ZnO Nanoparticles Research Articles

Novel Trimethoprim-Based Metal Complexes and Nanoparticle Functionalization: Synthesis, Structural Analysis, and Anticancer Properties

In this study, we synthesized a novel trimethoprim derivative, 4-(((2-amino-5-(3,4,5-trimethoxybenzyl) pyrimidine-4-yl)imino)methyl)benzene-1,3-diol (HD), by the reaction of trimethoprim with 2,4-dihydroxybenzaldehyde. We then prepared metal complexes of this derivative with Cu(II), Co(II), Ni(II), Ag(I), and Zn(II) and functionalized them with ZnO and Au nanoparticles. Their structures were confirmed through 1H NMR, mass spectrometry, FTIR, conductivity, thermal analysis, magnetic susceptibility, X-ray diffraction, UV-Vis spectroscopy, and TEM, revealing octahedral geometries for all complexes. Surface features were investigated using density functional theory (DFT) analysis. Pharmacokinetic parameters and target enzymes for HD and its complexes were computed using the SwissADME web tool, with the BOILED-Egg model indicating that HD and its Cu complex should be passively permeable via the blood-brain barrier and highly absorbed by the gastrointestinal tract (GIT), unlike the Ni, Co, Ag, and Zn complexes, which are predicted to show low GIT absorption. Molecular docking studies with the Caspase-3 enzyme (PDB code: 3GJQ) using the AutoDock 4.2 software demonstrated binding energies of −7.66, −8.36, −9.05, −8.62, −6.90, and −7.81 kcal/mol for HD and the Cu, Co, Ni, Ag, and Zn complexes, respectively, compared to −6.54 and −4.63 kcal/mol for TMP and 5-FU (5-fluorouracil), indicating a potential superior anticancer potential of the novel compounds. The anticancer activities of these complexes were evaluated using the MTT assay. The IC50 values for 5-FU, TMP, HD, Cu-HD, HD@ZnONPs, Cu-HD@ZnONPs, HD@AuNPs, and Cu-HD@AuNPs were found to be 32.53, 80.76, 114.7, 61.66, 77, 53.13, 55.06, and 50.81 µg/mL, respectively. Notably, all derivatives exhibited higher activity against the HepG-2 cancer cell line than TMP, except for HD, which showed similar effectiveness to TMP. Real-time PCR analysis revealed that the Au-HD@AuNPs and Cu-HD@AuNPs significantly increased caspase-3 inhibition by 4.35- and 4.5-fold and P53 expression by 3.05- and 3.41-fold, respectively, indicating enhanced pro-apoptotic gene expression and apoptosis induction in HepG2 cells. Our findings demonstrate that these novel derivatives possess significant anticancer properties, with some complexes showing superior activity compared to standard drugs such as 5-Fluorouracil (5-FU) and Trimethoprim (TMP). This study highlights the potential of these nanocomposites as promising candidates for cancer therapy.

Exploring Preparation of Zinc Oxide Nanoparticles Synthesis Mechanisms and Applications: A Comprehensive Review

Exploring Preparation of Zinc Oxide Nanoparticles Synthesis Mechanisms and Applications: A Comprehensive Review

β-cyclodextrine coated zinc oxide decorated graphene oxide nano hybrid for photocataylytic, antibacterial, and antifungal applications.

β-cyclodextrine coated zinc oxide decorated graphene oxide nano hybrid for photocataylytic, antibacterial, and antifungal applications.

Ultrasound stimulated piezoelectric antibacterial silk composite films guiding differentiation of mesenchymal stem cells.

Ultrasound stimulated piezoelectric antibacterial silk composite films guiding differentiation of mesenchymal stem cells.

Driving sustainability at early-stage innovation in production of zinc oxide nanoparticles

Driving sustainability at early-stage innovation in production of zinc oxide nanoparticles

Green synthesis of Zinc Oxide nanoparticles using Sorghum halepense (L.) pers and assessment of their antibacterial and antioxidant potential

Green synthesis of Zinc Oxide nanoparticles using Sorghum halepense (L.) pers and assessment of their antibacterial and antioxidant potential

Interaction of zinc oxide nanoparticles and nanorods with immunoglobulin G and underlying effects on MCF-7 breast cancer cells.

Interaction of zinc oxide nanoparticles and nanorods with immunoglobulin G and underlying effects on MCF-7 breast cancer cells.

Synthesis of zinc oxide nanoparticles (ZnO NPs) via modified chemical method for potential effectiveness against SW982 cells in osteoarthritis management

Synthesis of zinc oxide nanoparticles (ZnO NPs) via modified chemical method for potential effectiveness against SW982 cells in osteoarthritis management

Biomedical potential of alginate wound dressings - From preclinical studies to clinical applications: A review.

Biomedical potential of alginate wound dressings - From preclinical studies to clinical applications: A review.

Recent Advances in Zinc Oxide Nanoparticles for Dye Removal: Challenges and Future Directions – A Review.

Recent Advances in Zinc Oxide Nanoparticles for Dye Removal: Challenges and Future Directions – A Review.

Application of machine learning models for predicting zinc oxide nanoparticle size

Application of machine learning models for predicting zinc oxide nanoparticle size

Antimicrobial and antifungal edible coatings with ZnO nanoparticles dispersed in a chitosan-guar gum matrix for hass avocado preservation.

Antimicrobial and antifungal edible coatings with ZnO nanoparticles dispersed in a chitosan-guar gum matrix for hass avocado preservation.

Revolutionizing dielectric and electrical properties of carboxymethylcellulose/ZnO nanocomposites: A detailed exploration of experimental findings and computational insights for advanced material engineering.

Revolutionizing dielectric and electrical properties of carboxymethylcellulose/ZnO nanocomposites: A detailed exploration of experimental findings and computational insights for advanced material engineering.

Enhancing the generation and stabilization of ZnO nanoparticles on modified clay with polyethylenimine to improve the photodegradation of dyes in textile wastewater

Enhancing the generation and stabilization of ZnO nanoparticles on modified clay with polyethylenimine to improve the photodegradation of dyes in textile wastewater

Delving into the effect of ZnO nanoparticles on the chemistry and electronic properties of aminated graphene: Ab initio and experimental probing

Delving into the effect of ZnO nanoparticles on the chemistry and electronic properties of aminated graphene: Ab initio and experimental probing

Development and characterization of ZnO nanoparticles incorporated diosgenin@chitosan nanocomposite for enhanced photocatalytic and antibacterial applications

Development and characterization of ZnO nanoparticles incorporated diosgenin@chitosan nanocomposite for enhanced photocatalytic and antibacterial applications

ZnO nanoparticles coated with EDTA and Ag nanoparticles (ZnO@EDTA-Ag NPs) for enhanced electrochemical detection of Cu2+ ions in food and environmental samples

ZnO nanoparticles coated with EDTA and Ag nanoparticles (ZnO@EDTA-Ag NPs) for enhanced electrochemical detection of Cu2+ ions in food and environmental samples

Development of Ag doped ZnO nanoparticle loaded carboxymethyl cellulose/polyvinyl alcohol hydrogel film for enhanced wound dressing

Development of Ag doped ZnO nanoparticle loaded carboxymethyl cellulose/polyvinyl alcohol hydrogel film for enhanced wound dressing

Enhancement in Power Conversion Efficiency of Dye Sensitized Solar Cell by Using Nanocomposite Photoanode Material TiO2 - Zno

Abstract: This study represents the important role of dye sensitizer selection for best photovoltaic response and the photo anode thickness of semiconducting layer for determining the efficiency of dye-sensitized solar cells (DSSCs). For obtaining these objectives we employ an ex-situ methodology to prepare the composite materials. So we prepare nanocomposite by adding 20 wt.% of ZnO nanoparticles into TiO2 nanoparticles (20TZ). We fabricate dye sensitized solar cell by using the doctor blade technique. Furthermore our key findings are to extends the duration of dye loading, highlighting its significant influence on DSSC performance. The research also encompasses variations in the thickness of the semiconducting layer, providing critical insights into DSSC efficiency. Significance of present research work represent , photoanode thickness of 300-micron 20TZ-based DSSC, sensitized with 3% of N749 dye for a 2-hour loading period, achieves an impressive power conversion efficiency of 15.1%. The stability of 20TZ-based DSSCs was evaluated under continuous light illumination, revealing a minimal decrease in power conversion efficiency of 1.61% over 240 hours. Significance of present study is that we achieve power conversion efficiency 15.1% for the assemble dye sensitized solar cell and its stability duration time.

Capping agent control over the physicochemical and antibacterial properties of ZnO nanoparticles

Capping agent control over the physicochemical and antibacterial properties of ZnO nanoparticles