Articles published on Zingiberaceae
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- Research Article
- 10.3390/molecules30224340
- Nov 9, 2025
- Molecules
- Yuhao Long + 5 more
Curcuma phaeocaulis, a perennial herb of the ginger family, has been used to treat many diseases in traditional medicine systems. This study aimed to extract, isolate, and purify a homogeneous polysaccharide from C. phaeocaulis, conduct preliminary structural characterization, and evaluate its antioxidant activity at the cellular level. The structure of the purified polysaccharide (CPAP-1) was characterized using size exclusion chromatography (SEC), chemical derivatization analysis (CDA), GC-MS, FT-IR, and NMR. The results showed that CPAP-1 has an apparent molecular weight of 118.122 kDa and is hypothesized to be an arabinogalactan with a backbone composed of →3,6)-β-d-Galp-(1→ and →3)-β-d-Galp-(1→ residues, a structure that is relatively novel in Curcuma longa. In vitro antioxidant assays demonstrated that CPAP-1 possesses potent antioxidative stress activity, effectively scavenging both DPPH and hydroxyl radicals. Furthermore, cellular experiments revealed that at concentrations of 500 and 750 mg/L, CPAP-1 significantly protected human umbilical vein endothelial cells (HUVECs) against H2O2-induced oxidative damage. In conclusion, these findings suggest that CPAP-1 could be developed as a natural antioxidant, functional food, or therapeutic agent for preventing and mitigating oxidative stress-related vascular injury, providing a theoretical basis for further development and application.
- Research Article
- 10.1002/ardp.70129
- Nov 1, 2025
- Archiv der Pharmazie
- Huda M Younis + 1 more
Turmeric is a common spice obtained from the rhizomes of the Curcuma longa plant. It belongs to the Zingiberaceae (ginger family). The rhizome is a horizontally growing stem that sends roots and shoots from below ground. Turmeric has many uses, including spice, food preservation, flavor enhancement, and coloring. Also, it is used in conventional medicine as a home treatment for many diseases. Turmeric obtains its yellow color from curcuminoids, polyphenolic pigments that dissolve in fat. The primary curcuminoid form in turmeric is curcumin or diferuloylmethane (1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione). It is the most active element and is responsible for its biological characteristics. Curcumin exhibits significant benefits in many human disease treatments. Generally, curcumin is beneficial to human health due to its therapeutic characteristics. These involve antioxidant, anti-inflammatory, anticancer, antiangiogenic, hepatoprotective, neuroprotective, antidiabetic, immunomodulatory, antimicrobial, wound healing, and cardiovascular diseases. Although comprehensive studies have been conducted on curcumin's ability to treat many human diseases, major challenges remain, especially regarding its therapeutic efficacy and bioavailability. This review presents an overview of curcumin's therapeutic applications, its benefits for human health, and the challenges to its broad use. It also highlighted existing solutions and approaches to enhance curcumin's therapeutic potential.
- Research Article
- 10.15294/jstrp.v5i1.27250
- Jul 25, 2025
- Journal of Science and Technology Research for Pharmacy
- Valerie Gerail Sitompul + 1 more
Diabetes mellitus (DM) is a metabolic disease in which blood sugar levels are uncontrolled. Type 2 diabetes mellitus is uncontrolled blood sugar levels that occur due to insulin resistance or reduced body sensitivity to insulin. Treatment of type 2 diabetes mellitus, pharmacologically, uses oral antihyperglycemic drugs and injectable antihyperglycemic drugs. Although effective, antidiabetic drugs often cause adverse side effects. Indonesian people are concerned about synthetic drugs because of the potential side effects caused so that people are encouraged to look for more natural or herbal alternative treatments that are believed to have antidiabetic activity, one of which is ginger. Bangle (Zingiber purpureum Roxb.) is one of the plants that belongs to the zingiberaceae or ginger family. Bangle rhizome has a major compound of curcumin of 2,633% w/w and phenylbutanoid which has antioxidant, anti-inflammatory, and AMPK (AMP-activated protein kinase) agonist activity. With this activity, the antidiabetic potential of bangle rhizome was tested in vivo using alloxan-induced hyperglycemic mice, observed in 14 days with bangle rhizome extract doses of 100mg/kgBW, 200mg/kgBW, 400mg/kgBW, and in silico to determine compounds that have antidiabetic activity. The results obtained from the in vivo test for reducing blood sugar on days 7 and 14 had a significance value of 0.383 (p>0.05) and 0.253 (p>0.05) which means that the administration of bangle rhizome extract did not have a significant effect on reducing blood sugar in hyperglycemic male mice. The in silico test conducted was in line with the in vivo results where bangle rhizome extract had greater potential for anticancer, anti-inflammatory, and fat metabolism activities. The PASS Online results did not show any activity related to insulin sensitivity or alpha glucosidase inhibitor activity.
- Research Article
4
- 10.3390/ijms26115093
- May 26, 2025
- International journal of molecular sciences
- Ratchaniporn Kongsui + 2 more
Ischemic stroke is the most common type of stroke and poses a major global health challenge due to its high mortality and lasting disability impact. The onset and progression of ischemic stroke are largely linked to oxidative stress and inflammatory responses. Alpinetin, a natural flavonoid found in the ginger family, exhibits various pharmacological properties, including antioxidant and anti-inflammatory activities. In this study, the neuroprotective potential of alpinetin in attenuating oxidative stress and inflammation against cerebral ischemic stroke was evaluated. Ninety male Wistar rats were randomly assigned to the sham operation group, the Rt.MCAO group, the Rt.MCAO+piracetam group, and the Rt.MCAO+alpinetin groups (25, 50, and 100 mg/kg BW). Cerebral infarction size, neuronal density, and antioxidant and anti-inflammatory activities were measured. Three days of treatment with alpinetin markedly reduced the infarct volume by 30% compared to the Rt.MCAO+vehicle-treated group. Additionally, rats treated with alpinetin exhibited a significant increase in neuronal density in the cortex, as well as in the CA1 and CA3 regions of the hippocampus. Furthermore, treatment with alpinetin ameliorated both the Rt.MCAO-induced increase in malondialdehyde (MDA) activity and the Rt.MCAO-induced decrease in catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities in the cortex and hippocampus. Moreover, COX-2 and IL-6 protein levels were assessed using western blotting. The results showed that treatment with alpinetin (100 mg/kg BW) significantly reduced the expression levels of COX-2 and IL-6 in both the cortex and hippocampus. Our findings suggest that alpinetin significantly mitigates the effects of cerebral ischemia-induced brain damage through its antioxidant and anti-inflammatory properties and could potentially be developed as a therapeutic agent for stroke treatment.
- Research Article
- 10.1002/mnfr.70034
- Apr 3, 2025
- Molecular nutrition & food research
- Shiho Kasai + 3 more
Bangle, a perennial herb belonging to the ginger family with antiinflammatory properties, has been under-researched in ulcerative colitis. This study aimed to investigate the effects of Bangle extract (BaE) on inflammation and autophagy in the colons of mice with dextran sulfate sodium (DSS)-induced colitis. Male C57BL/6J mice were assigned to four groups: control, DSS+0% BaE, DSS+1% BaE, and DSS+3% BaE. The BaE groups were fed BaE diets for 3 weeks, followed by an additional week of BaE diets and 3% DSS in the water. The control group received a standard chow diet and water for 4 weeks. Plasma leucine-rich α2-glycoprotein (LRG) levels, macrophage count, and the levels of nuclear factor kappa B (NFκB) p65, tumor necrosis factor-α (TNF-α), adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), mechanistic target of rapamycin (mTOR), and autophagy markers were analyzed. In the DSS+0% BaE group, LRG levels, macrophage count, NFκB p65 protein, and TNF-α mRNA levels were significantly higher compared to the control group. However, in the DSS+3% BaE group, these levels were significantly reduced. Additionally, PGC-1α and phosphorylated AMPK levels were increased, while phosphorylated mTOR levels decreased, and autophagy marker microtubule-associated protein 1 light chain 3B (LC3B)-II levels were increased in the DSS+3% BaE group. BaE may ameliorate colonic inflammation and upregulate autophagy via the modulation of the AMPK/mTOR/NFκB pathway in DSS-induced colitis.
- Research Article
3
- 10.1016/j.foodchem.2025.142984
- Apr 1, 2025
- Food chemistry
- Mei Su + 6 more
Composition and antioxidant activity of flavonoids from two different species of Amomi Fructus extracted using natural deep eutectic solvents.
- Research Article
1
- 10.3390/separations12040077
- Mar 28, 2025
- Separations
- Yang Chen + 6 more
Amomum villosum L. is a perennial herbaceous belonging to the ginger family. Due to its unique aroma, it is widely used in alcoholic beverages and food processing. Unfortunately, issues with bitterness and sourness occur, which affect the taste and quality of processed products. In this study, the non-volatile sour and bitter substances in Amomum villosum L. were systematically isolated, purified, and characterized through a combination of chromatographic separation techniques and ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS). The results indicate that three sour compounds (DL-malic acid, protocatechuic acid, and p-hydroxybenzoic acid) and one bitter compound (catechin) were identified for the first time in Amomum villosum L. The in vitro anti-tumor activity was screened and determined using Cell Counting Kit-8 (CCK-8) assays, a 5-Ethynyl-2′-deoxyuridine (EdU) staining experiment, and scratch assays. The results reveal that the bitter substance of catechin (25–100 μg/mL) exhibited significant inhibitory effects, which inhibited the proliferation and migration of human non-small cell lung cancer A549 cells through dose-dependent mechanisms. This investigation also reveals the influence of different traditional extraction solvents on the degree of bitterness and sourness in Amomum villosum extracts, providing a theoretical basis for improving the quality and pharmacological utilization of Amomum villosum extracts.
- Research Article
- 10.12968/denu.2025.52.3.206
- Mar 2, 2025
- Dental Update
- Magdalena Chan + 2 more
A naturally occurring plant of the ginger family, Curcuma longa (turmeric), has an established therapeutic role in tackling a wide variety of inflammatory conditions. In view of curcumin's long-standing history and continual growth in the UK herbal remedy market, a literature review was a carried out to assess its potential role in the management of oral mucosal disease. The administration of topical and oral curcumin has been shown to have positive effects, such as alleviating symptoms and reducing lesion sizes in recurrent aphthous stomatitis, potentially malignant conditions, oral mucositis and denture stomatitis. The application of topical curcumin has been found to reduce concentration of bacteroides species and inflammatory cytokine concentrations in oral cancer patients. CPD/Clinical Relevance: Curcumin may be used as a therapeutic agent in managing potentially malignant conditions, mucositis and recurrent aphthous stomatitis.
- Research Article
2
- 10.7717/peerj.18948
- Feb 24, 2025
- PeerJ
- Pornpimon Wongsuwan + 4 more
Kaempferia is a genus belonging to the ginger family. Currently, this genus is comprised of about 63 species, mainly distributed from India to Southeast Asia. During our fieldwork, a new species of Kaempferia was found in Chon Buri Province, Thailand. The objective of this article was to provide morphological evidence and confirm its relationships in Kaempferia through molecular phylogenetic analysis. Plant samples were collected from field sites and investigated by conventional taxonomy and molecular techniques. The phylogenetic trees were reconstructed using the maximum likelihood criterion and Bayesian inference. The morphological evolution was also examined to elaborate the relationships among representative Kaempferia taxa. Kaempferia chonburiensis from southeastern Thailand is described and illustrated based on morphological features and its taxonomic placement was confirmed by molecular phylogenetic analyses and morphological evolution. An identification key is provided for the new Kaempferia species occurring in Thailand. Kaempferia chonburiensis is a new enumerated species of Kaempferia from Thailand.
- Research Article
- 10.1186/s12870-025-06132-6
- Feb 20, 2025
- BMC Plant Biology
- Yu Liu + 5 more
Curcuma wenyujin, a perennial herb of the ginger family, is renowned for its significant medicinal properties. Phosphorus (P), a vital nutrient for plant growth and development, has seen its levels, particularly organic P, increase in the soils of agricultural regions in southern China, presenting new challenges for nutrient management. This study aimed to uncover the molecular responses of C. wenyujin seedlings to both normal and high phosphorus (HP) conditions, shedding light on their adaptation strategies to P stress. Through transcriptome and metabolome analyses of the seedlings under normal and HP conditions, we identified 1,793 metabolites, with 195 showing differential expression. Notably, KEGG enrichment analysis highlighted 35 significantly differential accumulation metabolites (DAMs). Comparing the control group (CK) and HP treated groups (T) revealed 840 differentially expressed genes (DEGs), pinpointing the molecular divergences in response to varying P levels. Importantly, we found a potential gene, purple acid phosphatase 17 (pap17) that may cofer HP stress conditions in C. wenyujin. That elucidated the response variations of C. wenyujin seedlings to diverse P concentrations. The research suggested that C. wenyujin may adjust to varying P levels by modulating metabolites and genes linked to amino acid and phenylpropane metabolism. It highlighted the sophisticated mechanisms plants utilize to manage P stress, offering insights into their survival tactics in settings where P availability changes.
- Research Article
1
- 10.3390/ph18020278
- Feb 19, 2025
- Pharmaceuticals (Basel, Switzerland)
- Rubén Pérez-Machín + 5 more
Background and aims:Aframomum melegueta (A. melegueta) from the ginger family is appreciated for its pungent seeds widely used in African ethno-medicine. Among the several biological activities associated with the seed's preparations, some preclinical studies suggest a set of neuroactive properties that have not been tested in humans to date. We performed a clinical trial to investigate the effects of A. melegueta seed extracts on anxiety, stress, mood, and sleep in healthy subjects with moderate anxiety levels. In vitro pharmacological assays targeting the endocannabinoid, serotoninergic, and GABAergic systems were conducted to elucidate the underlying mechanism of action. Methods:A. melegueta standardized to 10% total vanilloids (primarily 6-gingerol, 6-shogaol, and 6-paradol) was obtained after hydroalcoholic extraction and the spray-drying microencapsulation process. Subjects consumed 50, 100, or 150 mg of the extract daily for two days. A set of validated psychometric test questionnaires was collected before and 48 h after the first intake. A. melegueta extract interaction with canonical endocannabinoid receptors (hCB1R and hCB2R), the serotonin receptor (5HT1AR) and gamma-aminobutyric acid receptor (GABAA1R) was evaluated by the radioligand binding assay. Additionally, receptor functional assays and enzyme inhibition assays were conducted to test the extract's functional activity on the non-canonical endocannabinoid receptor (TRPV1) and the cannabinoid fatty-acid amide hydrolase enzyme (FAAH), respectively. Results: In vitro pharmacological tests showed that the A. melegueta extract activated TRPV1, modulated both hCB2R and 5HT1AR and inhibited FAAH, which is the enzyme primarily responsible for hydrolyzing endogenous anandamide. After a 48 h intake period, the extract significantly reduced anxiety and tension related to stress, improved overall mood, and enhanced sleep quality in the participants at doses ranging from 50 to 150 mg, with no reported side effects. Conclusions: This study supports the potential of the A. melegueta extract for anxiety reduction, mood improvement, stress mitigation, and sleep enhancement. The in vitro tests suggest that the extract's primary mechanism of action may involve the inhibition of FAAH, which is a key target in anxiety management.
- Research Article
2
- 10.1016/j.fct.2024.115200
- Feb 1, 2025
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Yuming Kuang + 2 more
Deoxynivalenol induces spleen damage, apoptosis, and inflammation in mice by increasing mitochondrial reactive oxygen species: Protective effects of curcumin.
- Research Article
- 10.14719/pst.4215
- Jan 17, 2025
- Plant Science Today
- S Jitjum + 5 more
Plants in the ginger family are globally utilized in diverse ways, varying from region to region. This study aims to compile the uses of ginger family plants by traditional healers in five districts of Nakhon Si Thammarat Province. These districts include Thung Song, Na Bon, Lan Saka, Chang Klang, and Ron Phibun, which have not been previously studied. Ten traditional healers were selected based on specific criteria. This qualitative research was conducted through semi-structured interviews combined with observations. The data were analyzed descriptively, including frequency, fidelity level (FL), and use value (UV). The study found that traditional healers use 16 species of ginger family plants, including Curcuma longa L., Zingiber ligulatum Roxb., Boesenbergia rotunda (L.) Mansf., Zingiber cassumunar Roxb., Amomum testaceum Ridl., Zingiber officinale Roscoe, Alpinia galanga (L.) Willd., Curcuma zedoaria (Christm.) Roscoe, Curcuma comosa Roxb., Zingiber zerumbet (L.) Roscoe ex Sm., Kaempferia galanga L., Kaempferia parviflora Wall. Ex Baker, Amomum biflorum Jack, Curcuma mangga Valeton & Zijp, Alpinia purpurata (Vieill.) K.Schum., and Etlingera coccinea (Blume) S.Sakai & Nagam. The highest FL values (100%) were found for four species, including Amomum biflorum Jack, Curcuma mangga Valeton & Zijp, Alpinia purpurata (Vieill.) K.Schum. and Etlingera coccinea (Blume) S.Sakai & Nagam. The highest UV value was found for Zingiber officinale Roscoe (0.4). Scientific evidence has identified 14 pharmacological activities, including anti-inflammatory, antifungal, gastroprotective, anthelmintic, anti-emetic, anti-platelet, antioxidant, analgesic, neuroprotective, renoprotective, aphrodisiac, anti-ulcer, antipyretic, and anti-asthma properties. These activities support the therapeutic effects used by traditional healers. Traditional healers use these ginger family plants as ingredients in polyherbal and monoherbal medicinal formulas. Ginger family plants play a crucial role in community healthcare and are employed in various ways. This constitutes a cultural heritage worthy of preservation and documentation for the benefit of global healthcare.
- Research Article
- 10.1007/s44372-024-00085-0
- Jan 15, 2025
- Discover Plants
- Jonas Kappen + 9 more
Abstract Hornstedtia scyphifera (J.Koenig) Steud. represents a lesser-known member of the ginger family (Zingiberaceae) that is used in Malaysia as spice and traditional medicine. The phytochemical investigation of leaves from this species utilizing diverse analytical methods has provided comprehensive insights into its chemical profile for the first time. Headspace gas chromatography-mass spectrometry (HS-GCMS) and GCMS analyses of essential oil and nonpolar extracts verified α-pinene, camphene, p-cymene, and camphor as main volatile compounds. Metabolite profiling of the crude extract by ultra-high-performance-liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) unveiled terpenoids, flavonoids and other phenolics as major compound classes. Isolation and follow-up structure elucidation, involving 1D and 2D NMR, HRMS, UV and CD analysis, yielded two new sesquiterpenoids, (1R,5S,6S,7R,10R)-mustak-14-oic acid (1) and (1R,6S,7S,10R)-6-hydroxy-anhuienosol (2), along with 24 known compounds (seven terpenoids, seven flavonoids, ten phenolics), 21 of these never reported for H. scyphifera. Additionally, the crude extract and fractions from the purification process were screened for antibacterial and antifungal activity. This is supplemented by an extensive literature research for described bioactivities of all isolated compounds. Our results support and explain previously detected antimicrobial, antifungal and neuroprotective effects of H. scyphifera extracts and provide evidence for its potential pharmacological importance.
- Research Article
- 10.37598/abdimu.v4i2.2213
- Jan 12, 2025
- ABDIMU: Jurnal Pengabdian Muhammadiyah
- Intan Rizkia Chudri + 1 more
Red Ginger is popularly consumed worldwide as a pleasant drink and for its health benefits, which are largely due to its composition. The utilization of Red Ginger has not been maximized. Most people are not interested in red ginger because it tastes bad and do not know much about how to process it. Red Ginger contains good nutritional composition for health such as containing mineral elements including potassium, sodium, calcium, magnesium, phosphorus, chlorine and a number of vitamins although in small amounts. This Red Ginger has been processed into several products such as flavorings in food, compositions in herbal medicine. For this reason, it is necessary to diversify processed products from red ginger such as making syrup. The method of implementing community service is by conducting training on how to make syrup from red ginger. Syrup from red ginger is an innovation from agricultural products that can be processed into something that has high economic value.Keywords : Red Ginger, Syrup, Improves Family Health and Economy
- Research Article
- 10.1177/1934578x251314080
- Jan 1, 2025
- Natural Product Communications
- Nguyen Thi Ngan + 8 more
Objective/Background: Alpinia gagnepainii K.Schum, a member of the ginger family, is predominantly found in northern Vietnam. Methods: Essential oils (EOs) of A. gagnepainii leaves and rhizomes were extracted through hydrodistillation and their chemical composition was analyzed using gas chromatography-mass spectrometry. The antioxidant activity of the EOs was assessed via DPPH and ABTS radical scavenging assays, and their in vitro inhibitory effects on α-amylase and tyrosinase were also evaluated. Results: The leaf EO comprised 46 compounds (95.83% of the total composition), while the rhizome EO contained 49 compounds (98.37%). β-Pinene was identified as the most abundant component, accounting for 27.09% in the leaf EO and 20.45% in the rhizome EO. The former demonstrated a stronger DPPH radical scavenging ability (IC 50 = 1070.35 ± 9.17 μg/mL), whereas the latter was more effective against ABTS radicals (IC 50 = 1519.18 ± 112.58 μg/mL). No significant difference in antityrosinase activity was observed between the two EOs; however, the rhizome EO (IC 50 = 195.14 ± 6.49 μg/mL) exhibited a more potent anti-α-amylase activity than the leaf EO. Conclusion: This study reported the chemical composition, antioxidant, anti-α-amylase, and antityrosinase activities of A. gagnepainii EOs for the first time. The bioactivities of the plant indicate their potential applications in the nutraceutical and cosmeceutical industries.
- Research Article
- 10.48175/ijarsct-22902
- Jan 1, 2025
- International Journal of Advanced Research in Science, Communication and Technology
- Yash Sunil Gulhane
Turmeric is an ancient spice derived from the rhizomes of Curcuma longa, which is part of the ginger family (Zingiberaceae). Also known as the “Golden Spice of India”, turmeric has been used in India for medicinal purposes for centuries. It is used in traditional medicine as a home remedy for many ailments, including biliary disorders, anorexia, cough, diabetic ulcers, peptic disorders, rheumatism and sinusitis. In addition to its use as a spice and pigment, turmeric and its components, mainly curcumin and essential oils, exhibit a wide range of biological activities. These include its anti-inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antifertility, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, antifibrotic, antivenom, antiulcer, hypotensive and hypocholesterolemic activities. Modern interest in turmeric began in the 1970s when researchers discovered that the herb may have anti-inflammatory and antioxidant properties. Safety evaluation studies show that turmeric and curcumin are well tolerated at very high doses without toxic effects. Thus, turmeric and its components have the potential to advance modern medicine for the treatment of various diseases. Keywords-Turkuma Curcuma longa sprain Haridra" or "Haldi, Curcumin
- Research Article
1
- 10.30574/wjbphs.2024.20.3.1010
- Dec 30, 2024
- World Journal of Biology Pharmacy and Health Sciences
- S Gopi Krishnan + 3 more
Curcuma aromatic Salisb. (C. aromatica) is commonly known as wild turmeric mentioned as ‘Vanaharidra’ in Ayurveda, belongs to the ‘ginger family’ Zingiberaceae. It is a perennial herb with characteristic aromatic rhizomes used in many traditional systems of medicines in India, China and other Southeast Asian countries. The rhizome of the plant is rich in alkaloids, flavonoids, curcuminoids, tannins and terpenoids which are reported to be the reasons for its various pharmacological properties. The extraction of compounds in different solvents shows that the plant contains curdione, neocurdione, germacrone as its major components. Extensive literature survey showed that the plant has anti- angiogenic, cholerectic and cholagougic, anthelmintic, antimicrobial, wound healing, anticancer, antioxidant, antidiabetic, anti-inflammmatory, analgesic, antitussive, larvicidal, antimelonogenic, anti-nephrotic, antiplatelet, anti-hyperlipidemic, antivenom, and neuroprotective properties. The plant thus proves to be a promising candidate for the development and designing of modern drugs for several diseases. The present study was aimed to review the phytochemical and pharmacological properties of C. aromatic Salisb.
- Research Article
- 10.9734/ejmp/2024/v35i61225
- Nov 15, 2024
- European Journal of Medicinal Plants
- Srikrishna Lingadahalli Puttachar + 10 more
Curcuminoids are naturally occurring phytocompound extracted from the turmeric rhizome Curcuma longa, a member of the ginger (Zingiberaceae) family. Through the development of a trademark product called Bio-Curcumin, this study seeks to increase the bioavailability and absorption of regular marketed curcumin by 95%. This finding has important implications for the academic and scientific community. The pharmacokinetic study of CurcuminAura™ and its innovation of biocurcuminoids is detailed in detail. Innovation of BioCurcuminoids and its Pharmacokinetic Study of CurcuminAura™ with regular curcuminoids is significantly described which is the need of the hour. This enhanced sunflower lecithin is an effective ingredient in the trademark product CurcuminAuraTM, which was created by Bio-Med Ingredients Pvt.Ltd. Its potency in the market can be increased by lecithin's capacity to efficiently encapsulate active substances, improve bioavailability, and increase absorption. Regular curcumin's weak solubility and poor absorption in its free form. Regular Curcumin due to its poor solubility and poor absorption in the free form in the gastrointestinal tract and its rapid biotransformation to inactive metabolites can greatly limit its utility as a health-promoting agent and dietary supplement. Hence to make it more readily available in the body. CurcuminovaTM is developed will enhance the properties of Curcumin making it more potent in the market. The Evaluation of the Comparative Pharmacokinetic Study of CurcuminAuraTM with Marketed Curcumin 95.0% was carried out through pre-clinical investigations in Sprague Dawley Rats via Oral Route which is the aim of this study with two groups in the study design, with four rats of each sex. Oral administration of CurcuminAuraTM and Curcumin 95.0% was administered to rats in the G1 and G3 groups, respectively. A dosage volume of 10 milliliters per kilogram of body weight was maintained for the oral route. After Dosage, under isofluorane,the blood samples were taken from the retroorbital sinuses after the dose was administered under varying periods of anaesthesia. Animals were split up into two sets for each group, and blood samples were taken at 30-, 2-, and 4-hour intervals. Samples were taken for analysis after being kept at -800C. Designed to increase the bioavailability of curcuminoids, CurcuminAuraTM is standardized to 60.9% total curcuminoids by HPLC, as opposed to marked conventional curcumin 95%. This has been confirmed by HPLC analysis. According to comparison studies, CurcuminAuraTM has a bioavailability that is 3.8 times greater than the reference standard. Additionally, in this study it is shown that the maximum absorption happens in the timeline 3 hrs after feeding the drug.
- Research Article
- 10.24127/bioedukasi.v15i2.8929
- Nov 8, 2024
- BIOEDUKASI (Jurnal Pendidikan Biologi)
- Khoirunnisa Khoirunnisa + 2 more
The development of popular scientific books with local potential is believed to be able to support learning resources based on local potential. Popular scientific books are structured as learning resources for enrichment materials for the Zingiberidae subclass in the Phanerogamae course. Known as the ginger family, Zingiberaceae is widely used in Southeast Asia, especially Indonesia for its unique taste, ornamental appeal, and medicinal value. The purpose of this study was to describe the species diversity of Zingiberaceae in Barimbun Village, Tabalong Regency, and to describe the suitability, feasibility, and readability of the results of the development of a popular scientific book on Zingiberaceae Diversity in Barimbun Village, Tabalong Regency. The research method used is research and development (R&D) concerning the 4D development model. Based on the research results, 7 species were obtained consisting of the genera Amomum, Alpinia, Curcuma, Zingiber, and Kaempferia. The results of the suitability test were stated to be very suitable with a value of 4.5. The results of the feasibility test were declared very feasible with a value of 4.3. The results of the readability test by students were stated to be very good with a value of 4.5.