Zinc-based Metal-organic Framework Research Articles

Metal organic framework-derived nitrogen-doped porous carbon sustained Prussian blue analogues for efficient and fast hybrid capacitive deionization

Prussian blue analogues (PBAs) are considered as exceptionally promising faradic electrode materials for next-generation capacitive deionization (CDI) electrodes due to their superior theoretical specific capacity, non-toxic property and simple preparation. However, the desalination performances of PBAs are hampered by their sluggish intrinsic kinetics and insufficient utilization of active sites. Herein, we demonstrate an advanced hybrid material constructed by anchoring nickel hexacyanoferrate (Ni-PBA) onto three-dimensional (3D) nitrogen-doped porous carbon (ZC) derived from zinc-based metal–organic frameworks (MOFs, ZIF-8) polyhedron. ZC with a 3D open structure not only provides multiple spatial supports for the in-situ growth of Ni-PBA with extraordinary redox capacity, but also features high electrical conductivity, excellent hydrophilicity and large surface area to facilitate the electron/ion transport and improve the ion accommodation. Therefore, the Ni-PBA/ZC composite electrode achieves an outstanding CDI desalination performance with an ultrahigh salt adsorption capacity (SAC) of 43.9 mg g−1 and maximum salt adsorption rate (mSAR) of 20.82 mg g−1 min−1, outperforming those of most of the recently reported MOF-derived porous carbon materials and PBAs-based materials. The strategy in this work presents a novel avenue by combining the advantages of MOF-derived porous carbon and redox-active materials for designing high-performance CDI electrode materials.

Fabrication and characterization of poly (vinylidene fluoride) hybrid ultrafiltration membranes with silver loaded MOF-5 for enhanced permeation, antifouling and antibiofouling performance

The zinc-based metal-organic frameworks (MOFs) such as MOF-5 and silver-loaded MOF-5 (Ag@MOF-5) are synthesized by facile solvothermal method and utilized to fabricate poly (vinylidenefluoride)(PVDF) hybrid ultrafiltration (UF) membranes for water treatment applications. As-synthesized MOF-5 and Ag@MOF-5 are characterized by ATR-FTIR, XRD, and SEM. The ATR-FTIR is used to validate the successful production of MOFs while the XRD pattern and SEM revealed their high crystallinity and cubical structure, respectively. The Ag@MOF-5 is verified by FTIR, XRD and SEM for its chemical functionality and morphology. From the SEM images, it is clearly seen the flaky structure of MOFs. The membranes are examined by ATR-FTIR, XRD, and SEM/EDAX. From the cross-section SEM images, macrovoids formed are visibly seen and the increase in roughness is obviously seen in AFM. The dispersion of MOF-5 and Ag@MOF-5 in the PVDF membrane matrix is validated via elemental mapping by the EDAX spectrum. The PVDF/Ag@MOF-5 hybrid membranes outperformed bare PVDF and PVDF/MOF-5 membranes in permeation and fouling properties, especially, the PVDF/Ag@MOF-0.5 (0.5 wt% of Ag@MOF-5) hybrid membrane exhibited higher pure water flux (PWF) of 236.5 Lm−2h−1 and superior hydrophilicity with contact angle of 52.3°. Besides, PVDF/Ag@MOF-0.5 membranes demonstrated the enhancement in rejection of 98.4% and 96.5% and better antifouling with flux recovery ratio (FRR) of 89.7% and 92.4% for BSA and HA respectively. Moreover, PVDF/Ag@MOF-0.5 hybrid membranes displayed excellent antibacterial properties in the zone of inhibition test against E. coli and S. aureus. The overall findings indicate that the PVDF/Ag@MOF-0.5 hybrid membrane shows potential for the treatment of water and wastewater.

Dual-functional fluorescent metal-organic framework based beads for visual detection and removal of oxytetracycline in real aqueous solution

The development of metal-organic frameworks (MOFs) based materials with specific structures and functions has important significance and application value in energy, environment, and material science. Herein, we developed a novel zinc-based MOF with 2-(4-carboxyphenyl)-1H-benzo[d]imidazole-5-carboxylic acid (CBC) as ligand, Zn-CBC, which exhibited large surface area, porous structure, and blue fluorescence. The material was demonstrated for simultaneous visual detection and removal of oxytetracycline (OTC) as a dual-functional platform. With the introducing of OTC that can be adsorbed by the surface group of Zn-CBC, the fluorescence emission intensity centered at 472 nm was significantly decreased attributed to the internal filtering effect (IFE) between OTC and Zn-CBC. In addition, due to the aggregation-induced emission (AIE) of OTC in the porous structure of Zn-CBC, a new fluorescence emission maximum at 540 nm appeared, which constructed a blue to yellow-green ratiometric fluorescence system. Combing the optical and adsorption properties of Zn-CBC, we innovatively prepared Zn-CBC MOF-alginate-Ca2+-polyacrylic acid polymer beads (MACPs) for sensing and removing of OTC in real water samples, which showed wide applicability in practical applications.

ZIF-8-based micro-arc oxidation composite coatings enhanced the corrosion resistance and superhydrophobicity of a Mg alloy

Mg alloys are considered the most promising engineering materials because of their unique properties. However, the uncontrolled corrosion rate of these alloys limits their applications. Therefore, in this study, a micro-arc oxidation layer was used as a transition layer to “directly” grow a zinc-based metal-organic framework (MOF) composite coating on the surface of a Mg alloy (AZ91D). Herein, the two zeolitic imidazolate framework (ZIF-8) coatings with different morphologies were separately prepared by homologous metal oxide induction and a one-step in-situ growth method. The superhydrophobic composite coating showed strong hydrophobicity and self-cleaning properties, which could prevent the penetration of water and corrosive ions (Cl−) into the surface of AZ91D. Electrochemical tests demonstrated that the super-hydrophobic composite coatings greatly enhanced the corrosion resistance of AZ91D, and the corrosion current density decreased from 10−5 to 10−9 A/cm2. These results indicate that the ZIF-8 coatings are beneficial for improving the hydrophobicity and enhancing the corrosion resistance of Mg alloys. Therefore, MOF composite coatings provide a new strategy that can be used to prepare multifunctional anticorrosion coatings on metal substrates.

Concurrent electrospinning of microporous metal-organic framework-laden casein/PVA nanofibrous composites for potential antibacterial wound dressing applications

This study describes the fabrication of electrospun casein/PVA nanofibers containing metal-organic framework (MOF) with antibacterial and hemostatic properties. Different amounts of MOF particles (1–5 wt.%) were incorporated into casein/PVA nanofibers through a concurrent electrospinning technique. The surface property, structure, and morphology of fabricated nanofibrous composites were characterized by different techniques, including field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, and contact angle measurement. The results revealed the formation of uniform and bead-free nanofibers with an average diameter between 80 and 150 nm. It is shown that the MOF addition during the electrospinning of casein/PVA nanofibers enhances the wettability properties and hemostatic performance. The highest hydrophilicity was obtained for casein/PVA-MOF-1% with a contact angle of about 42°. Blood clotting time results revealed the significant role of MOF in the shortening of the clotting time, beneficial from the porous nature of MOF and the hydrophilic nature of casein/PVA-MOF nanofibrous composites. Additionally, the casein/PVA-MOF nanofibrous composites exhibited excellent antibacterial activity against gram-positive and gram-negative bacteria, thanks to the presence of zinc-based MOF. The results of this study suggest that the developed casein/PVA-MOF nanofibrous composite can be considered an excellent candidate for utilization in hemostatic wound dressing applications.

Nanoscale Zinc-Based Metal-Organic Frameworks Induce Neurotoxicity by Disturbing the Metabolism of Catecholamine Neurotransmitters.

As a group of new nanomaterials, nanoscale metal-organic frameworks (MOFs) are widely applied in the biomedical field, exerting unknown risks to the human body, especially the central nervous system. Herein, the impacts of MOF-74-Zn nanoparticles on neurological behaviors and neurotransmitter metabolism are explored in both in vivo and in vitro assays modeled by C57BL/6 mice and PC12 cells, respectively. The mice exhibit increased negative-like behaviors, as demonstrated by the observed decrease in exploring behaviors and increase in despair-like behaviors in the open field test and forced swimming test after exposure to low doses of MOF-74-Zn nanoparticles. Disorders in the catecholamine neurotransmitter metabolism may be responsible for the MOF-74-Zn-induced abnormal behaviors. Part of the reason for this is the inhibition of neurotransmitter synthesis caused by restrained neurite extension. In addition, MOF-74-Zn promotes the translocation of more calcium into the cytoplasm, accelerating the release and uptake and finally resulting in an imbalance between synthesis and catabolism. Taken together, the results from this study indicate the human toxicity risks of nanoscale low-toxicity metal-based MOFs and provide valuable insight into the rational and safe use of MOF nanomaterials.

High-performance aqueous zinc-ion hybrid capacitors based on 3D printed metal-organic framework cathodes

The zinc-ion hybrid capacitor is a promising energy storage device, but current overall capacity is limited by the capacitance of the carbon cathode. We produced a hierarchically porous, nitrogen-doped carbon cathode with good cycling and mechanical stability by 3D printing and pyrolysis of the zinc-based metal–organic framework ZIF-8. When incorporated into a zinc-ion hybrid capacitor, we achieved an areal capacitance of 16.9 F cm−2 and energy density of 7.23 mW h cm−2, outperforming zinc-ion hybrid capacitors based on conventional cathodes.

Antibiotic quantitative fluorescence chemical sensor based on Zn-MOF aggregation-induced emission characteristics

Antibiotic residues in water and food can aggravate the development of antibiotic-resistant bacteria. As a result, that is critical to creating a practical approach for detecting leftover antibiotics in a timely and sensitive manner. This research utilize the water instability of MOFs, and uses the zinc-based metal–organic framework of tetra (4-carboxyphenyl) ethylene (Zn-TCPE) as the sensing unit to create a new fluorescence sensing platform based on multiple colorimetric responses for ultra-fast and sensitive detection of tobramycin. Due to poor water stability, Zn-TCPE with aggregation-induced emission (AIE) would break into untidy pieces following immersion in aqueous solution. More importantly, the fluorescence of the Zn-TCPE aqueous solution was dimmed because the crystal framework of the Zn-TCPE was destroyed by the coordination of water molecules, causing the AIE-active organic linkers (H4TCPE) to undergo non-radiative emission motion, implying underlying mechanism research in the fluorescence “turn-off-on” mode. Because hydrophilic functional groups such as amino and hydroxyl can coordinate with metal ions, the Zn-TCPE aqueous solution showed great sensitivity for the response of amino, hydroxyl, and ether groups. The coordinated coordination of amino, hydroxyl, and ether groups with Zn2+ explains the reaction mechanism, culminating in the full destruction of Zn-TCPE. With the crystal structure collapse of Zn-TCPE, the AIE organic linkers are freed and then reassemble to form emissive aggregates with increased fluorescence. Because aminoglycoside (AG) antibiotics have hydrophilic functional groups such as amino, hydroxyl, and ether groups, they are employed as a molecular model for study. Interestingly, the Zn-TCPE probe has a strong selectivity for distinguishing AG antibiotics sulfate from other antibiotics.

Curcumin-regulated constructing of defective zinc-based polymer-metal-organic framework as long-acting antibacterial platform for efficient wound healing

A dual-modal antibacterial platform has been established for highly efficient wound healing infected by bacteria based on a defective zinc-based metal–organic framework composite, which was synthesized using 1,4-phthalic acid-based polyether polymer (L8) as ligand, curcumin as regulator, and Zn2+ as metal coordinated center (Cur@Zn-MOF). In addition to the integration of the features of polymer-MOF synthesized using L8 (such as high water stability and controllable and long-term release of Zn2+) and Zn-bioMOF prepared using curcumin as ligand (such as feasible release of curcumin and Zn2+ and good biocompatibility), the Cur@Zn-MOF bioplatform also possessed plenty of structure defects. Comparing with Zn-bioMOF and polyZn-MOF synthesized using the sole ligand, the smaller released amount of curcumin (6.08 μg mL−1) and higher release level of Zn2+ ions (5.68 μg mL−1) were simultaneously achieved for the defective Cur@Zn-MOF within a long-term duration (48 h). The synergistic effect afforded Cur@Zn-MOF the high sterilization performance toward Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) even at the low usage of 125 μg mL−1. The in vivo wound healing effect further confirmed the superior treatment ability of Cur@Zn-MOF toward the bacterium-infected wound. Also, the negligible cytotoxicity and low hemolysis of Cur@Zn-MOF greatly promoted the viability of human skin fibroblasts. Accordingly, this work can provide a new dual-modal bioplatform based on the functional MOF via the controllable release of antibacterial drug and metal ions for the efficient wound healing.

Dual-quenching mechanisms in electrochemiluminescence immunoassay based on zinc-based MOFs of ruthenium hybrid for D-dimer detection

The successful application of electrochemiluminescence (ECL) in immunoassay for clinical diagnosis requires improving sensitivity and accuracy. Herein was reported an ECL analytical model based zinc-based metal-organic frameworks of ruthenium hybrid (RuZn MOFs) as the signal emitter. To enlarge the output difference, the quenching effect of three different noble metal nanoparticles included palladium seeds (Pdseeds), palladium octahedrons (Pdoct), and Pt-based palladium (Pd@Ptoct) core-shell were researched. Among them, Pd@Ptoct core-shell possessed higher activity and improved durability than Pd-only (NPs), they could load more protein macromolecules amicably and stabilized in the analysis system. Furthermore, since the charge redistribution owing to the hybridization of the Pt and Pd atoms in Pd@Ptoct, it could generate the electron flow maximumly from the emitter RuZn MOFs to Pd@Ptoct and result in the enhancement of quenching ECL. And the UV absorption of noble metal nanoparticles overlapped with the ECL emission of RuZn MOFs to varying degrees, which caused the behavior of resonance energy transfer (RET) reaction at the same time. This would greatly promote the sensitivity of this ECL system compared with the traditional single quenching mechanism. Based on this, a signal-off immunsensor was constructed to sensitive detection of D-dimer with linearity range from 0.001 to 200 ng mL−1, limit of detection (LOD) was 0.20 pg mL−1 and provide a further theoretical basis for the clinical application of ECL technology.

Pore Aperture Control Toward Size-Exclusion-Based Hydrocarbon Separations.

Metal-organic frameworks (MOFs) have been proposed as a promising material for non-thermal chemical separations owing to their high structural diversity and tunability. Here, we report the synthesis of a zinc-based MOF containing a three-dimensional (3D) linker, bicyclo[2.2.2]octane-1,4-dicarboxylic acid, with high thermal stability towards the separation of hexane isomers. The incorporation of the 3D linker enhances the structural stability and provides well-defined pore apertures/channels with sub-Ångstrom precision. This precision allowed for the separation of similarly sized hexane isomers based on subtle differences in their kinetic diameters. Multi-component liquid phase batch experiments confirmed the separation of hexanes mixture into linear, monobranched, and dibranched isomers. This work represents a significant milestone in the construction of stable Zn-based MOFs and the incorporation of 3D linkers as a potential solution to challenging separations.

A molecularly imprinted fluorescence sensor for sensitive detection of tetracycline using nitrogen-doped carbon dots-embedded zinc-based metal-organic frameworks as signal-amplifying tags

Tetracycline (TC) residues not only endanger human health, but also are detrimental to the sustainable development of aquaculture and animal husbandry. Herein, a novel fluorescence sensor with high sensitivity and selectivity was developed based on nitrogen-doped carbon dots embedded in zinc-based metal-organic frameworks and incorporating molecularly imprinted polymer (ZIF-8&N-CDs@MIP). The physical and chemical properties of the ZIF-8&N-CDs@MIP had been characterized by SEM, TEM, FTIR, XRD, BET, TGA, etc. Under optimal conditions, the limit of detection (LOD) of the novel sensor was 0.045 μg mL−1 with the concentration of TC in the range of 0.1–4.0 μg mL−1. In addition, the prepared imprinted polymers showed superior adsorption selectivity to tetracycline compared with non-imprinted polymers, and the quenching mechanism of ZIF-8&N-CDs@MIP was demonstrated to be attributed to the inner filter effect (IFE). This work provided an effective and reliable method for the specific detection of tetracycline and was successfully applied in milk and egg samples with satisfactory recoveries (80.67–95.22%).

Chromium(Ⅵ) removal in a solar-driven photocatalytic fuel cell with carbon quantum dots modified p-type zinc-based metal−organic framework photocathode

High-efficiency photoelectrode played a significant role in photocatalytic fuel cell (PFC) systems. In this study, a zinc-based metal-organic framework modified by carbon quantum dots (N-Zn-MOF/CQDs) and the BiVO4 were respectively presented as the photocathode and photoanode of the PFC system toward Cr(Ⅵ) reduction. Various analytical techniques were utilized to characterize the physicochemical, optical and photoelectrochemical properties of the as-prepared samples. With the addition of CQDs, the visible-light response and charge separation rate were remarkably enhanced. In the PFC system, the circuit current density of 58.04 mA cm−2 and max power density of 1.35 mW cm−2 were achieved, which was superior to other reported PFC systems. Under optimized conditions, 100% Cr(Ⅵ) can be removed within 120 min of visible-light illumination. This work provided a new method to decorate the zinc-based metal−organic framework cathode to dramatically improve the photocatalytic performance.

ZnO Nanoparticles Modified by Carbon Quantum Dots for the Photocatalytic Removal of Synthetic Pigment Pollutants.

Synthetic pigment pollutants caused by the rapid development of the modern food industry have become a serious threat to people's health and quality of life. Environmentally friendly ZnO-based photocatalytic degradation exhibits satisfactory efficiency, but some shortcomings of large band gap and rapid charge recombination reduce the removal of synthetic pigment pollutants. Here, carbon quantum dots (CQDs) with unique up-conversion luminescence were applied to decorate ZnO nanoparticles to effectively construct the CQDs/ZnO composites via a facile and efficient route. The ZnO nanoparticles with a spherical-like shape obtained from a zinc-based metal organic framework (zeolitic imidazolate framework-8, ZIF-8) were coated by uniformly dispersive quantum dots. Compared with single ZnO particles, the obtained CQDs/ZnO composites exhibit enhanced light absorption capacity, decreased photoluminescence (PL) intensity, and improved visible-light degradation for rhodamine B (RhB) with the large apparent rate constant (k app). The largest k app value in the CQDs/ZnO composite obtained from 75 mg of ZnO nanoparticles and 12.5 mL of the CQDs solution (∼1 mg·mL-1) was 2.6 times that in ZnO nanoparticles. This phenomenon may be attributed to the introduction of CQDs, leading to the narrowed band gap, an extended lifetime, and the charge separation. This work provides an economical and clean strategy to design visible-light-responsive ZnO-based photocatalysts, which is expected to be used for the removal of synthetic pigment pollutants in food industry.

Superhydrophobic cellulose paper with sustained antibacterial activity prepared by in-situ growth of carvacrol-loaded zinc-based metal organic framework nanorods for food packaging application

Cellulose paper packaging materials have gained considerable attention as substitutes for petroleum-based plastics owing to their biodegradability, renewability, flexibility, and good mechanical strength. However, high hydrophilicity and the absence of essential antibacterial activity limit their application in food packaging. In this study, a facile and energy-saving method was developed to improve the hydrophobicity of cellulose paper and endow it with a long-acting antibacterial effect by integrating cellulose paper substrate with metal–organic frameworks (MOFs). A dense and homogenous coating of regular hexagonal ZnMOF-74 nanorods was in-situ formed on a paper surface by layer-by-layer assembly followed by low-surface-energy polydimethylsiloxane (PDMS) modification to prepare a superhydrophobic PDMS@(ZnMOF-74)5@paper. Excellent anti-fouling, self-cleaning, and antibacterial adhesion performances were obtained for this superhydrophobic paper. In addition, active carvacrol was loaded into the pores of ZnMOF-74 nanorods on PDMS@(ZnMOF-74)5@paper to combine antibacterial adhesion together with bactericidal ability, ultimately resulting in a completely “bacteria-free” surface and sustained antibacterial performance. The resultant superhydrophobic papers not only showed overall migration values within the limit of 10 mg/dm2 but also good stability against various harsh mechanical, environmental, and chemical treatments. This work gave insights into the potential of in-situ-developed MOFs-dopped coating as a functionally modified platform for preparing active superhydrophobic paper-based packaging.

Improving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks

Multi-drug resistant (MDR) bactearial strains have posed serious health issues, thus leading to a significant increase in mortality, morbidity, and the expensive treatment of infections. Metal-organic frameworks (MOFs), comprising metal ions and a variety of organic ligands, have been employed as an effective drug deliveryy vehicle due to their low toxicity, biodegradability, higher structural integrity and diverse surface functionalities. Polydopamine (PDA) is a versatile biocompatible polymer with several interesting properties, including the ability to adhere to biological surfaces. As a result, modifying drug delivery vehicles with PDA has the potential to improve their antimicrobial properties. This work describes the preparation of PDA-coated Zn-MOFs for improving curcumin’s antibacterial properties against S. aureus and E. coli. Powder X-ray diffraction (P-XRD), FT-IR, scanning electron microscopy (SEM), and DLS were utilized to characterize PDA-coated Zn-MOFs. The curcumin loading and in vitro release of the prepared MOFs were also examined. Finally, the MOFs were tested for bactericidal ability against E. coli and S. aureus using an anti-bacterial assay and surface morphological analysis. Smaller size MOFs were capable of loading and releasing curcumin. The findings showed that as curcumin was encapsulated into PDA-coated MOFs, its bactericidal potential was significantly enhanced, and the findings were further supported by SEM which indicated the complete morphological distortion of the bacteria after treatment with PDA-Cur-Zn-MOFs. These studies clearly indicate that the PDA-Cur-Zn-MOFs developed in this study are extremely promising for long-term release of drugs to treat a wide range of microbial infections.

Synthesis of zinc-based metal–organic framework as highly efficient photocatalyst for decomposition of organic dyes in aqueous solution

Synthesis of zinc-based metal–organic framework as highly efficient photocatalyst for decomposition of organic dyes in aqueous solution

A zinc-based metal–organic framework with a triazine moiety: effective detection of antibiotics and photodegradation dyes in aqueous solution

Effective detection of antibiotics and photodegradation using a novel zinc-based metal–organic framework.

A molecularly imprinted polypyrrole electrochemiluminescence sensor based on a novel zinc-based metal-organic framework and chitosan for determination of enrofloxacin.

Nowadays, bacterial resistance caused by the abuse of antibiotics has become a worldwide problem. In this work, a quinolone antibiotic, enrofloxacin (ENR), was rapidly monitored by combining a selective molecular imprinting polymer (MIP) with the electrochemiluminescence (ECL) method. Zn-PTC, a novel zinc-based metal-organic framework (MOF) that has a large specific surface area and ultra-high luminous efficiency, was used as the ECL luminophore. Chitosan (CHIT) was used to contact the specific surface area of molecularly imprinted polymer films and further improved the detection sensitivity. Subsequently, the molecularly imprinted polypyrrole was electropolymerized on the surface of the Zn-PTC and CHIT modified glassy carbon electrode (GCE). The specific sites that could target recombining ENR were shaped on the surface of MIP after extracting the ENR templates. The specific concentrations of ENR could be detected according to the difference in ECL intensity (ΔECL) between the eluting and rebinding of ENR. After optimization, a good linear response of ΔECL and a logarithm of specific ENR concentrations could be obtained in the range of 1.0 × 10-12-1.0 × 10-4 mol L-1, with a detection limit of 9.3 × 10-13 mol L-1 (S/N = 3). Notably, this study provided a rapid, convenient, and cheap method for the detection of ENR in actual samples.

Preparation of metal-organic framework combined with Portulaca oleracea L. extract electrostatically spun nanofiber membranes delayed release wound dressing.

In this study, we prepared a polyacrylonitrile (PAN) composite nanofiber membrane comprising Portulaca oleracea L. extract (POE) and a zinc-based metal-organic framework (MOF) by an in situ growth method as a potentially new type of wound dressing with a slow drug-release effect, to solve the problem of the burst release of drugs in wound dressings. The effects of the MOF and POE doping on the nanofiber membranes were examined using scanning electron microscopy (SEM) and FTIR spectroscopy. SEM analysis revealed the dense and uniform attachment of MOF particles to the surface of the nanofiber membrane, while FTIR spectroscopy confirmed the successful fusion of MOF and POE. Furthermore, investigations into the water contact angle and swelling property demonstrated that the incorporation of the MOF and POE enhanced the hydrophilicity of the material. The results of the in vitro release test showed that the cumulative release rate for PAN/MOF/POE60 decreased from 66.5 ± 2.34% to 32.18 ± 1.31% in the initial 4 h and from 90.54 ± 0.79% to 65.92 ± 1.95% in 72 h compared to PAN/POE, indicating a slowing down of the drug release. In addition, the antimicrobial properties of the fiber membranes were evaluated by the disc diffusion method, and it was evident that the PAN/MOF/POE nanofibers exhibited strong inhibition against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The antioxidant properties of the nanofiber membranes loaded with POE were further validated through the DPPH radical scavenging test. These findings highlight the potential application of the developed nanofiber membranes in wound dressings, offering controlled and sustained drug-release capabilities.