Wise Way Research Articles

Computer-driven formulation development of Ginsenoside Rh2 ternary solid dispersion.

(20S)-Ginsenoside Rh2 is a natural saponin derived from Panax ginseng Meyer (P. ginseng), which showed significantly potent anticancer properties. However, its low water solubility and bioavailability strongly restrict its pharmaceutical applications. The aim of current research is to develop a modified (20S)-Ginsenoside Rh2 formulation with high solubility, dissolution rate and bioavailability by combined computational and experimental methodology. The "PharmSD" model was employed to predict the optimal polymer for (20S)-Ginsenoside Rh2 solid dispersion formulations. The solubility of (20S)-Ginsenoside Rh2 in various polymers was assessed, and the optimal ternary solid dispersion was evaluated across different dissolution mediums. Characterization techniques included the Powder X-ray diffraction (PXRD) and Fourier transform infrared spectroscopy (FTIR). Molecular dynamics simulations were employed to elucidate the formation mechanism of the solid dispersion and the interactions among active pharmaceutical ingredient (API) and excipient molecules. Cell and animal experiments were conducted to evaluate the in vivo performance of the modified formulation. The "PharmSD" solid dispersion model identified Gelucire 44/14 as the most effective polymer for enhancing the dissolution rate of Rh2. Subsequent experiment also confirmed that Gelucire 44/14 outperformed the other selected polymers. Moreover, the addition of the third component, sodium dodecyl sulfate (SDS), in the ternary solid dispersion formulation significantly amplified dissolution rates than the binary systems. Characterization experiments revealed that the API existed in an amorphous state and interacted via hydrogen bonding with SDS and Gelucire. Moreover, molecular modeling results provided additional evidence of hydrogen bonding interactions between the API and excipient molecules within the optimal ternary solid dispersion. Cell experiments demonstrated efflux ratio (EfR) of Rh2 ternary solid dispersion was lower than that of pure Rh2. In vivo experiments revealed that the modified formulation substantially improved the absorption of Rh2 in rats. Our research successfully developed an optimal ternary solid dispersion for Rh2 with high solubility, dissolution rate and bioavailability by integrated computational and experimental tools. The combination of Artificial Intelligence (AI) technology and molecular dynamics simulation is a wise way to support the future formulation development.

Anak Yang Takut Akan Tuhan Beroleh Harapan Masa Depan Yang Indah Amsal 23:15-18

In Proverbs 23:15-18, we are told that children who fear the Lord will have hope for a bright future. This means that when someone has a healthy fear of God, they will live in a righteous and wise way. They will respect their parents and follow God's teachings, which in turn will lead them in a good direction. A child who always listens to his parents' advice and follows their religious teachings. The child will grow up to be a responsible, honest and loving person. They will have confidence that their future will be good because they live according to the values ​​instilled by God. What is written in this verse is the importance of having a healthy fear of God in shaping a bright and hopeful future.

A process for Indigenous community research through meaningful engagement with Grandmother’s Bay

Historically, research partnerships between Indigenous communities and academic institutions were often harmful for communities; wise ways of achieving more balanced and just relationships are emerging. This project focuses on the research partnership between Grandmother’s Bay and the University of Saskatchewan with the objectives of providing knowledge on initiating Indigenous community-based research and maintaining good relationships between collaborators. One-on-one interviews were conducted with participants and analysed using etuaptmumk (two-eyed seeing), a thematic analysis approach. These themes indicated that research partnerships must proceed through relationships of trust that provide meaningful results and benefit to the community; that traditional approaches, culture, and intergenerational knowledge sharing are key to the research; effective communication and the Indigenous language are encouraged where possible; and ownership, creative design, and dissemination of the research belong to community. This project is the beginning of an ongoing relationship between Grandmother’s Bay and University of Saskatchewan.

경영학에서의 지혜(Managerial Wisdom) 연구에 대한 고찰: 아리스토텔레스의 철학과 기독교를 중심으로

Management goes beyond simply knowledge and information and must reflect various social demands such as ethics, leadership, and social responsibility in corporate management. Wisdom in management studies can be an alternative to the demands of the times in that it includes these elements. there is. In conceptualizing wisdom management, philosophy and Christianity are studies that present a perspective on the world through human exploration, so they provide excellent validity as materials that provide an academic foundation. From a philosophical perspective, the truth called theoretical knowledge and the activities called practical knowledge are all related in a causal relationship, and it is believed that happiness can be achieved only by pursuing both. This is the practice of the mean spoken by Socrates and Aristotle. From a philosophical perspective, the concept that wisdom can be known to pursue management as a practice of morality and ethics toward the public good through the realization of ignorance about oneself has the same direction as the practical aspect of wisdom management. Christian wisdom is also wisdom that humans obtain through long-term observation and practice between their own lives and the existence of God through Chokmah in the Old Testament. In business administration, this means that managers themselves recognize or reflect on their own ignorance. It is consistent with the ability to apply high-level knowledge along with existing management knowledge to the management field. It is accepted as an important practical element of wisdom to clearly recognize the wise way of life obtained through the relationship with God that Paul spoke of, to change oneself through practice, and to spread this good influence throughout the community. It is a very similar concept to practical knowledge, which is one of the characteristics of wisdom from a perspective.
 This study can be said to be of great significance in examining the wisdom of managers from a philosophical and Christian perspective and enabling it to be applied as practical wisdom to individual managers.

INTERPRETASI MAKNA SULHU DALAM PENYELESAIAN KASUS NUSYUZ SUAMI PERSPEKTIF TAFSIR

In Islamic law domestic conflict is referred to by the term nusyuz. The concept was taken from the Q.S. An-Nisa': 34 and 128. From this verse, when a comparison is made between the wife's nusyuz settlement and the husband, there is a difference in settlement pattern, both of which indicate discrimination against the wife. Therefore, it is necessary to examine the meaning of the sulhu in depth by interpreting the meaning of the sulhu in the settlement of the case from the nusyuz husband's interpretation perspective. This study used the content analysis method, a research technique to draw conclusions from legitimate data by considering the context. As for the results of this study, the reason for using the word "sulhu" in the settlement of the nusyuz husband is because it gives the parties freedom and opportunity to think about the best way to resolve their disputes even to cancel each other's rights from the latter, so that they can be able to do so. satisfying the parties to the dispute, bringing peace of mind and strengthening the bonds of friendship. In the settlement of the nusyuz wife according to the duties of a man in the family is as a leader who aims to protect and protect his family by educating and teaching it. As for the nusyuz husband, by way of sulhu (peace). Even when viewed from the asbabun-nuzul verse it is only one example of completion of the sulhu. Furthermore, the wife can also choose another way in order to benefit both. Which is essentially that sulhu is a very wise way for women to solve the nusyuz husband problem in the various ways they agree. It means that it is not true that sulhu makes women's position weak or there is discrimination against women, but sulhu is actually glorifying women themselves.

Using Website Health Information to Manage Children’s Asthma

Bronchial Asthma is a chronic inflammatory disorder of respiratory airways that affects loads of children worldwide. It is characterized by tightening of respiratory airways, making it hard to breathe. There is no curing treatment for asthma, but its management using medication and routine modifications can be achieved. The use of online information for bronchial asthma control was recently introduced and markedly being an emergent trend of parents to manage their asthmatic children. This research discovers the probable advantages and disadvantages of using online health information for asthma management in children. This work found that online health data can be a significant resource for parents of asthmatic children. It can offer correct information about the status of the patient, therapy choices, and lifestyle modifications that can aid to control manifestations. Online health data can also support parents' connection with other parents of asthmatic children and to discover support groups. However, the study also detected that there are some disadvantages related to the use of online health information in asthma pediatric patients. Parents may be exposed to incorrect or confusing data, and they may not be able to discriminate between dependable and untrustworthy sources. Moreover, parents may depend on online information and disregard consulting with their child's physician. Generally, this work proposes that online health data can be a useful method for parents of children with asthma. Though, it is vital to use this information in a wise way and keep consulting child's physician before choosing to make any modifications to a child's treatment strategy.

Membangun Ketahanan Pangan Ternak Unggas melalui Budidaya Larva Maggot di Desa Binong Pamarayan Kabupaten Serang

Purpose: The increase in population has an impact on the increase in waste and becomes environmental pollution. Waste management often offered, so we initiated the productivity of waste management in a wise way, including cultivating the Black Soldier Fly (BSF) maggot fly. Food security for livestock has become an important issue because food prices continue to skyrocket. Binong Village, Serang Regency, is a village assisted by Bina Bangsa University in processing organic waste for the cultivation of BSF maggot flies. Its advantages include being an alternative solution for processing vegetable/fruit waste naturally (does not contain chemicals) and reducing the burden of animal feed. Methodology: The research method is through an active participation approach (Participatory Action Research), namely the involvement of researchers with local communities in order to develop groups of potential breeders. Results: The results of BSF fly maggot cultivation have contributed to reducing the cost of animal feed production, and reducing food waste (vegetables/fruits) so that they can be developed into national livestock food security.

PAI Teachers' Perceptions of Humanist Literacy

The perception of humanist literacy is an individual's or society's understanding of concepts that focus on human aspects, such as tolerance, empathy, justice and human rights. Humanist literacy perceptions can help individuals or communities to understand and respond to social and humanitarian issues in a wiser way and encourage them to participate in life. This paper aims to analyze the perceptions of PAI teachers about humanist literacy. This study uses a qualitative approach with field research methods to uncover and collect research data through interview techniques and document studies. Through this research, results were found, namely teachers considered that with humanist literacy they could understand and appreciate cultural diversity, outlooks on life, and have the ability to think critically and reflectively on humanitarian and social issues.

Endogenous like sequence Rice Tungro Bacilliform Virus (RTBV) fragments in the local rice genome and its role in controlling tungro disease

Tungro disease is one of the important diseases in rice plants because it can cause a large decrease in production. Therefore, tungro disease needs to be controlled in wise ways that ensure environmental sustainability. This can be done by using resistant varieties, while also preventing rice from resistance to the green leafhopper vector Nepothettix virescens, the death of natural enemies, resurgence and emergence of secondary pests which become the main pests. The territory of Indonesia has many very diverse rice germ plasm which its resistance properties can be used to control tungro disease. Resistance genes are an effective control machine especially when combined with other control strategies. One of the triggers for the resistance of rice varieties is eRTBV, which is a group of RTBV nucleotides in rice DNA. The purpose of this study was to detect the presence of the eRTBV piece in the rice genome and its role in controlling tungro disease. The method used wasthe insilico method by comparing the eRTBV found in local rice varieties with that found in Genbank. The results indicated that endogenous RTBV was joined into the rice genome at 1200 bp using the primer eRTBV-7. Nucleotide blast results showed that the similarity of endogenous Indonesian local rice RTBV to endogenous RTBV in the genbank ranged between 95% and 99%, then protein blast results showed that the eRTBV fragment of local rice varieties contained ORF 3 RTBV protein with a range of similarity to the genbank of 66.9% and 93.35%. The role of eRTBV is to produce the Isoleucine protein motif which produces a physical, chemical and biochemical resistance system capable of inhibiting the green leafhopper virus vector (Nepothettix virescens) and the growth and development of tungro disease, RTBV.

Metal Music as a Medium of Da'wah Communication (Album “7:172” Band Purgatory)

Purgatory is a metal band from Jakarta that creates Music that contains a Message of da'wah in it. Purgatory released an album entitled "7:172" which describes describes the meaning of letters and verses in the holy book of the Quran. Some of the songs On the album have lyrics and diction that contain elements of Da'wah or conveying the teachings of the Islamic religion to the listener in a wise Way. This study Aims to find Out how the Communication effect of the album "7:172" Purgatory axle a medium of Communication for proselytizing. The Research uses a qualitative descriptive approach, Music Communication theory as the play theory and Da'wah Communication theory axle a Support axle Well axle Ferdinand De Saussure's Semiotic method. Data Collection techniques include observation, in-depth interviews, and documentation. The results showed that the Communication effect of several songs On the album "7:172" Purgatory discusses human Nature and Bad behavior, the importance of Modeling the Prophet Muhammad SAW, Criticism of those Who Want to Divide the Islamic ummah, and also the Feelings of a Person Who experiences regret for the Sins he tenderloin committed.

Pelatihan Internet Sebagai Media Informasi dan Komunikasi Untuk Meningkatkan Skill Keperawatan Siswa SMK

Citra Medika Sukoharjo Health Vocational School students live far from urban areas and the lack of attention from the local government in conducting outreach, guidance and internet training has made many students, especially those living in rural areas, less aware of the importance of using the internet in a positive way. Internet training as a medium of information and communication to improve nursing skills to be able to maximize the function of healthy information for good communication facilities. The development of technology, especially the internet has brought many changes. Thanks to the help of the internet, all work becomes light. Therefore training and guidance activities in the use of the internet really need to be done to remind and provide awareness for students how to use the internet in a wise way so that in the future their academic abilities and knowledge of the world of education and information will increase. This training will be explained in the form of a presentation using power point. The implementation of this training and guidance is expected that nursing students, especially at this school, are able to use the internet wisely and prudently in order to support efforts to develop civilized human resources who have the ability to compete globally, not only able to compete intellectually but also have good manners and behavior.

Transformative learning to promote transformative evaluation of food system praxis

Evaluation ideally plays an important role in determining the value and impact of community food system initiatives and movements, providing recommendations for informed decision-making, learning, and programmatic adjustments. Given that community food system work is characterized by critical praxis rooted in deconstructing dominant epistemologies and addressing social and systemic injustices—including discourses and practices from agroecology, food justice, and food sovereignty movements—simple, technical-rationalist approaches to evaluation are inadequate and inappropriate. In parallel with recent developments in critical food system work, the field of evaluation has evolved toward more critical and transformative approaches—including Culturally Responsive and Equitable Evaluation, indigenous evaluation, feminist evaluation, all generally regrouped within the framework of the transformative evaluation paradigm. At the nexus of these trends, to meet the rising demand for critical evaluative thinkers ready to grapple with the complex, dynamic, and contested questions of community food system praxis evaluation, there is a need to equip emerging evaluators with the requisite knowledge of evaluation approaches. To be ready to be critically reflective evaluators, in food system praxis and beyond, the next generation of emerging evaluators must engage fruitfully and in practically wise ways with the complex and contested aspects of critical food system work. Reflecting on the burgeoning literature on evaluator education and evaluation capacity building (ECB), and given the centrality of critical praxis and transformation in both food system work and evaluation alike, we posit that transformative learning theory has a potential role to play in preparing evaluators to meet these challenges. As such, the purpose of this conceptual paper is to highlight the intersections between critical evaluation approaches and critical food system praxis, and propose transformative learning theory as one way to help emerging evaluators prepare to meaningfully grasp and engage with the complexities manifest at this nexus of critical food evaluation praxis.

How to Scramble? A 'Wise Way' to Achieve a Useful Control Peptide Sequence

How to Scramble? A 'Wise Way' to Achieve a Useful Control Peptide Sequence

The attitudes of high school students and teachers toward mobile apps for learning English: A Q methodology study

This study aims to find out the attitudes of high school students and teachers toward mobile apps for learning English and how the opinions of the two groups relate to or differ from each other. As there is an E-learning trend worldwide, the findings of this research can help English learners gain a broader view of language learning, identify their own demands, and choose applications in a wiser way. Meanwhile, with the support of our findings, it is believed that application developers could review and polish the existing functions of their apps and develop new ones to meet the needs of student users. The research adopted the Q methodology to provide a more comprehensive understanding of the attitudes varied in different subjects. Interviews were conducted among students and teachers in Chinese high schools. Our study investigated three prominent opinions from the students and two from the teachers. PQMethod and Ken-Q Analysis were used for data analysis. Three factors of attitudes were found among students: 1) learning outcome-oriented; 2) function-oriented; 3) motivation-oriented. Two factors of attitudes were found among teachers: a) learning outcome-oriented; b) platform-oriented. This study is a new attempt to apply the Q methodology in related language research. Remarkably, the Q methodology offers comprehensive and deep insights into the subjective attitudes of students and teachers. Based on the findings, it is recommended that mobile application developers attach more importance to the achievement and encouragement of students in the design; students should take advantage of the mobile apps to achieve their expected outcome under the suggestions from their teachers; English learning apps can be promoted as a helpful auxiliary tool for language learning.

Hybrid Multi-Criteria Decision-Making for Marine SOx Scrubber Systems

This paper aims to identify the best solution for three SOx scrubber systems by evaluating their economic, environmental and technical performances: open-loop, closed-loop and hybrid scrubber systems. It adopted a novel muti-criteria decision-making model which can be introduced as the combination of lifecycle cost and lifecycle assessments, and fuzzy-TOPSIS and fuzzy-AHP. The analysis results of the case study of 72,100 gross-ton cargo ships suggested that the closed-loop scrubber systems would be the most effective in the consideration of all of the aspects, overall. It also shows the excellence of the proposed decision-making model to remedy the shortcomings of the conventional multi-criteria decision-making process by directing the analytic process in a wiser way, by means of fuzzy elements. For the environmental impact assessment, the lifecycle assessment approach enables one to obtain a holistic view of the Lifecycle emissions from the cradle to the grave. This paper finally shows the effectiveness of the proposed method, which can improve confidence in decision-making by extending a short-term view widely. Therefore, it was strongly believed that the proposed model is not necessarily/limitedly applied to marine systems but can be broad and noteworthy for a variety of studies requiring appropriate decision-making.

Windowish Practices, Unreadable Backgrounds and Raw Semiotics. Tracing Minor Architectures and Ecologies of Signs in Women’s Writing

Minor architectures can be defined as an open set of spatial practices and know-hows based on the agency of bodies. While these practices escape representation, codification or measurement, they have a fertile relation with literature. After framing this relationship, we analyze the work of three women writers (Carmen Martín Gaite, Ali Smith and Toni Morrison) to unveil them as minor spatial and material practitioners. While they have not been trained as architects many women throughout history have practiced and organized space in meaningful and wise ways, and they have become aware of minor spatial knowledges resting at the core of what architecture can be (and do). By inventing forms of embodied writing and material inscription, they have expanded a minor repertoire of spatial practices.

Isoniazid in Children – Any Rationale for Post Isoniazid Liver Function Test?

Isoniazid (INH) therapy remains the treatment of choice in latent tuberculosis infection (LTBI). However, drug-induced liver injury (DILI) is a known adverse effect of isoniazid. Serum transaminase elevation occurs in about 10% of children receiving INH monotherapy. Drug-induced liver injury can range from asymptomatic increase of aminotransferase to severe liver injury, or in some cases hepatic failure. Even though INH-induced liver injury has been known and extensively studied, its underlying mechanisms are still not fully understood. The liver injury comprises hepatotoxicity and a rarer form of hepatitis hypersensitive allergic reaction. Since the facility to do liver function (LFT) is widely available, monitoring liver function while on INH therapy is the wisest way of monitoring acute liver injury (ATLI).

The skillful living in the Zhuangzi, Buddhism, and Stoicism

ABSTRACT The significant role of skill in Zhuangzi’s good life has been argued by most Zhuangzi scholars. However, there is ongoing debate concerning the psychological and behavioral mechanisms that underwrite the skillful activity and the way it contributes to a good life. Based on previous research, this paper makes a comparative study between Buddhism, Daoism, and Stoicism. The aim is to prove that practical wisdom, which involves both reflection and spontaneity, plays a helpful role in understanding Zhuangzian skillful activity by connecting skilled performance to the wise way of living. Importantly, this can be compared to the Buddhist teachings of skillful (kusala) action and skillful means (upāya) as well as the Stoic account of skill (technē) and art of life. A three-way comparison shows that skillful activity is deeply bound up with practical wisdom in the three traditions, which enables one to act appropriately and live skillfully.

The Role of Wisdom in the Cross-Cultural Adaptation of Chinese Visiting Scholars to Canada: A Mediation Model.

This study examines the role of wisdom in the cross-cultural adaptation of Chinese visiting scholars in Canada, as mediated by different coping styles. Path analysis was used to for hypotheses testing. The findings suggest that (1) wisdom measured by 3D-WS and Adult Self-Transcendence Inventory (ASTI), independently had direct correlation with social and psychological adaptation, and positively associated with engaged coping (active coping and proactive–reflective coping); (2) the independent effects of 3D-WS and ASTI on social adaptation, psychological adaptation, and life satisfaction were mediated by proactive–reflective coping; (3) wisdom, when measured by 3D-WS, promoted positive psychological adaptation through decreasing passive coping. This study shows that wisdom is a critical factor affecting cross-cultural adaptation, and the use of proactive–reflective coping is a wise way of handling future life challenges.

Using Negative Ideas as a Tool to Maximize Positive Influence in Trust Social Networks

Influence Maximization (IM) is the problem of finding k influential nodes in a network to increase the spread or influence of a specific matter. It has been an amazing topic through recent years. Later studies proposed algorithms and heuristics to either accelerate seed selection process or introduce new diffusion models. Two of important aspects in diffusion are trust and time. There have been several studies in either aspect, but to our best knowledge there is a great lack in considering both time and trust together in articles. Still one other important problem is the propagation of negative ideas. It is obvious that we cannot neglect this type of effects and must find a way to reduce it or “USE” it in a wise way. We chose to use this effect against their selves and maximize the positive effect. In addition, we considered time constraint to better sculpt the real world in our diffusion model. We used a greedy based framework to select seed nodes. By utilizing an approximation for marginal influence, the seed selection process is accelerated. Comparing with other related methods, results show the superiority of our proposed method while dealing with two important and complex matters.