Wound Diameter Research Articles

Progress in the Development of a Superconducting 32 T Magnet With REBCO High Field Coils

The design and development of a 32 T, 32 mm cold bore superconducting magnet with high field REBCO inner coils are underway at the NHMFL. The two nested REBCO coils that form the high field section are dry wound, with uninsulated conductor and insulated stainless steel cowind reinforcement. Active quench protection uses distributed protection heaters. As part of the development activity, prototype coils of the two REBCO coils with full scale radial dimensions and final design features, but with reduced axial length are being constructed. The first of these prototype coils was tested in a 15 T resistive background field magnet. The coil has inner and outer winding diameters of 40 mm and 140 mm, respectively, and consists of six double pancakes with a total conductor length of roughly 900 m. The construction of this prototype coil is described, including the protection heaters. Coil test results are reported including coil critical current, coil ramping characteristics, thermal stability, joint, and terminal resistance with field cycling. The corresponding operating stress in the windings is calculated. Importantly, the performance characteristics of the protection heaters will be measured including activation time.

Macroscopic effect of blue light cure on wound healing in NMRI mice NMRI.

Background:Wound healing is a complex process and has been an ongoing challenge all over the world. Some studies have suggested light cure as a modality to accelerate wound repair. It can induce fibroblast proliferation, increase collagen synthesis and activate cellular processes involved in expression of procollagen type I and III mRNA. This study was designed to assess the macroscopic effect of halogen dental curing blue light on full-thickness open wound healing in NMRI mice.Materials and Methods:Forty male NMRI mice were divided into control and treatment groups. A full-thickness wound of 6 mm in diameter was induced on the lower back of all mice under general anesthesia and sterile conditions. The mice of the treatment group received a 5-min exposure of halogen light Coltolux II (QHL), 420-500 nm, daily for 7 days. The diameter of the wound was measured in both the treatment and the control groups every second day up to Day 14. Data were analyzed by SPSS version 12 software using Student's t-test. A significance level of P ≤ 0.05 was considered for each comparison.Results:There was a significant difference in wound diameter between the control and the treatment groups at all measurements after Day 3 (P ≤ 0/05).Conclusion:The results of this study suggest improvement of full-thickness wound healing by daily irradiation of halogen dental curing blue light of 420-500 nm for 7 days.

Evaluation of the extract of Zeyheria tuberculosa with a view to products for wound healing

Objectivesto evaluate the antimicrobial, cytotoxic and healing activities of the ethanolic extract of the stems of Z. tuberculosa via topical use and/or oral ingestion.Methodantimicrobial assays in vitro using the disk diffusion method, the Artemia salina toxicity test, and in vivo assays with Wistar rats. From these was collected clinical, histological and biochemical data for evaluating the healing process.Resultsin vitro antimicrobial testing showed activity in relation to Streptococcus pyogenes, Staphylococcus aureus and Staphylococcus epidermidis, with zones of inhibition of 18, 14 and 10 mm, respectively. The best minimum inhibitory concentration was 62.5 µg/ml for S. aureus, this bacteria being chosen for the in vitro assays. Animals treated with the ointments with the extract of Z. tuberculosa showed the best results in the reduction of the wound diameter, data confirmed by the presence of re-epithelialization in the histological samples.Conclusionthe extract was shown to be promising for the continuation of studies which may identify the active ingredients responsible for the pharmacological activity and its mechanism of action in the process of wound healing, so as to develop a product which may be used as an alternate means in the repair of infected cutaneous wounds.

Wound Healing Potential Of Water And Ethanol Extract Of Fresh Leaves And Bark Ofgambia Albidum In Albino Rats

Water and ethanol extracts of Gambia albidumleaf and bark were studied for their wound healing potential. The biochemical parameters studied were: serum total protein, monoamine oxidase (MAO) activity, ascorbic acid, protease activity and cysteine. The rats were grouped into control (C) on which about 20mm wounds were made but not treated, while groups A1, A2, B1 and B2 were treated with 500mg/kg body weight of the extracts for 10 days. Olive oil suspensions of the extracts were also applied topically to the wounds throughout the period of the study. The mean percentage reductions of the wound diameters were: control (43.60%); A1 (treated with water extract of bark - 65.30%); A2 (treated with ethanol extract of bark - 76.79%); B1 (treated with water extract of leaves - 53.96%); and B2 (treated with ethanol extract of leaves - 60.84%). The serum levels of the parameters after administering water extract of the leaves were: total protein (0.686±0.000mg/100ml), MAO (1.325±0.023µ/l), ascorbic acid (51.50±0.736mg/100ml), protease (1.880±0.047µg/100ml) and cysteine (22.22±0.686mg/100ml). The mean levels after water extracts of the bark were: total protein (0.754±0.026mg/100ml), MAO (1.103±0.195µ/l), ascorbic acid (50.08±2.383mg/100ml), protease (1.743±0.063µg/100ml), and cysteine (23.37±0.635mg/100ml). The mean levels in the animals given ethanol extract of the leaves were: total protein (0.767±0.012mg/100ml), MAO (1.424±0.031µ/l), ascorbic acid (54.50±0.408mg/100ml), protease (1.700±0.034µg/100ml) and cysteine (24.66±0.316mg/100ml). The mean values caused by ethanol extract of the bark were: total protein (0.824±0.018mg/100ml), MAO (1.374±0.045µ/l), ascorbic acid (56.75±1.541mg/100ml), protease (1.552±0.051µg/100ml) and cysteine (25.07±0.469mg/100ml). The results of this study showed that both water and ethanol extracts were effective in promotion wound healing. However, the ethanol extracts of both the leaves and bark were more effective than those of water. Keywords:Gambia albidum,total protein,monoamine oxidase,ascorcbic acid,protease,

Low-level laser therapy: an experimental design for wound management: a case-controlled study in rabbit model.

Background:There is a wide array of articles in medical literature for and against the laser effect on wound healing but without discrete effect determination or conclusion. This experimental study aims to evaluate the efficacy of low-level laser therapy on wound healing.Materials and Methods:Thirty-four rabbits were randomly enrolled in two groups after creating a full thickness of 3 × 3 cm wound. The intervention group received low density laser exposure (4 J/cm2) on days 0, 3 and 6 with diode helium-neon low-intensity laser device (wl = 808 nm) and in control group moist wound dressing applied. Finally, wound-healing process was evaluated by both gross and pathological assessment.Results:Fibrin formation was the same in the two groups (P = 0.4) but epithelialisation was much more in laser group (P = 0.02). Wound inflammation of the laser group was smaller than that of the control groups but statistical significance was not shown (P = 0.09). Although more smooth muscle actin was found in the wounds of the laser group but it was not statistically significant (P = 0.3). Wound diameter showed significant decrease in wound area in laser group (P = 0.003).Conclusion:According to our study, it seems that low-level laser therapy accelerates wound healing at least in some phases of healing process. So, we can conclude that our study also shows some hopes for low level laser therapy effect on wound healing at least in animal model.

Homogeneous performance and strain tolerance of long Bi-2223 HTS conductors under hoop stress

Two types of high-strength industrial Bi-2223 conductor, one laminated by copper alloy and the other laminated by stainless steel, have been tested to examine the effect of hoop stress on the transport property. The specimens (∼2 m long) were prepared by winding one layer around a GFRP mandrel and the measurements were made in a liquid helium bath with the hoop stress calculated from the BJR product applied by external magnetic field. A careful measurement wire configuration was necessary to cancel the noise pick-up from the environment for more accurate determination of Ic and n-value. We show for the first time that both conductors showed homogeneous voltage–current characteristics over a long length and degradations with hoop stress occurred uniformly, which is crucial information for the development of HTS magnet technology. The onset of degradation occurred at 200 MPa and 220 MPa, with additional bending stress present from the winding diameter of 108 mm, for copper alloy laminated and stainless steel laminated conductors, respectively. After considering the effect of bending strain, our result agrees well with the previously measured data.

Celastrol Inhibits Lipopolysaccharide-Induced Angiogenesis by Suppressing TLR4-Triggered Nuclear Factor-Kappa B Activation

Celastrol is an active compound extracted from the root bark of the traditional Chinese medicine Tripterygium wilfordii Hook F. In this study, we investigated the effect of celastrol on lipopolysaccharide (LPS)-activated LP-1 human multiple myeloma cell-induced angiogenesis, and identified its molecular mechanism of action. Migration of human umbilical vein endothelial cells (HUVECs) was tested using a wound-healing assay. HUVEC invasion was assayed using a Transwell chamber. Cell surface expression of Toll-like receptor 4 (TLR4) was analyzed by flow cytometry. Angiogenic factor vascular endothelial growth factor (VEGF) level was quantified by LUMINEX and protein expression was analyzed by Western blot. Translocation of nuclear factor-kappa B (NF-κB) was observed by fluorescence microscopy. Celastrol inhibited LPS-stimulated LP-1 human multiple myeloma-induced HUVEC migration and invasion in a concentration-dependent manner. Wound diameters increased by 72.9, 165.4 and 246.2% at 0.025, 0.05 and 0.1 µ<smlcap>M</smlcap>, respectively, compared to LPS alone. A 45-74% inhibition of LPS-dependent cell invasion was achieved in the presence of 0.025-0.1 µ<smlcap>M</smlcap> celastrol. Celastrol significantly downregulated LPS-induced TLR4 expression and inhibited LPS-induced VEGF secretion in LP-1 cells. VEGF levels decreased by 64.8, 84.4 and 92.9% after coexposure to celastrol at 0.025, 0.05 and 0.1 µ<smlcap>M</smlcap>, respectively, compared to LPS alone. Celastrol also inhibited the IκB kinase (IKK)/NF-κB pathway induced by LPS. Protein levels of NF-κB p65, IKKa and IκB-a decreased in a dose-dependent manner after coexposure to celastrol. Celastrol also blocked nuclear translocation of the p65 subunit. These results suggest that celastrol inhibits LPS-induced angiogenesis by suppressing TLR4-triggered NF-κB activation.

Emprego de membrana de quitosana em feridas cutâneas induzidas experimentalmente em equinos

O objetivo deste estudo foi avaliar os efeitos da membrana (filme) de quitosana no processo de reparação de feridas cutâneas distais em equinos. Foram induzidas feridas cutâneas nas regiões metacarpianas e metatarsianas de quatro equinos adultos. No grupo tratado, oito feridas foram recobertas com membrana de quitosana e, no grupo controle, apenas higienização com solução de cloreto de sódio 0,9%. No período experimental, foram avaliados o diâmetro da ferida, formação de tecido de granulação exuberante, tipo de exsudato que a recobria, análise histológica, bem como as características da membrana de quitosana (plasticidade durante manipulação e presença ou ausência da membrana a cada troca). A membrana de quitosana não interferiu no tempo de cicatrização, podendo servir como material de recobrimento de feridas cutâneas, potencialmente com vantagens, se for empregada como meio condutor de substâncias que interfiram positivamente no processo cicatricial, abrindo campo para novos estudos.

Development of a 0.5-T/240-mm MgB2 MRI Magnet: Assembly Design and Module Coils.

This paper presents the latest results from our continued development of a 0.5-T/240-mm MgB2 MRI magnet at the MIT Francis Bitter Magnet Laboratory. Because we have successfully developed our superconducting joint technique with a monofilament MgB2 wire, manufactured by Hyper Tech Research, Inc. (Columbus, OH), we have decided to use a monofilament wire to wind our MgB2 MRI magnet. The magnet, comprising eight module coils, has a winding inner diameter of 276 mm, an outer diameter of 290 mm, and a total height of 460 mm. Each coil has its own persistent-current switch (PCS) and a superconducting joint. In order to guard against a few bad coils forcing the entire magnet to be inoperative, each coil will be heat-treated and tested individually. After eight coils are successfully operated, they will be assembled into an MRI magnet and series-connected with soldering joints between adjacent coils. The PCS in each coil is designed in such way that it will also serve as a detect-and-heat protection absorber when the magnet quenches over a small "localized" region: The conductor volume in the eight switches is designed to absorb the entire magnet energy while still remaining below 200 K. This paper reports 1) the design of the whole magnet and 2) the fabrication and test results of the two real-size test coils, with their PCSs and superconducting joints. The tests were conducted in gas helium in the temperature range of 10-15 K and in the self-field of the coils.

Analytical optimisation of solid‐round‐wire windings conducting dc and ac non‐sinusoidal periodic currents

In this study, an analytical optimisation of solid-round-wire windings conducting both the dc and ac non-sinusoidal periodic currents is performed. A closed-form analytical equation is derived for the normalised solid-round-wire diameter to achieve the minimum power loss for inductors conducting ac non-sinusoidal periodic currents superimposed on the dc component. The low- and medium-frequency normalised winding ac resistance for the nth harmonic frequency is derived and used to obtain the normalised total-power-valley diameter at the local minimum of the winding dc and ac power losses. Additionally, an equation for the local minimum of the winding dc and ac power losses is derived. A high-frequency approximation of Dowell's equation at the nth harmonic frequency is used to derive the normalised total-power-critical wire diameter at which the total winding power loss (dc and ac) is equal to the total winding power loss at the local minimum. A design procedure of the inductor with an optimised winding diameter operating in pulsewidth-modulated dc–dc buck converter in discontinuous conduction mode is presented. Experimental verification of the presented theory and comparison of the total winding power loss of the inductors with different solid-round-wire gauge are performed.

Development of Central Solenoid for JT-60SA

Several components for central solenoid (CS) of JT-60 Super Advanced (JT-60SA) were newly developed and tested. The butt-type joint, the electrical resistance of which is about 2 nΩ, was developed to increase the winding diameter. The insulation system, which consists of Glass/Kapton/Glass tape and Bisphenol A diglycidyl ether (DGEBA) epoxy, showed sufficient tensile strength after the irradiation of 100 kGy. Insulation characteristics of 4 × 4 winding stack sample after the compression of 705 kN 36 000 times was able to withstand voltages larger than 21 kV. The heat treatment and transfer of the CS model coil with superconductor were conducted. The pancake temperature during flat top was maintained at 923 ± 4 K. The maximum temperature difference in the pancake was 30 K. All manufacturing processes were confirmed so that the mass production of CS will be started in 2013.

Deep sternal osteomyelitis: An algorithm for reconstruction based on wound width

Patients with sternum osteomyelitis are transferred to plastic surgery departments for wound coverage. Several options of flap coverage are known; however, various wound diameters need different flaps. In a retrospective study, 135 patients from 2006–2010 with deep sternal wound infections were evaluated. From 2006–2009 various flaps were used for wound coverage, as described in published reports. In 2010 a developed algorithm was used for defect coverage based on wound width using pectoralis muscle flaps or the latissimus dorsi muscle flap. Two groups of patients were analyzed, from 2006–2009 and 2010, and in a matched pair analysis patients with small wound width less than 6 cm, medium wounds widths between 6–12 cm, and large wound width larger than 12 cm. End-point was wound dehiscence larger than 1 cm. Statistical analysis was done by Mann Whitney U-test using the SPSS program. Forty-eight patients were included in the match from a total of 130 study patients. Statistical analysis did not show significant difference in patient population of the two groups. In the group with wound sizes less than 6 cm a significant difference was found when using the algorithm. In the other groups no statistically significant difference was seen; however lesser numbers in wound dehiscence were found. In addition, a significantly lesser length of stay was found in the ICU and length of the hospital stay for all groups treated according to the algorithm. A reduction of costs may be achieved when using the algorithm based on wound size.

The varying size of exit wounds from center-fire rifles as a consequence of the temporary cavity

To study the question whether and how the size and position of the temporary cavity influence the morphology and especially the size of a bullet exit wound, test shots were fired to composite models consisting of gelatine and pig soft tissue covered with skin (at the exit site). The dimensions of the composite model were determined such that the exit planes were located either at the level of the narrow channel or within the temporary cavity or behind it. The chronological sequence of wound formation and its relation to the current position of the bullet were documented by means of a high-speed camera. Test shots were fired from a distance of 10 m using 5.56 × 45 mm cartridges with full metal-jacketed pointed bullets (v 0 ∼ 912 m/s, E 0 ∼ 1,663 J). The study proved that the extension and position of the temporary wound cavity was decisive for the size of the exit wound: An exit plane within the cavity resulted in particularly large skin lesions, whereas the wound diameters were much smaller if the exit plane was located in front or behind the cavity. The exit hole reaches its maximum size only after the bullet has left the target synchronous to the staggered expansion of the temporary cavity.

Small gauge vitrectomy: Recent update

Small gauge vitrectomy, also known as minimally invasive vitreous surgery (MIVS), is a classic example of progress in biomedical engineering. Disparity in conjunctival and scleral wound location and reduction in wound diameter are its core principles. Fluidic changes include increased pressure head loss with consequent reduction in infusional flow rate and use of higher aspiration vacuum at the cutter port. Increase An increase in port open/port closed time maintains an adequate rate of vitreous removal. High Intensity Discharge (HID) lamps maintain adequate illumination in spite of a decrease in the number of fiberoptic fibers. The advantages of MIVS are, a shorter surgical time, minimal conjunctival damage, and early postoperative recovery. Most complications are centered on wound stability and risk of postoperative hypotony, endophthalmitis, and port site retinal break formation. MIVS is suited in most cases, however, it can cause dehiscence of recent cataract wounds. Retraction of the infusion cannula in the suprachoroidal space may occur in eyes with scleral thinning. As a lot has been published and discussed about sutureless vitrectomy a review of this subject is necessary. A PubMed search was performed in December 2011 with terms small gauge vitrectomy, 23-gauge vitrectomy, 25-gauge vitrectomy, and 27 gauge vitrectomy, which were revised in August 2012. There were no restrictions on the date of publication but it was restricted to articles in English or other languages, if there abstracts were available in English.

Analysis and Design of a Push–Pull Quasi-Resonant Boost Power Factor Corrector

This paper proposes a novel power-factor corrector (PFC), which is mainly composed of two-phase transition-mode (TM) boost-type power-factor correctors (PFCs) and a coupled inductor. By integrating two boost inductors into one magnetic core, not only the circuit volume is reduced, but also the operating frequency of the core is double of the switching frequency. Comparing with single-phase TM boost PFC, both the input and output current ripples of the proposed PFC can be reduced if the equivalent inductance of the coupled inductor equals the inductance of single-phase TM boost PFC. Therefore, both the power-factor value and the power density are increased. The proposed topology is capable of sharing the input current and output current equally. A cut-in-half duty cycle can reduce the conduction losses of the switches and both the turns and diameters of the inductor windings. The advantages of a TM boost PFC, such as quasi-resonant (QR) valley switching on the switch and zero-current switching (ZCS) of the output diode, are maintained to improve the overall conversion efficiency. Detailed analysis and design procedures of the proposed topology are given. Simulations and experiments are conducted on a prototype with a universal line voltage, a 380-V output dc voltage and a 200-W output power to verify its feasibility.

WOUND HEALING POTENTIAL OF ZIZIPHUS JUJUBA BARK EXTRACT ON ALBINO RATS

The wound healing activity of topically app lied extract of bark of Ziziphus jujuba was evaluated in albino rat by excision wound model for a period of 24 days. In this study, the rats were divided into four groups, each groups continued healing process with 5 and 10% w/w methanolic extract of Zizip hus jujuba mg/cm 2 . Test duration was 24 days, wound diameter measurement using digital image analysis on days 0, 8 th , 16 th , 21 st and 24 th with biopsy of two rats from each group were taken . The results revealed that treatment with low - dose group of met hanolic extract of Ziziphus jujuba (5%) less shrinkage of wound area and also from the perspective of Histopathological change. In the second and third week, tissue had better organization than most other groups (p<0.0 1 ), but the group treated with high do ses of methanolic extract of Ziziphus jujuba (10%) had most wound

Are lead-free hunting rifle bullets as effective at killing wildlife as conventional lead bullets? A comparison based on wound size and morphology

Fragmentation of the lead core of conventional wildlife hunting rifle bullets causes contamination of the target with lead. The community of scavenger species which feed on carcasses or viscera discarded by hunters are regularly exposed to these lead fragments and may die by acute or chronic lead intoxication, as demonstrated for numerous species such as white-tailed eagles (Haliaeetus albicilla) where it is among the most important sources of mortality. Not only does hunting with conventional ammunition deposit lead in considerable quantities in the environment, it also significantly delays or threatens the recovery of endangered raptor populations. Although lead-free bullets might be considered a suitable alternative that addresses the source of these problems, serious reservations have been expressed as to their ability to quickly and effectively kill a hunted animal. To assess the suitability of lead-free projectiles for hunting practice, the wounding potential of conventional bullets was compared with lead-free bullets under real life hunting conditions. Wound dimensions were regarded as good markers of the projectiles' killing potential. Wound channels in 34 killed wild ungulates were evaluated using computed tomography and post-mortem macroscopical examination. Wound diameters caused by conventional bullets did not differ significantly to those created by lead-free bullets. Similarly, the size of the maximum cross-sectional area of the wound was similar for both bullet types. Injury patterns suggested that all animals died by exsanguination. This study demonstrates that lead-free bullets are equal to conventional hunting bullets in terms of killing effectiveness and thus equally meet the welfare requirements of killing wildlife as painlessly as possible. The widespread introduction and use of lead-free bullets should be encouraged as it prevents environmental contamination with a seriously toxic pollutant and contributes to the conservation of a wide variety of threatened or endangered raptors and other members of the guild of scavengers.

A reconstructive algorithm for deep sternal wound coverage: the Cologne-Merheim approach

Several options are known for treatment of the sternal wounds. However, various wound diameters need various flaps. 135 patients with sternum osteomyelitis from 2006 to 2010 of our institution were analyzed in a retrospective study. After using various flaps from 2006 to 2009 we developed an algorithm based on wound width, using pectoralis muscle flaps or the latissimus dorsi muscle flap. Two groups from 2006 - 2009, and 2010 were analyzed. A matched pair analysis was done for groups with small ( 12 cm). Endpoint for each analysis was wound dehiscence larger than 1cm. Factors influencing wound dehiscence were analyzed, such as infectious agents, applied flap for coverage, gender, co-morbidities, number of debridements before closure, ICU length of stay. Statistical analysis was done by Mann Whitney U-Test using the SPSS program. 130 patients were included in the study and 48 in the match. No significant difference in patient population between the two groups was detected. Total number of wound dehiscence in the 2010 group was lesser, however without statistical significance. Groups with wound sizes lesser than 6 cm showed a significant difference in wound dehiscence when using our algorithm. However, significant lesser length of ICU and hospital stay for all groups treated according to our algorithm was seen. ICU and hospital length of stay can be significantly reduced when using our algorithm, reducing costs for treatment of deep sternal osteomyelitis. Level of Evidence: Level IV, therapeutic study.

Wound healing properties of modified silver nanoparticles and their distribution in mouse organs after topical application

Normal 0 7.8 磅 0 2 false false false EN-US ZH-CN X-NONE Colloidal silver nanoparticles (AgNPs) as synthesized and modified with oligonucleotides (Oligo-AgNPs) are comparatively evaluated for their wound healing propert ies on animal models. The healing progress was monitored daily during nine days by measuring the wound diameter. The tissue samples from the healed regions were analyzed for epithelial damage, congestion, inflammatory cell infiltration, fibroblast proliferation, and new collagen synthesis. The AgNPs and Oligo-AgNPs had statically significant impact on the healing process compared to control. The histological analysis revealed that the AgNPs and Oligo-AgNPs improved the congestion, inflammatory cell infiltration, fibroblast proliferation and new collagen synthesis as compared to control. Although the fibroblast proliferation seems to be the same for both AgNPs and Oligo-AgNPs, the collagen synthesis is markedly improved with the Oligo-AgNPs. The atomic spectroscopy analysis of the samples from different tissues showed that the AgNPs applied topically to the skin does not pass through the other organs. Our data suggest that topical application of AgNP-Oligos improve wound healing by promoting increased collagen synthesis and tissue re-modeling without any side effects.

Wound healing using ionic silver dressing and nonocrystalline silver dressing in rats

To investigate the results of the healing process on surgical wounds in the back of Wistar rats using nanocristaline and ionic silver dressing. Sixty rats Wistar were submitted to surgical wounds with punch of 8 mm in diameter. In 30 animals (groups PN - nanocristaline and AD - control) two surgical wounds were done diametrically opposite on the upper back side. On the right side was used nanocristaline (PN) silver dressing and on the left side, distilled water dressing (AD). On the other group of 30 rats, only one wound was made with the punch, on the right side, and was used ionic silver dressing. So, the groups were divided into three subgroups, according to the day of death (7(th), 14(th) and 21(st) day). In each of these days the wounds diameter were measured to evaluate the wound contraction. Microscopic data were analyzed using the H&E staining to verify the inflammatory process and neovascularization. The Masson trichrome staining was used to verify the fibrosis. Macroscopically only the subgroup of 21(st) day showed statistical significance; between the groups AD and PI inflammatory process appeared in the 7(th) day subgroup in 90% of the cases. In neovascularization there was statistical significance between the groups PN and AD in the subgroup of 7(th) day. Fibrosis did not show statistical significance in the studied groups. In relation to wound contraction, PN and PI groups showed better results than the AD group. In regard to histological analysis, H&E staining showed that there was presence of inflammation in all groups, and at the end, the control group (AD) on 7(th) day, was superior to PN and PI groups. In relationship to fibrosis, no differences were obtained among groups.