Woman's Reproductive Life Research Articles

A Miscarriage of Justice: Women's Reproductive Lives and the Law in Early Twentieth Century Brazil

A Miscarriage of Justice: Women's Reproductive Lives and the Law in Early Twentieth Century Brazil

Transmutation of The Reproductive Life of Women in Southern/West Cameroon(S) 1922-1972: A Colonial Manipulation

In all human communities, societal continuity depended on the quality and availability of infant and maternity welfare services. Conscious of the outcomes of infancy care on the productive efficiency of individuals at adulthood, the reproductive life of women and child welfare became an area of European domination during colonialism. Using British Southern/West Cameroon(s) as the theatre, this paper sets out to uncover colonial motives in the transformation of reproductive practices among women as it examines the different strategies and mechanisms employed in extending maternity and infant welfare as a measure of colonial imperialism. Archival information and oral interviews made up primary sources while books, published articles and dissertations constituted the secondary sources. The descriptive historical approach was employed in the analysis of the work. This paper submits that: the British colonial administration in Southern Cameroons had a mask colonial exploitative economic agenda behind the assignment put forth by the League of Nations Mandate Commission in its Article II of the British Mandate agreement. A baseless racial discrimination and cultural domination motivated the transformation of the reproductive life of indigenous women and the extension of basic infant welfare services during the Mandate and trusteeship periods in Southern Cameroons. These services were mostly provided by Western Mission agencies and plantation firms who recognized the independence of Southern Cameroons but withheld the rights to medical autonomy. In some cases, the transfer of rights to manage the medical arm of the different agencies was partially transferred during the last years of the Cameroon federation and in some cases after the abrogation of the Cameroon federation. The British decision to administer Southern Cameroons as a mandate was a conspiracy to enforce the tentacles of colonialism and its diverse arms with hope of greater economic and cultural gains.

"Just forget about it and move on": Stillbirth ruptured and repaired narratives beyond expectant futures.

The critical sociological literature has explored social prescriptions on women's reproductive lives, trajectories, outcomes and aftermaths. However, little attention has been given to how these prescriptions are expressed through temporal negotiations. This article delves into the narratives of Jewish-Israeli women who have experienced stillbirths. In their narratives, these women contest expectations directed towards them in interactions with professionals, family and friends. Within these expectations, a form of dictation over their future comes into being, where a new pregnancy should quickly precede the stillbirth. The focus here lies on how these women navigate and contest these temporal expectations, carving out space for stillbirth as a meaningful and painful event that should be granted attention and for alternative forms of remembering their stillborn and caring for them after their death. They reshape their narratives through what I call "thickening a present tense" and extend care to the stillborn in the aftermath of the stillbirth. This work contributes to scholarly inquiries into reproductive life and probing time as a socially prescribed mechanism for the value and social distribution of care.

Menstrual cycle disorders: a correlation with genetic alterations

The menstrual cycle is considered the fifth vital sign among women. The pituitary, thyroid, pancreas, adrenal, and ovaries are endocrine glands that play a crucial role in governing the menstrual cycle. Endocrine ailments trigger periods of menstruation disturbances throughout a woman's reproductive life. The duration and volume of menstrual bleeding can serve as indicators of endocrine problems. Oligomenorrhea, which refers to monthly periods longer than 35 days, is the most prevalent menstrual disruption observed in endocrine illnesses such as thyrotoxicosis, hypothyroidism, polycystic ovarian syndrome, Cushing's syndrome, and diabetes, based on the existing evidence. The intricate endocrine pathways are crucial in regulating a woman's menstrual cycle.. Menstrual Irregularities are caused due to eating disorders, extreme weight loss or too much exercising, Polycystic ovary syndrome (PCOS), Premature ovarian failure, Pelvic inflammatory disease (PID) and Pregnancy or breast-feeding. Mensesare affected by various factors like junk food, obesity, skipping breakfast lack of physical activity etc. PCOS, Diabetes, Hyperprolactinemia, Hypothyroidism, Thyrotoxicosis, and Cushing’s syndrome are some menstrual disorders which occur due to genetic alterations. All these disorders can be primarily treated by Nutritional Considerations and herbal treatments. In order to achieve a regular menstrual cycle and overcome these diseases, nutritional supplements and lifestyle modifications must be prioritized.

Literature Review: the Effect of Ajwa Dates on Hemoglobin Levels in Perimenopause Women

Ajwa dates or often called prophet dates are types of dates that grow in Saudi Arabia / Al-Madinah Al-Munawara and have significant value in healing several diseases. The content of active substances contained in date extracts such as vitamins B1, B2, nicotinic acid, vitamin complex A, magnesium, calcium and iron which has a function to help the formation of hemoglobin. Perimenopause is an indefinite period of time that surrounds the final years of a woman's reproductive life, usually between the ages of 30-40 years when estrogen levels slowly decline causing menstrual abnormalities. The decrease in estrogen levels in perimenopausal women causes excessive blood loss so that iron deficiency anemia will occur. Objective : To determine the effect of consumption of ajwa dates (Pheonix Dactylifera L) on hemoglobin levels in perimenopausal women. Method : Literature Review with Design Narrative review. Results : Based on the results of research from several literatures that discuss the effects of giving Ajwa Dates (Phoenix Dactylifera L) before and after administration, it shows that there are differences in hemoglobin levels. Especially in perimenopausal women who are prone to iron deficiency anemia because Ajwa dates contain high iron, which increases hemoglobin levels. So it is highly recommended for consumption. Conclusion : Ajwa Dates (Phoenix Dactylifera L) can increase hemoglobin levels in perimenopausal women.

PCOS Disease Prediction Using Machine Learning Algorithms

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder affecting reproductive-aged women, characterized by hormonal imbalances, irregular menstrual cycles, and the presence of cysts on the ovaries. One of the most worrying diseases today is Polycystic Ovarian Syndrome (PCOS) which is highly dangerous to an extent of affecting women's reproductive life to a huge extent. The dataset includes a diverse set of features such as age, body mass index (BMI), hormonal levels, menstrual irregularities, and lifestyle factors. We explore various machine learning algorithms, including linear regression, decision tree, and random forests to identify the most effective model for PCOS prediction. [1] The study focuses on the development of a robust and clinically applicable predictive model that can aid healthcare professionals in early identification of individuals at risk of PCOS. The results obtained from this research have the potential to significantly impact the field of women's health by offering a reliable and efficient tool for PCOS prediction. Early identification of individuals at risk can facilitate timely interventions, personalized treatment plans, and improved outcomes. Furthermore, the study contributes to the growing body of literature on the application of machine learning in healthcare, demonstrating its potential as a valuable tool for predictive modelling in complex endocrine disorders such as PCOS.

HUBUNGAN PENGETAHUAN DAN SIKAP IBU TENTANG KB 3 BULAN TERHADAP KEPATUHAN JADWAL SUNTIK DI DESA SUDIREJO KECAMATAN NAMO RAMBE

Family planning (KB) is one of the most basic and primary preventive health services. To optimize the health benefits of family planning, these services must be provided for women by combining and fulfilling the needs of the main reproductive health services and others. In addition, reproductive health services are also responsive to various stages of a woman's reproductive life. Improving and expanding family planning services is one of the efforts to reduce the high maternal morbidity and mortality due to pregnancy experienced by women. This type of research is an analytic study with a cross-sectional study design that is used to determine the relationship between knowledge and attitudes of mothers about 3-month injection contraception against adherence to repeat injection schedules. The research was carried out in Sudirejo Village, Namo Rambe District, Deli Serdang Regency in January-July 2022 where the number of samples was 38 people by taking total sampling.

Reproduction Period Of Javanese Women

A woman's reproductive life goes through several phases including menstruation, childbirth and menopause. The first menstrual event experienced by a woman is called menarche, while the end of the menstrual period is called menopause. The age intervals for menarche and menopause describe the reproductive period or fertile age for a woman to become pregnant and give birth. The postreproductive period characterized by menopause is related to a woman's life expectancy and is important for assessing the quality of life. This research aims to determine the reproductive period of Javanese women in Oransbari, South Manokwari Regency. Cross-sectional research was conducted on women with an average age of 51.73 years with an interval of 40.18-69.59 years. The inclusion criteria were women who had experienced menopause. The age of menarche and menopause were analyzed using the Generalized Linear Model (GLM) in the R program. We found that the age at menarche (12.3 years) and age at menopause (43.1 years) of Javanese women in Oransbari were relatively young. This condition results in a shorter reproductive period (30.8 years) compared to several populations in Indonesia such as Sunda, Baduy, Tengger, Lampung, and Semendo. The reproductive period, which tends to be short, might be an adaptive response to environmental challenges that were less favourable as a pioneer transmigration society, such as high physical activity and low socio-economic conditions. The biocultural conditions experienced in the early life of Oransbari form a reproductive period that starts and ends early as an adaptive response to maximize reproductive success. Thus, women's reproductive health especially communities in isolated and remote areas, needs to be studied and become one of the government's focuses in considering intervention policies related to the health and welfare of the elderly and demographics

Impact of inflammatory bowel disease on women's reproductive life: a questionnaire-based study.

Inflammatory bowel diseases (IBDs) have a peak incidence between the second and fourth decades of life and can affect women's reproductive life. Our study aimed to assess the impact of IBD on the reproductive life of female patients with this condition. Cross-sectional study. Women with IBD followed at our IBD Unit and a group of healthy controls were enrolled. Data on reproductive life were collected using a dedicated questionnaire. The study included 457 women, of whom 228 had IBD, and 229 age-matched healthy controls. No differences were found in the use of contraceptives, infertility, and endometriosis. The risk of spontaneous and voluntary abortions was significantly higher in IBD patients than in healthy controls [odds ratio (OR) 2 and 3.62, respectively]. The risk of obstetrical complications in the IBD population was more than six times higher in patients who experienced disease reactivations during pregnancy than in those with persistent remission [OR 6.9, 95% confidence interval (CI) 1.51-31.28]. Finally, we found that the chances of breastfeeding were 66% lower in patients with IBD than in controls (OR 0.44, 95% CI 0.22-0.91). Our study underlines the negative impact of IBD on women's reproductive life, supporting the need for proactive preconception counseling.

Melanoma Cell Adhesion Molecule (CD 146) in Endometrial Physiology and Disorder.

The human endometrium, the innermost lining of the uterus, is the anatomic prerequisite for pregnancy. It is the only dynamic tissue that undergoes more than 400cycles of regeneration throughout the reproductive life of women. Key to this function are endometrial stem cells as well as cell adhesion molecules. Melanoma cell adhesion molecule (MCAM/CD146/MUC18) is a membrane glycoprotein of the mucin family and a key cell adhesion protein, highly expressed by endometrial cells. CD146 is a significant molecule pivotal in endometrial physiology, assisting tissue regeneration and angiogenesis. Endometrium also acts as a culprit in causing several endometrial dysfunctions, such as endometriosis, endometrial hyperplasia, and endometrial carcinoma, due to interrupted molecular and functional mechanisms. Though most of the endometrial dysfunctions arise as a result of endocrine disturbance, it has a major pathological role associated with angiogenesis. It has already been proven that CD146 is a potential marker for the diagnosis of angiogenic dysfunctions and malignancy, including endometrial cancer. However, its mechanistic role in causing the pathology is a mystery. This chapter explores the role of CD146 in normal and pathological endometrial conditions and the therapeutic implications of CD146.

Gender medicine and sleep disorders: from basic science to clinical research.

Several pivotal differences in sleep and sleep disorders are recognized between women and men. This is not only due to changes in hormonal balance during women's reproductive life, such as in pregnancy and menopause. Women are more likely to report insomnia and non-specific symptoms of apneas, such as fatigue or mood disturbance, compared to men. Thus, it is important for clinicians and researchers to take sex and gender differences into account when addressing sleep disorders in order to acknowledge the biology unique to women. We present a narrative review that delves into the primary sleep disorders, starting from basic science, to explore the impact of gender differences on sleep and the current status of research on women's sleep health.

Deciphering reproductive aging in women using a NOD/SCID mouse model for distinct physiological ovarian phenotypes.

Female fertility is negatively correlated with age, with noticeable declines in oocyte quantity and quality until menopause. To understand this physiological process and evaluate human approaches for treating age-related infertility, preclinical studies in appropriate animal models are needed. Thus, we aimed to characterize an immunodeficient physiological aging mouse model displaying ovarian characteristics of different stages during women's reproductive life. NOD/SCID mice of different ages (8-, 28-, and 36-40-week-old) were employed to mimic ovarian phenotypes of young, Advanced Maternal Age (AMA), and old women (~18-20-, ~36-38-, and >45-years-old, respectively). Mice were stimulated, mated, and sacrificed to recover oocytes and embryos. Then, ovarian reserve, follicular growth, ovarian stroma, mitochondrial dysfunction, and proteomic profiles were assessed. Age-matched C57BL/6 mice were employed to cross-validate the reproductive outcomes. The quantity and quality of oocytes were decreased in AMA and Old mice. These age-related effects associated spindle and chromosome abnormalities, along with decreased developmental competence to blastocyst stage. Old mice had less follicles, impaired follicle activation and growth, an ovarian stroma inconducive to growth, and increased mitochondrial dysfunctions. Proteomic analysis corroborated these histological findings. Based on that, NOD/SCID mice can be used to model different ovarian aging phenotypes and potentially test human anti-aging treatments.

Climate and Environmental Change: A Generation at Risk.

Climate and environmental changes have been described as the biggest global health threat of the 21st century, with the potential to cause immediate harm in early life with important lifelong effects, and important consequences for future generations. Pregnant women and children are increasingly being recognized as vulnerable populations in the context of climate change. The effects can be direct or indirect through heat stress, extreme weather events, and air pollution, potentially affecting both the immediate and long-term health of pregnant women and newborns through a broad range of mechanisms. Climate and environmental changes have wide-ranging effects on a woman's reproductive life including sexual maturation and fertility, pregnancy outcomes, lactation, breastfeeding, and menopause. A comprehensive overview of these impacts is presented as well as opportunities for interventions for nurses practicing in perinatal, neonatal, midwifery, and pediatric specialties.

The expression levels of NOS2, HMOX1, and VEGFC in cumulus cells are markers of oocyte maturation and fertilization rate.

Throughout the reproductive life of women, cumulus cells (CC) protect the dormant oocyte from damage, act as sensors of the follicular microenvironment, and act as a gatekeeper for oocyte developmental potential. One such mechanism relies on the hypoxia-tolerance response, which, with age, decreases systematically, including in the ovary. We aimed to evaluate the association between gene expression related to hypoxia and aging in CC and reproductive results in in vitro fertilization cycles. We recruited 94 women undergoing controlled ovarian stimulation. Total RNA was extracted from pooled CCs collected after oocyte pick-up (OPU) and reverse-transcribed to complementary DNA using random hexamers to test 14 genes related to hypoxia response via HIF1α activation, oxidative stress, and angiogenic responses. The expression of CLU, NOS2, and TXNIP had a positive correlation with age (rs = 0.25, rs = 0.24, and rs = 0.35, respectively). Additionally, NOS2 and HMOX1 expression correlated positively with the retrieval of immature oocytes (rs = 0.22 and rs = 0.40, respectively). Moreover, VEGFC levels decreased overall with increasing fertilization rate, independently of age (rs = -0.29). We found that the fertilization potential of a cohort of oocytes is related to the ability of CC to respond to oxidative stress and hypoxia with age, pointing at NOS2, HMOX1, and VEGFC expression as markers for oocyte maturation and fertilization success.

Pesquisa Nacional de Aborto - Brasil, 2021

The National Abortion Survey 2021 (PNA 2021) utilized face-to-face structured interviews and a self-administered questionnaire placed in a sealed box to collect data on abortions in Brazil. Interviews were held with a nationally representative sample of 2,000 women, randomly selected from among literate women ages 18 to 39 residing in urban areas. We compared some of the results with previous waves of the survey, PNA 2010 and PNA 2016. Findings show that abortion is in decline but remains a major public health issue. Around 10% of the women interviewed in 2021 said they had had at least one abortion in their lives (compared to 15% in 2010). We estimate that nearly one in every seven women (15%) have had an abortion by the age of 40. We identified a decline in the proportion of women who needed to be hospitalized to finalize their abortions (55% in 2010; 43% in 2021; p = 0.003) and in the proportion of women who used medication for the abortion (48% in 2010; 39% in 2021; p = 0.028). Abortion is an event that generally happens early on in women's reproductive lives: the PNA 2021 found that 52% of women were 19 years old or younger when they had their first abortion. Higher rates were detected among respondents with lower educational levels, Black and Indigenous women, and women residing in poorer regions.

Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy.

The human endometrium shows a remarkable regenerative capacity that enables cyclical regeneration and remodeling throughout a woman's reproductive life. Although early postnatal uterine developmental cues direct this regeneration, the vital factors that govern early endometrial programming are largely unknown. We report that Beclin-1, an essential autophagy-associated protein, plays an integral role in uterine morphogenesis during the early postnatal period. We show that conditional depletion of Beclin-1 in the uterus triggers apoptosis and causes progressive loss of Lgr5+/Aldh1a1+ endometrial progenitor stem cells, with concomitant loss of Wnt signaling, which is crucial for stem cell renewal and epithelial gland development. Beclin-1 knockin (Becn1 KI) mice with disabled apoptosis exhibit normal uterine development. Importantly, the restoration of Beclin-1-driven autophagy, but not apoptosis, promotes normal uterine adenogenesis and morphogenesis. Together, the data suggest that Beclin-1-mediated autophagy acts as a molecular switch that governs the early uterine morphogenetic program by maintaining the endometrial progenitor stem cells.

Diagnostic markers of insulin resistance to discriminate between prediabetes and diabetes in menopausal women.

Menopause is an important transition period in a woman's reproductive life during which hormonal changes occur, resulting in an increased risk of cardiovascular disease and type 2 diabetes. In this study, we assessed the possibility of using surrogate measures of insulin resistance (IR) to predict the risk of insulin resistance in perimenopausal women. The study involved 252 perimenopausal women living in the West Pomeranian Voivodeship. The methods employed in this study were diagnostic survey based on the original questionnaire, anthropometric measurement, and laboratory tests performed to determine the levels of selected biochemical parameters. In the entire study population, the highest area under the curve was found for the homeostasis model assessment-insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Triglyceride-glucose index (TyG index) showed a higher diagnostic value as a distinction tool between prediabetes and diabetes in perimenopausal women than the other markers. HOMA-IR significantly positively correlated with fasting blood glucose (r = 0.72; p = 0.001), glycated hemoglobin (HbA1C, r = 0.74; p = 0.001), triglycerides (TG, r = 0.18; p < 0.005), and systolic blood pressure (SBP, r = 0.15; p= 0.021), and negatively with high-density lipoprotein (HDL, r = -0.28; p = 0.001). QUICKI negatively correlated with fasting blood (r = -0.051; p = 0.001), HbA1C (r = -0.51; p = 0.001), TG (r = -0.25; p = 0.001), low-density lipoprotein (LDL, r = -0.13; p= 0.045), and SBP (r = -0.16; p = 0.011), and positively with HDL (r = 0.39; p = 0.001). Anthropometric and cardiometabolic parameters were found to significantly correlate with IR markers. HOMA-beta, the McAuley index (McA), visceral adiposity index (VAI), and lipid accumulation product (LAP) may be useful as predictors of pre-diabetes and diabetes in postmenopausal women.

Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.

In 1985 to 1986, the CARDIA (Coronary Artery Risk Development in Young Adults) study enrolled 5115 Black or White participants, including 2788 women, aged 18 to 30 years. Over the following 35 years, the CARDIA study amassed extensive longitudinal data on women's reproductive milestones, spanning menarche to menopause. Although not initially conceived as a study of women's health, >75 CARDIA study publications address relationships between reproductive factors and events with cardiovascular and metabolic risk factors, subclinical and clinical cardiovascular disease, and social determinants of health. The CARDIA study was one of the earliest population-based reports to note Black-White differences in age at menarche and associations with cardiovascular risk factors. Adverse pregnancy outcomes, particularly gestational diabetes and preterm birth, have been assessed along with postpartum behaviors, such as lactation. Existing studies have examined risk factors for adverse pregnancy outcomes and lactation, as well as their relationship to future cardiovascular and metabolic risk factors, diagnoses, and subclinical atherosclerosis. Ancillary studies examining components of polycystic ovary syndrome and ovarian biomarkers, such as anti-Müllerian hormone, have facilitated examination of reproductive health in a population-based cohort of young adult women. As the cohort transitioned through menopause, examination of the importance of premenopausal cardiovascular risk factors along with menopause has improved our understanding of shared mechanisms. The cohort is now aged in the 50s to mid-60s, and women will begin to experience a greater number of cardiovascular events as well as other conditions, such as cognitive impairment. Thus, in the next decade, the CARDIA study will provide a unique resource for understanding how the women's reproductive life course epidemiology informs cardiovascular risk, as well as reproductive and chronological aging.

Single intraovarian dose of stem cell– and platelet-secreted factors mitigates age-related ovarian infertility in a murine model

Systemic administration of soluble factors from bone marrow-derived stem cells combined with activated platelet-rich plasma (SC-PRP) restored ovarian function, mediated through paracrine signaling, in murine models of chemotherapy-induced ovarian damage and human tissue from poor responder patients. However, the effects against age-related infertility and the efficacy of local administration have not been evaluated yet. This study aimed to assess whether a single intraovarian dose of stem cells combined with activated platelet-rich plasma can recover ovarian function, oocyte quality, and developmental competence in older mice. The effects of stem cells combined with activated platelet-rich plasma against age-related infertility were assessed following controlled ovarian stimulation in an aging murine model reproducing 3 physiological stages of women's reproductive life, namely young, advanced maternal age, and menopausal (n=12 animals per group). Female mice were randomized to receive a single intraovarian injection (10 μL/ovary) of either saline, activated platelet-rich plasma, or stem cells combined with activated platelet-rich plasma. Seven days later, the mice were stimulated, naturally mated, and sacrificed to harvest their ovaries for histologic assessment and molecular analysis and their oviducts to evaluate oocyte maturation and to assess early embryo development. A single intraovarian injection of stem cells combined with activated platelet-rich plasma promoted follicle activation and development in young, advanced maternal age, and old mice. Furthermore, stem cells combined with activated platelet-rich plasma rescued fertility in older mice by enhancing the quantity and quality of ovulated mature oocytes and supporting early embryo development to the blastocyst stage in all the evaluated ages. These fertility outcomes were positively associated with mitochondrial quality, treatment-increased mitochondrial DNA copy numbers, and reduced oxidative damage and apoptosis. Finally, the effects observed by histologic analysis were supported at the proteomic level. Functional proteomic analyses revealed molecular mechanisms involved in oocyte maturation and quality, mitochondrial function, and recovery of the ovarian stroma. Bone marrow-derived stem cells combined with activated platelet-rich plasma is a promising treatment with the potential to improve the reproductive outcomes of women with age-related infertility, exceeding the restorative effects of platelet-rich plasma alone. Although further research in human ovarian samples is still required, the autologous nature of stem cell factors collected by noninvasive mobilization, their combination with platelet-rich plasma, and the local administration route suggest that stem cells combined with activated platelet-rich plasma treatment could be a potentially effective and safe application for future clinical practice.

Effectiveness of different behavioral interventions on gestational weight gain, post-partum weight retention and anthropometric measures in pregnancy: A randomized controlled trial.

Background: The antenatal and postnatal periods are critical stages in a woman's reproductive life. Many physical changes occur during pregnancy, such as water retention and excessive weight gain. The aim of the present study is to find out the effectiveness of various behavioral interventions during pregnancy to prevent excessive gestational weight gain (GWG) and postpartum weight retention (PPWR). Methods: In this parallel-group randomized controlled trial, 150 pregnant women with singleton pregnancy, aged 20-30 years, body mass index (BMI)≥18.5 kg/m2 and gestational age of less than 16 weeks were randomly allocated into five groups (N=30 in each group): Group A: Control; Group B: Supervised exercise; Group C: Pedometer; Group D: Text message; and Group E: Pedometer plus text message group. Group B received four supervised exercise sessions per month up to delivery; Groups C and E were urged to increase their levels of physical activity, focusing on pedometer-measured step counts of at least 5000-7500 steps per day on seven consecutive days each month. Group E along with group D also received standard SMS messages about physical activity, diet, motivation, and educational-specific topics. Results: The between-group comparisons revealed a statistically significant reduction in PPWR but insignificant difference in GWG. The greatest reduction in PPWR was found in the supervised exercise group (MD=3.25 kg, 95% CI: [1.75, 4.75], P=0.0001 with effect size (η2 )=0.155). Conclusion: The study found that the supervised exercise can be seen as an effective way of improving the physical activity level and reducing excessive PPWR in pregnant women.