Summary An anesthetic method for young minipigs is described which permits carryingout lengthy operations such as transplantation of the small intestine. Premedication with an intramuscular injection of a mixture of phencyclidine, azaperone, and atropine sulfate given 15 min before the commencement of anesthesia has been useful. A detailed description of the anesthetic method, the monitoring and the correction of the metabolic disturbances during anesthesia is given. More than 100 anesthesias were given for operations lasting up to 5 hr with one anesthetic death.