Word Scores Research Articles

Auditory function and prevalence of specific ear and hearing related pathologies in the general population at age 70

Objective: To describe the auditory function in early old age in detail based on both psychoacoustic and physiological measures, and to investigate the prevalence of specific audiological and otological pathologies.Design: An unscreened subsample from a population-based geriatric investigation was examined with otoscopy; tympanometry; pure-tone audiometry; word-recognition-in-noise test; distortion-product otoacoustic emissions; and auditory-evoked brainstem responses. Audiometric subtypes and diagnoses were established based on set criteria. The association between word scores and ABR was examined with linear regression analysis.Study Sample: 251 persons aged 70 (113 men, 138 women, born in 1944) that were representative of the inhabitants of the city of Gothenburg.Results: The prevalence of conductive pathology was 2% versus 49% for cochlear and 2% for auditory-neural pathology. Four percent had indeterminate type. Cochlear dysfunction was present in the majority of ears and around 20% performed worse-than-expected on speech testing. Poor performance on the speech in noise test was associated with prolonged interpeak latency interval of ABR waves I-V.Conclusion: Specific otological and audiological pathologies, other than cochlear hearing loss, are rare in the general population at age 70. Additionally, there is subtle evidence of age-related decline of the auditory nerve. Longitudinal follow-up would be of great interest.

Middle Ear Muscle Reflex and Word Recognition in "Normal-Hearing" Adults: Evidence for Cochlear Synaptopathy?

Permanent threshold elevation after noise exposure, ototoxic drugs, or aging is caused by loss of sensory cells; however, animal studies show that hair cell loss is often preceded by degeneration of synapses between sensory cells and auditory nerve fibers. The silencing of these neurons, especially those with high thresholds and low spontaneous rates, degrades auditory processing and may contribute to difficulties in understanding speech in noise. Although cochlear synaptopathy can be diagnosed in animals by measuring suprathreshold auditory brainstem responses, its diagnosis in humans remains a challenge. In mice, cochlear synaptopathy is also correlated with measures of middle ear muscle (MEM) reflex strength, possibly because the missing high-threshold neurons are important drivers of this reflex. The authors hypothesized that measures of the MEM reflex might be better than other assays of peripheral function in predicting difficulties hearing in difficult listening environments in human subjects. The authors recruited 165 normal-hearing healthy subjects, between 18 and 63 years of age, with no history of ear or hearing problems, no history of neurologic disorders, and unremarkable otoscopic examinations. Word recognition in quiet and in difficult listening situations was measured in four ways: using isolated words from the Northwestern University auditory test number six corpus with either (a) 0 dB signal to noise, (b) 45% time compression with reverberation, or (c) 65% time compression with reverberation, and (d) with a modified version of the QuickSIN. Audiometric thresholds were assessed at standard and extended high frequencies. Outer hair cell function was assessed by distortion product otoacoustic emissions (DPOAEs). Middle ear function and reflexes were assessed using three methods: the acoustic reflex threshold as measured clinically, wideband tympanometry as measured clinically, and a custom wideband method that uses a pair of click probes flanking an ipsilateral noise elicitor. Other aspects of peripheral auditory function were assessed by measuring click-evoked gross potentials, that is, summating potential (SP) and action potential (AP) from ear canal electrodes. After adjusting for age and sex, word recognition scores were uncorrelated with audiometric or DPOAE thresholds, at either standard or extended high frequencies. MEM reflex thresholds were significantly correlated with scores on isolated word recognition, but not with the modified version of the QuickSIN. The highest pairwise correlations were seen using the custom assay. AP measures were correlated with some of the word scores, but not as highly as seen for the MEM custom assay, and only if amplitude was measured from SP peak to AP peak, rather than baseline to AP peak. The highest pairwise correlations with word scores, on all four tests, were seen with the SP/AP ratio, followed closely by SP itself. When all predictor variables were combined in a stepwise multivariate regression, SP/AP dominated models for all four word score outcomes. MEM measures only enhanced the adjusted r values for the 45% time compression test. The only other predictors that enhanced model performance (and only for two outcome measures) were measures of interaural threshold asymmetry. Results suggest that, among normal-hearing subjects, there is a significant peripheral contribution to diminished hearing performance in difficult listening environments that is not captured by either threshold audiometry or DPOAEs. The significant univariate correlations between word scores and either SP/AP, SP, MEM reflex thresholds, or AP amplitudes (in that order) are consistent with a type of primary neural degeneration. However, interpretation is clouded by uncertainty as to the mix of pre- and postsynaptic contributions to the click-evoked SP. None of the assays presented here has the sensitivity to diagnose neural degeneration on a case-by-case basis; however, these tests may be useful in longitudinal studies to track accumulation of neural degeneration in individual subjects.

Accommodation of gender-related phonetic differences by listeners with cochlear implants and in a variety of vocoder simulations

Speech perception requires accommodation of a wide range of acoustic variability across talkers. A classic example is the perception of "sh" and "s" fricative sounds, which are categorized according to spectral details of the consonant itself, and also by the context of the voice producing it. Because women's and men's voices occupy different frequency ranges, a listener is required to make a corresponding adjustment of acoustic-phonetic category space for these phonemes when hearing different talkers. This pattern is commonplace in everyday speech communication, and yet might not be captured in accuracy scores for whole words, especially when word lists are spoken by a single talker. Phonetic accommodation for fricatives "s" and "sh" was measured in 20 cochlear implant (CI) users and in a variety of vocoder simulations, including those with noise carriers with and without peak picking, simulated spread of excitation, and pulsatile carriers. CI listeners showed strong phonetic accommodation as a group. Each vocoder produced phonetic accommodation except the 8-channel noise vocoder, despite its historically good match with CI users in word intelligibility. Phonetic accommodation is largely independent of linguistic factors and thus might offer information complementary to speech intelligibility tests which are partially affected by language processing.

Hearing Preservation Outcomes Using a Precurved Electrode Array Inserted With an External Sheath.

Describe audiologic outcomes in hearing preservation cochlear implantation (CI) using a precurved electrode array inserted using an external sheath and evaluate association of electrode positioning and preservation of residual hearing. Retrospective review. Tertiary otologic center. Twenty-four adult patients who underwent hearing preservation CI with precurved electrode array. CI, intraoperative computed tomography (CT) OUTCOME MEASURES:: Audiologic measures (consonant-nucleus-consonant [CNC] words, AzBio sentences, low-frequency pure tone averages [LFPTA]) and electrode location (scalar location, electrode-to-modiolus distance ((Equation is included in full-text article.)), angular insertion depth). Twenty-four adults with less than 80 dB LFPTA with a precurved electrode array inserted using an external sheath; 16 underwent intraoperative CT. LFPTA was 58.5 dB HL preoperatively, with a 17.3 dB threshold shift at CI activation (p = 0.005). CNC word scores improved from 6% preoperatively to 64% at 6 months postoperatively (p < 0.0001). There was one scalar translocation and no tip fold-overs. The average angular insertion depth was 388.2 degrees, and the average (Equation is included in full-text article.)across all electrodes was 0.36 mm. Multivariate regression revealed a significant correlation between CNC scores at 6 months and angular insertion depth (p = 0.0122; r = 0.45, adjusted r = 0.35). Change in LFPTA was not significantly associated with angular insertion depth or (Equation is included in full-text article.). A low rate of translocation allows a precurved electrode array inserted using an external sheath to maintain hearing preservation rates comparable to straight electrode arrays. With scala tympani insertion, angular insertion depth is a positive marker of improved speech performance postoperatively but may be a confounder variable based on individual cochlear size.

Comparison of Cortical Auditory Evoked Potential Findings in Presbycusis with Low and High Word Recognition Score.

Deteriorated speech understanding is a common complaint in elderly people, and behavioral tests are used for routine clinical assessment of this problem. Cortical auditory evoked potentials (CAEPs) are frequently used for assessing speech detection and discrimination abilities of the elderly, and give promise for differential diagnosis of speech understanding problems. The aim of the study was to compare the P1, N1, and P2 CAEP latencies and amplitudes in presbycusis with low and high word recognition score (WRS). A cross-sectional study design was used for the study. Two groups were formed from the patients with presbycusis based on their scores on the speech recognition test. Fifty-seven elderly volunteers participated in the study. The first group composed of 27 participants with high WRS, the other group composed of 30 participants with low WRS. The CAEP waves were recorded from these participants using speech signals. Latencies and amplitudes of P1-N1-P2 waves of the two groups were compared with the t-test statistic. There were significant prolongation of P1 and N1 latencies in presbycusis with low WRS when compared with presbycusis with a relatively high word score (p < 0.05). According to the result of the research, P1 and N1 latencies of presbycusis with low WRS were longer than the participants with high WRS. Factors affecting peripheral auditory system, such as stimulus sensation level, might be responsible for P1 and N1 latency prolongation of the low WRS group.

Sentiment Neural Network(SNN)-for Knowledge based Recommender System

Recommendation systems play a crucial role in e-commerce by recommending products that suit for the consumers also providing exact information to users. For the past few decades, researchers used many machine learning techniques on recommender system. In recommender system ML based algorithms providing a better detection of user preferences, item features and users-items. In this way deep learning play an increasingly vital role in review recommender systems, since they used a bunch of discrete values for review. However, a problem arises regarding that feedbacks. Discrete values are those which are hard to describe user’s interests. This problem makes it impossible to specifically model user’s choice for recommendation. Purpose of this paper is to introduce a new novel SNN (Sentiment Neural Network) framework for effective recommendation system. SNN frameworks consider two phases. In first phase of SNN framework, this work introduces NLP techniques for converting unstructured data into structured data. This technique includes pre-processing data, feature extraction, word scoring, polarity classification and sentiment analysis. The second phase of SNN framework used for verifying the polarity classes with the real world examples. SNN structures are not only among the best models with reference to prediction accuracy, they also consider the weighting factor on classifier to reduce the training time. A novel Sentiment Neural Network along with knowledge recommender system is suggested for review features extraction, text classification and analyzing review features in the various domains.

Long-term audiologic outcomes after cochlear implantation for single-sided deafness.

To evaluate the long-term audiometric outcomes, sound localization abilities, binaural benefits, and tinnitus assessment of subjects with cochlear implant (CI) after a diagnosis of unilateral severe-to-profound hearing loss. The study group consisted of 60 (mean age 52 years, range 19-84) subjects with profound hearing loss in one ear and normal to near-normal hearing in the other ear who underwent CI. Data analysis included pre- and postoperative Consonant-Nucleus-Consonant (CNC) Word scores, AzBio Sentence scores, pure tone thresholds, sound localization, and Iowa Tinnitus Handicap Questionnaire scores. Preoperative average duration of deafness was 3.69 years (standard deviation 4.31), with an average follow-up time of 37.9 months (range 1-87). CNC and AzBio scores significantly improved (both P < 0.001) postoperatively among the entire cohort, and there was much heterogeneity in outcomes with respect to deafness etiology subgroup analysis. Sound localization abilities tended to improve longitudinally in the entire cohort. Binaural benefits using an adaptive Hearing in Noise Test test showed a significant (P < 0.001) improvement with head shadow effect. Utilizing the Iowa Tinnitus Handicap Questionnaire, there was significant improvement in social, physical, and emotional well-being (P = 0.011), along with hearing abilities (P = 0.001). This case series is the largest cohort of CI SSD subjects to date and systematically analyzes their functional outcomes. Subjects have meaningful improvement in word understanding, and sound localization tends to gradually improve over time. Binaural benefit analysis showed significant improvement with head shadow effect, which likely provides ease of listening. 4 Laryngoscope, 130:1805-1811, 2020.

Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression.

AimThe impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method providing a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). In the present study, we investigated whether a relationship exists between improvements in frontal lobe dysfunction induced by rTMS and improvement of white matter integrity revealed by diffusion tensor imaging (DTI) in TRD patients receiving rTMS treatment.MethodsA total of 12 patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study (August 2013–January 2019). Frontal lobe function and depressive symptoms were assessed at baseline and at the endpoint of rTMS treatment. Fractional anisotropy (FA), as a measure of white matter integrity obtained from DTI, was investigated using a region-of-interest (ROI) approach.ResultsrTMS treatment significantly improved depressive symptom scores and some subscales of frontal lobe dysfunction. Category scores in the Word Fluency Test and scores on part 3 of the Color Stroop Test were improved independently of the improvement of depressive symptoms. In the ROI analysis, none of the FA increases in any region were correlated with improvement of any frontal lobe function (n = 12).ConclusionAlthough rTMS resulted in partial improvement of frontal lobe dysfunction as well as white matter integrity, we found no correlation between improved frontal lobe dysfunction and improved white matter integrity in TRD patients.

Public engagement in health technology assessment in Brazil: the case of the Trastuzumab public consultation

BackgroundPublic engagement in health technology assessment (HTA) is increasing worldwide. There are several forms of public engagement and it is not always possible to determine which stakeholders participate in the HTA process and how they contribute. Our objective was to investigate which types of social representatives contributed to the public consultation on the incorporation of Trastuzumab for early-stage breast cancer treatment within the public health system in Brazil, held in 2012 by the National Committee for Health Technology Incorporation (CONITEC).MethodsA mixed methods approach was used to analyze social representativeness and the composition of the corpus from the public consultation, which consisted of 127 contributions. Three types of analysis were performed using IRaMuTeQ software: classic lexical analysis, descending hierarchical classification and specificities analysis. The contributions were clustered according to the main categories of discourse observed, into four social representation categories: 1) patient representation/advocacy; 2) pharmaceutical industry/advocacy; 3) healthcare professionals; and 4) individual contributions.ResultsCategory 1 contained words related to increased survival due to use of the drug and a low score for words pertaining to studies on Trastuzumab. The word “safety” obtained a positive score only in category 2, which was also the only category that exhibited a negative score for the word “risk”. Category 3 displayed the lowest scores for “diagnosis” and “safety”. The word “efficacy” had a negative score only in category 4.ConclusionsEach category exhibited different results for words related to health systems and to key concepts linked to HTA. Our analysis enabled the identification of the most prominent contributions for each category. Despite the promising results obtained, further research is needed to validate this software for use in analyzing public contributions.

Management of sporadic vestibular schwannoma with contralateral nonserviceable hearing.

To outline a possible decision-making process for sporadic vestibular schwannoma (VS) with contralateral nonserviceable hearing at diagnosis. Retrospective case series. Diagnosed VS was studied in a tertiary referral center from 1995 to 2013. Twenty-eight patients were included, with a mean follow-up of 6.9 years (range = 0.5-20 years). Ten were stage 1, 10 were stage 2, five were stage 3, and three were stage 4. Ipsilateral hearing levels were A (n = 3), B (n = 10), C (n = 7) and D (n = 8) American Academy of Otolaryngology-Head and Neck Surgery classification. Contralateral hearing levels were C (n = 11) and D (n = 17). Initial VS management included surveillance (n = 12) or surgery (n = 16), and four patients were later treated with surgery (n = 3) or stereotactic irradiation (n = 1). Hearing was improved by hearing aids and/or etiological treatment (n = 8), restored by contralateral (n = 15) or ipsilateral (n = 4) cochlear implants (CIs), or ipsilateral auditory brainstem implants (ABIs) (n = 3). Finally, 18 CIs were active daily; 14 of them presented high or moderate benefit with mean open-set dissyllabic word scores (WRS) of 58.1% and sentence recognition scores (SRS) of 69.7%, but only one ABI was still active (WRS of 70% and SRS of 87% with lip reading). When early removal of VS was not necessary, contralateral CI or etiological treatment for hearing loss might be recommended initially. Ipsilateral CI is proposed, whereas VS should be operated on if previous hearing restoration was not successful. ABI should be reserved for the rare cases where a contralateral CI could not be implanted or the cochlear nerve was sectioned during VS removal. 3 Laryngoscope, 130:E407-E415, 2020.

The Effect of Stereoscopic Three-Dimensional Images on Vocabulary Learning

Vocabulary is crucial for language learning. Therefore, searching for the most effective methods to master vocabulary is an important quest. This study investigated the effect of stereoscopic three-dimensional (S3D) images on recall and retention of foreign language vocabulary. S3D images, frequently used in virtual reality visualizations, are highly realistic and differ from non-stereoscopic three-dimensional (NS3D) images in that they provide an impression of depth. In this within-subject study, American subjects (N = 82) were exposed to 16 Polish words accompanied by corresponding images. Half of these images were in NS3D format, and half were in S3D format. The vocabulary was counterbalanced throughout four randomly distributed versions of the experiment. Quantitative data were drawn from immediately administered and one-week-delayed productive and receptive vocabulary tests. Qualitative data were gathered through background questionnaires and follow-up surveys, which included a mixture of open-ended and Likert scale questions. Two-tailed, paired t-tests showed no significant difference on vocabulary recall and retention of test scores for words represented with NS3D and S3D images. Post hoc tests revealed that lower performance on S3D images occurred only for those subgroups of subjects who exhibited discomfort or lack of experience with S3D technology, or both.

Evidence-Based Recommendation for Bilateral Cochlear Implantation in Adults.

Purpose Most adult cochlear implant (CI) users in developed countries benefit from the use of a hearing aid in conjunction with their implant device (bimodal hearing). Benefits have also been documented for the use of bilateral CIs for speech perception in quiet, localization, and speech perception in noise. This study attempted to quantify speech perception results for bimodal and bilateral CIs in adults and provide a guide for those considering a 2nd CI. Method Speech perception outcomes were reviewed for 1,394 adults with acquired hearing loss who received a CI at the Melbourne Cochlear Implant Clinic between 2000 and 2015. Results Bimodal and bilateral users significantly outperformed unilateral CI users on consonant-vowel-consonant word recognition in quiet. For the bilateral group, word recognition scores with the 1st CI were predictive of 2nd CI word scores. The analysis suggested that bimodal users who were gaining less than 19% benefit from the nonimplanted ear were likely to perform better with a 2nd implant. Conclusions CI users who score less than 19% on consonant-vowel-consonant words in the nonimplanted ear have a good chance of benefiting from a 2nd implant. Consideration of many other factors including age, hearing goals, medical factors, and the risk to residual hearing also needs to play a part in recommending a 2nd CI.

Palliation of Thirst in Intensive Care Unit Patients: Translating Research Into Practice.

Thirst is prevalent among patients in intensive care units. A research-based "thirst bundle" was shown to significantly decrease thirst in these patients. To implement a research-based thirst intervention performed by intensive care unit nurses and patients' family members. Nurses and family members were taught the thirst intervention through video training and project team reinforcement. The intervention was performed by nurses for 123 patients and by family members for 13 patients. Thirst was measured with a numeric rating scale of 0 to 10, a word scale of 0 to 3, or "yes/no" answers, whichever was easiest for the patient. Inferential statistics were used to assess changes in thirst scores over time. Also assessed were nurse and family member burden levels, family level of satisfaction, and patient enjoyment. Thirst scores on the numeric rating scale decreased significantly: from a mean (SD) of 7.9 (2.0) before to 3.9 (2.7) after the intervention for nurses (P < .001); and from 9.2 (1.5) to 5.3 (2.6) for family members (n = 13; P = .002). Word scale scores also decreased significantly, from a median (interquartile range) of 3 (3-3) before to 2 (1-2) after the intervention for nurses (P < .001). Most patients (96%) reported enjoying the procedure. Median burden levels were less than 2 on a numeric rating scale of 0 to 10. The palliative "thirst bundle" significantly alleviated patients' thirst and resulted in little caregiver burden. Further efforts are warranted to incorporate this intervention into intensive care unit practice.

Factors Influencing Pediatric Cochlear Implant Outcomes: Carolina Sibling Study.

To determine the correlation between speech perception performance between pediatric sibling pairs with severe to profound sensory hearing loss receiving cochlear implants, and in cases of discordance in performance, determine which variables negatively impacted performance. Retrospective chart review. Tertiary academic referral center. Eighty-nine pediatric subjects, 43 sibling groups, under the age of 18 with severe to profound sensory hearing loss who received a cochlear implant with a sibling who also received a cochlear implant. Cochlear implantation. Speech perception scores, consonant-nucleus- consonant score. A statistically significant correlation was found between speech perception performance of pediatric siblings. Depth of insertion is positively correlated with better speech perception in siblings with discordant results. There was no significant relationship with either electrode type, unilateral/bilateral status, or age of implantation. Pediatric siblings have a high correlation in speech perception outcomes following cochlear implantation, suggesting family environment plays a strong role. In circumstances in which outcomes between siblings are substantially different, greater depth of implant insertion is correlated with better consonant-nucleus- consonant word scores.

Enhanced Twitter Sentiment Analysis Using Hybrid Approach and by Accounting Local Contextual Semantic

Abstract This paper addresses the problem of Twitter sentiment analysis through a hybrid approach in which SentiWordNet (SWN)-based feature vector acts as input to the classification model Support Vector Machine. Our main focus is to handle lexical modifier negation during SWN score calculation for the improvement of classification performance. Thus, we present naive and novel shift approach in which negation acts as both sentiment-bearing word and modifier, and then we shift the score of words from SWN based on their contextual semantic, inferred from neighbouring words. Additionally, we augment negation accounting procedure with a few heuristics for handling the cases in which negation presence does not necessarily mean negation. Experimental results show that the contextual-based SWN feature vector obtained through shift polarity approach alone led to an improved Twitter sentiment analysis system that outperforms the traditional reverse polarity approach by 2–6%. We validate the effectiveness of our hybrid approach considering negation on benchmark Twitter corpus from SemEval-2013 Task 2 competition.

Cochlear Implant Outcomes in Large Vestibular Aqueduct Syndrome-Should We Provide Cochlear Implants Earlier?

Examine postoperative speech perception outcomes in a large vestibular aqueduct syndrome (LVAS) patients at a major cochlear implantation center. Retrospective analysis of the Sydney Cochlear Implant Centre (SCIC) database and medical records from January 1994 to December 2015 was performed. Tertiary referral center. Patients with a diagnosis of LVAS who received a cochlear implant (CI). Only those with speech perception outcomes recorded at least 12 months post implant were included in our analysis. Therapeutic. Postoperative speech perception scores. Between 1994 and 2015, 176 adult and pediatric patients with a diagnosis of LVAS underwent cochlear implantation at SCIC. Postoperative Bamford-Kowal Bench (BKB) sentence test scores were obtained for 97 patients. The postoperative median BKB score was 93% with a lower quartile score of 85% and an upper quartile score of 98%. Smaller numbers were available for post-CI City University of New York (CUNY) and Consonant-Nucleus-Consonant (CNC) word scores yet similar excellent results were seen. Our study results suggest the CI should be considered when BKB scores have dropped to 85%. We suggest that rather than LVAS cases representing a challenge to cochlear implantation, they are amongst the best candidates for surgery, and should receive a CI at an earlier stage in hearing loss, when they have better speech perception. This allows stable hearing to be established earlier along with excellent speech perception outcomes.

INVESTIGATING LEXICAL DIVERSITY OF ONLINE ENGLISH NEWSPAPER EDITORIALS ACROSS COUNTRIES

Online media or digital media is an internet based communication technology to share and to exchange the latest information throughout the world. This study aims to investigate the lexical diversity of editorials section published in English online media from across ten countries; Egypt, UK, Indonesia, Japan, Malaysia, Russia, USA, Pakistan, Singapore and Nigeria. By using a batch mode of web-based interface to the lexical calculation proposed by Laufer and Nation (1995), namely Second Language Lexical Frequency Profile (L2LFP), this paper focused on the production of tokens, types, type-token ratio (TTR) and academic words of ten online English newspaper editorials from two native English countries and eight non-native English countries. The results show that an editorial published in The Today Online newspaper from Singapore consists the highest score of tokens (987), types (431) and academic words (52), but the least score of TTR (0.44). Nevertheless, the highest score of TTR is not produced by The Today Online. The highest score of TTR (0.60) is gained by The Pakistan Today, even though The Pakistan Today only consists 273 tokens, 223 types and 38 academic words. Despite of Laufer and Nation’s (1995) argumentation that native writer has higher TTR’s score than non-native writer, this paper showed different results. The native online newspaper: The Guardian from U.K and The New York Times from USA has TTR’s score of 0.48 and 0.47. Meanwhile, most of non-native online newspapers has higher TTR’s scores.

Pediatric cochlear implantation: A quarter century in review

Objective: To review the growth of a pediatric cochlear implant (CI) program at one large tertiary care medical center over a 25-year period in order to (1) describe the population of pediatric cochlear implant recipients, (2) document word recognition outcomes, and (3) describe changes in candidacy criteria over time.Design: A retrospective review of population demographics and trends included etiology of hearing loss, device use and type, expansion of inclusion criteria, and word recognition outcomes.Results: Ninety-one percent of the children studied were from North Carolina and reflect the ethnic distribution of the state. The population is heterogeneous for etiology and the presence of syndromes and/or co-morbidities. A trend of lower age of implant and greater residual hearing was documented overtime. As a single metric, monosyllable word recognition for the children assessed is good with the mean CNC test word score of 76.13% (range 0–100, S.D = 19.94).Conclusions: Pediatric cochlear implant candidacy criteria have evolved despite no change in FDA-approved regulations since 2000. There is great diversity among recipients but word recognition outcomes are generally good in this population and have improved over time. Professionals who may refer children for cochlear implantation should be aware of current clinical practices and general outcomes.

Serum BDNF and GDNF in Chinese male patients with deficit schizophrenia and their relationships with neurocognitive dysfunction

BackgroundTo measure the serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in deficit schizophrenia (DS), in order to examine the association between these two neurotrophic factors (NFs) and cognitive performance.MethodsA total of 109 male patients [51 DS and 58 non-deficit schizophrenia (NDS)] with schizophrenia and 40 sex and age matched healthy controls (HC) participated in this study. Processing speed, attention, executive function, and working memory of all subjects were assessed by means of a battery of classical neuropsychological tests. Serum BDNF and GDNF levels were measured simultaneously using a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA).ResultsThere were significant differences in the overall cognitive test scores between three groups (all p < 0.001). Serum BDNF levels were significantly lower in patients (DS and NDS) than in HC (p < 0.001). Furthermore, BDNF levels were lower in the DS compared to the NDS group, although not significantly. However, there was no difference in the GDNF levels between patients (DS and NDS) and HC. GDNF levels were positively correlated with scores of Stroop words only (r = 0.311, p = 0.033), Stroop colors only (r = 0.356, p = 0.014) and Stroop interference (r = 0.348, p = 0.016) in DS group.ConclusionSerum BDNF may be an unsuitable biomarker for DS, despite a significant decrease in schizophrenia patients. The different neurocognitive performance between the DS and NDS patients indicates that DS may be a separate clinical entity of schizophrenia. Finally, higher serum GDNF levels are associated with better cognitive performance in DS patients, indicating a possible neuroprotective function in DS.

Pattern Perception in Quiet and at Different Signal to Noise Ratio in Children with Learning Disability

This study aimed to assess pattern perception at different signal-to-noise ratio (SNR) in children with learning disability (LD) and typically developing children. The first objective of this study was to estimate the identification scores in quiet and at different SNR (0 dB SNR and -5 dB SNR) in children with LD and to compare the result with the typically developing children. The second objective of the study was to estimate identification scores for words differing in syllable length (monosyllable, bisyllable, and trisyllable) for both the groups of children with LD and typically developing children and to compare the result for both the groups. Participants included 60 children including 40 typically developing children and 20 children with LD in the age range 7-11 years. Speech perception was assessed using words varying in syllable length (monosyllables, bisyllables, and trisyllables), and was tested in quiet and at different SNR (0 dB SNR and -5 dB SNR). Compared to typically developing children, perception was affected in children with LD. For children with LD, the perception was best in quiet condition and was least at -5 dB SNR. Trisyllables showed the best result followed by bisyllables and monosyllables. Children with LD showed poor pattern perception compared to typically developing children. SNR had a significant effect on the performance of children with LD. The length of the stimuli also had an effect on the perception in children with LD.