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Big data and artificial intelligence in post-stroke aphasia: A mapping review

BACKGROUND: Aphasia is an impairment of language as a result of brain damage which can affect individuals after a stroke. Recent research in aphasia has highlighted new technologies and techniques that fall under the umbrella of big data and artificial intelligence (AI). OBJECTIVES: This review aims to examine the extent, range and nature of available research on big data and AI relating to aphasia post stroke. METHODS: A mapping review is the most appropriate format for reviewing the evidence on a broad and emerging topic such as big data and AI in post-stroke aphasia. Following a systematic search of online databases and a two-stage screening process, data was extracted from the included studies. This analysis process included grouping the research into inductively created categories as the different areas within the research topic became apparent. RESULTS: Seventy-two studies were included in the review. The results showed an emergent body of research made up of meta-analyses and quasi-experimental studies falling into defined categories within big data and AI in post-stroke aphasia. The two largest categories were automation, including automated assessment and diagnosis as well as automatic speech recognition, and prediction and association, largely through symptom-lesion mapping and meta-analysis. CONCLUSIONS: The framework of categories within the research field of big data and AI in post-stroke aphasia suggest this broad topic has the potential to make an increasing contribution to aphasia research. Further research is needed to evaluate the specific areas within big data and AI in aphasia in terms of efficacy and accuracy within defined categories.

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Binomial Confidence Intervals for Rare Events: Importance of Defining Margin of Error Relative to Magnitude of Proportion

Confidence interval performance is typically assessed in terms of two criteria: coverage probability and interval width (or margin of error). In this article, we assess the performance of four common proportion interval estimators: the Wald, Clopper-Pearson (exact), Wilson and Agresti-Coull, in the context of rare-event probabilities. We define the interval precision in terms of a relative margin of error which ensures consistency with the magnitude of the proportion. Thus, confidence interval estimators are assessed in terms of achieving a desired coverage probability whilst simultaneously satisfying the specified relative margin of error. We illustrate the importance of considering both coverage probability and relative margin of error when estimating rare-event proportions, and show that within this framework, all four interval estimators perform somewhat similarly for a given sample size and confidence level. We identify relative margin of error values that result in satisfactory coverage while being conservative in terms of sample size requirements, and hence suggest a range of values that can be adopted in practice. The proposed relative margin of error scheme is evaluated analytically, by simulation, and by application to a number of recent studies from the literature.

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Modification of Living Diatom, Thalassiosira weissflogii, with a Calcium Precursor through a Calcium Uptake Mechanism: A Next Generation Biomaterial for Advanced Delivery Systems.

The diatom's frustule, characterized by its rugged and porous exterior, exhibits a remarkable biomimetic morphology attributable to its highly ordered pores, extensive surface area, and unique architecture. Despite these advantages, the toxicity and nonbiodegradable nature of silica-based organisms pose a significant challenge when attempting to utilize these organisms as nanotopographically functionalized microparticles in the realm of biomedicine. In this study, we addressed this limitation by modulating the chemical composition of diatom microparticles by modulating the active silica metabolic uptake mechanism while maintaining their intricate three-dimensional architecture through calcium incorporation into living diatoms. Here, the diatom Thalassiosira weissflogii was chemically modified to replace its silica composition with a biodegradable calcium template, while simultaneously preserving the unique three-dimensional (3D) frustule structure with hierarchical patterns of pores and nanoscale architectural features, which was evident by the deposition of calcium as calcium carbonate. Calcium hydroxide is incorporated into the exoskeleton through the active mechanism of calcium uptake via a carbon-concentrating mechanism, without altering the microstructure. Our findings suggest that calcium-modified diatoms hold potential as a nature-inspired delivery system for immunotherapy through antibody-specific binding.

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