125 I]alpha-dendrotoxin from its site on rat brain synaptosomes with an IC50 value of 16 nm. The amino acid sequence of HTX shows that it is a 35-mer basic peptide with eight cysteine residues, sharing 29-69% sequence identity with other K+ channel toxins, especially with those of the alphaKTX6 family. A homology-based molecular model generated for HTX shows the characteristic alpha/beta-scaffold of scorpion toxins. The pairing of its disulfide bridges, deduced from MS of trypsin-digested peptide, is similar to that of classical four disulfide bridged scorpion toxins (Cys1-Cys5, Cys2-Cys6, Cys3-Cys7 and Cys4-Cys8). Although it shows the highest sequence similarity with maurotoxin, HTX displays different affinities for Kv1 channel subtypes. It blocks rat Kv1.1, Kv1.2 and Kv1.3 channels expressed in Xenopus oocytes with IC50 values of 13, 16 and 2 nM, respectively. As previous studies have shown the critical role played by the beta-sheet in Kv1.3 blockers, we suggest that Arg231 is also important for Kv1.3 versus Kv1.2 HTX positive discrimination. This article gives information on the structure-function relationships of Kv1.2 and Kv1.3 inhibitors targeting developing peptidic inhibitors for the rational design of new toxins targeting given K+ channels with high selectivity.

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Open Access
Evidence for Triassic salt domes in the Tunisian Atlas from gravity and geological data

Detailed gravity data were analyzed to constrain two controversial geological models of evaporitic structures within the Triassic diapiric zone (Triassic massifs of Jebel Debadib and Ben Gasseur) of the northern Tunisian Atlas. Based on surface observations, two geological models have been used to explain the origin of the Triassic evaporitic bodies: (1) salt dome/diapiric structure or (2) a “salt glacier”. The gravity analysis included the construction of a complete Bouguer gravity anomaly map, horizontal gravity gradient (HGG) map and two and a half-dimensional (2.5D) forward models. The complete Bouguer gravity anomaly map shows a prominent negative anomaly over the Triassic evaporite outcrops. The HGG map showed the location of the lateral density changes along northeast structural trends caused by Triassic/Cretaceous lithological differences. The modeling of the complete Bouguer gravity anomaly data favored the diapiric structure as the origin of the evaporitic bodies. The final gravity model constructed over Jebel Debadib indicates that the Triassic evaporitic bodies are thick and deeply rooted involving a dome/diapiric structure and that the Triassic material has pulled upward the younger sediment cover by halokinesis. Taking in account kinematic models and the regional tectonic events affecting the northern margin of Africa, the above diapirs formed during the reactive to active to passive stages of continental margin evolution with development of sinks. Otherwise, this study shows that modeling of detailed gravity data adds useful constraints on the evolution of salt structures that may have an important impact on petroleum exploration models.

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