Sub-Saharan Africa remains the least urbanized region of the world and more than 60% of the population, 570 million people, still live in rural areas [1]. Over the next few decades Africa will be one of the most rapidly urbanizing regions [2], and with this transition is an expected rise in cardiovascular risk factors and disease (CVD) [3]. Across sub-Saharan Africa, many adults migrate back and forth from rural home communities to more urban areas for work and education; others have moved to urban areas; and in still other cases, rural communities themselves have urbanized. In this issue of PLOS Medicine, a study by Riha and colleagues is directly concerned with the latter scenario within the context of urbanizing rural Uganda [4]. As the authors aptly note, the crude dichotomy of urban-rural difference obscures the changes occurring within rural regions themselves, as characteristics of urban environments, defined as urbanicity [5], become more prominent. Urbanization is a complex worldwide phenomenon and challenges global populations to recalibrate a set of far reaching behaviors as the meaning of communities change, networks widen, and globalization influences attitudes and access to new resources. Some of these phenomena are likely to be health promoting, while others expose formerly rural populations to new risks. Riha and colleagues’ study is the first in Sub-Saharan Africa, to our knowledge, to examine how urbanicity relates to the development of CVD risk factors in rural regions [4]. It is an important and revealing study. The population was drawn from 25 Ugandan villages that were unambiguously rural by conventional standards. A previously developed multicountry urbanicity scale was applied to score each village on seven domains meant to capture the hallmarks of urbanization: increasing population size and density, declining role of agriculture as the principal source of employment, rising education and diversity in educational achievement, increasing access to electricity and modern sanitation, and the presence of communication infrastructure [5,6]. Compared to villages in the lowest quartile of urbanicity (most rural), individuals living in villages in the highest quartile (least rural) had a 50% increase in overweight, more than a 3-fold increase in heavy drinking, and were about 20% more likely to have low physical activity levels or a diet low in fruits in vegetables. This association showed minimal attenuation despite adjustment for individual level socioeconomic status (SES) quantified through a household asset and wealth index. There was no difference in smoking prevalence or hypertension. Given the great variability among countries in subSaharan Africa, it is unclear how generalizable these results are beyond Uganda.
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